2g3m - Revision history

OCA at 09:35, 30 August 2023

OCA — Wed, 30 Aug 2023 09:35:29 GMT

←Older revision		Revision as of 09:35, 30 August 2023
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	<StructureSection load='2g3m' size='340' side='right'caption='[[2g3m]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2g3m' size='340' side='right'caption='[[2g3m]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2g3m]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~'saccharolobus_solfataricus' 'saccharolobus~~ solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G3M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2g3m]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G3M FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2g3n\|2g3n]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">malA ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=2287 'Saccharolobus solfataricus'])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3m OCA], [https://pdbe.org/2g3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g3m RCSB], [https://www.ebi.ac.uk/pdbsum/2g3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g3m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3m OCA], [https://pdbe.org/2g3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g3m RCSB], [https://www.ebi.ac.uk/pdbsum/2g3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g3m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~AGLU_SULSO AGLU_SULSO]~~] Major soluble alpha-glucosidase ~~(By similarity)~~.	+	[https://www.uniprot.org/uniprot/AGLU_SACS2 AGLU_SACS2] Major soluble alpha-glucosidase.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Saccharolobus solfataricus]]
-	[[Category: Alpha-glucosidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Blum, P~~]]	+	[[Category: Saccharolobus solfataricus]]
-	[[Category: ~~Ernst, H A~~]]	+	[[Category: Blum P]]
-	[[Category: ~~Larsen, S~~]]	+	[[Category: Ernst HA]]
-	[[Category: ~~Leggio, L Lo~~]]	+	[[Category: Larsen S]]
-	[[Category: Leonard, G]]	+	[[Category: Leonard G]]
-	[[Category: ~~Willemoes, M~~]]	+	[[Category: Lo Leggio L]]
-	[[Category: ~~Glycoside hydrolase family 31]]~~	+	[[Category: Willemoes M]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Multidomain protein]]~~	+
-	~~[[Category: Retaining mechanism~~]]	+

OCA at 18:45, 10 March 2021

OCA — Wed, 10 Mar 2021 18:45:35 GMT

←Older revision		Revision as of 18:45, 10 March 2021
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	==Crystal structure of the Sulfolobus solfataricus alpha-glucosidase MalA==		==Crystal structure of the Sulfolobus solfataricus alpha-glucosidase MalA==
-	<StructureSection load='2g3m' size='340' side='right' caption='[[2g3m]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='2g3m' size='340' side='right'caption='[[2g3m]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2g3m]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/'saccharolobus_solfataricus' 'saccharolobus solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2G3M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2g3m]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/'saccharolobus_solfataricus' 'saccharolobus solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G3M FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g3n\|2g3n]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2g3n\|2g3n]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 'Saccharolobus solfataricus'])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 'Saccharolobus solfataricus'])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2g3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3m OCA], [~~http~~://pdbe.org/2g3m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2g3m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2g3m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2g3m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3m OCA], [https://pdbe.org/2g3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g3m RCSB], [https://www.ebi.ac.uk/pdbsum/2g3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g3m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AGLU_SULSO AGLU_SULSO]] Major soluble alpha-glucosidase (By similarity).	+	[[https://www.uniprot.org/uniprot/AGLU_SULSO AGLU_SULSO]] Major soluble alpha-glucosidase (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Alpha-glucosidase\|Alpha-glucosidase]]	+	*[[Alpha-glucosidase 3D structures\|Alpha-glucosidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Saccharolobus solfataricus]]		[[Category: Saccharolobus solfataricus]]
	[[Category: Alpha-glucosidase]]		[[Category: Alpha-glucosidase]]
		+	[[Category: Large Structures]]
	[[Category: Blum, P]]		[[Category: Blum, P]]
	[[Category: Ernst, H A]]		[[Category: Ernst, H A]]

