2esd - Revision history

OCA at 08:44, 25 October 2023

OCA — Wed, 25 Oct 2023 08:44:02 GMT

←Older revision		Revision as of 08:44, 25 October 2023
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	<StructureSection load='2esd' size='340' side='right'caption='[[2esd]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2esd' size='340' side='right'caption='[[2esd]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2esd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_25175 Atcc 25175~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ESD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2esd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ESD FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=G3H:GLYCERALDEHYDE~~-~~3-PHOSPHATE'>G3H</scene>~~, ~~<scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1euh\|1euh]], [[2euh\|2euh]], [[1qi1\|1qi1]], [[1qi6\|1qi6]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G3H:GLYCERALDEHYDE-3-PHOSPHATE'>G3H</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(~~NADP(+~~)) Glyceraldehyde~~-3-~~phosphate dehydrogenase (NADP(~~+~~))], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.9 1.2.1.9]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2esd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2esd OCA], [https://pdbe.org/2esd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2esd RCSB], [https://www.ebi.ac.uk/pdbsum/2esd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2esd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2esd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2esd OCA], [https://pdbe.org/2esd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2esd RCSB], [https://www.ebi.ac.uk/pdbsum/2esd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2esd ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GAPN_STRMU GAPN_STRMU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 25175]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ambrosio, K D~~]]	+	[[Category: Streptococcus mutans]]
-	[[Category: Aubry, A]]	+	[[Category: Aubry A]]
-	[[Category: Benedetti, E]]	+	[[Category: Benedetti E]]
-	[[Category: Corbier, C]]	+	[[Category: Corbier C]]
-	[[Category: ~~Didierjean, C~~]]	+	[[Category: D'Ambrosio K]]
-	[[Category: ~~Aldh]]~~	+	[[Category: Didierjean C]]
-	~~[[Category: Gapn]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Ternary complex~~]]	+

OCA at 09:50, 5 May 2021

OCA — Wed, 05 May 2021 09:50:50 GMT

←Older revision		Revision as of 09:50, 5 May 2021
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	<StructureSection load='2esd' size='340' side='right'caption='[[2esd]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2esd' size='340' side='right'caption='[[2esd]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2esd]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_25175 Atcc 25175]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ESD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2esd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_25175 Atcc 25175]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ESD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G3H:GLYCERALDEHYDE-3-PHOSPHATE'>G3H</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G3H:GLYCERALDEHYDE-3-PHOSPHATE'>G3H</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1euh\|1euh]], [[2euh\|2euh]], [[1qi1\|1qi1]], [[1qi6\|1qi6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1euh\|1euh]], [[2euh\|2euh]], [[1qi1\|1qi1]], [[1qi6\|1qi6]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(NADP(+)) Glyceraldehyde-3-phosphate dehydrogenase (NADP(+))], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.9 1.2.1.9] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(NADP(+)) Glyceraldehyde-3-phosphate dehydrogenase (NADP(+))], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.9 1.2.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2esd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2esd OCA], [~~http~~://pdbe.org/2esd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2esd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2esd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2esd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2esd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2esd OCA], [https://pdbe.org/2esd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2esd RCSB], [https://www.ebi.ac.uk/pdbsum/2esd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2esd ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:20, 24 July 2019

OCA — Wed, 24 Jul 2019 09:20:49 GMT

←Older revision		Revision as of 09:20, 24 July 2019
Line 1:		Line 1:

	==Crystal Structure of thioacylenzyme intermediate of an Nadp Dependent Aldehyde Dehydrogenase==		==Crystal Structure of thioacylenzyme intermediate of an Nadp Dependent Aldehyde Dehydrogenase==
-	<StructureSection load='2esd' size='340' side='right' caption='[[2esd]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='2esd' size='340' side='right'caption='[[2esd]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2esd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_25175 Atcc 25175]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ESD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2esd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_25175 Atcc 25175]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ESD FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/2esd_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/2esd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2esd" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2esd" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aldehyde dehydrogenase 3D structures\|Aldehyde dehydrogenase 3D structures]]
		+	*[[Glyceraldehyde-3-phosphate dehydrogenase 3D structures\|Glyceraldehyde-3-phosphate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 25175]]		[[Category: Atcc 25175]]
		+	[[Category: Large Structures]]
	[[Category: Ambrosio, K D]]		[[Category: Ambrosio, K D]]
	[[Category: Aubry, A]]		[[Category: Aubry, A]]

