2fyl - Revision history

OCA at 15:36, 3 March 2021

OCA — Wed, 03 Mar 2021 15:36:07 GMT

←Older revision		Revision as of 15:36, 3 March 2021
Line 1:		Line 1:

	==Haddock model of the complex between double module of LRP, CR56, and first domain of receptor associated protein, RAP-d1.==		==Haddock model of the complex between double module of LRP, CR56, and first domain of receptor associated protein, RAP-d1.==
-	<StructureSection load='2fyl' size='340' side='right' caption='[[2fyl]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='2fyl' size='340' side='right'caption='[[2fyl]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2fyl]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FYL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2fyl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FYL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fyj\|2fyj]], [[1lre\|1lre]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fyj\|2fyj]], [[1lre\|1lre]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LRPAP1, A2MRAP ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LRP1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LRPAP1, A2MRAP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LRP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2fyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fyl OCA], [~~http~~://pdbe.org/2fyl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2fyl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2fyl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fyl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fyl OCA], [https://pdbe.org/2fyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fyl RCSB], [https://www.ebi.ac.uk/pdbsum/2fyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fyl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN]] Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.	+	[[https://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN]] Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN]] Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. [[~~http~~://www.uniprot.org/uniprot/LRP1_HUMAN LRP1_HUMAN]] Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.<ref>PMID:1702392</ref> <ref>PMID:1618748</ref> <ref>PMID:11907044</ref> <ref>PMID:12888553</ref> <ref>PMID:12713657</ref> Functions as a receptor for Pseudomonas aeruginosa exotoxin A.<ref>PMID:1702392</ref> <ref>PMID:1618748</ref> <ref>PMID:11907044</ref> <ref>PMID:12888553</ref> <ref>PMID:12713657</ref>	+	[[https://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN]] Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. [[https://www.uniprot.org/uniprot/LRP1_HUMAN LRP1_HUMAN]] Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.<ref>PMID:1702392</ref> <ref>PMID:1618748</ref> <ref>PMID:11907044</ref> <ref>PMID:12888553</ref> <ref>PMID:12713657</ref> Functions as a receptor for Pseudomonas aeruginosa exotoxin A.<ref>PMID:1702392</ref> <ref>PMID:1618748</ref> <ref>PMID:11907044</ref> <ref>PMID:12888553</ref> <ref>PMID:12713657</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Andersen, O M]]		[[Category: Andersen, O M]]
	[[Category: Bjerrum-Bohr, I]]		[[Category: Bjerrum-Bohr, I]]

OCA at 07:26, 20 June 2018

OCA — Wed, 20 Jun 2018 07:26:07 GMT

←Older revision		Revision as of 07:26, 20 June 2018
Line 1:		Line 1:
		+
	==Haddock model of the complex between double module of LRP, CR56, and first domain of receptor associated protein, RAP-d1.==		==Haddock model of the complex between double module of LRP, CR56, and first domain of receptor associated protein, RAP-d1.==
	<StructureSection load='2fyl' size='340' side='right' caption='[[2fyl]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2fyl' size='340' side='right' caption='[[2fyl]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fyj\|2fyj]], [[1lre\|1lre]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fyj\|2fyj]], [[1lre\|1lre]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LRPAP1, A2MRAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LRP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LRPAP1, A2MRAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LRP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fyl OCA], [http://pdbe.org/2fyl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fyl RCSB], [http://www.ebi.ac.uk/pdbsum/2fyl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fyl OCA], [http://pdbe.org/2fyl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fyl RCSB], [http://www.ebi.ac.uk/pdbsum/2fyl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fyl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 16:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/2fyl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/2fyl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:14, 8 February 2016

OCA — Mon, 08 Feb 2016 12:14:14 GMT

←Older revision		Revision as of 12:14, 8 February 2016
Line 20:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fyl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:28, 10 September 2015

OCA — Thu, 10 Sep 2015 11:28:22 GMT

←Older revision		Revision as of 11:28, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2fyl' size='340' side='right' caption='[[2fyl]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='2fyl' size='340' side='right' caption='[[2fyl]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2fyl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FYL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2fyl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FYL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fyj\|2fyj]], [[1lre\|1lre]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fyj\|2fyj]], [[1lre\|1lre]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LRPAP1, A2MRAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), LRP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LRPAP1, A2MRAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LRP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fyl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fyl RCSB], [http://www.ebi.ac.uk/pdbsum/2fyl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fyl OCA], [http://pdbe.org/2fyl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fyl RCSB], [http://www.ebi.ac.uk/pdbsum/2fyl PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2fyl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Andersen, O M]]		[[Category: Andersen, O M]]
	[[Category: Bjerrum-Bohr, I]]		[[Category: Bjerrum-Bohr, I]]

