2exq - Revision history

OCA at 15:58, 22 December 2021

OCA — Wed, 22 Dec 2021 15:58:44 GMT

←Older revision		Revision as of 15:58, 22 December 2021
Line 4:		Line 4:
	<StructureSection load='2exq' size='340' side='right'caption='[[2exq]]' scene=''>		<StructureSection load='2exq' size='340' side='right'caption='[[2exq]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2EXQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EXQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2exq FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/2exq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2exq ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2exq FirstGlance], [https://www.ebi.ac.uk/pdbsum/2exq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2exq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:42, 18 March 2020

OCA — Wed, 18 Mar 2020 10:42:57 GMT

←Older revision		Revision as of 10:42, 18 March 2020
Line 2:		Line 2:

	==STRUCTURAL SUPERPOSITION OF MAB 806- EGFR PEPTIDE COMPLEX WITH EGFR HYPOTHETICAL EXTENDED MONOMER==		==STRUCTURAL SUPERPOSITION OF MAB 806- EGFR PEPTIDE COMPLEX WITH EGFR HYPOTHETICAL EXTENDED MONOMER==
-	<StructureSection load='2exq' size='340' side='right' caption='[[2exq]]' scene=''>	+	<StructureSection load='2exq' size='340' side='right'caption='[[2exq]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EXQ FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EXQ FirstGlance]. <br>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Chao, G]]		[[Category: Chao, G]]
	[[Category: Gray, J J]]		[[Category: Gray, J J]]

OCA at 09:24, 14 June 2018

OCA — Thu, 14 Jun 2018 09:24:07 GMT

←Older revision		Revision as of 09:24, 14 June 2018
Line 5:		Line 5:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EXQ FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EXQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2exq FirstGlance], [http://www.ebi.ac.uk/pdbsum/2exq PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2exq FirstGlance], [http://www.ebi.ac.uk/pdbsum/2exq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2exq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:33, 11 February 2016

OCA — Thu, 11 Feb 2016 10:33:58 GMT

←Older revision		Revision as of 10:33, 11 February 2016
Line 1:		Line 1:
		+	{{Theoretical_model}}
		+
	==STRUCTURAL SUPERPOSITION OF MAB 806- EGFR PEPTIDE COMPLEX WITH EGFR HYPOTHETICAL EXTENDED MONOMER==		==STRUCTURAL SUPERPOSITION OF MAB 806- EGFR PEPTIDE COMPLEX WITH EGFR HYPOTHETICAL EXTENDED MONOMER==
	<StructureSection load='2exq' size='340' side='right' caption='[[2exq]]' scene=''>		<StructureSection load='2exq' size='340' side='right' caption='[[2exq]]' scene=''>
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Chao, G]]		[[Category: Chao, G]]
	[[Category: Gray, J J]]		[[Category: Gray, J J]]

OCA at 09:00, 10 September 2015

OCA — Thu, 10 Sep 2015 09:00:30 GMT

←Older revision		Revision as of 09:00, 10 September 2015
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2exq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:56, 18 December 2014

OCA — Thu, 18 Dec 2014 12:56:45 GMT

←Older revision		Revision as of 12:56, 18 December 2014
Line 1:		Line 1:
-	~~{{Theoretical_model}}~~	+	==STRUCTURAL SUPERPOSITION OF MAB 806- EGFR PEPTIDE COMPLEX WITH EGFR HYPOTHETICAL EXTENDED MONOMER==
		+	<StructureSection load='2exq' size='340' side='right' caption='[[2exq]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EXQ FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2exq FirstGlance], [http://www.ebi.ac.uk/pdbsum/2exq PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In this work, we combined computational protein-protein docking with computational and experimental mutagenesis to predict the structure of the complex formed by monoclonal antibody 806 (mAb 806) and the epidermal growth factor receptor (EGFR). We docked mAb 806, an antitumor antibody, to its epitope of EGFR residues 287-302. Potential mAb 806-EGFR orientations were generated, and computational mutagenesis was used to filter them according to their agreement with experimental mutagenesis data. Further computational mutagenesis suggested additional mutations, which were tested to arrive at a final structure that was most consistent with experimental mutagenesis data. We propose that this is the EGFR-mAb 806 structure, in which mAb 806 binds to an untethered form of the receptor, consistent with published experimental results. The steric hindrance created by the antibody near the EGFR dimer interface interferes with receptor dimerization, and we postulate this as the structural origin for the antitumor effect of mAb 806.

