2fel - Revision history

OCA at 09:25, 30 August 2023

OCA — Wed, 30 Aug 2023 09:25:54 GMT

←Older revision		Revision as of 09:25, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2fel' size='340' side='right'caption='[[2fel]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2fel' size='340' side='right'caption='[[2fel]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2fel]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"achromobacter_radiobacter"_(beijerinck_and_van_delden_1902)_bergey_et_al._1934 "achromobacter radiobacter" (beijerinck and van delden 1902) bergey et al. 1934~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2fel]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FEL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height~~: ~~3em;~~'>~~[[2fen\|2fen]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fel OCA], [https://pdbe.org/2fel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fel RCSB], [https://www.ebi.ac.uk/pdbsum/2fel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fel ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fel OCA], [https://pdbe.org/2fel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fel RCSB], [https://www.ebi.ac.uk/pdbsum/2fel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fel ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q2HNZ1_RHIRD Q2HNZ1_RHIRD]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Agrobacterium tumefaciens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Goldman, A]]	+	[[Category: Goldman A]]
-	[[Category: Lehtio, L]]	+	[[Category: Lehtio L]]
-	~~[[Category: 3-sulphomuconate]]~~	+
-	~~[[Category: Agrobacterium radiobacter s2]]~~	+
-	~~[[Category: Biodegradation]]~~	+
-	~~[[Category: Cycloisomerase]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Sulphonic acid~~]]	+

OCA at 16:04, 22 December 2021

OCA — Wed, 22 Dec 2021 16:04:15 GMT

←Older revision		Revision as of 16:04, 22 December 2021
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	<StructureSection load='2fel' size='340' side='right'caption='[[2fel]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2fel' size='340' side='right'caption='[[2fel]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2fel]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"achromobacter_radiobacter"_(beijerinck_and_van_delden_1902)_bergey_et_al._1934 "achromobacter radiobacter" (beijerinck and van delden 1902) bergey et al. 1934]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2fel]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/"achromobacter_radiobacter"_(beijerinck_and_van_delden_1902)_bergey_et_al._1934 "achromobacter radiobacter" (beijerinck and van delden 1902) bergey et al. 1934]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FEL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fen\|2fen]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fen\|2fen]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2fel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fel OCA], [~~http~~://pdbe.org/2fel PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2fel RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2fel PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fel ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fel OCA], [https://pdbe.org/2fel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fel RCSB], [https://www.ebi.ac.uk/pdbsum/2fel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fel ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:49, 18 March 2020

OCA — Wed, 18 Mar 2020 10:49:09 GMT

←Older revision		Revision as of 10:49, 18 March 2020
Line 1:		Line 1:

	==3-carboxy-cis,cis-muconate lactonizing enzyme from Agrobacterium radiobacter S2==		==3-carboxy-cis,cis-muconate lactonizing enzyme from Agrobacterium radiobacter S2==
-	<StructureSection load='2fel' size='340' side='right' caption='[[2fel]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2fel' size='340' side='right'caption='[[2fel]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fel]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"achromobacter_radiobacter"_(beijerinck_and_van_delden_1902)_bergey_et_al._1934 "achromobacter radiobacter" (beijerinck and van delden 1902) bergey et al. 1934]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FEL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fel]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"achromobacter_radiobacter"_(beijerinck_and_van_delden_1902)_bergey_et_al._1934 "achromobacter radiobacter" (beijerinck and van delden 1902) bergey et al. 1934]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FEL FirstGlance]. <br>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Goldman, A]]		[[Category: Goldman, A]]
	[[Category: Lehtio, L]]		[[Category: Lehtio, L]]

OCA at 08:31, 14 June 2018

OCA — Thu, 14 Jun 2018 08:31:11 GMT

←Older revision		Revision as of 08:31, 14 June 2018
Line 1:		Line 1:
		+
	==3-carboxy-cis,cis-muconate lactonizing enzyme from Agrobacterium radiobacter S2==		==3-carboxy-cis,cis-muconate lactonizing enzyme from Agrobacterium radiobacter S2==
	<StructureSection load='2fel' size='340' side='right' caption='[[2fel]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2fel' size='340' side='right' caption='[[2fel]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fen\|2fen]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fen\|2fen]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fel OCA], [http://pdbe.org/2fel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fel RCSB], [http://www.ebi.ac.uk/pdbsum/2fel PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fel OCA], [http://pdbe.org/2fel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fel RCSB], [http://www.ebi.ac.uk/pdbsum/2fel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fel ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fe/2fel_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fe/2fel_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fel ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 2fel" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2fel" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Muconate cycloisomerase\|Muconate cycloisomerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:44, 11 September 2015

