2f5c - Revision history

OCA at 07:43, 23 August 2023

OCA — Wed, 23 Aug 2023 07:43:22 GMT

←Older revision		Revision as of 07:43, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='2f5c' size='340' side='right'caption='[[2f5c]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2f5c' size='340' side='right'caption='[[2f5c]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2f5c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F5C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2f5c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F5C FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1on1\|1on1]], [[2f5d\|2f5d]], [[2f5e\|2f5e]], [[2f5f\|2f5f]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">mntR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5c OCA], [https://pdbe.org/2f5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f5c RCSB], [https://www.ebi.ac.uk/pdbsum/2f5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f5c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5c OCA], [https://pdbe.org/2f5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f5c RCSB], [https://www.ebi.ac.uk/pdbsum/2f5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f5c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU]] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.	+	[https://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835~~]]	+	[[Category: Bacillus subtilis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brennan~~, R G~~]]	+	[[Category: Brennan RG]]
-	[[Category: Glasfeld, A]]	+	[[Category: Glasfeld A]]
-	[[Category: Griner~~, S L~~]]	+	[[Category: Griner SL]]
-	[[Category: Helmann~~, J D~~]]	+	[[Category: Helmann JD]]
-	[[Category: Kliegman~~, J I]]~~	+	[[Category: Kliegman JI]]
-	~~[[Category: Dna-binding protein]]~~	+
-	~~[[Category: Helix-turn-helix]]~~	+
-	~~[[Category: Metalloregulatory protein]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 10:38, 17 February 2021

OCA — Wed, 17 Feb 2021 10:38:23 GMT

←Older revision		Revision as of 10:38, 17 February 2021
Line 1:		Line 1:

	==Bacillus subtilis Manganese transport regulator (MNTR) bound to manganese, hexagonal crystal form==		==Bacillus subtilis Manganese transport regulator (MNTR) bound to manganese, hexagonal crystal form==
-	<StructureSection load='2f5c' size='340' side='right' caption='[[2f5c]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2f5c' size='340' side='right'caption='[[2f5c]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2f5c]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2F5C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2f5c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F5C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]], [[2f5d\|2f5d]], [[2f5e\|2f5e]], [[2f5f\|2f5f]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1on1\|1on1]], [[2f5d\|2f5d]], [[2f5e\|2f5e]], [[2f5f\|2f5f]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5c OCA], [~~http~~://pdbe.org/2f5c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2f5c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2f5c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2f5c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5c OCA], [https://pdbe.org/2f5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f5c RCSB], [https://www.ebi.ac.uk/pdbsum/2f5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f5c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU]] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.	+	[[https://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU]] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Vibrio subtilis ehrenberg 1835]]		[[Category: Vibrio subtilis ehrenberg 1835]]
		+	[[Category: Large Structures]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Glasfeld, A]]		[[Category: Glasfeld, A]]

OCA at 08:36, 14 June 2018

OCA — Thu, 14 Jun 2018 08:36:40 GMT

←Older revision		Revision as of 08:36, 14 June 2018
Line 1:		Line 1:
		+
	==Bacillus subtilis Manganese transport regulator (MNTR) bound to manganese, hexagonal crystal form==		==Bacillus subtilis Manganese transport regulator (MNTR) bound to manganese, hexagonal crystal form==
	<StructureSection load='2f5c' size='340' side='right' caption='[[2f5c]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2f5c' size='340' side='right' caption='[[2f5c]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2f5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"~~bacillus_globigii~~"~~_migula_1900~~ "~~bacillus globigii~~" ~~migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2f5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5C FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]], [[2f5d\|2f5d]], [[2f5e\|2f5e]], [[2f5f\|2f5f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]], [[2f5d\|2f5d]], [[2f5e\|2f5e]], [[2f5f\|2f5f]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "~~Bacillus globigii~~" ~~Migula 1900~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5c OCA], [http://pdbe.org/2f5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f5c RCSB], [http://www.ebi.ac.uk/pdbsum/2f5c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5c OCA], [http://pdbe.org/2f5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f5c RCSB], [http://www.ebi.ac.uk/pdbsum/2f5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2f5c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/2f5c_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/2f5c_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus globigii migula 1900~~]]	+	[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Glasfeld, A]]		[[Category: Glasfeld, A]]

OCA at 06:23, 7 February 2016

OCA — Sun, 07 Feb 2016 06:23:40 GMT

←Older revision		Revision as of 06:23, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f5c ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:41, 9 September 2015

OCA — Wed, 09 Sep 2015 22:41:58 GMT

←Older revision		Revision as of 22:41, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='2f5c' size='340' side='right' caption='[[2f5c]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2f5c' size='340' side='right' caption='[[2f5c]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2f5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2f5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5C FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]], [[2f5d\|2f5d]], [[2f5e\|2f5e]], [[2f5f\|2f5f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]], [[2f5d\|2f5d]], [[2f5e\|2f5e]], [[2f5f\|2f5f]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus ~~subtilis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f5c RCSB], [http://www.ebi.ac.uk/pdbsum/2f5c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5c OCA], [http://pdbe.org/2f5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f5c RCSB], [http://www.ebi.ac.uk/pdbsum/2f5c PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2f5c" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~subtilis~~]]	+	[[Category: Bacillus globigii migula 1900]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Glasfeld, A]]		[[Category: Glasfeld, A]]