OCA at 09:29, 16 January 2015

OCA — Fri, 16 Jan 2015 09:29:53 GMT

←Older revision		Revision as of 09:29, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fyl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FYL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fyl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FYL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fyj\|2fyj]], [[1lre\|1lre]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fyj\|2fyj]], [[1lre\|1lre]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LRPAP1, A2MRAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), LRP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LRPAP1, A2MRAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), LRP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fyl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fyl RCSB], [http://www.ebi.ac.uk/pdbsum/2fyl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fyl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fyl RCSB], [http://www.ebi.ac.uk/pdbsum/2fyl PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN]] Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.		[[http://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN]] Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Andersen, O M.]]	+	[[Category: Andersen, O M]]
-	[[Category: Bjerrum-Bohr, I.]]	+	[[Category: Bjerrum-Bohr, I]]
-	[[Category: Bonvin, A M.]]	+	[[Category: Bonvin, A M]]
-	[[Category: Etzerodt, M.]]	+	[[Category: Etzerodt, M]]
-	[[Category: Jensen, G A.]]	+	[[Category: Jensen, G A]]
-	[[Category: Kragelund, B B.]]	+	[[Category: Kragelund, B B]]
-	[[Category: Poulsen, F M.]]	+	[[Category: Poulsen, F M]]
-	[[Category: Shea, C O.]]	+	[[Category: Shea, C O]]
	[[Category: Complex]]		[[Category: Complex]]
	[[Category: Haddock]]		[[Category: Haddock]]

OCA at 09:04, 30 September 2014

OCA — Tue, 30 Sep 2014 09:04:41 GMT

←Older revision		Revision as of 09:04, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2fyl\| PDB=2fyl \| SCENE= }}~~	+	==Haddock model of the complex between double module of LRP, CR56, and first domain of receptor associated protein, RAP-d1.==
-	===Haddock model of the complex between double module of LRP, CR56, and first domain of receptor associated protein, RAP-d1.===	+	<StructureSection load='2fyl' size='340' side='right' caption='[[2fyl]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_16938309}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2fyl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FYL FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fyj\|2fyj]], [[1lre\|1lre]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LRPAP1, A2MRAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), LRP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fyl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fyl RCSB], [http://www.ebi.ac.uk/pdbsum/2fyl PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN]] Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.		[[http://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN]] Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN]] Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. [[http://www.uniprot.org/uniprot/LRP1_HUMAN LRP1_HUMAN]] Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.<ref>PMID:1702392</ref> <ref>PMID:1618748</ref> <ref>PMID:11907044</ref> <ref>PMID:12888553</ref> <ref>PMID:12713657</ref> Functions as a receptor for Pseudomonas aeruginosa exotoxin A.<ref>PMID:1702392</ref> <ref>PMID:1618748</ref> <ref>PMID:11907044</ref> <ref>PMID:12888553</ref> <ref>PMID:12713657</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/2fyl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The low-density lipoprotein receptor-related protein (LRP) interacts with more than 30 ligands of different sizes and structures that can all be replaced by the receptor-associated protein (RAP). The double module of complement type repeats, CR56, of LRP binds many ligands including all three domains of RAP and alpha2-macroglobulin, which promotes the catabolism of the Abeta-peptide implicated in Alzheimer's disease. To understand the receptor-ligand cross-talk, the NMR structure of CR56 has been solved and ligand binding experiments with RAP domain 1 (RAPd1) have been performed. From chemical shift perturbations of both binding partners upon complex formation, a HADDOCK model of the complex between CR56 and RAPd1 has been obtained. The binding residues are similar to a common binding motif suggested from alpha2-macroglobulin binding studies and provide evidence for an understanding of their mutual cross-competition pattern. The present structural results convey a simultaneous description of both binding partners of an LRP-ligand complex and open a route to a broader understanding of the binding specificity of the LRP receptor, which may involve a general four-residue receptor-ligand recognition motif common to all LRP ligands. The present result may be beneficial in the design of antagonists of ligand binding to the LDL receptor family, and especially of drugs for treatment of Alzheimer's disease.