OCA — Fri, 11 Sep 2015 21:44:47 GMT

←Older revision		Revision as of 21:44, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2fel' size='340' side='right' caption='[[2fel]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2fel' size='340' side='right' caption='[[2fel]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2fel]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Agrobacterium_tumefaciens Agrobacterium tumefaciens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2fel]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"achromobacter_radiobacter"_(beijerinck_and_van_delden_1902)_bergey_et_al._1934 "achromobacter radiobacter" (beijerinck and van delden 1902) bergey et al. 1934]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FEL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fen\|2fen]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fen\|2fen]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fel RCSB], [http://www.ebi.ac.uk/pdbsum/2fel PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fel OCA], [http://pdbe.org/2fel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fel RCSB], [http://www.ebi.ac.uk/pdbsum/2fel PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2fel" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Agrobacterium tumefaciens]]
	[[Category: Goldman, A]]		[[Category: Goldman, A]]
	[[Category: Lehtio, L]]		[[Category: Lehtio, L]]

OCA at 08:02, 16 January 2015

OCA — Fri, 16 Jan 2015 08:02:17 GMT

←Older revision		Revision as of 08:02, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fel]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FEL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fel]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FEL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fen\|2fen]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fen\|2fen]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fel RCSB], [http://www.ebi.ac.uk/pdbsum/2fel PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fel RCSB], [http://www.ebi.ac.uk/pdbsum/2fel PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Agrobacterium tumefaciens]]		[[Category: Agrobacterium tumefaciens]]
-	[[Category: Goldman, A.]]	+	[[Category: Goldman, A]]
-	[[Category: Lehtio, L.]]	+	[[Category: Lehtio, L]]
	[[Category: 3-sulphomuconate]]		[[Category: 3-sulphomuconate]]
	[[Category: Agrobacterium radiobacter s2]]		[[Category: Agrobacterium radiobacter s2]]

OCA at 01:36, 30 September 2014

OCA — Tue, 30 Sep 2014 01:36:18 GMT

←Older revision		Revision as of 01:36, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2fel.~~png~~\|~~left~~\|200px]]	+	==3-carboxy-cis,cis-muconate lactonizing enzyme from Agrobacterium radiobacter S2==
		+	<StructureSection load='2fel' size='340' side='right' caption='[[2fel]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2fel]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FEL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fen\|2fen]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fel RCSB], [http://www.ebi.ac.uk/pdbsum/2fel PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fe/2fel_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	3-carboxy-cis,cis-muconate lactonizing enzymes participate in the protocatechuate branch of the 3-oxoadipate pathway of various aerobic bacteria. The gene encoding a 3-carboxy-cis,cis-muconate lactonizing enzyme (pcaB1S2) was cloned from a gene cluster involved in protocatechuate degradation by Agrobacterium radiobacter strain S2. This gene encoded for a 3-carboxy-cis,cis-muconate lactonizing enzyme of 353 amino acids - significantly smaller than all previously studied 3-carboxy-cis,cis-muconate lactonizing enzymes. This enzyme, ArCMLE1, was produced in Escherichia coli and shown to convert not only 3-carboxy-cis,cis-muconate but also 3-sulfomuconate. ArCMLE1 was purified as a His-tagged enzyme variant, and the basic catalytic constants for the conversion of 3-carboxy-cis,cis-muconate and 3-sulfomuconate were determined. In contrast, Agrobacterium tumefaciens 3-carboxy-cis,cis-muconate lactonizing enzyme 1 could not, despite 87% sequence identity to ArCMLE1, use 3-sulfomuconate as substrate. The crystal structure of ArCMLE1 was determined at 2.2 A resolution. Consistent with the sequence, it showed that the C-terminal domain, present in all other members of the fumarase II family, is missing in ArCMLE1. Nonetheless, both the tertiary and quaternary structures, and the structure of the active site, are similar to those of Pseudomonas putida 3-carboxy-cis,cis-muconate lactonizing enzyme. One principal difference is that ArCMLE1 contains an Arg, as opposed to a Trp, in the active site. This indicates that activation of the carboxylic nucleophile by a hydrophobic environment is not required for lactonization, unlike earlier proposals [Yang J, Wang Y, Woolridge EM, Arora V, Petsko GA, Kozarich JW & Ringe D (2004) Biochemistry43, 10424-10434]. We identified citrate and isocitrate as noncompetitive inhibitors of ArCMLE1, and found a potential binding pocket for them on the enzyme outside the active site.

