2ef6 - Revision history

OCA at 08:39, 25 October 2023

OCA — Wed, 25 Oct 2023 08:39:12 GMT

←Older revision		Revision as of 08:39, 25 October 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:~~MANGANESE+(II)+ION~~'>MN</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-MANNOSE'>~~MAN~~</scene>, <scene name='pdbligand=~~MMA~~:~~O1-METHYL-MANNOSE~~'>~~MMA~~</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [https://pdbe.org/2ef6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ef6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ef6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [https://pdbe.org/2ef6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ef6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ef6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL]] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref>	+	[https://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 38:
	[[Category: Canavalia gladiata]]		[[Category: Canavalia gladiata]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Azevedo, W F.de]]~~	+	[[Category: Benevides RG]]
-	[[Category: Benevides~~, R G~~]]	+	[[Category: Bezerra GA]]
-	[[Category: Bezerra~~, G A~~]]	+	[[Category: Cavada BS]]
-	[[Category: Cavada~~, B S~~]]	+	[[Category: Delatorre P]]
-	[[Category: Delatorre, P]]	+	[[Category: Moreno FBMB]]
-	[[Category: Moreno~~, F B.M B~~]]	+	[[Category: Oliveira TM]]
-	[[Category: Oliveira~~, T M~~]]	+	[[Category: Da Rocha BAM]]
-	[[Category: Rocha~~, B A.M da~~]]	+	[[Category: De Azevedo Jr WF]]
-	[[Category: ~~Souza, E P.de~~]]	+	[[Category: De Souza EP]]
-	[[Category: ~~Dimannoside]]~~	+
-	~~[[Category: Lectin]]~~	+
-	~~[[Category: Plant protein]]~~	+
-	~~[[Category: Seed~~]]	+

OCA at 09:50, 5 May 2021

OCA — Wed, 05 May 2021 09:50:26 GMT

←Older revision		Revision as of 09:50, 5 May 2021
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	<StructureSection load='2ef6' size='340' side='right'caption='[[2ef6]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2ef6' size='340' side='right'caption='[[2ef6]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Cangl Cangl~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=~~MDM~~:~~METHYL-O3-~~(~~ALPHA-D-MANNOSE~~)-ALPHA-D-MANNOSE'>~~MDM~~</scene>, <scene name='pdbligand=MN:~~MANGANESE+(II)+ION~~'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [~~http~~://pdbe.org/2ef6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ef6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ef6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [https://pdbe.org/2ef6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ef6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ef6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL]] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref>	+	[[https://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL]] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cangl~~]]	+	[[Category: Canavalia gladiata]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Azevedo, W F.de]]		[[Category: Azevedo, W F.de]]
Line 46:		Line 46:
	[[Category: Rocha, B A.M da]]		[[Category: Rocha, B A.M da]]
	[[Category: Souza, E P.de]]		[[Category: Souza, E P.de]]
-	[[Category: Canavalia gladiata]]
	[[Category: Dimannoside]]		[[Category: Dimannoside]]
	[[Category: Lectin]]		[[Category: Lectin]]
	[[Category: Plant protein]]		[[Category: Plant protein]]
	[[Category: Seed]]		[[Category: Seed]]

OCA at 09:32, 24 July 2019

OCA — Wed, 24 Jul 2019 09:32:23 GMT

←Older revision		Revision as of 09:32, 24 July 2019
Line 1:		Line 1:

	==Canavalia gladiata lectin complexed with Man1-3Man-OMe==		==Canavalia gladiata lectin complexed with Man1-3Man-OMe==
-	<StructureSection load='2ef6' size='340' side='right' caption='[[2ef6]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2ef6' size='340' side='right'caption='[[2ef6]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cangl Cangl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cangl Cangl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/2ef6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/2ef6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2ef6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2ef6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Concanavalin 3D structures\|Concanavalin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Cangl]]		[[Category: Cangl]]
		+	[[Category: Large Structures]]
	[[Category: Azevedo, W F.de]]		[[Category: Azevedo, W F.de]]
	[[Category: Benevides, R G]]		[[Category: Benevides, R G]]

