2ffc - Revision history

OCA at 09:26, 30 August 2023

OCA — Wed, 30 Aug 2023 09:26:10 GMT

←Older revision		Revision as of 09:26, 30 August 2023
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	<StructureSection load='2ffc' size='340' side='right'caption='[[2ffc]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2ffc' size='340' side='right'caption='[[2ffc]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ffc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Haemamoeba_vivax Haemamoeba~~ vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FFC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ffc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FFC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=U5P:URIDINE~~-~~5-MONOPHOSPHATE'>U5P</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https://en.wikipedia.org/wiki/Decylcitrate_synthase Decylcitrate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.2 2.3.3.2]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffc OCA], [https://pdbe.org/2ffc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ffc RCSB], [https://www.ebi.ac.uk/pdbsum/2ffc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffc OCA], [https://pdbe.org/2ffc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ffc RCSB], [https://www.ebi.ac.uk/pdbsum/2ffc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffc ProSAT]</span></td></tr>
	</table>		</table>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Decylcitrate synthase]]
-	[[Category: Haemamoeba vivax]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Amani, M]]	+	[[Category: Plasmodium vivax]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Amani M]]
-	[[Category: Bochkarev, A]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Dong, A]]	+	[[Category: Bochkarev A]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Dong A]]
-	[[Category: Hui, R]]	+	[[Category: Edwards AM]]
-	[[Category: Koeieradzki, I]]	+	[[Category: Hui R]]
-	[[Category: Lew, J]]	+	[[Category: Koeieradzki I]]
-	[[Category: Melone, M]]	+	[[Category: Lew J]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Melone M]]
-	[[Category: Sundstrom, M]]	+	[[Category: Sundstrom M]]
-	[[Category: Vedadi, M]]	+	[[Category: Vedadi M]]
-	[[Category: Wasney, G]]	+	[[Category: Wasney G]]
-	[[Category: Weigelt, J]]	+	[[Category: Weigelt J]]
-	[[Category: Zhao, Y]]	+	[[Category: Zhao Y]]
-	~~[[Category: Decarboxylase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Pv-pf10_0225]]~~	+
-	~~[[Category: Sgc~~]]	+

OCA at 16:04, 22 December 2021

OCA — Wed, 22 Dec 2021 16:04:27 GMT

←Older revision		Revision as of 16:04, 22 December 2021
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	<StructureSection load='2ffc' size='340' side='right'caption='[[2ffc]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2ffc' size='340' side='right'caption='[[2ffc]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ffc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Haemamoeba_vivax Haemamoeba vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FFC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ffc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemamoeba_vivax Haemamoeba vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FFC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Decylcitrate_synthase Decylcitrate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.2 2.3.3.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Decylcitrate_synthase Decylcitrate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.2 2.3.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffc OCA], [~~http~~://pdbe.org/2ffc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ffc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ffc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffc OCA], [https://pdbe.org/2ffc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ffc RCSB], [https://www.ebi.ac.uk/pdbsum/2ffc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffc ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:49, 18 March 2020

OCA — Wed, 18 Mar 2020 10:49:27 GMT

←Older revision		Revision as of 10:49, 18 March 2020
Line 1:		Line 1:

	==Crystal Structure of Plasmodium Vivax Orotidine-Monophosphate-Decarboxyl UMP Bound==		==Crystal Structure of Plasmodium Vivax Orotidine-Monophosphate-Decarboxyl UMP Bound==
-	<StructureSection load='2ffc' size='340' side='right' caption='[[2ffc]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='2ffc' size='340' side='right'caption='[[2ffc]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ffc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemamoeba_vivax Haemamoeba vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ffc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemamoeba_vivax Haemamoeba vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFC FirstGlance]. <br>
Line 33:		Line 33:
	[[Category: Decylcitrate synthase]]		[[Category: Decylcitrate synthase]]
	[[Category: Haemamoeba vivax]]		[[Category: Haemamoeba vivax]]
		+	[[Category: Large Structures]]
	[[Category: Amani, M]]		[[Category: Amani, M]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 08:36, 14 June 2018