OCA at 07:22, 20 June 2018

OCA — Wed, 20 Jun 2018 07:22:55 GMT

←Older revision		Revision as of 07:22, 20 June 2018
Line 1:		Line 1:
		+
	==Crystal structure of the Sulfolobus solfataricus alpha-glucosidase MalA==		==Crystal structure of the Sulfolobus solfataricus alpha-glucosidase MalA==
	<StructureSection load='2g3m' size='340' side='right' caption='[[2g3m]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2g3m' size='340' side='right' caption='[[2g3m]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2g3m]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Atcc_35091 Atcc 35091~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G3M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2g3m]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/'saccharolobus_solfataricus' 'saccharolobus solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G3M FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g3n\|2g3n]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g3n\|2g3n]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ~~ATCC 35091~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 'Saccharolobus solfataricus'])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3m OCA], [http://pdbe.org/2g3m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g3m RCSB], [http://www.ebi.ac.uk/pdbsum/2g3m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3m OCA], [http://pdbe.org/2g3m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g3m RCSB], [http://www.ebi.ac.uk/pdbsum/2g3m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2g3m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g3/2g3m_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g3/2g3m_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Saccharolobus solfataricus]]
	[[Category: Alpha-glucosidase]]		[[Category: Alpha-glucosidase]]
-	[[Category: Atcc 35091]]
	[[Category: Blum, P]]		[[Category: Blum, P]]
	[[Category: Ernst, H A]]		[[Category: Ernst, H A]]

OCA at 13:50, 7 February 2016

OCA — Sun, 07 Feb 2016 13:50:11 GMT

←Older revision		Revision as of 13:50, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g3m ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:05, 10 September 2015

OCA — Thu, 10 Sep 2015 02:05:25 GMT

←Older revision		Revision as of 02:05, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2g3m' size='340' side='right' caption='[[2g3m]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2g3m' size='340' side='right' caption='[[2g3m]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2g3m]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sulfolobus_solfataricus Sulfolobus solfataricus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G3M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2g3m]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G3M FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g3n\|2g3n]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g3n\|2g3n]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ~~Sulfolobus solfataricus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g3m RCSB], [http://www.ebi.ac.uk/pdbsum/2g3m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3m OCA], [http://pdbe.org/2g3m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g3m RCSB], [http://www.ebi.ac.uk/pdbsum/2g3m PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2g3m" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Alpha-glucosidase]]		[[Category: Alpha-glucosidase]]
-	[[Category: ~~Sulfolobus solfataricus~~]]	+	[[Category: Atcc 35091]]
	[[Category: Blum, P]]		[[Category: Blum, P]]
	[[Category: Ernst, H A]]		[[Category: Ernst, H A]]

OCA at 15:37, 24 December 2014

OCA — Wed, 24 Dec 2014 15:37:43 GMT

←Older revision		Revision as of 15:37, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2g3m]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G3M FirstGlance]. <br>		<table><tr><td colspan='2'>[[2g3m]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G3M FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g3n\|2g3n]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g3n\|2g3n]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g3m RCSB], [http://www.ebi.ac.uk/pdbsum/2g3m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g3m RCSB], [http://www.ebi.ac.uk/pdbsum/2g3m PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AGLU_SULSO AGLU_SULSO]] Major soluble alpha-glucosidase (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Alpha-glucosidase]]		[[Category: Alpha-glucosidase]]
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
-	[[Category: Blum, P.]]	+	[[Category: Blum, P]]
-	[[Category: Ernst, H A.]]	+	[[Category: Ernst, H A]]
-	[[Category: Larsen, S.]]	+	[[Category: Larsen, S]]
-	[[Category: Leggio, L Lo.]]	+	[[Category: Leggio, L Lo]]
-	[[Category: Leonard, G.]]	+	[[Category: Leonard, G]]
-	[[Category: Willemoes, M~~.]]~~	+	[[Category: Willemoes, M]]
-	~~[[Category: Alpha-glucosidase~~]]	+
	[[Category: Glycoside hydrolase family 31]]		[[Category: Glycoside hydrolase family 31]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Multidomain protein]]		[[Category: Multidomain protein]]
	[[Category: Retaining mechanism]]		[[Category: Retaining mechanism]]