OCA at 09:43, 12 October 2017

OCA — Thu, 12 Oct 2017 09:43:24 GMT

←Older revision		Revision as of 09:43, 12 October 2017
Line 3:		Line 3:
	<StructureSection load='2ef6' size='340' side='right' caption='[[2ef6]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2ef6' size='340' side='right' caption='[[2ef6]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Canavalia_gladiata Canavalia gladiata~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cangl Cangl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MDM:METHYL-O3-(ALPHA-D-MANNOSE)-ALPHA-D-MANNOSE'>MDM</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MDM:METHYL-O3-(ALPHA-D-MANNOSE)-ALPHA-D-MANNOSE'>MDM</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [http://pdbe.org/2ef6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [http://www.ebi.ac.uk/pdbsum/2ef6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ef6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [http://pdbe.org/2ef6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [http://www.ebi.ac.uk/pdbsum/2ef6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ef6 ProSAT]</span></td></tr>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2ef6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2ef6" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Concanavalin A\|Concanavalin A]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Canavalia gladiata~~]]	+	[[Category: Cangl]]
	[[Category: Azevedo, W F.de]]		[[Category: Azevedo, W F.de]]
	[[Category: Benevides, R G]]		[[Category: Benevides, R G]]
Line 45:		Line 42:
	[[Category: Rocha, B A.M da]]		[[Category: Rocha, B A.M da]]
	[[Category: Souza, E P.de]]		[[Category: Souza, E P.de]]
		+	[[Category: Canavalia gladiata]]
	[[Category: Dimannoside]]		[[Category: Dimannoside]]
	[[Category: Lectin]]		[[Category: Lectin]]
	[[Category: Plant protein]]		[[Category: Plant protein]]
	[[Category: Seed]]		[[Category: Seed]]

OCA at 09:46, 3 August 2017

OCA — Thu, 03 Aug 2017 09:46:08 GMT

←Older revision		Revision as of 09:46, 3 August 2017
Line 1:		Line 1:
		+
	==Canavalia gladiata lectin complexed with Man1-3Man-OMe==		==Canavalia gladiata lectin complexed with Man1-3Man-OMe==
	<StructureSection load='2ef6' size='340' side='right' caption='[[2ef6]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2ef6' size='340' side='right' caption='[[2ef6]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MDM:METHYL-O3-(ALPHA-D-MANNOSE)-ALPHA-D-MANNOSE'>MDM</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MDM:METHYL-O3-(ALPHA-D-MANNOSE)-ALPHA-D-MANNOSE'>MDM</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [http://pdbe.org/2ef6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [http://www.ebi.ac.uk/pdbsum/2ef6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [http://pdbe.org/2ef6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [http://www.ebi.ac.uk/pdbsum/2ef6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ef6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 19:40, 7 February 2016

OCA — Sun, 07 Feb 2016 19:40:08 GMT

←Older revision		Revision as of 19:40, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ef6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:25, 10 September 2015

OCA — Thu, 10 Sep 2015 04:25:40 GMT

←Older revision		Revision as of 04:25, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MDM:METHYL-O3-(ALPHA-D-MANNOSE)-ALPHA-D-MANNOSE'>MDM</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MDM:METHYL-O3-(ALPHA-D-MANNOSE)-ALPHA-D-MANNOSE'>MDM</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [http://www.ebi.ac.uk/pdbsum/2ef6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [http://pdbe.org/2ef6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [http://www.ebi.ac.uk/pdbsum/2ef6 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ef6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:46, 24 December 2014