OCA — Thu, 14 Jun 2018 08:36:42 GMT

←Older revision		Revision as of 08:36, 14 June 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Plasmodium Vivax Orotidine-Monophosphate-Decarboxyl UMP Bound==		==Crystal Structure of Plasmodium Vivax Orotidine-Monophosphate-Decarboxyl UMP Bound==
	<StructureSection load='2ffc' size='340' side='right' caption='[[2ffc]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2ffc' size='340' side='right' caption='[[2ffc]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ffc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plavi Plavi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ffc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemamoeba_vivax Haemamoeba vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Decylcitrate_synthase Decylcitrate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.2 2.3.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Decylcitrate_synthase Decylcitrate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.2 2.3.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffc OCA], [http://pdbe.org/2ffc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ffc RCSB], [http://www.ebi.ac.uk/pdbsum/2ffc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffc OCA], [http://pdbe.org/2ffc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ffc RCSB], [http://www.ebi.ac.uk/pdbsum/2ffc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffc ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/2ffc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/2ffc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Decylcitrate synthase]]		[[Category: Decylcitrate synthase]]
-	[[Category: ~~Plavi~~]]	+	[[Category: Haemamoeba vivax]]
	[[Category: Amani, M]]		[[Category: Amani, M]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 14:28, 7 February 2016

OCA — Sun, 07 Feb 2016 14:28:23 GMT

←Older revision		Revision as of 14:28, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ffc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:23, 10 September 2015

OCA — Thu, 10 Sep 2015 02:23:08 GMT

←Older revision		Revision as of 02:23, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2ffc' size='340' side='right' caption='[[2ffc]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2ffc' size='340' side='right' caption='[[2ffc]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ffc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_vivax Plasmodium vivax~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ffc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plavi Plavi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Decylcitrate_synthase Decylcitrate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.2 2.3.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Decylcitrate_synthase Decylcitrate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.2 2.3.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ffc RCSB], [http://www.ebi.ac.uk/pdbsum/2ffc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffc OCA], [http://pdbe.org/2ffc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ffc RCSB], [http://www.ebi.ac.uk/pdbsum/2ffc PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ffc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Decylcitrate synthase]]		[[Category: Decylcitrate synthase]]
-	[[Category: ~~Plasmodium vivax~~]]	+	[[Category: Plavi]]
	[[Category: Amani, M]]		[[Category: Amani, M]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 08:06, 16 January 2015

OCA — Fri, 16 Jan 2015 08:06:08 GMT

←Older revision		Revision as of 08:06, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ffc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ffc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Decylcitrate_synthase Decylcitrate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.2 2.3.3.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Decylcitrate_synthase Decylcitrate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.2 2.3.3.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ffc RCSB], [http://www.ebi.ac.uk/pdbsum/2ffc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ffc RCSB], [http://www.ebi.ac.uk/pdbsum/2ffc PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	[[Category: Decylcitrate synthase]]		[[Category: Decylcitrate synthase]]
	[[Category: Plasmodium vivax]]		[[Category: Plasmodium vivax]]
-	[[Category: Amani, M.]]	+	[[Category: Amani, M]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bochkarev, A.]]	+	[[Category: Bochkarev, A]]
-	[[Category: Dong, A.]]	+	[[Category: Dong, A]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Hui, R.]]	+	[[Category: Hui, R]]
-	[[Category: Koeieradzki, I.]]	+	[[Category: Koeieradzki, I]]
-	[[Category: Lew, J.]]	+	[[Category: Lew, J]]
-	[[Category: Melone, M.]]	+	[[Category: Melone, M]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Sundstrom, M.]]	+	[[Category: Sundstrom, M]]
-	[[Category: Vedadi, M.]]	+	[[Category: Vedadi, M]]
-	[[Category: Wasney, G.]]	+	[[Category: Wasney, G]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Zhao, Y.]]	+	[[Category: Zhao, Y]]
	[[Category: Decarboxylase]]		[[Category: Decarboxylase]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Pv-pf10_0225]]		[[Category: Pv-pf10_0225]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]