-	~~{{STRUCTURE_2exq\| PDB=2exq \| SCENE= }}~~	+	Structural model of the mAb 806-EGFR complex using computational docking followed by computational and experimental mutagenesis.,Sivasubramanian A, Chao G, Pressler HM, Wittrup KD, Gray JJ Structure. 2006 Mar;14(3):401-14. PMID:16531225<ref>PMID:16531225</ref>
-	~~===STRUCTURAL SUPERPOSITION OF MAB~~ 806- EGFR ~~PEPTIDE COMPLEX WITH EGFR HYPOTHETICAL EXTENDED MONOMER===~~	+
-	~~{{ABSTRACT_PUBMED_16531225}}~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:016531225</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Chao, G]]		[[Category: Chao, G]]
	[[Category: Gray, J J]]		[[Category: Gray, J J]]

OCA at 06:18, 25 March 2013

OCA — Mon, 25 Mar 2013 06:18:33 GMT

←Older revision		Revision as of 06:18, 25 March 2013
Line 1:		Line 1:
	{{Theoretical_model}}		{{Theoretical_model}}
-
-	[[Image:2exq.png\|left\|200px]]

	{{STRUCTURE_2exq\| PDB=2exq \| SCENE= }}		{{STRUCTURE_2exq\| PDB=2exq \| SCENE= }}
-
	===STRUCTURAL SUPERPOSITION OF MAB 806- EGFR PEPTIDE COMPLEX WITH EGFR HYPOTHETICAL EXTENDED MONOMER===		===STRUCTURAL SUPERPOSITION OF MAB 806- EGFR PEPTIDE COMPLEX WITH EGFR HYPOTHETICAL EXTENDED MONOMER===
-
	{{ABSTRACT_PUBMED_16531225}}		{{ABSTRACT_PUBMED_16531225}}

	==Reference==		==Reference==
-	<ref group="xtra">PMID:016531225</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016531225</ref><references group="xtra"/><references/>
	[[Category: Chao, G]]		[[Category: Chao, G]]
	[[Category: Gray, J J]]		[[Category: Gray, J J]]

OCA: Protected "2exq" [edit=sysop:move=sysop]

OCA — Sun, 21 Oct 2012 09:21:45 GMT

Protected "2exq" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:21, 21 October 2012

OCA at 09:21, 21 October 2012

OCA — Sun, 21 Oct 2012 09:21:41 GMT

←Older revision		Revision as of 09:21, 21 October 2012
Line 1:		Line 1:
	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:2exq.png\|left\|200px]]		[[Image:2exq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2exq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2exq\| PDB=2exq \| SCENE= }}		{{STRUCTURE_2exq\| PDB=2exq \| SCENE= }}

	===STRUCTURAL SUPERPOSITION OF MAB 806- EGFR PEPTIDE COMPLEX WITH EGFR HYPOTHETICAL EXTENDED MONOMER===		===STRUCTURAL SUPERPOSITION OF MAB 806- EGFR PEPTIDE COMPLEX WITH EGFR HYPOTHETICAL EXTENDED MONOMER===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16531225}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16531225 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16531225}}		{{ABSTRACT_PUBMED_16531225}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EXQ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16531225~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016531225</ref><references group="xtra"/>
	[[Category: Chao, G]]		[[Category: Chao, G]]
	[[Category: Gray, J J]]		[[Category: Gray, J J]]
Line 30:		Line 16:
	[[Category: Sivasubramanian, A]]		[[Category: Sivasubramanian, A]]
	[[Category: Wittrup, K D]]		[[Category: Wittrup, K D]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:10:38 2010''

OCA at 05:10, 8 April 2010

OCA — Thu, 08 Apr 2010 05:10:38 GMT

←Older revision		Revision as of 05:10, 8 April 2010
Line 1:		Line 1:
-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:2exq.png\|left\|200px]]

-	The ~~entry 2EXQ~~ is ~~a Theoretical Model titled 'Structural Superposition of MAB 806- EGFR Peptide Complex with EGFR Hypothetical Extended Monomer'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2exq", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2exq\| PDB=2exq \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===STRUCTURAL SUPERPOSITION OF MAB 806- EGFR PEPTIDE COMPLEX WITH EGFR HYPOTHETICAL EXTENDED MONOMER===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:56:~~28 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_16531225}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16531225 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16531225}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EXQ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:16531225</ref><references group="xtra"/>
		+	[[Category: Chao, G]]
		+	[[Category: Gray, J J]]
		+	[[Category: Pressler, H M]]
		+	[[Category: Sivasubramanian, A]]
		+	[[Category: Wittrup, K D]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:10:38 2010''