2emt - Revision history

OCA at 08:42, 25 October 2023

OCA — Wed, 25 Oct 2023 08:42:52 GMT

←Older revision		Revision as of 08:42, 25 October 2023
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	<StructureSection load='2emt' size='340' side='right'caption='[[2emt]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2emt' size='340' side='right'caption='[[2emt]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2emt]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EMT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2emt]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EMT FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1j19\|1j19]]~~, [[~~1gc6~~\|~~1gc6~~]]~~, [[1gc7\|1gc7]], [[2d11\|2d11]], [[2d10\|2d10]], [[2d2q\|2d2q]], [[2ems\|2ems]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2emt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2emt OCA], [https://pdbe.org/2emt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2emt RCSB], [https://www.ebi.ac.uk/pdbsum/2emt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2emt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2emt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2emt OCA], [https://pdbe.org/2emt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2emt RCSB], [https://www.ebi.ac.uk/pdbsum/2emt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2emt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RADI_MOUSE RADI_MOUSE]] Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. [[https://www.uniprot.org/uniprot/SELPL_MOUSE SELPL_MOUSE]] A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture.<ref>PMID:11104809</ref> <ref>PMID:12370362</ref> <ref>PMID:17442598</ref>	+	[https://www.uniprot.org/uniprot/RADI_MOUSE RADI_MOUSE] Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Hakoshima, T]]	+	[[Category: Hakoshima T]]
-	[[Category: Kitano, K]]	+	[[Category: Kitano K]]
-	[[Category: Maesaki, R]]	+	[[Category: Maesaki R]]
-	[[Category: Takai, Y]]	+	[[Category: Takai Y]]
-	[[Category: Terawaki, S]]	+	[[Category: Terawaki S]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Protein-peptide complex~~]]	+

OCA at 09:50, 5 May 2021

OCA — Wed, 05 May 2021 09:50:43 GMT

←Older revision		Revision as of 09:50, 5 May 2021
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	<StructureSection load='2emt' size='340' side='right'caption='[[2emt]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2emt' size='340' side='right'caption='[[2emt]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2emt]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EMT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2EMT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2emt]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EMT FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j19\|1j19]], [[1gc6\|1gc6]], [[1gc7\|1gc7]], [[2d11\|2d11]], [[2d10\|2d10]], [[2d2q\|2d2q]], [[2ems\|2ems]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j19\|1j19]], [[1gc6\|1gc6]], [[1gc7\|1gc7]], [[2d11\|2d11]], [[2d10\|2d10]], [[2d2q\|2d2q]], [[2ems\|2ems]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2emt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2emt OCA], [~~http~~://pdbe.org/2emt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2emt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2emt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2emt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2emt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2emt OCA], [https://pdbe.org/2emt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2emt RCSB], [https://www.ebi.ac.uk/pdbsum/2emt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2emt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RADI_MOUSE RADI_MOUSE]] Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. [[~~http~~://www.uniprot.org/uniprot/SELPL_MOUSE SELPL_MOUSE]] A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture.<ref>PMID:11104809</ref> <ref>PMID:12370362</ref> <ref>PMID:17442598</ref>	+	[[https://www.uniprot.org/uniprot/RADI_MOUSE RADI_MOUSE]] Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. [[https://www.uniprot.org/uniprot/SELPL_MOUSE SELPL_MOUSE]] A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture.<ref>PMID:11104809</ref> <ref>PMID:12370362</ref> <ref>PMID:17442598</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:19, 24 July 2019

OCA — Wed, 24 Jul 2019 09:19:58 GMT

←Older revision		Revision as of 09:19, 24 July 2019
Line 1:		Line 1:

	==Crystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule PSGL-1==		==Crystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule PSGL-1==
-	<StructureSection load='2emt' size='340' side='right' caption='[[2emt]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='2emt' size='340' side='right'caption='[[2emt]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2emt]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EMT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2emt]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EMT FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/2emt_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/2emt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2emt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2emt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Radixin\|Radixin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Hakoshima, T]]		[[Category: Hakoshima, T]]

OCA at 15:50, 12 October 2017

OCA — Thu, 12 Oct 2017 15:50:52 GMT

←Older revision		Revision as of 15:50, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule PSGL-1==		==Crystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule PSGL-1==
	<StructureSection load='2emt' size='340' side='right' caption='[[2emt]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2emt' size='340' side='right' caption='[[2emt]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2emt]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EMT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2emt]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EMT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j19\|1j19]], [[1gc6\|1gc6]], [[1gc7\|1gc7]], [[2d11\|2d11]], [[2d10\|2d10]], [[2d2q\|2d2q]], [[2ems\|2ems]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j19\|1j19]], [[1gc6\|1gc6]], [[1gc7\|1gc7]], [[2d11\|2d11]], [[2d10\|2d10]], [[2d2q\|2d2q]], [[2ems\|2ems]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2emt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2emt OCA], [http://pdbe.org/2emt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2emt RCSB], [http://www.ebi.ac.uk/pdbsum/2emt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2emt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2emt OCA], [http://pdbe.org/2emt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2emt RCSB], [http://www.ebi.ac.uk/pdbsum/2emt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2emt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 01:00, 8 February 2016

OCA — Mon, 08 Feb 2016 01:00:02 GMT

←Older revision		Revision as of 01:00, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2emt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:24, 10 September 2015