-	~~==Function==~~	+	Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif.,Jensen GA, Andersen OM, Bonvin AM, Bjerrum-Bohr I, Etzerodt M, Thogersen HC, O'Shea C, Poulsen FM, Kragelund BB J Mol Biol. 2006 Sep 29;362(4):700-16. Epub 2006 Jul 15. PMID:16938309<ref>PMID:16938309</ref>
-	~~[[http://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN]] Interacts with LRP1/alpha~~-~~2-macroglobulin receptor and glycoprotein 330. [[http~~:~~//www.uniprot.org/uniprot/LRP1_HUMAN LRP1_HUMAN]] Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required~~ for ~~early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2~~-~~macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors~~. ~~May modulate cellular events~~, ~~such as APP metabolism~~, ~~kinase~~-~~dependent intracellular signaling~~, ~~neuronal calcium signaling as well as neurotransmission~~.~~<ref>PMID~~:~~1702392</ref><ref>PMID:1618748</ref><ref>PMID:11907044</ref><ref>PMID:12888553</ref><ref>PMID:12713657</ref> Functions as a receptor for Pseudomonas aeruginosa exotoxin A~~.~~<ref>~~PMID:~~1702392</ref>~~<ref>PMID:~~1618748~~</ref>~~<ref>PMID:11907044</ref><ref>PMID:12888553</ref><ref>PMID:12713657</ref>~~	+
-		+
-	~~==About this Structure==~~	+
-	[[2fyl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYL OCA].	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:016938309</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Andersen, O M.]]		[[Category: Andersen, O M.]]

OCA at 11:49, 24 March 2013

OCA — Sun, 24 Mar 2013 11:49:09 GMT

←Older revision		Revision as of 11:49, 24 March 2013
Line 1:		Line 1:
-	[[Image:2fyl.png\|left\|200px]]
-
	{{STRUCTURE_2fyl\| PDB=2fyl \| SCENE= }}		{{STRUCTURE_2fyl\| PDB=2fyl \| SCENE= }}
-
	===Haddock model of the complex between double module of LRP, CR56, and first domain of receptor associated protein, RAP-d1.===		===Haddock model of the complex between double module of LRP, CR56, and first domain of receptor associated protein, RAP-d1.===
		+	{{ABSTRACT_PUBMED_16938309}}

-	~~{{ABSTRACT_PUBMED_16938309}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN]] Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN]] Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. [[http://www.uniprot.org/uniprot/LRP1_HUMAN LRP1_HUMAN]] Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.<ref>PMID:1702392</ref><ref>PMID:1618748</ref><ref>PMID:11907044</ref><ref>PMID:12888553</ref><ref>PMID:12713657</ref> Functions as a receptor for Pseudomonas aeruginosa exotoxin A.<ref>PMID:1702392</ref><ref>PMID:1618748</ref><ref>PMID:11907044</ref><ref>PMID:12888553</ref><ref>PMID:12713657</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:016938309</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016938309</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Andersen, O M.]]		[[Category: Andersen, O M.]]

OCA: Protected "2fyl" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:23:44 GMT

Protected "2fyl" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:23, 7 January 2013

OCA at 11:23, 7 January 2013

OCA — Mon, 07 Jan 2013 11:23:40 GMT

←Older revision		Revision as of 11:23, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2fyl.png\|left\|200px]]		[[Image:2fyl.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2fyl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2fyl\| PDB=2fyl \| SCENE= }}		{{STRUCTURE_2fyl\| PDB=2fyl \| SCENE= }}

	===Haddock model of the complex between double module of LRP, CR56, and first domain of receptor associated protein, RAP-d1.===		===Haddock model of the complex between double module of LRP, CR56, and first domain of receptor associated protein, RAP-d1.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16938309}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16938309 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16938309}}		{{ABSTRACT_PUBMED_16938309}}

	==About this Structure==		==About this Structure==
-	~~2FYL~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYL OCA].	+	[[2fyl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYL OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16938309~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016938309</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Andersen, O M.]]		[[Category: Andersen, O M.]]
Line 36:		Line 24:
	[[Category: Haddock]]		[[Category: Haddock]]
	[[Category: Interface]]		[[Category: Interface]]
-	[[Category: Nmr]]
	[[Category: Shift-mapping]]		[[Category: Shift-mapping]]
-		+	[[Category: Surface active protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 21:55:16 2009''~~	+

OCA at 19:55, 16 February 2009

OCA — Mon, 16 Feb 2009 19:55:17 GMT

←Older revision		Revision as of 19:55, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2FYL is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYL OCA].	+	2FYL is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYL OCA].

	==Reference==		==Reference==
-	Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif., Jensen GA, Andersen OM, Bonvin AM, Bjerrum-Bohr I, Etzerodt M, Thogersen HC, O'Shea C, Poulsen FM, Kragelund BB, J Mol Biol. 2006 Sep 29;362(4):700-16. Epub 2006 Jul 15. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16938309 16938309]~~	+	<ref group="xtra">PMID:16938309</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Protein complex]]
	[[Category: Andersen, O M.]]		[[Category: Andersen, O M.]]
	[[Category: Bjerrum-Bohr, I.]]		[[Category: Bjerrum-Bohr, I.]]
Line 40:		Line 39:
	[[Category: Shift-mapping]]		[[Category: Shift-mapping]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon ~~Jul 28 02~~:53:~~31 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:55:16 2009''