2f05 - Revision history

OCA at 18:55, 29 May 2024

OCA — Wed, 29 May 2024 18:55:36 GMT

←Older revision		Revision as of 18:55, 29 May 2024
Line 1:		Line 1:

	==Solution structure of free PAH2 domain of mSin3B==		==Solution structure of free PAH2 domain of mSin3B==
-	<StructureSection load='2f05' size='340' side='right'caption='[[2f05~~]], [[NMR_Ensembles_of_Models \| 30 NMR models~~]]' scene=''>	+	<StructureSection load='2f05' size='340' side='right'caption='[[2f05]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2f05]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F05 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2f05]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F05 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1pd7\|1pd7]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sin3b, Kiaa0700 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f05 OCA], [https://pdbe.org/2f05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f05 RCSB], [https://www.ebi.ac.uk/pdbsum/2f05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f05 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f05 OCA], [https://pdbe.org/2f05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f05 RCSB], [https://www.ebi.ac.uk/pdbsum/2f05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f05 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SIN3B_MOUSE SIN3B_MOUSE]] Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.<ref>PMID:7889570</ref> <ref>PMID:10620510</ref>	+	[https://www.uniprot.org/uniprot/SIN3B_MOUSE SIN3B_MOUSE] Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.<ref>PMID:7889570</ref> <ref>PMID:10620510</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Aelen, J]]	+	[[Category: Aelen J]]
-	[[Category: Baltussen~~, M A]]~~	+	[[Category: Baltussen MA]]
-	~~[[Category: Ingen, H van~~]]	+	[[Category: Vuister GW]]
-	[[Category: Vuister~~, G W~~]]	+	[[Category: Van Ingen H]]
-	[[Category: ~~Helix bundle]]~~	+
-	~~[[Category: Transcription repressor~~]]	+

OCA at 12:36, 10 February 2021

OCA — Wed, 10 Feb 2021 12:36:14 GMT

←Older revision		Revision as of 12:36, 10 February 2021
Line 1:		Line 1:

	==Solution structure of free PAH2 domain of mSin3B==		==Solution structure of free PAH2 domain of mSin3B==
-	<StructureSection load='2f05' size='340' side='right' caption='[[2f05]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>	+	<StructureSection load='2f05' size='340' side='right'caption='[[2f05]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2f05]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F05 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2F05 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2f05]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F05 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pd7\|1pd7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1pd7\|1pd7]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sin3b, Kiaa0700 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sin3b, Kiaa0700 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2f05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f05 OCA], [~~http~~://pdbe.org/2f05 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2f05 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2f05 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2f05 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f05 OCA], [https://pdbe.org/2f05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f05 RCSB], [https://www.ebi.ac.uk/pdbsum/2f05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f05 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SIN3B_MOUSE SIN3B_MOUSE]] Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.<ref>PMID:7889570</ref> <ref>PMID:10620510</ref>	+	[[https://www.uniprot.org/uniprot/SIN3B_MOUSE SIN3B_MOUSE]] Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.<ref>PMID:7889570</ref> <ref>PMID:10620510</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Aelen, J]]		[[Category: Aelen, J]]

OCA at 08:50, 14 June 2018

OCA — Thu, 14 Jun 2018 08:50:12 GMT

←Older revision		Revision as of 08:50, 14 June 2018
Line 1:		Line 1:
		+
	==Solution structure of free PAH2 domain of mSin3B==		==Solution structure of free PAH2 domain of mSin3B==
	<StructureSection load='2f05' size='340' side='right' caption='[[2f05]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='2f05' size='340' side='right' caption='[[2f05]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pd7\|1pd7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pd7\|1pd7]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sin3b, Kiaa0700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sin3b, Kiaa0700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f05 OCA], [http://pdbe.org/2f05 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f05 RCSB], [http://www.ebi.ac.uk/pdbsum/2f05 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f05 OCA], [http://pdbe.org/2f05 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f05 RCSB], [http://www.ebi.ac.uk/pdbsum/2f05 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2f05 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/2f05_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/2f05_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:47, 7 February 2016

OCA — Sun, 07 Feb 2016 06:47:49 GMT

←Older revision		Revision as of 06:47, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f05 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:51, 9 September 2015

OCA — Wed, 09 Sep 2015 22:51:57 GMT

←Older revision		Revision as of 22:51, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='2f05' size='340' side='right' caption='[[2f05]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='2f05' size='340' side='right' caption='[[2f05]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2f05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F05 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2f05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F05 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pd7\|1pd7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pd7\|1pd7]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sin3b, Kiaa0700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sin3b, Kiaa0700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f05 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f05 RCSB], [http://www.ebi.ac.uk/pdbsum/2f05 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f05 OCA], [http://pdbe.org/2f05 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f05 RCSB], [http://www.ebi.ac.uk/pdbsum/2f05 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2f05" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Aelen, J]]		[[Category: Aelen, J]]
	[[Category: Baltussen, M A]]		[[Category: Baltussen, M A]]