OCA at 01:39, 30 September 2014

OCA — Tue, 30 Sep 2014 01:39:16 GMT

←Older revision		Revision as of 01:39, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2ffc.~~png\|left~~\|200px]]	+	==Crystal Structure of Plasmodium Vivax Orotidine-Monophosphate-Decarboxyl UMP Bound==
		+	<StructureSection load='2ffc' size='340' side='right' caption='[[2ffc]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ffc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Decylcitrate_synthase Decylcitrate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.2 2.3.3.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ffc RCSB], [http://www.ebi.ac.uk/pdbsum/2ffc PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/2ffc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Parasites from the protozoan phylum Apicomplexa are responsible for diseases, such as malaria, toxoplasmosis and cryptosporidiosis, all of which have significantly higher rates of mortality and morbidity in economically underdeveloped regions of the world. Advances in vaccine development and drug discovery are urgently needed to control these diseases and can be facilitated by production of purified recombinant proteins from Apicomplexan genomes and determination of their 3D structures. To date, both heterologous expression and crystallization of Apicomplexan proteins have seen only limited success. In an effort to explore the effectiveness of producing and crystallizing proteins on a genome-scale using a standardized methodology, over 400 distinct Plasmodium falciparum target genes were chosen representing different cellular classes, along with select orthologues from four other Plasmodium species as well as Cryptosporidium parvum and Toxoplasma gondii. From a total of 1008 genes from the seven genomes, 304 (30.2%) produced purified soluble proteins and 97 (9.6%) crystallized, culminating in 36 crystal structures. These results demonstrate that, contrary to previous findings, a standardized platform using Escherichia coli can be effective for genome-scale production and crystallography of Apicomplexan proteins. Predictably, orthologous proteins from different Apicomplexan genomes behaved differently in expression, purification and crystallization, although the overall success rates of Plasmodium orthologues do not differ significantly. Their differences were effectively exploited to elevate the overall productivity to levels comparable to the most successful ongoing structural genomics projects: 229 of the 468 target genes produced purified soluble protein from one or more organisms, with 80 and 32 of the purified targets, respectively, leading to crystals and ultimately structures from one or more orthologues.

-	~~{{STRUCTURE_2ffc\| PDB=2ffc \| SCENE= }}~~	+	Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.,Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney GA, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, Mulichak A, Wernimont A, Bray J, Loppnau P, Plotnikova O, Newberry K, Sundararajan E, Houston S, Walker J, Tempel W, Bochkarev A, Kozieradzki I, Edwards A, Arrowsmith C, Roos D, Kain K, Hui R Mol Biochem Parasitol. 2007 Jan;151(1):100-10. Epub 2006 Nov 13. PMID:17125854<ref>PMID:17125854</ref>

-	~~===Crystal Structure~~ of ~~Plasmodium Vivax Orotidine-Monophosphate-Decarboxyl UMP Bound===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17125854}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2ffc]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_vivax Plasmodium vivax]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2FFC OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017125854<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Decylcitrate synthase]]		[[Category: Decylcitrate synthase]]
	[[Category: Plasmodium vivax]]		[[Category: Plasmodium vivax]]

OCA: Protected "2ffc" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:12:43 GMT

Protected "2ffc" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:12, 7 January 2013

OCA at 14:12, 7 January 2013

OCA — Mon, 07 Jan 2013 14:12:39 GMT

←Older revision		Revision as of 14:12, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2ffc.png\|left\|200px]]		[[Image:2ffc.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ffc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2ffc\| PDB=2ffc \| SCENE= }}		{{STRUCTURE_2ffc\| PDB=2ffc \| SCENE= }}

	===Crystal Structure of Plasmodium Vivax Orotidine-Monophosphate-Decarboxyl UMP Bound===		===Crystal Structure of Plasmodium Vivax Orotidine-Monophosphate-Decarboxyl UMP Bound===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17125854}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17125854 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17125854}}		{{ABSTRACT_PUBMED_17125854}}

	==About this Structure==		==About this Structure==
-	~~2FFC~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFC OCA].	+	[[2ffc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFC OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17125854~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017125854</ref><references group="xtra"/>
	[[Category: Decylcitrate synthase]]		[[Category: Decylcitrate synthase]]
	[[Category: Plasmodium vivax]]		[[Category: Plasmodium vivax]]
Line 42:		Line 30:
	[[Category: Zhao, Y.]]		[[Category: Zhao, Y.]]
	[[Category: Decarboxylase]]		[[Category: Decarboxylase]]
		+	[[Category: Lyase]]
	[[Category: Pv-pf10_0225]]		[[Category: Pv-pf10_0225]]
	[[Category: Sgc]]		[[Category: Sgc]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:27:51 2009''