2g0u - Revision history

OCA at 18:57, 29 May 2024

OCA — Wed, 29 May 2024 18:57:49 GMT

←Older revision		Revision as of 18:57, 29 May 2024
Line 1:		Line 1:

	==Solution Structure of Monomeric BsaL, the Type III Secretion Needle Protein of Burkholderia pseudomallei==		==Solution Structure of Monomeric BsaL, the Type III Secretion Needle Protein of Burkholderia pseudomallei==
-	<StructureSection load='2g0u' size='340' side='right'caption='[[2g0u~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2g0u' size='340' side='right'caption='[[2g0u]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2g0u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_pseudomallei"_whitmore_1913 "bacillus~~ pseudomallei~~" whitmore 1913~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G0U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2g0u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G0U FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0u OCA], [https://pdbe.org/2g0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g0u RCSB], [https://www.ebi.ac.uk/pdbsum/2g0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g0u ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0u OCA], [https://pdbe.org/2g0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g0u RCSB], [https://www.ebi.ac.uk/pdbsum/2g0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g0u ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q63K18_BURPS Q63K18_BURPS]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ pseudomallei ~~whitmore 1913~~]]	+	[[Category: Burkholderia pseudomallei]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Guzman, R N.~~De]]	+	[[Category: De Guzman RN]]
-	[[Category: Picking~~, W D~~]]	+	[[Category: Picking WD]]
-	[[Category: Picking~~, W L~~]]	+	[[Category: Picking WL]]
-	[[Category: Wang, Y]]	+	[[Category: Wang Y]]
-	[[Category: Zhang, L]]	+	[[Category: Zhang L]]
-	~~[[Category: Helix-turn-helix]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 14:38, 29 December 2021

OCA — Wed, 29 Dec 2021 14:38:52 GMT

←Older revision		Revision as of 14:38, 29 December 2021
Line 3:		Line 3:
	<StructureSection load='2g0u' size='340' side='right'caption='[[2g0u]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2g0u' size='340' side='right'caption='[[2g0u]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2g0u]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2G0U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2g0u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G0U FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0u OCA], [~~http~~://pdbe.org/2g0u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2g0u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2g0u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2g0u ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0u OCA], [https://pdbe.org/2g0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g0u RCSB], [https://www.ebi.ac.uk/pdbsum/2g0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g0u ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:07, 27 March 2020

OCA — Fri, 27 Mar 2020 11:07:33 GMT

←Older revision		Revision as of 11:07, 27 March 2020
Line 1:		Line 1:

	==Solution Structure of Monomeric BsaL, the Type III Secretion Needle Protein of Burkholderia pseudomallei==		==Solution Structure of Monomeric BsaL, the Type III Secretion Needle Protein of Burkholderia pseudomallei==
-	<StructureSection load='2g0u' size='340' side='right' caption='[[2g0u]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2g0u' size='340' side='right'caption='[[2g0u]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2g0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G0U FirstGlance]. <br>		<table><tr><td colspan='2'>[[2g0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G0U FirstGlance]. <br>
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus pseudomallei whitmore 1913]]		[[Category: Bacillus pseudomallei whitmore 1913]]
		+	[[Category: Large Structures]]
	[[Category: Guzman, R N.De]]		[[Category: Guzman, R N.De]]
	[[Category: Picking, W D]]		[[Category: Picking, W D]]

OCA at 06:47, 20 June 2018

OCA — Wed, 20 Jun 2018 06:47:13 GMT

←Older revision		Revision as of 06:47, 20 June 2018
Line 1:		Line 1:
		+
	==Solution Structure of Monomeric BsaL, the Type III Secretion Needle Protein of Burkholderia pseudomallei==		==Solution Structure of Monomeric BsaL, the Type III Secretion Needle Protein of Burkholderia pseudomallei==
	<StructureSection load='2g0u' size='340' side='right' caption='[[2g0u]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2g0u' size='340' side='right' caption='[[2g0u]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2g0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G0U FirstGlance]. <br>		<table><tr><td colspan='2'>[[2g0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G0U FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0u OCA], [http://pdbe.org/2g0u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g0u RCSB], [http://www.ebi.ac.uk/pdbsum/2g0u PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0u OCA], [http://pdbe.org/2g0u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g0u RCSB], [http://www.ebi.ac.uk/pdbsum/2g0u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2g0u ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 9:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g0/2g0u_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g0/2g0u_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 23:20, 9 February 2016

OCA — Tue, 09 Feb 2016 23:20:03 GMT

←Older revision		Revision as of 23:20, 9 February 2016
Line 13:		Line 13:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g0u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:02, 11 September 2015

OCA — Fri, 11 Sep 2015 03:02:52 GMT

←Older revision		Revision as of 03:02, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2g0u' size='340' side='right' caption='[[2g0u]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2g0u' size='340' side='right' caption='[[2g0u]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2g0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Burkholderia_pseudomallei Burkholderia~~ pseudomallei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G0U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2g0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G0U FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g0u RCSB], [http://www.ebi.ac.uk/pdbsum/2g0u PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0u OCA], [http://pdbe.org/2g0u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g0u RCSB], [http://www.ebi.ac.uk/pdbsum/2g0u PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2g0u" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Burkholderia~~ pseudomallei]]	+	[[Category: Bacillus pseudomallei whitmore 1913]]
	[[Category: Guzman, R N.De]]		[[Category: Guzman, R N.De]]
	[[Category: Picking, W D]]		[[Category: Picking, W D]]

