2evt - Revision history

OCA at 07:40, 23 August 2023

OCA — Wed, 23 Aug 2023 07:40:24 GMT

←Older revision		Revision as of 07:40, 23 August 2023
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	<StructureSection load='2evt' size='340' side='right'caption='[[2evt]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='2evt' size='340' side='right'caption='[[2evt]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2evt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EVT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2evt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EVT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HEX:HEXANE'>HEX</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.99Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1swx\|1swx]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2evt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evt OCA], [https://pdbe.org/2evt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2evt RCSB], [https://www.ebi.ac.uk/pdbsum/2evt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2evt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2evt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evt OCA], [https://pdbe.org/2evt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2evt RCSB], [https://www.ebi.ac.uk/pdbsum/2evt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2evt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GLTP_HUMAN GLTP_HUMAN]] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<ref>PMID:18261224</ref> <ref>PMID:15504043</ref> <ref>PMID:17980653</ref> <ref>PMID:15329726</ref>	+	[https://www.uniprot.org/uniprot/GLTP_HUMAN GLTP_HUMAN] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<ref>PMID:18261224</ref> <ref>PMID:15504043</ref> <ref>PMID:17980653</ref> <ref>PMID:15329726</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brown~~, R E~~]]	+	[[Category: Brown RE]]
-	[[Category: Malakhova~~, M L~~]]	+	[[Category: Malakhova ML]]
-	[[Category: Malinina, L]]	+	[[Category: Malinina L]]
-	[[Category: Patel~~, D J~~]]	+	[[Category: Patel DJ]]
-	[[Category: Teplov, A]]	+	[[Category: Teplov A]]
-	~~[[Category: D48v mutant human gltp]]~~	+
-	~~[[Category: Lipid transport~~]]	+

OCA at 09:51, 5 May 2021

OCA — Wed, 05 May 2021 09:51:07 GMT

←Older revision		Revision as of 09:51, 5 May 2021
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	<StructureSection load='2evt' size='340' side='right'caption='[[2evt]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='2evt' size='340' side='right'caption='[[2evt]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2evt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2EVT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2evt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EVT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1swx\|1swx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1swx\|1swx]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2evt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evt OCA], [~~http~~://pdbe.org/2evt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2evt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2evt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2evt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2evt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evt OCA], [https://pdbe.org/2evt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2evt RCSB], [https://www.ebi.ac.uk/pdbsum/2evt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2evt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GLTP_HUMAN GLTP_HUMAN]] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<ref>PMID:18261224</ref> <ref>PMID:15504043</ref> <ref>PMID:17980653</ref> <ref>PMID:15329726</ref>	+	[[https://www.uniprot.org/uniprot/GLTP_HUMAN GLTP_HUMAN]] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<ref>PMID:18261224</ref> <ref>PMID:15504043</ref> <ref>PMID:17980653</ref> <ref>PMID:15329726</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:58, 24 July 2019

OCA — Wed, 24 Jul 2019 08:58:36 GMT

←Older revision		Revision as of 08:58, 24 July 2019
Line 1:		Line 1:

	==Crystal structure of D48V mutant of human Glycolipid Transfer Protein==		==Crystal structure of D48V mutant of human Glycolipid Transfer Protein==
-	<StructureSection load='2evt' size='340' side='right' caption='[[2evt]], [[Resolution\|resolution]] 1.99Å' scene=''>	+	<StructureSection load='2evt' size='340' side='right'caption='[[2evt]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2evt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EVT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2evt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EVT FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/2evt_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/2evt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Brown, R E]]		[[Category: Brown, R E]]
	[[Category: Malakhova, M L]]		[[Category: Malakhova, M L]]

OCA at 07:29, 18 October 2017

OCA — Wed, 18 Oct 2017 07:29:23 GMT

←Older revision		Revision as of 07:29, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of D48V mutant of human Glycolipid Transfer Protein==		==Crystal structure of D48V mutant of human Glycolipid Transfer Protein==
	<StructureSection load='2evt' size='340' side='right' caption='[[2evt]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='2evt' size='340' side='right' caption='[[2evt]], [[Resolution\|resolution]] 1.99Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1swx\|1swx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1swx\|1swx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2evt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evt OCA], [http://pdbe.org/2evt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2evt RCSB], [http://www.ebi.ac.uk/pdbsum/2evt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2evt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evt OCA], [http://pdbe.org/2evt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2evt RCSB], [http://www.ebi.ac.uk/pdbsum/2evt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2evt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:59, 9 February 2016

OCA — Tue, 09 Feb 2016 08:59:54 GMT

←Older revision		Revision as of 08:59, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2evt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:41, 10 September 2015

OCA — Thu, 10 Sep 2015 20:41:04 GMT

←Older revision		Revision as of 20:41, 10 September 2015
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	<StructureSection load='2evt' size='340' side='right' caption='[[2evt]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='2evt' size='340' side='right' caption='[[2evt]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2evt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EVT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2evt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EVT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1swx\|1swx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1swx\|1swx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2evt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2evt RCSB], [http://www.ebi.ac.uk/pdbsum/2evt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2evt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evt OCA], [http://pdbe.org/2evt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2evt RCSB], [http://www.ebi.ac.uk/pdbsum/2evt PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2evt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Brown, R E]]		[[Category: Brown, R E]]
	[[Category: Malakhova, M L]]		[[Category: Malakhova, M L]]