OCA — Thu, 10 Sep 2015 06:24:58 GMT

←Older revision		Revision as of 06:24, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2emt' size='340' side='right' caption='[[2emt]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2emt' size='340' side='right' caption='[[2emt]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2emt]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EMT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2emt]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EMT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j19\|1j19]], [[1gc6\|1gc6]], [[1gc7\|1gc7]], [[2d11\|2d11]], [[2d10\|2d10]], [[2d2q\|2d2q]], [[2ems\|2ems]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j19\|1j19]], [[1gc6\|1gc6]], [[1gc7\|1gc7]], [[2d11\|2d11]], [[2d10\|2d10]], [[2d2q\|2d2q]], [[2ems\|2ems]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2emt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2emt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2emt RCSB], [http://www.ebi.ac.uk/pdbsum/2emt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2emt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2emt OCA], [http://pdbe.org/2emt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2emt RCSB], [http://www.ebi.ac.uk/pdbsum/2emt PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2emt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Hakoshima, T]]		[[Category: Hakoshima, T]]
	[[Category: Kitano, K]]		[[Category: Kitano, K]]

OCA at 19:25, 24 December 2014

OCA — Wed, 24 Dec 2014 19:25:14 GMT

←Older revision		Revision as of 19:25, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2emt]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EMT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2emt]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EMT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j19\|1j19]], [[1gc6\|1gc6]], [[1gc7\|1gc7]], [[2d11\|2d11]], [[2d10\|2d10]], [[2d2q\|2d2q]], [[2ems\|2ems]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j19\|1j19]], [[1gc6\|1gc6]], [[1gc7\|1gc7]], [[2d11\|2d11]], [[2d10\|2d10]], [[2d2q\|2d2q]], [[2ems\|2ems]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2emt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2emt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2emt RCSB], [http://www.ebi.ac.uk/pdbsum/2emt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2emt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2emt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2emt RCSB], [http://www.ebi.ac.uk/pdbsum/2emt PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RADI_MOUSE RADI_MOUSE]] Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. [[http://www.uniprot.org/uniprot/SELPL_MOUSE SELPL_MOUSE]] A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture.<ref>PMID:11104809</ref> <ref>PMID:12370362</ref> <ref>PMID:17442598</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Hakoshima, T.]]	+	[[Category: Hakoshima, T]]
-	[[Category: Kitano, K.]]	+	[[Category: Kitano, K]]
-	[[Category: Maesaki, R.]]	+	[[Category: Maesaki, R]]
-	[[Category: Takai, Y.]]	+	[[Category: Takai, Y]]
-	[[Category: Terawaki, S.]]	+	[[Category: Terawaki, S]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Protein-peptide complex]]		[[Category: Protein-peptide complex]]

OCA at 02:44, 30 September 2014

OCA — Tue, 30 Sep 2014 02:44:49 GMT

←Older revision		Revision as of 02:44, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2emt.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule PSGL-1==
		+	<StructureSection load='2emt' size='340' side='right' caption='[[2emt]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2emt]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EMT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j19\|1j19]], [[1gc6\|1gc6]], [[1gc7\|1gc7]], [[2d11\|2d11]], [[2d10\|2d10]], [[2d2q\|2d2q]], [[2ems\|2ems]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2emt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2emt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2emt RCSB], [http://www.ebi.ac.uk/pdbsum/2emt PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/2emt_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	P-selectin glycoprotein ligand-1 (PSGL-1), an adhesion molecule with O-glycosylated extracellular sialomucins, is involved in leukocyte inflammatory responses. On activation, ezrin-radixin-moesin (ERM) proteins mediate the redistribution of PSGL-1 on polarized cell surfaces to facilitate binding to target molecules. ERM proteins recognize a short binding motif, Motif-1, conserved in cytoplasmic tails of adhesion molecules, whereas PSGL-1 lacks Motif-1 residues important for binding to ERM proteins. The crystal structure of the complex between the radixin FERM domain and a PSGL-1 juxtamembrane peptide reveals that the peptide binds the groove of FERM subdomain C by forming a beta-strand associated with strand beta5C, followed by a loop flipped out towards the solvent. The Motif-1 3(10) helix present in the FERM-ICAM-2 complex is absent in PSGL-1 given the absence of a critical Motif-1 alanine residue, and PSGL-1 reduces its contact area with subdomain C. Non-conserved positions are occupied by large residues Met9 and His8, which stabilize peptide conformation and enhance groove binding. Non-conserved residues play an important role in compensating for loss of binding energy resulting from the absence of conserved residues important for binding.

-	~~{{STRUCTURE_2emt\| PDB=2emt \| SCENE= }}~~	+	Structural basis of PSGL-1 binding to ERM proteins.,Takai Y, Kitano K, Terawaki S, Maesaki R, Hakoshima T Genes Cells. 2007 Dec;12(12):1329-38. PMID:18076570<ref>PMID:18076570</ref>

-	~~===Crystal Structure Analysis~~ of the ~~radixin FERM domain complexed with adhesion molecule PSGL-1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18076570}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2emt]] is a 5 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2EMT OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018076570<~~/~~ref~~><~~ref group="xtra">PMID:017183174</ref><references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hakoshima, T.]]		[[Category: Hakoshima, T.]]

OCA at 12:13, 23 January 2013

OCA — Wed, 23 Jan 2013 12:13:06 GMT

←Older revision		Revision as of 12:13, 23 January 2013
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	[[Image:2emt.png\|left\|200px]]		[[Image:2emt.png\|left\|200px]]

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	===Crystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule PSGL-1===		===Crystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule PSGL-1===

-
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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18076570~~</ref><ref group="xtra">PMID:~~17183174~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018076570</ref><ref group="xtra">PMID:017183174</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hakoshima, T.]]		[[Category: Hakoshima, T.]]

OCA: Protected "2emt" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 23:55:48 GMT

Protected "2emt" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:55, 14 March 2011