OCA at 10:11, 25 December 2014

OCA — Thu, 25 Dec 2014 10:11:53 GMT

←Older revision		Revision as of 10:11, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2g0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G0U FirstGlance]. <br>		<table><tr><td colspan='2'>[[2g0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G0U FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g0u RCSB], [http://www.ebi.ac.uk/pdbsum/2g0u PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g0u RCSB], [http://www.ebi.ac.uk/pdbsum/2g0u PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Burkholderia pseudomallei]]		[[Category: Burkholderia pseudomallei]]
-	[[Category: Guzman, R N.De.]]	+	[[Category: Guzman, R N.De]]
-	[[Category: Picking, W D.]]	+	[[Category: Picking, W D]]
-	[[Category: Picking, W L.]]	+	[[Category: Picking, W L]]
-	[[Category: Wang, Y.]]	+	[[Category: Wang, Y]]
-	[[Category: Zhang, L.]]	+	[[Category: Zhang, L]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Unknown function]]		[[Category: Unknown function]]

OCA at 09:16, 30 September 2014

OCA — Tue, 30 Sep 2014 09:16:00 GMT

←Older revision		Revision as of 09:16, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2g0u.~~png\|left~~\|200px]]	+	==Solution Structure of Monomeric BsaL, the Type III Secretion Needle Protein of Burkholderia pseudomallei==
		+	<StructureSection load='2g0u' size='340' side='right' caption='[[2g0u]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2g0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G0U FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g0u RCSB], [http://www.ebi.ac.uk/pdbsum/2g0u PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g0/2g0u_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many gram-negative bacteria that are important human pathogens possess type III secretion systems as part of their required virulence factor repertoire. During the establishment of infection, these pathogens coordinately assemble greater than 20 different proteins into a macromolecular structure that spans the bacterial inner and outer membranes and, in many respects, resembles and functions like a syringe. This type III secretion apparatus (TTSA) is used to inject proteins into a host cell's membrane and cytoplasm to subvert normal cellular processes. The external portion of the TTSA is a needle that is composed of a single type of protein that is polymerized in a helical fashion to form an elongated tube with a central channel of 2-3 nm in diameter. TTSA needle proteins from a variety of bacterial pathogens share sequence conservation; however, no atomic structure for any TTSA needle protein is yet available. Here, we report the structure of a TTSA needle protein called BsaL from Burkholderia pseudomallei determined by nuclear magnetic resonance (NMR) spectroscopy. The central part of the protein assumes a helix-turn-helix core domain with two well-defined alpha-helices that are joined by an ordered, four-residue linker. This forms a two-helix bundle that is stabilized by interhelix hydrophobic contacts. Residues that flank this presumably exposed core region are not completely disordered, but adopt a partial helical conformation. The atomic structure of BsaL and its sequence homology with other TTSA needle proteins suggest potentially unique structural dynamics that could be linked with a universal mechanism for control of type III secretion in diverse gram-negative bacterial pathogens.

-	~~{{STRUCTURE_2g0u\| PDB=2g0u \| SCENE= }}~~	+	Solution structure of monomeric BsaL, the type III secretion needle protein of Burkholderia pseudomallei.,Zhang L, Wang Y, Picking WL, Picking WD, De Guzman RN J Mol Biol. 2006 Jun 2;359(2):322-30. Epub 2006 Mar 30. PMID:16631790<ref>PMID:16631790</ref>

-	~~===Solution Structure~~ of ~~Monomeric BsaL,~~ the ~~Type III Secretion Needle Protein of Burkholderia pseudomallei===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16631790}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2g0u]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016631790<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Burkholderia pseudomallei]]		[[Category: Burkholderia pseudomallei]]
	[[Category: Guzman, R N.De.]]		[[Category: Guzman, R N.De.]]

OCA: Protected "2g0u" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:10:37 GMT

Protected "2g0u" [edit=sysop:move=sysop]

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Revision as of 14:10, 7 January 2013

OCA at 14:10, 7 January 2013

OCA — Mon, 07 Jan 2013 14:10:33 GMT

←Older revision		Revision as of 14:10, 7 January 2013
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	[[Image:2g0u.png\|left\|200px]]		[[Image:2g0u.png\|left\|200px]]

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	{{STRUCTURE_2g0u\| PDB=2g0u \| SCENE= }}		{{STRUCTURE_2g0u\| PDB=2g0u \| SCENE= }}

	===Solution Structure of Monomeric BsaL, the Type III Secretion Needle Protein of Burkholderia pseudomallei===		===Solution Structure of Monomeric BsaL, the Type III Secretion Needle Protein of Burkholderia pseudomallei===

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	{{ABSTRACT_PUBMED_16631790}}		{{ABSTRACT_PUBMED_16631790}}

	==About this Structure==		==About this Structure==
-	~~2G0U~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA].	+	[[2g0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0U OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16631790~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016631790</ref><references group="xtra"/>
	[[Category: Burkholderia pseudomallei]]		[[Category: Burkholderia pseudomallei]]
	[[Category: Guzman, R N.De.]]		[[Category: Guzman, R N.De.]]
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	[[Category: Zhang, L.]]		[[Category: Zhang, L.]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
-		+	[[Category: Unknown function]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 13:32:49 2009''~~	+