2fs7 - Revision history

OCA at 09:25, 14 February 2024

OCA — Wed, 14 Feb 2024 09:25:14 GMT

←Older revision		Revision as of 09:25, 14 February 2024
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	<StructureSection load='2fs7' size='340' side='right'caption='[[2fs7]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2fs7' size='340' side='right'caption='[[2fs7]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2fs7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FS7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2fs7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FS7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~, ~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2fr3\|2fr3]], [[2frr\|2frr]], [[2frs\|2frs]], [[2fru\|2fru]], [[2fs0\|2fs0]], [[2fs6\|2fs6]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">CRABP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fs7 OCA], [https://pdbe.org/2fs7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fs7 RCSB], [https://www.ebi.ac.uk/pdbsum/2fs7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fs7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fs7 OCA], [https://pdbe.org/2fs7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fs7 RCSB], [https://www.ebi.ac.uk/pdbsum/2fs7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fs7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN]] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.	+	[https://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fs7 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fs7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	CRABPII is a small, cytosolic protein that solubilizes and transfers retinoic acid (RA) to the nucleus while also enhancing its transcriptional activity. We have determined the first high-resolution structure of apo-wild type (WT) CRABPII at 1.35 A. Using three different data sets collected on apo-WT CRABPII we have shown that apo- and holo-CRABPII share very similar structures. Binding of RA appears to increase the overall rigidity of the structure, although the induced structural changes are not as pronounced as previously thought. The enhanced structural rigidity may be an important determinant for the enhanced nuclear localization of the RA-bound protein. Comparison of our apo-WT with a mutant apo-CRABPII structure shows that mutation of Arg111, a conserved residue of CRABPII and a key residue in RA binding, causes structural changes in the molecule. We further investigated the structural importance of conserved residues by determining the structure of the F15W mutant CRABPII (F15W-CRABPII). Our structures also demonstrate structural changes induced by crystal packing and show that a crystal can harbor demonstrative structural differences in the asymmetric unit.
-
-	The structure of Apo-wild-type cellular retinoic acid binding protein II at 1.4 A and its relationship to ligand binding and nuclear translocation.,Vaezeslami S, Mathes E, Vasileiou C, Borhan B, Geiger JH J Mol Biol. 2006 Oct 27;363(3):687-701. Epub 2006 Aug 26. PMID:16979656<ref>PMID:16979656</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2fs7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]		*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]		*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Geiger~~, J H~~]]	+	[[Category: Geiger JH]]
-	[[Category: Vaezeslami, S]]	+	[[Category: Vaezeslami S]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Crabpii]]~~	+
-	~~[[Category: High resolution]]~~	+
-	~~[[Category: Retinoic acid]]~~	+
-	~~[[Category: Retinoid]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 15:32, 3 March 2021

OCA — Wed, 03 Mar 2021 15:32:35 GMT

←Older revision		Revision as of 15:32, 3 March 2021
Line 1:		Line 1:

	==Crystal Structure of Apo-Cellular Retinoic Acid Binding Protein Type II At 1.55 Angstroms Resolution==		==Crystal Structure of Apo-Cellular Retinoic Acid Binding Protein Type II At 1.55 Angstroms Resolution==
-	<StructureSection load='2fs7' size='340' side='right' caption='[[2fs7]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='2fs7' size='340' side='right'caption='[[2fs7]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2fs7]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FS7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FS7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2fs7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FS7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fr3\|2fr3]], [[2frr\|2frr]], [[2frs\|2frs]], [[2fru\|2fru]], [[2fs0\|2fs0]], [[2fs6\|2fs6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fr3\|2fr3]], [[2frr\|2frr]], [[2frs\|2frs]], [[2fru\|2fru]], [[2fs0\|2fs0]], [[2fs6\|2fs6]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2fs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fs7 OCA], [~~http~~://pdbe.org/2fs7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2fs7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2fs7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fs7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fs7 OCA], [https://pdbe.org/2fs7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fs7 RCSB], [https://www.ebi.ac.uk/pdbsum/2fs7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fs7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN]] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.	+	[[https://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN]] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fs/2fs7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fs/2fs7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2fs7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2fs7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[CRABP I ( Cellular Retinoic Acid Binding Protein )\|CRABP I ( Cellular Retinoic Acid Binding Protein )]]
		+	*[[Cellular retinoic acid-binding protein 3D structures\|Cellular retinoic acid-binding protein 3D structures]]
		+	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
		+	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 41:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Geiger, J H]]		[[Category: Geiger, J H]]
	[[Category: Vaezeslami, S]]		[[Category: Vaezeslami, S]]