OCA at 07:27, 18 October 2017

OCA — Wed, 18 Oct 2017 07:27:30 GMT

←Older revision		Revision as of 07:27, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of thioacylenzyme intermediate of an Nadp Dependent Aldehyde Dehydrogenase==		==Crystal Structure of thioacylenzyme intermediate of an Nadp Dependent Aldehyde Dehydrogenase==
	<StructureSection load='2esd' size='340' side='right' caption='[[2esd]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2esd' size='340' side='right' caption='[[2esd]], [[Resolution\|resolution]] 2.55Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1euh\|1euh]], [[2euh\|2euh]], [[1qi1\|1qi1]], [[1qi6\|1qi6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1euh\|1euh]], [[2euh\|2euh]], [[1qi1\|1qi1]], [[1qi6\|1qi6]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(NADP(+)) Glyceraldehyde-3-phosphate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.9 1.2.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(NADP(+)) Glyceraldehyde-3-phosphate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.9 1.2.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2esd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2esd OCA], [http://pdbe.org/2esd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2esd RCSB], [http://www.ebi.ac.uk/pdbsum/2esd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2esd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2esd OCA], [http://pdbe.org/2esd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2esd RCSB], [http://www.ebi.ac.uk/pdbsum/2esd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2esd ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</div>		</div>
	<div class="pdbe-citations 2esd" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2esd" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]
-	*[[Glyceraldehyde-3-Phosphate Dehydrogenase\|Glyceraldehyde-3-Phosphate Dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:44, 9 February 2016

OCA — Tue, 09 Feb 2016 11:44:58 GMT

←Older revision		Revision as of 11:44, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2esd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:54, 10 September 2015

OCA — Thu, 10 Sep 2015 21:54:20 GMT

←Older revision		Revision as of 21:54, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2esd' size='340' side='right' caption='[[2esd]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2esd' size='340' side='right' caption='[[2esd]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2esd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_mutans Streptococcus mutans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ESD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2esd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_25175 Atcc 25175]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ESD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G3H:GLYCERALDEHYDE-3-PHOSPHATE'>G3H</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G3H:GLYCERALDEHYDE-3-PHOSPHATE'>G3H</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1euh\|1euh]], [[2euh\|2euh]], [[1qi1\|1qi1]], [[1qi6\|1qi6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1euh\|1euh]], [[2euh\|2euh]], [[1qi1\|1qi1]], [[1qi6\|1qi6]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(NADP(+)) Glyceraldehyde-3-phosphate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.9 1.2.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(NADP(+)) Glyceraldehyde-3-phosphate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.9 1.2.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2esd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2esd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2esd RCSB], [http://www.ebi.ac.uk/pdbsum/2esd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2esd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2esd OCA], [http://pdbe.org/2esd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2esd RCSB], [http://www.ebi.ac.uk/pdbsum/2esd PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2esd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
		+	*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]
	*[[Glyceraldehyde-3-Phosphate Dehydrogenase\|Glyceraldehyde-3-Phosphate Dehydrogenase]]		*[[Glyceraldehyde-3-Phosphate Dehydrogenase\|Glyceraldehyde-3-Phosphate Dehydrogenase]]
	== References ==		== References ==
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Streptococcus mutans~~]]	+	[[Category: Atcc 25175]]
	[[Category: Ambrosio, K D]]		[[Category: Ambrosio, K D]]
	[[Category: Aubry, A]]		[[Category: Aubry, A]]

OCA at 18:09, 15 January 2015

OCA — Thu, 15 Jan 2015 18:09:46 GMT

←Older revision		Revision as of 18:09, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2esd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ESD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2esd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ESD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G3H:GLYCERALDEHYDE-3-PHOSPHATE'>G3H</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G3H:GLYCERALDEHYDE-3-PHOSPHATE'>G3H</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1euh\|1euh]], [[2euh\|2euh]], [[1qi1\|1qi1]], [[1qi6\|1qi6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1euh\|1euh]], [[2euh\|2euh]], [[1qi1\|1qi1]], [[1qi6\|1qi6]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(NADP(+)) Glyceraldehyde-3-phosphate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.9 1.2.1.9] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(NADP(+)) Glyceraldehyde-3-phosphate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.9 1.2.1.9] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2esd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2esd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2esd RCSB], [http://www.ebi.ac.uk/pdbsum/2esd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2esd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2esd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2esd RCSB], [http://www.ebi.ac.uk/pdbsum/2esd PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Streptococcus mutans]]		[[Category: Streptococcus mutans]]
-	[[Category: Ambrosio, K D.]]	+	[[Category: Ambrosio, K D]]
-	[[Category: Aubry, A.]]	+	[[Category: Aubry, A]]
-	[[Category: Benedetti, E.]]	+	[[Category: Benedetti, E]]
-	[[Category: Corbier, C.]]	+	[[Category: Corbier, C]]
-	[[Category: Didierjean, C.]]	+	[[Category: Didierjean, C]]
	[[Category: Aldh]]		[[Category: Aldh]]
	[[Category: Gapn]]		[[Category: Gapn]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Ternary complex]]		[[Category: Ternary complex]]