OCA at 05:52, 25 December 2014

OCA — Thu, 25 Dec 2014 05:52:44 GMT

←Older revision		Revision as of 05:52, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2evt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EVT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2evt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EVT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1swx\|1swx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1swx\|1swx]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2evt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2evt RCSB], [http://www.ebi.ac.uk/pdbsum/2evt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2evt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2evt RCSB], [http://www.ebi.ac.uk/pdbsum/2evt PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GLTP_HUMAN GLTP_HUMAN]] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<ref>PMID:18261224</ref> <ref>PMID:15504043</ref> <ref>PMID:17980653</ref> <ref>PMID:15329726</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Brown, R E.]]	+	[[Category: Brown, R E]]
-	[[Category: Malakhova, M L.]]	+	[[Category: Malakhova, M L]]
-	[[Category: Malinina, L.]]	+	[[Category: Malinina, L]]
-	[[Category: Patel, D J.]]	+	[[Category: Patel, D J]]
-	[[Category: Teplov, A.]]	+	[[Category: Teplov, A]]
	[[Category: D48v mutant human gltp]]		[[Category: D48v mutant human gltp]]
	[[Category: Lipid transport]]		[[Category: Lipid transport]]

OCA at 01:35, 30 September 2014

OCA — Tue, 30 Sep 2014 01:35:08 GMT

←Older revision		Revision as of 01:35, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2evt.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of D48V mutant of human Glycolipid Transfer Protein==
		+	<StructureSection load='2evt' size='340' side='right' caption='[[2evt]], [[Resolution\|resolution]] 1.99Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2evt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EVT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEX:HEXANE'>HEX</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1swx\|1swx]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2evt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2evt RCSB], [http://www.ebi.ac.uk/pdbsum/2evt PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/2evt_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glycosphingolipids (GSLs) play major roles in cellular growth and development. Mammalian glycolipid transfer proteins (GLTPs) are potential regulators of cell processes mediated by GSLs and display a unique architecture among lipid binding/transfer proteins. The GLTP fold represents a novel membrane targeting/interaction domain among peripheral proteins. Here we report crystal structures of human GLTP bound to GSLs of diverse acyl chain length, unsaturation, and sugar composition. Structural comparisons show a highly conserved anchoring of galactosyl- and lactosyl-amide headgroups by the GLTP recognition center. By contrast, acyl chain chemical structure and occupancy of the hydrophobic tunnel dictate partitioning between sphingosine-in and newly-observed sphingosine-out ligand-binding modes. The structural insights, combined with computed interaction propensity distributions, suggest a concerted sequence of events mediated by GLTP conformational changes during GSL transfer to and/or from membranes, as well as during GSL presentation and/or transfer to other proteins.

-	~~{{STRUCTURE_2evt\| PDB=2evt \| SCENE= }}~~	+	The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure.,Malinina L, Malakhova ML, Kanack AT, Lu M, Abagyan R, Brown RE, Patel DJ PLoS Biol. 2006 Nov;4(11):e362. PMID:17105344<ref>PMID:17105344</ref>

-	~~===Crystal structure~~ of ~~D48V mutant of human Glycolipid Transfer Protein===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17105344}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2evt]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2EVT OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017105344<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Brown, R E.]]		[[Category: Brown, R E.]]

OCA: Protected "2evt" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2013 07:16:42 GMT

Protected "2evt" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:16, 2 January 2013

OCA at 07:16, 2 January 2013

OCA — Wed, 02 Jan 2013 07:16:40 GMT

←Older revision		Revision as of 07:16, 2 January 2013
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-	{{Seed}}
	[[Image:2evt.png\|left\|200px]]		[[Image:2evt.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2evt\| PDB=2evt \| SCENE= }}		{{STRUCTURE_2evt\| PDB=2evt \| SCENE= }}

	===Crystal structure of D48V mutant of human Glycolipid Transfer Protein===		===Crystal structure of D48V mutant of human Glycolipid Transfer Protein===

-		+	{{ABSTRACT_PUBMED_17105344}}
-	~~<!--~~	+
-	~~The line below this paragraph,~~ {{~~ABSTRACT_PUBMED_15329726}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at http://www.pubmed.gov), where 15329726 is the PubMed ID number.~~	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_15329726~~}}	+

	==About this Structure==		==About this Structure==
-	~~2EVT~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVT OCA].	+	[[2evt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EVT OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15329726~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017105344</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Brown, R E.]]		[[Category: Brown, R E.]]
Line 31:		Line 19:
	[[Category: Teplov, A.]]		[[Category: Teplov, A.]]
	[[Category: D48v mutant human gltp]]		[[Category: D48v mutant human gltp]]
-		+	[[Category: Lipid transport]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 08:35:01 2009''~~	+