OCA — Wed, 24 Dec 2014 17:46:58 GMT

←Older revision		Revision as of 17:46, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MDM:METHYL-O3-(ALPHA-D-MANNOSE)-ALPHA-D-MANNOSE'>MDM</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MDM:METHYL-O3-(ALPHA-D-MANNOSE)-ALPHA-D-MANNOSE'>MDM</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [http://www.ebi.ac.uk/pdbsum/2ef6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [http://www.ebi.ac.uk/pdbsum/2ef6 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL]] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Canavalia gladiata]]		[[Category: Canavalia gladiata]]
-	[[Category: Azevedo, W F.de.]]	+	[[Category: Azevedo, W F.de]]
-	[[Category: Benevides, R G.]]	+	[[Category: Benevides, R G]]
-	[[Category: Bezerra, G A.]]	+	[[Category: Bezerra, G A]]
-	[[Category: Cavada, B S.]]	+	[[Category: Cavada, B S]]
-	[[Category: Delatorre, P.]]	+	[[Category: Delatorre, P]]
-	[[Category: Moreno, F B.M B.]]	+	[[Category: Moreno, F B.M B]]
-	[[Category: Oliveira, T M.]]	+	[[Category: Oliveira, T M]]
-	[[Category: Rocha, B A.M da.]]	+	[[Category: Rocha, B A.M da]]
-	[[Category: Souza, E P.de~~.]]~~	+	[[Category: Souza, E P.de]]
-	~~[[Category: Canavalia gladiata~~]]	+
	[[Category: Dimannoside]]		[[Category: Dimannoside]]
	[[Category: Lectin]]		[[Category: Lectin]]
	[[Category: Plant protein]]		[[Category: Plant protein]]
	[[Category: Seed]]		[[Category: Seed]]

OCA at 02:37, 29 September 2014

OCA — Mon, 29 Sep 2014 02:37:39 GMT

←Older revision		Revision as of 02:37, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2ef6.~~png\|left~~\|200px]]	+	==Canavalia gladiata lectin complexed with Man1-3Man-OMe==
		+	<StructureSection load='2ef6' size='340' side='right' caption='[[2ef6]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EF6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MDM:METHYL-O3-(ALPHA-D-MANNOSE)-ALPHA-D-MANNOSE'>MDM</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [http://www.ebi.ac.uk/pdbsum/2ef6 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/2ef6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plant lectins, especially those purified from species of the Leguminosae family, represent the best studied group of carbohydrate-binding proteins. The legume lectins from Diocleinae subtribe are highly similar proteins that present significant differences in the potency/efficacy of their biological activities. The structural studies of the interactions between lectins and sugars may clarify the origin of the distinct biological activities observed in this high similar class of proteins. In this way, this work presents a crystallographic study of the ConM and CGL (agglutinins from Canavalia maritima and Canavalia gladiata, respectively) in the following complexes: ConM/CGL:Man(alpha1-2)Man(alpha1-O)Me, ConM/CGL:Man(alpha1-3)Man(alpha1-O)Me and ConM/CGL:Man(alpha1-4)Man(alpha1-O)Me, which crystallized in different conditions and space group from the native proteins. The structures were solved by molecular replacement, presenting satisfactory values for R(factor) and R(free). Comparisons between ConM, CGL and ConA (Canavalia ensiformis lectin) binding mode with the dimannosides in subject, presented different interactions patterns, which may account for a structural explanation of the distincts biological properties observed in the lectins of Diocleinae subtribe.

-	~~{{STRUCTURE_2ef6\| PDB=2ef6 \| SCENE= }}~~	+	Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: new insights into the understanding of the structure-biological activity relationship in legume lectins.,Bezerra GA, Oliveira TM, Moreno FB, de Souza EP, da Rocha BA, Benevides RG, Delatorre P, de Azevedo WF Jr, Cavada BS J Struct Biol. 2007 Nov;160(2):168-76. Epub 2007 Aug 16. PMID:17881248<ref>PMID:17881248</ref>

-	~~===Canavalia gladiata lectin complexed with Man1-3Man-OMe===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17881248}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2ef6]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Canavalia_gladiata Canavalia gladiata]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA].~~	+

	==See Also==		==See Also==
	*[[Concanavalin A\|Concanavalin A]]		*[[Concanavalin A\|Concanavalin A]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017881248<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Canavalia gladiata]]		[[Category: Canavalia gladiata]]
	[[Category: Azevedo, W F.de.]]		[[Category: Azevedo, W F.de.]]

OCA at 07:39, 20 October 2012

OCA — Sat, 20 Oct 2012 07:39:53 GMT

←Older revision		Revision as of 07:39, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2ef6]] is a 4 chain structure ~~of [[Concanavalin A]]~~ with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA].	+	[[2ef6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA].

	==See Also==		==See Also==