OCA at 08:44, 24 December 2014

OCA — Wed, 24 Dec 2014 08:44:02 GMT

←Older revision		Revision as of 08:44, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2f05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F05 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F05 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pd7\|1pd7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pd7\|1pd7]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sin3b, Kiaa0700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sin3b, Kiaa0700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f05 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f05 RCSB], [http://www.ebi.ac.uk/pdbsum/2f05 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f05 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f05 RCSB], [http://www.ebi.ac.uk/pdbsum/2f05 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SIN3B_MOUSE SIN3B_MOUSE]] Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.<ref>PMID:7889570</ref> <ref>PMID:10620510</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Aelen, J.]]	+	[[Category: Aelen, J]]
-	[[Category: Baltussen, M A.]]	+	[[Category: Baltussen, M A]]
-	[[Category: Ingen, H van.]]	+	[[Category: Ingen, H van]]
-	[[Category: Vuister, G W.]]	+	[[Category: Vuister, G W]]
-	[[Category: ~~4 helix~~ bundle]]	+	[[Category: Helix bundle]]
	[[Category: Transcription repressor]]		[[Category: Transcription repressor]]

OCA at 01:48, 30 September 2014

OCA — Tue, 30 Sep 2014 01:48:38 GMT

←Older revision		Revision as of 01:48, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2f05.~~png~~\|~~left~~\|200px]]	+	==Solution structure of free PAH2 domain of mSin3B==
		+	<StructureSection load='2f05' size='340' side='right' caption='[[2f05]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2f05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F05 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pd7\|1pd7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sin3b, Kiaa0700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f05 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f05 RCSB], [http://www.ebi.ac.uk/pdbsum/2f05 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/2f05_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The co-repressor Sin3 is the essential scaffold protein of the Sin3/HDAC co-repressor complex, which is recruited to the DNA by a diverse group of transcriptional repressors, targeting genes involved in the regulation of the cell cycle, proliferation and differentiation. Sin3 contains four repeats commonly denoted as paired amphipathic helix (PAH1-4) domains that provide the principal interaction surface for various repressors. Here, we present the first structure of the free state of the PAH2 domain and discuss its implications for interaction with the repressors. The unbound conformation is very similar to the conformation observed when bound to either the Mad1 or HBP1 repressor, suggesting that the PAH2 domain serves as a template that guides proper folding of the unstructured repressor. The free PAH2 domain shows micro- to millisecond conformational exchange between the folded, major state and a partially unfolded, minor state. Upon complex formation, we observe a significant decrease in fast time-scale flexibility of local regions of the protein, correlated with the formation of intermolecular contacts, and an overall decrease in the slow time-scale conformational exchange. On the basis of our data and using a multiple sequence alignment of all PAH domains, we suggest that the PAH1, PAH2 and PAH3 domains form pre-folded binding modules in full-length Sin3 like beads-on-a-string, and act as folding templates for the interaction domains of their targets.

-	~~{{STRUCTURE_2f05\| PDB=2f05 \| SCENE= }}~~	+	Role of structural and dynamical plasticity in Sin3: the free PAH2 domain is a folded module in mSin3B.,van Ingen H, Baltussen MA, Aelen J, Vuister GW J Mol Biol. 2006 Apr 28;358(2):485-97. Epub 2006 Feb 13. PMID:16519900<ref>PMID:16519900</ref>

-	~~===Solution structure~~ of ~~free PAH2 domain of mSin3B===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16519900}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2f05]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2F05 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016519900<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Aelen, J.]]		[[Category: Aelen, J.]]

OCA: Protected "2f05" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:44:06 GMT

Protected "2f05" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:44, 7 January 2013

OCA at 11:44, 7 January 2013

OCA — Mon, 07 Jan 2013 11:44:04 GMT

←Older revision		Revision as of 11:44, 7 January 2013
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-	{{Seed}}
	[[Image:2f05.png\|left\|200px]]		[[Image:2f05.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2f05", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2f05\| PDB=2f05 \| SCENE= }}		{{STRUCTURE_2f05\| PDB=2f05 \| SCENE= }}

	===Solution structure of free PAH2 domain of mSin3B===		===Solution structure of free PAH2 domain of mSin3B===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16519900}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16519900 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16519900}}		{{ABSTRACT_PUBMED_16519900}}

	==About this Structure==		==About this Structure==
-	~~2F05~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F05 OCA].	+	[[2f05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F05 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16519900~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016519900</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Aelen, J.]]		[[Category: Aelen, J.]]
Line 30:		Line 18:
	[[Category: Vuister, G W.]]		[[Category: Vuister, G W.]]
	[[Category: 4 helix bundle]]		[[Category: 4 helix bundle]]
-		+	[[Category: Transcription repressor]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 12:03:31 2009''~~	+

OCA at 10:03, 16 February 2009

OCA — Mon, 16 Feb 2009 10:03:33 GMT

←Older revision		Revision as of 10:03, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2F05 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F05 OCA].	+	2F05 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F05 OCA].

	==Reference==		==Reference==
-	Role of structural and dynamical plasticity in Sin3: the free PAH2 domain is a folded module in mSin3B., van Ingen H, Baltussen MA, Aelen J, Vuister GW, J Mol Biol. 2006 Apr 28;358(2):485-97. Epub 2006 Feb 13. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16519900 16519900]~~	+	<ref group="xtra">PMID:16519900</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Single protein]]
	[[Category: Aelen, J.]]		[[Category: Aelen, J.]]
	[[Category: Baltussen, M A.]]		[[Category: Baltussen, M A.]]
Line 32:		Line 31:
	[[Category: 4 helix bundle]]		[[Category: 4 helix bundle]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 14:~~12:~~52 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:03:31 2009''