OCA at 07:43, 18 October 2017

OCA — Wed, 18 Oct 2017 07:43:39 GMT

←Older revision		Revision as of 07:43, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Apo-Cellular Retinoic Acid Binding Protein Type II At 1.55 Angstroms Resolution==		==Crystal Structure of Apo-Cellular Retinoic Acid Binding Protein Type II At 1.55 Angstroms Resolution==
	<StructureSection load='2fs7' size='340' side='right' caption='[[2fs7]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2fs7' size='340' side='right' caption='[[2fs7]], [[Resolution\|resolution]] 1.55Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fr3\|2fr3]], [[2frr\|2frr]], [[2frs\|2frs]], [[2fru\|2fru]], [[2fs0\|2fs0]], [[2fs6\|2fs6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fr3\|2fr3]], [[2frr\|2frr]], [[2frs\|2frs]], [[2fru\|2fru]], [[2fs0\|2fs0]], [[2fs6\|2fs6]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fs7 OCA], [http://pdbe.org/2fs7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fs7 RCSB], [http://www.ebi.ac.uk/pdbsum/2fs7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fs7 OCA], [http://pdbe.org/2fs7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fs7 RCSB], [http://www.ebi.ac.uk/pdbsum/2fs7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fs7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2fs7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2fs7" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[CRABP I ( Cellular Retinoic Acid Binding Protein )\|CRABP I ( Cellular Retinoic Acid Binding Protein )]]
-	*[[Cellular retinoic acid-binding protein\|Cellular retinoic acid-binding protein]]
-	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
-	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:27, 8 February 2016

OCA — Mon, 08 Feb 2016 00:27:37 GMT

←Older revision		Revision as of 00:27, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fs7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:12, 10 September 2015

OCA — Thu, 10 Sep 2015 06:12:56 GMT

←Older revision		Revision as of 06:12, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2fs7' size='340' side='right' caption='[[2fs7]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2fs7' size='340' side='right' caption='[[2fs7]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2fs7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FS7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2fs7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FS7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fr3\|2fr3]], [[2frr\|2frr]], [[2frs\|2frs]], [[2fru\|2fru]], [[2fs0\|2fs0]], [[2fs6\|2fs6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fr3\|2fr3]], [[2frr\|2frr]], [[2frs\|2frs]], [[2fru\|2fru]], [[2fs0\|2fs0]], [[2fs6\|2fs6]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fs7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fs7 RCSB], [http://www.ebi.ac.uk/pdbsum/2fs7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fs7 OCA], [http://pdbe.org/2fs7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fs7 RCSB], [http://www.ebi.ac.uk/pdbsum/2fs7 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2fs7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 38:		Line 39:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Geiger, J H]]		[[Category: Geiger, J H]]
	[[Category: Vaezeslami, S]]		[[Category: Vaezeslami, S]]

OCA at 19:14, 24 December 2014

OCA — Wed, 24 Dec 2014 19:14:53 GMT

←Older revision		Revision as of 19:14, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fs7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FS7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fs7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FS7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fr3\|2fr3]], [[2frr\|2frr]], [[2frs\|2frs]], [[2fru\|2fru]], [[2fs0\|2fs0]], [[2fs6\|2fs6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fr3\|2fr3]], [[2frr\|2frr]], [[2frs\|2frs]], [[2fru\|2fru]], [[2fs0\|2fs0]], [[2fs6\|2fs6]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fs7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fs7 RCSB], [http://www.ebi.ac.uk/pdbsum/2fs7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fs7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fs7 RCSB], [http://www.ebi.ac.uk/pdbsum/2fs7 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN]] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Geiger, J H.]]	+	[[Category: Geiger, J H]]
-	[[Category: Vaezeslami, S.]]	+	[[Category: Vaezeslami, S]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Crabpii]]		[[Category: Crabpii]]