OCA at 08:36, 24 December 2014

OCA — Wed, 24 Dec 2014 08:36:16 GMT

←Older revision		Revision as of 08:36, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2f5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5C FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5C FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]], [[2f5d\|2f5d]], [[2f5e\|2f5e]], [[2f5f\|2f5f]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]], [[2f5d\|2f5d]], [[2f5e\|2f5e]], [[2f5f\|2f5f]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f5c RCSB], [http://www.ebi.ac.uk/pdbsum/2f5c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f5c RCSB], [http://www.ebi.ac.uk/pdbsum/2f5c PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU]] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Brennan, R G.]]	+	[[Category: Brennan, R G]]
-	[[Category: Glasfeld, A.]]	+	[[Category: Glasfeld, A]]
-	[[Category: Griner, S L.]]	+	[[Category: Griner, S L]]
-	[[Category: Helmann, J D.]]	+	[[Category: Helmann, J D]]
-	[[Category: Kliegman, J I.]]	+	[[Category: Kliegman, J I]]
	[[Category: Dna-binding protein]]		[[Category: Dna-binding protein]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Metalloregulatory protein]]		[[Category: Metalloregulatory protein]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 01:39, 30 September 2014

OCA — Tue, 30 Sep 2014 01:39:08 GMT

←Older revision		Revision as of 01:39, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2f5c.~~png~~\|~~left~~\|200px]]	+	==Bacillus subtilis Manganese transport regulator (MNTR) bound to manganese, hexagonal crystal form==
		+	<StructureSection load='2f5c' size='340' side='right' caption='[[2f5c]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2f5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5C FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]], [[2f5d\|2f5d]], [[2f5e\|2f5e]], [[2f5f\|2f5f]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f5c RCSB], [http://www.ebi.ac.uk/pdbsum/2f5c PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/2f5c_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The manganese transport regulator (MntR) of Bacillus subtilis is activated by Mn(2+) to repress transcription of genes encoding transporters involved in the uptake of manganese. MntR is also strongly activated by cadmium, both in vivo and in vitro, but it is poorly activated by other metal cations, including calcium and zinc. The previously published MntR.Mn(2+) structure revealed a binuclear complex of manganese ions with a metal-metal separation of 3.3 A (herein designated the AB conformer). Analysis of four additional crystal forms of MntR.Mn(2+) reveals that the AB conformer is only observed in monoclinic crystals at 100 K, suggesting that this conformation may be stabilized by crystal packing forces. In contrast, monoclinic crystals analyzed at room temperature (at either pH 6.5 or pH 8.5), and a second hexagonal crystal form (analyzed at 100 K), all reveal the shift of one manganese ion by 2.5 A, thereby leading to a newly identified conformation (the AC conformer) with an internuclear distance of 4.4 A. Significantly, the cadmium and calcium complexes of MntR also contain binuclear complexes with a 4.4 A internuclear separation. In contrast, the zinc complex of MntR contains only one metal ion per subunit, in the A site. Isothermal titration calorimetry confirms the stoichiometry of Mn(2+), Cd(2+), and Zn(2+) binding to MntR. We propose that the specificity of MntR activation is tied to productive binding of metal ions at two sites; the A site appears to act as a selectivity filter, determining whether the B or C site will be occupied and thereby fully activate MntR.

-	~~{{STRUCTURE_2f5c\| PDB=2f5c \| SCENE= }}~~	+	Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis.,Kliegman JI, Griner SL, Helmann JD, Brennan RG, Glasfeld A Biochemistry. 2006 Mar 21;45(11):3493-505. PMID:16533030<ref>PMID:16533030</ref>

-	~~===Bacillus subtilis Manganese transport regulator (MNTR) bound to manganese~~, ~~hexagonal crystal form===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16533030}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2f5c]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_subtilis Bacillus subtilis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2F5C OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016533030<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Brennan, R G.]]		[[Category: Brennan, R G.]]

OCA: Protected "2f5c" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:35:44 GMT

Protected "2f5c" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:35, 7 January 2013

OCA at 11:35, 7 January 2013

OCA — Mon, 07 Jan 2013 11:35:40 GMT

←Older revision		Revision as of 11:35, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2f5c.png\|left\|200px]]		[[Image:2f5c.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2f5c", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2f5c\| PDB=2f5c \| SCENE= }}		{{STRUCTURE_2f5c\| PDB=2f5c \| SCENE= }}

	===Bacillus subtilis Manganese transport regulator (MNTR) bound to manganese, hexagonal crystal form===		===Bacillus subtilis Manganese transport regulator (MNTR) bound to manganese, hexagonal crystal form===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16533030}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16533030 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16533030}}		{{ABSTRACT_PUBMED_16533030}}

	==About this Structure==		==About this Structure==
-	~~2F5C~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5C OCA].	+	[[2f5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5C OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16533030~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016533030</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Brennan, R G.]]		[[Category: Brennan, R G.]]
Line 33:		Line 21:
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Metalloregulatory protein]]		[[Category: Metalloregulatory protein]]
-		+	[[Category: Transcription]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 11:56:17 2009''~~	+

OCA at 09:56, 16 February 2009

OCA — Mon, 16 Feb 2009 09:56:17 GMT

←Older revision		Revision as of 09:56, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2F5C is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5C OCA].	+	2F5C is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5C OCA].

	==Reference==		==Reference==
-	Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis., Kliegman JI, Griner SL, Helmann JD, Brennan RG, Glasfeld A, Biochemistry. 2006 Mar 21;45(11):3493-505. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16533030 16533030]~~	+	<ref group="xtra">PMID:16533030</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Single protein]]
	[[Category: Brennan, R G.]]		[[Category: Brennan, R G.]]
	[[Category: Glasfeld, A.]]		[[Category: Glasfeld, A.]]
Line 35:		Line 34:
	[[Category: Metalloregulatory protein]]		[[Category: Metalloregulatory protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 14~~:03:~~15 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:56:17 2009''