2ela - Revision history

OCA at 13:50, 13 March 2024

OCA — Wed, 13 Mar 2024 13:50:00 GMT

←Older revision		Revision as of 13:50, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='2ela' size='340' side='right'caption='[[2ela]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2ela' size='340' side='right'caption='[[2ela]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ela]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ELA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ela]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ELA FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~2elb~~\|~~2elb~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ela FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ela OCA], [https://pdbe.org/2ela PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ela RCSB], [https://www.ebi.ac.uk/pdbsum/2ela PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ela ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ela FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ela OCA], [https://pdbe.org/2ela PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ela RCSB], [https://www.ebi.ac.uk/pdbsum/2ela PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ela ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DP13A_HUMAN DP13A_HUMAN]] Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:10490823</ref> <ref>PMID:15016378</ref>	+	[https://www.uniprot.org/uniprot/DP13A_HUMAN DP13A_HUMAN] Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:10490823</ref> <ref>PMID:15016378</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ela ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ela ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	APPL1 interacts with adiponectin receptors and other important signaling molecules. It contains a BAR and a PH domain near its N terminus, and the two domains may function as a unit (BAR-PH domain). We report here the crystal structures of the BAR-PH and PTB domains of human APPL1. The structures reveal novel features for BAR domain dimerization and for the interactions between the BAR and PH domains. The BAR domain dimer of APPL1 contains two four-helical bundles, whereas other BAR domain dimers have only three helices in each bundle. The PH domain is located at the opposite ends of the BAR domain dimer. Yeast two-hybrid assays confirm the interactions between the BAR and PH domains. Lipid binding assays show that the BAR, PH, and PTB domains can bind phospholipids. The ability of APPL1 to interact with multiple signaling molecules and phospholipids supports an important role for this adaptor in cell signaling.
-
-	Crystal structures of the BAR-PH and PTB domains of human APPL1.,Li J, Mao X, Dong LQ, Liu F, Tong L Structure. 2007 May;15(5):525-33. PMID:17502098<ref>PMID:17502098</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2ela" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dong~~, L Q~~]]	+	[[Category: Dong LQ]]
-	[[Category: Li, J]]	+	[[Category: Li J]]
-	[[Category: Liu, F]]	+	[[Category: Liu F]]
-	[[Category: Mao, X]]	+	[[Category: Mao X]]
-	[[Category: Tong, L]]	+	[[Category: Tong L]]
-	~~[[Category: Appl]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Ptb domain~~]]	+

OCA at 17:25, 15 December 2021

OCA — Wed, 15 Dec 2021 17:25:37 GMT

←Older revision		Revision as of 17:25, 15 December 2021
Line 3:		Line 3:
	<StructureSection load='2ela' size='340' side='right'caption='[[2ela]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2ela' size='340' side='right'caption='[[2ela]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ela]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ELA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ela]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ELA FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2elb\|2elb]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2elb\|2elb]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ela FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ela OCA], [~~http~~://pdbe.org/2ela PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ela RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ela PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ela ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ela FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ela OCA], [https://pdbe.org/2ela PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ela RCSB], [https://www.ebi.ac.uk/pdbsum/2ela PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ela ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DP13A_HUMAN DP13A_HUMAN]] Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:10490823</ref> <ref>PMID:15016378</ref>	+	[[https://www.uniprot.org/uniprot/DP13A_HUMAN DP13A_HUMAN]] Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:10490823</ref> <ref>PMID:15016378</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:34, 11 March 2020

OCA — Wed, 11 Mar 2020 08:34:54 GMT

←Older revision		Revision as of 08:34, 11 March 2020
Line 1:		Line 1:

	==Crystal Structure of the PTB domain of human APPL1==		==Crystal Structure of the PTB domain of human APPL1==
-	<StructureSection load='2ela' size='340' side='right' caption='[[2ela]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2ela' size='340' side='right'caption='[[2ela]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ela]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ela]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELA FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dong, L Q]]		[[Category: Dong, L Q]]
	[[Category: Li, J]]		[[Category: Li, J]]

OCA at 06:56, 6 June 2018

OCA — Wed, 06 Jun 2018 06:56:55 GMT

←Older revision		Revision as of 06:56, 6 June 2018
Line 1:		Line 1:
		+
	==Crystal Structure of the PTB domain of human APPL1==		==Crystal Structure of the PTB domain of human APPL1==
	<StructureSection load='2ela' size='340' side='right' caption='[[2ela]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2ela' size='340' side='right' caption='[[2ela]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2ela]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ela]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELA FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2elb\|2elb]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2elb\|2elb]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ela FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ela OCA], [http://pdbe.org/2ela PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ela RCSB], [http://www.ebi.ac.uk/pdbsum/2ela PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ela FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ela OCA], [http://pdbe.org/2ela PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ela RCSB], [http://www.ebi.ac.uk/pdbsum/2ela PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ela ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/2ela_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/2ela_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ela ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:17, 11 September 2015