OCA at 03:57, 29 September 2014

OCA — Mon, 29 Sep 2014 03:57:35 GMT

←Older revision		Revision as of 03:57, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2fs7.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Apo-Cellular Retinoic Acid Binding Protein Type II At 1.55 Angstroms Resolution==
		+	<StructureSection load='2fs7' size='340' side='right' caption='[[2fs7]], [[Resolution\|resolution]] 1.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2fs7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FS7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fr3\|2fr3]], [[2frr\|2frr]], [[2frs\|2frs]], [[2fru\|2fru]], [[2fs0\|2fs0]], [[2fs6\|2fs6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fs7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fs7 RCSB], [http://www.ebi.ac.uk/pdbsum/2fs7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fs/2fs7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CRABPII is a small, cytosolic protein that solubilizes and transfers retinoic acid (RA) to the nucleus while also enhancing its transcriptional activity. We have determined the first high-resolution structure of apo-wild type (WT) CRABPII at 1.35 A. Using three different data sets collected on apo-WT CRABPII we have shown that apo- and holo-CRABPII share very similar structures. Binding of RA appears to increase the overall rigidity of the structure, although the induced structural changes are not as pronounced as previously thought. The enhanced structural rigidity may be an important determinant for the enhanced nuclear localization of the RA-bound protein. Comparison of our apo-WT with a mutant apo-CRABPII structure shows that mutation of Arg111, a conserved residue of CRABPII and a key residue in RA binding, causes structural changes in the molecule. We further investigated the structural importance of conserved residues by determining the structure of the F15W mutant CRABPII (F15W-CRABPII). Our structures also demonstrate structural changes induced by crystal packing and show that a crystal can harbor demonstrative structural differences in the asymmetric unit.

-	~~{{STRUCTURE_2fs7\| PDB=2fs7 \| SCENE= }}~~	+	The structure of Apo-wild-type cellular retinoic acid binding protein II at 1.4 A and its relationship to ligand binding and nuclear translocation.,Vaezeslami S, Mathes E, Vasileiou C, Borhan B, Geiger JH J Mol Biol. 2006 Oct 27;363(3):687-701. Epub 2006 Aug 26. PMID:16979656<ref>PMID:16979656</ref>

-	~~===Crystal Structure~~ of ~~Apo-Cellular Retinoic Acid Binding Protein Type II At 1~~.~~55 Angstroms Resolution===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16979656}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2fs7]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FS7 OCA].~~	+

	==See Also==		==See Also==
Line 15:		Line 32:
	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]		*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]		*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016979656<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Geiger, J H.]]		[[Category: Geiger, J H.]]

OCA at 08:17, 20 October 2012

OCA — Sat, 20 Oct 2012 08:17:50 GMT

←Older revision		Revision as of 08:17, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2fs7]] is a 2 chain structure of [[CRABP I ( Cellular Retinoic Acid Binding Protein )]], [[Cellular retinoic acid-binding protein]], [[Gustavo Elberto Epalza Sanchez/Sandbox 1]] and [[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FS7 OCA].	+	[[2fs7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FS7 OCA].

	==See Also==		==See Also==

OCA: Protected "2fs7" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 19:05:11 GMT

Protected "2fs7" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:05, 25 July 2012

OCA at 19:05, 25 July 2012

OCA — Wed, 25 Jul 2012 19:05:10 GMT

←Older revision		Revision as of 19:05, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2fs7.png\|left\|200px]]		[[Image:2fs7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2fs7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2fs7\| PDB=2fs7 \| SCENE= }}		{{STRUCTURE_2fs7\| PDB=2fs7 \| SCENE= }}

	===Crystal Structure of Apo-Cellular Retinoic Acid Binding Protein Type II At 1.55 Angstroms Resolution===		===Crystal Structure of Apo-Cellular Retinoic Acid Binding Protein Type II At 1.55 Angstroms Resolution===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16979656}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16979656 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16979656}}		{{ABSTRACT_PUBMED_16979656}}

	==About this Structure==		==About this Structure==
-	~~2FS7~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FS7 OCA].	+	[[2fs7]] is a 2 chain structure of [[CRABP I ( Cellular Retinoic Acid Binding Protein )]], [[Cellular retinoic acid-binding protein]], [[Gustavo Elberto Epalza Sanchez/Sandbox 1]] and [[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FS7 OCA].
		+
		+	==See Also==
		+	*[[CRABP I ( Cellular Retinoic Acid Binding Protein )\|CRABP I ( Cellular Retinoic Acid Binding Protein )]]
		+	*[[Cellular retinoic acid-binding protein\|Cellular retinoic acid-binding protein]]
		+	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
		+	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16979656~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016979656</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Geiger, J H.]]		[[Category: Geiger, J H.]]
Line 29:		Line 23:
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Crabpii]]		[[Category: Crabpii]]
-	[[Category: Crystallography]]
	[[Category: High resolution]]		[[Category: High resolution]]
	[[Category: Retinoic acid]]		[[Category: Retinoic acid]]
	[[Category: Retinoid]]		[[Category: Retinoid]]
-	[[Category: ~~X-ray~~]]	+	[[Category: Transport protein]]
-		+
-	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:30:09 2009''~~	+