OCA at 10:04, 29 September 2014

OCA — Mon, 29 Sep 2014 10:04:45 GMT

←Older revision		Revision as of 10:04, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2esd.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of thioacylenzyme intermediate of an Nadp Dependent Aldehyde Dehydrogenase==
		+	<StructureSection load='2esd' size='340' side='right' caption='[[2esd]], [[Resolution\|resolution]] 2.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2esd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ESD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G3H:GLYCERALDEHYDE-3-PHOSPHATE'>G3H</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1euh\|1euh]], [[2euh\|2euh]], [[1qi1\|1qi1]], [[1qi6\|1qi6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glyceraldehyde-3-phosphate_dehydrogenase_(NADP(+)) Glyceraldehyde-3-phosphate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.9 1.2.1.9] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2esd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2esd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2esd RCSB], [http://www.ebi.ac.uk/pdbsum/2esd PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/2esd_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Crystal structures of several members of the nonphosphorylating CoA-independent aldehyde dehydrogenase (ALDH) family have shown that the peculiar binding mode of the cofactor to the Rossmann fold results in a conformational flexibility for the nicotinamide moiety of the cofactor. This has been hypothesized to constitute an essential feature of the catalytic mechanism because the conformation of the cofactor required for the acylation step is not appropriate for the deacylation step. In the present study, the structure of a reaction intermediate of the E268A-glyceraldehyde 3-phosphate dehydrogenase (GAPN) from Streptococcus mutans, obtained by soaking the crystals of the enzyme/NADP complex with the natural substrate, is reported. The substrate is bound covalently in the four monomers and presents the geometric characteristics expected for a thioacylenzyme intermediate. Control experiments assessed that reduction of the coenzyme has occurred within the crystal. The structure reveals that reduction of the cofactor upon acylation leads to an extensive motion of the nicotinamide moiety with a flip of the reduced pyridinium ring away from the active site without significant changes of the protein structure. This event positions the reduced nicotinamide moiety in a pocket that likely constitutes the exit door for NADPH. Arguments are provided that the structure reported here constitutes a reasonable picture of the first thioacylenzyme intermediate characterized thus far in the ALDH family and that the position of the reduced nicotinamide moiety observed in GAPN is the one suitable for the deacylation step within all of the nonphosphorylating CoA-independent ALDH family.

-	~~{{STRUCTURE_2esd\| PDB=2esd \| SCENE= }}~~	+	The first crystal structure of a thioacylenzyme intermediate in the ALDH family: new coenzyme conformation and relevance to catalysis.,D'Ambrosio K, Pailot A, Talfournier F, Didierjean C, Benedetti E, Aubry A, Branlant G, Corbier C Biochemistry. 2006 Mar 7;45(9):2978-86. PMID:16503652<ref>PMID:16503652</ref>

-	~~===Crystal Structure~~ of ~~thioacylenzyme intermediate of an Nadp Dependent Aldehyde Dehydrogenase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16503652}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2esd]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptococcus_mutans Streptococcus mutans]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ESD OCA].~~	+

	==See Also==		==See Also==
-	*[[~~Aldehyde dehydrogenase~~\|~~Aldehyde dehydrogenase~~]]	+	*[[Glyceraldehyde-3-Phosphate Dehydrogenase\|Glyceraldehyde-3-Phosphate Dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016503652<~~/~~ref~~><~~ref group="xtra">PMID:010864505</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Streptococcus mutans]]		[[Category: Streptococcus mutans]]
	[[Category: Ambrosio, K D.]]		[[Category: Ambrosio, K D.]]

OCA at 13:43, 20 October 2012

OCA — Sat, 20 Oct 2012 13:43:50 GMT

←Older revision		Revision as of 13:43, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2esd]] is a 4 chain structure ~~of [[Aldehyde dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESD OCA].	+	[[2esd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESD OCA].

	==See Also==		==See Also==

OCA at 12:55, 26 July 2012

OCA — Thu, 26 Jul 2012 12:55:03 GMT

←Older revision		Revision as of 12:55, 26 July 2012
Line 1:		Line 1:
	[[Image:2esd.png\|left\|200px]]		[[Image:2esd.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2esd", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2esd\| PDB=2esd \| SCENE= }}		{{STRUCTURE_2esd\| PDB=2esd \| SCENE= }}

	===Crystal Structure of thioacylenzyme intermediate of an Nadp Dependent Aldehyde Dehydrogenase===		===Crystal Structure of thioacylenzyme intermediate of an Nadp Dependent Aldehyde Dehydrogenase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16503652}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16503652 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16503652}}		{{ABSTRACT_PUBMED_16503652}}

	==About this Structure==		==About this Structure==
-	[[2esd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESD OCA].	+	[[2esd]] is a 4 chain structure of [[Aldehyde dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESD OCA].
		+
		+	==See Also==
		+	*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16503652~~</ref><ref group="xtra">PMID:~~10864505~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016503652</ref><ref group="xtra">PMID:010864505</ref><references group="xtra"/>
	[[Category: Streptococcus mutans]]		[[Category: Streptococcus mutans]]
	[[Category: Ambrosio, K D.]]		[[Category: Ambrosio, K D.]]