OCA at 09:02, 30 September 2014

OCA — Tue, 30 Sep 2014 09:02:05 GMT

←Older revision		Revision as of 09:02, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2g3m.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the Sulfolobus solfataricus alpha-glucosidase MalA==
		+	<StructureSection load='2g3m' size='340' side='right' caption='[[2g3m]], [[Resolution\|resolution]] 2.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2g3m]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G3M FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g3n\|2g3n]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">malA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g3m RCSB], [http://www.ebi.ac.uk/pdbsum/2g3m PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g3/2g3m_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of alpha-glucosidase MalA from Sulfolobus solfataricus has been determined at 2.5Angstrom resolution. It provides a structural model for enzymes representing the major specificity in glycoside hydrolase family 31 (GH31), including alpha-glucosidases from higher organisms, involved in glycogen degradation and glycoprotein processing. The structure of MalA shows clear differences from the only other structure known from GH31, alpha-xylosidase YicI. MalA and YicI share only 23% sequence identity. Although the two enzymes display a similar domain structure and both form hexamers, their structures differ significantly in quaternary organization: MalA is a dimer of trimers, YicI a trimer of dimers. MalA and YicI also differ in their substrate specificities, as shown by kinetic measurements on model chromogenic substrates. In addition, MalA has a clear preference for maltose (Glc-alpha1,4-Glc), whereas YicI prefers isoprimeverose (Xyl-alpha1,6-Glc). The structural origin of this difference occurs in the -1 subsite where MalA residues Asp251 and Trp284 could interact with OH6 of the substrate. The structure of MalA in complex with beta-octyl-glucopyranoside has been determined. It reveals Arg400, Asp87, Trp284, Met321 and Phe327 as invariant residues forming the +1 subsite in the GH31 alpha-glucosidases. Structural comparisons with other GH families suggest that the GH31 enzymes belong to clan GH-D.

-	~~{{STRUCTURE_2g3m\| PDB=2g3m \| SCENE= }}~~	+	Structure of the Sulfolobus solfataricus alpha-glucosidase: implications for domain conservation and substrate recognition in GH31.,Ernst HA, Lo Leggio L, Willemoes M, Leonard G, Blum P, Larsen S J Mol Biol. 2006 May 12;358(4):1106-24. Epub 2006 Mar 13. PMID:16580018<ref>PMID:16580018</ref>

-	~~===Crystal structure~~ of the ~~Sulfolobus solfataricus alpha-glucosidase MalA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_16580018}}~~	+	==See Also==
-		+	*[[Alpha-glucosidase\|Alpha-glucosidase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2g3m~~]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3M OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:016580018<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Alpha-glucosidase]]		[[Category: Alpha-glucosidase]]
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]

OCA: Protected "2g3m" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 13:59:16 GMT

Protected "2g3m" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:59, 7 January 2013

OCA at 13:59, 7 January 2013

OCA — Mon, 07 Jan 2013 13:59:13 GMT

←Older revision		Revision as of 13:59, 7 January 2013
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-	{{Seed}}
	[[Image:2g3m.png\|left\|200px]]		[[Image:2g3m.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2g3m", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2g3m\| PDB=2g3m \| SCENE= }}		{{STRUCTURE_2g3m\| PDB=2g3m \| SCENE= }}

	===Crystal structure of the Sulfolobus solfataricus alpha-glucosidase MalA===		===Crystal structure of the Sulfolobus solfataricus alpha-glucosidase MalA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16580018}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16580018 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16580018}}		{{ABSTRACT_PUBMED_16580018}}

	==About this Structure==		==About this Structure==
-	~~2G3M~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3M OCA].	+	[[2g3m]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3M OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16580018~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016580018</ref><references group="xtra"/>
	[[Category: Alpha-glucosidase]]		[[Category: Alpha-glucosidase]]
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
Line 37:		Line 25:
	[[Category: Multidomain protein]]		[[Category: Multidomain protein]]
	[[Category: Retaining mechanism]]		[[Category: Retaining mechanism]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:13:53 2009''

OCA at 12:13, 16 February 2009

OCA — Mon, 16 Feb 2009 12:13:54 GMT

←Older revision		Revision as of 12:13, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2G3M is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3M OCA].	+	2G3M is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3M OCA].

	==Reference==		==Reference==
-	Structure of the Sulfolobus solfataricus alpha-glucosidase: implications for domain conservation and substrate recognition in GH31., Ernst HA, Lo Leggio L, Willemoes M, Leonard G, Blum P, Larsen S, J Mol Biol. 2006 May 12;358(4):1106-24. Epub 2006 Mar 13. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16580018 16580018]~~	+	<ref group="xtra">PMID:16580018</ref><references group="xtra"/>
	[[Category: Alpha-glucosidase]]		[[Category: Alpha-glucosidase]]
-	[[Category: Single protein]]
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
	[[Category: Blum, P.]]		[[Category: Blum, P.]]
Line 39:		Line 38:
	[[Category: Retaining mechanism]]		[[Category: Retaining mechanism]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27~~ 16:49:~~36 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:13:53 2009''