OCA — Fri, 11 Sep 2015 12:17:00 GMT

←Older revision		Revision as of 12:17, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2ela' size='340' side='right' caption='[[2ela]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2ela' size='340' side='right' caption='[[2ela]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ela]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ela]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELA FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2elb\|2elb]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2elb\|2elb]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ela FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ela OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ela RCSB], [http://www.ebi.ac.uk/pdbsum/2ela PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ela FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ela OCA], [http://pdbe.org/2ela PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ela RCSB], [http://www.ebi.ac.uk/pdbsum/2ela PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ela" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dong, L Q]]		[[Category: Dong, L Q]]
	[[Category: Li, J]]		[[Category: Li, J]]

OCA at 16:20, 25 December 2014

OCA — Thu, 25 Dec 2014 16:20:06 GMT

←Older revision		Revision as of 16:20, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ela]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ela]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELA FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2elb\|2elb]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2elb\|2elb]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ela FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ela OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ela RCSB], [http://www.ebi.ac.uk/pdbsum/2ela PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ela FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ela OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ela RCSB], [http://www.ebi.ac.uk/pdbsum/2ela PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DP13A_HUMAN DP13A_HUMAN]] Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:10490823</ref> <ref>PMID:15016378</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dong, L Q.]]	+	[[Category: Dong, L Q]]
-	[[Category: Li, J.]]	+	[[Category: Li, J]]
-	[[Category: Liu, F.]]	+	[[Category: Liu, F]]
-	[[Category: Mao, X.]]	+	[[Category: Mao, X]]
-	[[Category: Tong, L.]]	+	[[Category: Tong, L]]
	[[Category: Appl]]		[[Category: Appl]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Ptb domain]]		[[Category: Ptb domain]]

OCA at 01:57, 30 September 2014

OCA — Tue, 30 Sep 2014 01:57:27 GMT

←Older revision		Revision as of 01:57, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2ela.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the PTB domain of human APPL1==
		+	<StructureSection load='2ela' size='340' side='right' caption='[[2ela]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ela]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELA FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2elb\|2elb]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ela FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ela OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ela RCSB], [http://www.ebi.ac.uk/pdbsum/2ela PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/2ela_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	APPL1 interacts with adiponectin receptors and other important signaling molecules. It contains a BAR and a PH domain near its N terminus, and the two domains may function as a unit (BAR-PH domain). We report here the crystal structures of the BAR-PH and PTB domains of human APPL1. The structures reveal novel features for BAR domain dimerization and for the interactions between the BAR and PH domains. The BAR domain dimer of APPL1 contains two four-helical bundles, whereas other BAR domain dimers have only three helices in each bundle. The PH domain is located at the opposite ends of the BAR domain dimer. Yeast two-hybrid assays confirm the interactions between the BAR and PH domains. Lipid binding assays show that the BAR, PH, and PTB domains can bind phospholipids. The ability of APPL1 to interact with multiple signaling molecules and phospholipids supports an important role for this adaptor in cell signaling.

-	~~{{STRUCTURE_2ela\| PDB=2ela \| SCENE= }}~~	+	Crystal structures of the BAR-PH and PTB domains of human APPL1.,Li J, Mao X, Dong LQ, Liu F, Tong L Structure. 2007 May;15(5):525-33. PMID:17502098<ref>PMID:17502098</ref>

-	~~===Crystal Structure~~ of the ~~PTB domain of human APPL1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17502098}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2ela]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017502098<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dong, L Q.]]		[[Category: Dong, L Q.]]

OCA: Protected "2ela" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 11:10:57 GMT

Protected "2ela" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:10, 6 January 2013

OCA at 11:10, 6 January 2013

OCA — Sun, 06 Jan 2013 11:10:54 GMT

←Older revision		Revision as of 11:10, 6 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2ela.png\|left\|200px]]		[[Image:2ela.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ela", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2ela\| PDB=2ela \| SCENE= }}		{{STRUCTURE_2ela\| PDB=2ela \| SCENE= }}

	===Crystal Structure of the PTB domain of human APPL1===		===Crystal Structure of the PTB domain of human APPL1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17502098}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17502098 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17502098}}		{{ABSTRACT_PUBMED_17502098}}

	==About this Structure==		==About this Structure==
-	~~2ELA~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA].	+	[[2ela]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELA OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17502098~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017502098</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dong, L Q.]]		[[Category: Dong, L Q.]]
Line 33:		Line 21:
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Ptb domain]]		[[Category: Ptb domain]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 19 08:16:53 2009''

OCA at 05:16, 19 April 2009

OCA — Sun, 19 Apr 2009 05:16:54 GMT

←Older revision		Revision as of 05:16, 19 April 2009
Line 31:		Line 31:
	[[Category: Tong, L.]]		[[Category: Tong, L.]]
	[[Category: Appl]]		[[Category: Appl]]
		+	[[Category: Cell cycle]]
	[[Category: Ptb domain]]		[[Category: Ptb domain]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Feb 17 21~~:35:21 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 19 08:16:53 2009''