-	~~{{STRUCTURE_2fel\| PDB=2fel \| SCENE= }}~~	+	Structure and function of the 3-carboxy-cis,cis-muconate lactonizing enzyme from the protocatechuate degradative pathway of Agrobacterium radiobacter S2.,Halak S, Lehtio L, Basta T, Burger S, Contzen M, Stolz A, Goldman A FEBS J. 2006 Nov;273(22):5169-82. Epub 2006 Oct 20. PMID:17054713<ref>PMID:17054713</ref>

-	~~===3-carboxy-cis~~,~~cis-muconate lactonizing enzyme from Agrobacterium radiobacter S2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17054713}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2fel]] is~~ a ~~12 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2FEL OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017054713<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Agrobacterium tumefaciens]]		[[Category: Agrobacterium tumefaciens]]
	[[Category: Goldman, A.]]		[[Category: Goldman, A.]]

OCA: Protected "2fel" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:32:24 GMT

Protected "2fel" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:32, 7 January 2013

OCA at 11:32, 7 January 2013

OCA — Mon, 07 Jan 2013 11:32:21 GMT

←Older revision		Revision as of 11:32, 7 January 2013
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-	{{Seed}}
	[[Image:2fel.png\|left\|200px]]		[[Image:2fel.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2fel", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2fel\| PDB=2fel \| SCENE= }}		{{STRUCTURE_2fel\| PDB=2fel \| SCENE= }}

	===3-carboxy-cis,cis-muconate lactonizing enzyme from Agrobacterium radiobacter S2===		===3-carboxy-cis,cis-muconate lactonizing enzyme from Agrobacterium radiobacter S2===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17054713}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17054713 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17054713}}		{{ABSTRACT_PUBMED_17054713}}

	==About this Structure==		==About this Structure==
-	~~2FEL~~ is a 12 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEL OCA].	+	[[2fel]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEL OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17054713~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017054713</ref><references group="xtra"/>
	[[Category: Agrobacterium tumefaciens]]		[[Category: Agrobacterium tumefaciens]]
	[[Category: Goldman, A.]]		[[Category: Goldman, A.]]
Line 31:		Line 19:
	[[Category: Biodegradation]]		[[Category: Biodegradation]]
	[[Category: Cycloisomerase]]		[[Category: Cycloisomerase]]
		+	[[Category: Isomerase]]
	[[Category: Sulphonic acid]]		[[Category: Sulphonic acid]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:31:43 2009''

OCA at 03:31, 18 February 2009

OCA — Wed, 18 Feb 2009 03:31:45 GMT

←Older revision		Revision as of 03:31, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2FEL is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEL OCA].	+	2FEL is a 12 chains structure of sequences from [http://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEL OCA].

	==Reference==		==Reference==
-	Structure and function of the 3-carboxy-cis,cis-muconate lactonizing enzyme from the protocatechuate degradative pathway of Agrobacterium radiobacter S2., Halak S, Lehtio L, Basta T, Burger S, Contzen M, Stolz A, Goldman A, FEBS J. 2006 Nov;273(22):5169-82. Epub 2006 Oct 20. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17054713 17054713]~~	+	<ref group="xtra">PMID:17054713</ref><references group="xtra"/>
	[[Category: Agrobacterium tumefaciens]]		[[Category: Agrobacterium tumefaciens]]
-	[[Category: Single protein]]
	[[Category: Goldman, A.]]		[[Category: Goldman, A.]]
	[[Category: Lehtio, L.]]		[[Category: Lehtio, L.]]
Line 34:		Line 33:
	[[Category: Sulphonic acid]]		[[Category: Sulphonic acid]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 12~~:13:~~51 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:31:43 2009''