2erq - Revision history

OCA at 08:43, 25 October 2023

OCA — Wed, 25 Oct 2023 08:43:54 GMT

←Older revision		Revision as of 08:43, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2erq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ERQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2erq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ERQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ero\|2ero]], [[2erp\|2erp]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2erq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2erq OCA], [https://pdbe.org/2erq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2erq RCSB], [https://www.ebi.ac.uk/pdbsum/2erq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2erq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2erq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2erq OCA], [https://pdbe.org/2erq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2erq RCSB], [https://www.ebi.ac.uk/pdbsum/2erq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2erq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/VM3V1_CROAT VM3V1_CROAT] Zinc metalloprotease that has fibrinogenolytic and hemorrhagic activities. It induces apoptosis in vascular endothelial cells (VEC), without degrading extracellular matrix (it cannot cleave collagen) or inhibiting adhesion of VEC. VAP1-induced apoptosis is inhibited by antibodies for integrin alpha-3, alpha-6, beta-1 and CD9. Apoptosis is accompanied by severe cell fragmentation, which is controlled by caspases.<ref>PMID:11071872</ref> <ref>PMID:11821125</ref> <ref>PMID:15922392</ref> <ref>PMID:18657564</ref> <ref>PMID:9196035</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Crotalus atrox]]		[[Category: Crotalus atrox]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Araki, S]]	+	[[Category: Araki S]]
-	[[Category: Igarashi, T]]	+	[[Category: Igarashi T]]
-	[[Category: Takeda, S]]	+	[[Category: Takeda S]]
-	~~[[Category: Adam]]~~	+
-	~~[[Category: Calcium-binding]]~~	+
-	~~[[Category: Disintegrin]]~~	+
-	~~[[Category: Mdc protein]]~~	+
-	~~[[Category: Metalloprotease]]~~	+
-	~~[[Category: Svmp]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 15:57, 22 December 2021

OCA — Wed, 22 Dec 2021 15:57:17 GMT

←Older revision		Revision as of 15:57, 22 December 2021
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	<StructureSection load='2erq' size='340' side='right'caption='[[2erq]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2erq' size='340' side='right'caption='[[2erq]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2erq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ERQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2erq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ERQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ero\|2ero]], [[2erp\|2erp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ero\|2ero]], [[2erp\|2erp]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2erq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2erq OCA], [~~http~~://pdbe.org/2erq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2erq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2erq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2erq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2erq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2erq OCA], [https://pdbe.org/2erq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2erq RCSB], [https://www.ebi.ac.uk/pdbsum/2erq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2erq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:41, 18 March 2020

OCA — Wed, 18 Mar 2020 10:41:04 GMT

←Older revision		Revision as of 10:41, 18 March 2020
Line 1:		Line 1:

	==Crystal structure of vascular apoptosis-inducing protein-1(tetragonal crystal form)==		==Crystal structure of vascular apoptosis-inducing protein-1(tetragonal crystal form)==
-	<StructureSection load='2erq' size='340' side='right' caption='[[2erq]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2erq' size='340' side='right'caption='[[2erq]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2erq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2erq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERQ FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Crotalus atrox]]		[[Category: Crotalus atrox]]
		+	[[Category: Large Structures]]
	[[Category: Araki, S]]		[[Category: Araki, S]]
	[[Category: Igarashi, T]]		[[Category: Igarashi, T]]

OCA at 08:27, 14 June 2018

OCA — Thu, 14 Jun 2018 08:27:09 GMT

←Older revision		Revision as of 08:27, 14 June 2018
Line 1:		Line 1:
		+
	==Crystal structure of vascular apoptosis-inducing protein-1(tetragonal crystal form)==		==Crystal structure of vascular apoptosis-inducing protein-1(tetragonal crystal form)==
	<StructureSection load='2erq' size='340' side='right' caption='[[2erq]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2erq' size='340' side='right' caption='[[2erq]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ero\|2ero]], [[2erp\|2erp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ero\|2ero]], [[2erp\|2erp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2erq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2erq OCA], [http://pdbe.org/2erq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2erq RCSB], [http://www.ebi.ac.uk/pdbsum/2erq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2erq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2erq OCA], [http://pdbe.org/2erq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2erq RCSB], [http://www.ebi.ac.uk/pdbsum/2erq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2erq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/2erq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/2erq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:09, 9 February 2016

OCA — Tue, 09 Feb 2016 02:09:59 GMT

←Older revision		Revision as of 02:09, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2erq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:35, 10 September 2015

OCA — Thu, 10 Sep 2015 17:35:29 GMT

←Older revision		Revision as of 17:35, 10 September 2015
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ero\|2ero]], [[2erp\|2erp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ero\|2ero]], [[2erp\|2erp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2erq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2erq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2erq RCSB], [http://www.ebi.ac.uk/pdbsum/2erq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2erq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2erq OCA], [http://pdbe.org/2erq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2erq RCSB], [http://www.ebi.ac.uk/pdbsum/2erq PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2erq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:07, 15 January 2015

OCA — Thu, 15 Jan 2015 16:07:53 GMT

←Older revision		Revision as of 16:07, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2erq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2erq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ero\|2ero]], [[2erp\|2erp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ero\|2ero]], [[2erp\|2erp]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2erq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2erq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2erq RCSB], [http://www.ebi.ac.uk/pdbsum/2erq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2erq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2erq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2erq RCSB], [http://www.ebi.ac.uk/pdbsum/2erq PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Crotalus atrox]]		[[Category: Crotalus atrox]]
-	[[Category: Araki, S.]]	+	[[Category: Araki, S]]
-	[[Category: Igarashi, T.]]	+	[[Category: Igarashi, T]]
-	[[Category: Takeda, S.]]	+	[[Category: Takeda, S]]
	[[Category: Adam]]		[[Category: Adam]]
	[[Category: Calcium-binding]]		[[Category: Calcium-binding]]

OCA at 01:33, 30 September 2014

OCA — Tue, 30 Sep 2014 01:33:33 GMT

←Older revision		Revision as of 01:33, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2erq.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of vascular apoptosis-inducing protein-1(tetragonal crystal form)==
		+	<StructureSection load='2erq' size='340' side='right' caption='[[2erq]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2erq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ero\|2ero]], [[2erp\|2erp]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2erq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2erq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2erq RCSB], [http://www.ebi.ac.uk/pdbsum/2erq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/2erq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ADAMs (a disintegrin and metalloproteinase) are sheddases possessing extracellular metalloproteinase/disintegrin/cysteine-rich (MDC) domains. ADAMs uniquely display both proteolytic and adhesive activities on the cell surface, however, most of their physiological targets and adhesion mechanisms remain unclear. Here for the first time, we reveal the ADAMs' MDC architecture and a potential target-binding site by solving crystal structures of VAP1, a snake venom homolog of mammalian ADAMs. The D-domain protrudes from the M-domain opposing the catalytic site and constituting a C-shaped arm with cores of Ca2+ ions. The disintegrin-loop, supposed to interact with integrins, is packed by the C-domain and inaccessible for protein binding. Instead, the hyper-variable region (HVR) in the C-domain, which has a novel fold stabilized by the strictly conserved disulfide bridges, constitutes a potential protein-protein adhesive interface. The HVR is located at the distal end of the arm and faces toward the catalytic site. The C-shaped structure implies interplay between the ADAMs' proteolytic and adhesive domains and suggests a molecular mechanism for ADAMs' target recognition for shedding.

-	~~{{STRUCTURE_2erq\| PDB=2erq \| SCENE= }}~~	+	Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold.,Takeda S, Igarashi T, Mori H, Araki S EMBO J. 2006 Jun 7;25(11):2388-96. Epub 2006 May 11. PMID:16688218<ref>PMID:16688218</ref>

-	~~===Crystal structure~~ of ~~vascular apoptosis-inducing protein-1(tetragonal crystal form)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16688218}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2erq]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Crotalus_atrox Crotalus atrox]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ERQ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016688218<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Crotalus atrox]]		[[Category: Crotalus atrox]]
	[[Category: Araki, S.]]		[[Category: Araki, S.]]

OCA: Protected "2erq" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 10:47:54 GMT

Protected "2erq" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:47, 6 January 2013

OCA at 10:47, 6 January 2013

OCA — Sun, 06 Jan 2013 10:47:50 GMT

←Older revision		Revision as of 10:47, 6 January 2013
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-	{{Seed}}
	[[Image:2erq.png\|left\|200px]]		[[Image:2erq.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2erq\| PDB=2erq \| SCENE= }}		{{STRUCTURE_2erq\| PDB=2erq \| SCENE= }}

	===Crystal structure of vascular apoptosis-inducing protein-1(tetragonal crystal form)===		===Crystal structure of vascular apoptosis-inducing protein-1(tetragonal crystal form)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16688218}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_16688218}}		{{ABSTRACT_PUBMED_16688218}}

	==About this Structure==		==About this Structure==
-	~~2ERQ~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERQ OCA].	+	[[2erq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERQ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16688218~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016688218</ref><references group="xtra"/>
	[[Category: Crotalus atrox]]		[[Category: Crotalus atrox]]
	[[Category: Araki, S.]]		[[Category: Araki, S.]]
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	[[Category: Metalloprotease]]		[[Category: Metalloprotease]]
	[[Category: Svmp]]		[[Category: Svmp]]
-		+	[[Category: Toxin]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 05:37:04 2009''~~	+