2g6g - Revision history

OCA at 18:48, 10 March 2021

OCA — Wed, 10 Mar 2021 18:48:39 GMT

←Older revision		Revision as of 18:48, 10 March 2021
Line 1:		Line 1:

	==Crystal structure of MltA from Neisseria gonorrhoeae==		==Crystal structure of MltA from Neisseria gonorrhoeae==
-	<StructureSection load='2g6g' size='340' side='right' caption='[[2g6g]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2g6g' size='340' side='right'caption='[[2g6g]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2g6g]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Neig1 Neig1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2G6G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2g6g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neig1 Neig1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G6G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g5d\|2g5d]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2g5d\|2g5d]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GNA33 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242231 NEIG1])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GNA33 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242231 NEIG1])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2g6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g6g OCA], [~~http~~://pdbe.org/2g6g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2g6g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2g6g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2g6g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g6g OCA], [https://pdbe.org/2g6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g6g RCSB], [https://www.ebi.ac.uk/pdbsum/2g6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g6g ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/2g6g_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/2g6g_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Neig1]]		[[Category: Neig1]]
	[[Category: Davies, C]]		[[Category: Davies, C]]

OCA at 07:48, 18 October 2017

OCA — Wed, 18 Oct 2017 07:48:36 GMT

←Older revision		Revision as of 07:48, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of MltA from Neisseria gonorrhoeae==		==Crystal structure of MltA from Neisseria gonorrhoeae==
	<StructureSection load='2g6g' size='340' side='right' caption='[[2g6g]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2g6g' size='340' side='right' caption='[[2g6g]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g5d\|2g5d]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g5d\|2g5d]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GNA33 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242231 NEIG1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GNA33 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242231 NEIG1])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g6g OCA], [http://pdbe.org/2g6g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g6g RCSB], [http://www.ebi.ac.uk/pdbsum/2g6g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g6g OCA], [http://pdbe.org/2g6g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g6g RCSB], [http://www.ebi.ac.uk/pdbsum/2g6g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2g6g ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 06:15, 8 February 2016

OCA — Mon, 08 Feb 2016 06:15:21 GMT

←Older revision		Revision as of 06:15, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g6g ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:41, 10 September 2015

OCA — Thu, 10 Sep 2015 08:41:55 GMT

←Older revision		Revision as of 08:41, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2g6g' size='340' side='right' caption='[[2g6g]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2g6g' size='340' side='right' caption='[[2g6g]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2g6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Neisseria_gonorrhoeae_fa_1090 Neisseria gonorrhoeae fa 1090~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G6G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2g6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neig1 Neig1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G6G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g5d\|2g5d]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g5d\|2g5d]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GNA33 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242231 ~~Neisseria gonorrhoeae FA 1090~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GNA33 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242231 NEIG1])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g6g RCSB], [http://www.ebi.ac.uk/pdbsum/2g6g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g6g OCA], [http://pdbe.org/2g6g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g6g RCSB], [http://www.ebi.ac.uk/pdbsum/2g6g PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2g6g" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Neisseria gonorrhoeae fa 1090~~]]	+	[[Category: Neig1]]
	[[Category: Davies, C]]		[[Category: Davies, C]]
	[[Category: Liu, Z J]]		[[Category: Liu, Z J]]

OCA at 08:24, 16 January 2015

OCA — Fri, 16 Jan 2015 08:24:37 GMT

←Older revision		Revision as of 08:24, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2g6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae_fa_1090 Neisseria gonorrhoeae fa 1090]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G6G FirstGlance]. <br>		<table><tr><td colspan='2'>[[2g6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae_fa_1090 Neisseria gonorrhoeae fa 1090]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G6G FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g5d\|2g5d]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g5d\|2g5d]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GNA33 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242231 Neisseria gonorrhoeae FA 1090])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GNA33 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242231 Neisseria gonorrhoeae FA 1090])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g6g RCSB], [http://www.ebi.ac.uk/pdbsum/2g6g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g6g RCSB], [http://www.ebi.ac.uk/pdbsum/2g6g PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Neisseria gonorrhoeae fa 1090]]		[[Category: Neisseria gonorrhoeae fa 1090]]
-	[[Category: Davies, C.]]	+	[[Category: Davies, C]]
-	[[Category: Liu, Z J.]]	+	[[Category: Liu, Z J]]
-	[[Category: Nicholas, R A.]]	+	[[Category: Nicholas, R A]]
-	[[Category: Powell, A J.]]	+	[[Category: Powell, A J]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 09:35, 30 September 2014

OCA — Tue, 30 Sep 2014 09:35:24 GMT

←Older revision		Revision as of 09:35, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2g6g.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of MltA from Neisseria gonorrhoeae==
		+	<StructureSection load='2g6g' size='340' side='right' caption='[[2g6g]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2g6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae_fa_1090 Neisseria gonorrhoeae fa 1090]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G6G FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g5d\|2g5d]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GNA33 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242231 Neisseria gonorrhoeae FA 1090])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g6g RCSB], [http://www.ebi.ac.uk/pdbsum/2g6g PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/2g6g_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	MltA is a lytic transglycosylase of Gram-negative bacteria that cleaves the beta-1,4 glycosidic linkages between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) in peptidoglycan. We have determined the crystal structures of MltA from Neisseria gonorrhoeae and Escherichia coli (NgMltA and EcMltA), which have only 21.5% sequence identity. Both proteins have two main domains separated by a deep groove. Domain 1 shows structural similarity with the so-called double-psi barrel family of proteins. Comparison of the two structures reveals substantial differences in the relative positions of domains 1 and 2 such that the active site groove in NgMltA is much wider and appears more able to accommodate peptidoglycan substrate than EcMltA, suggesting that domain closure occurs after substrate binding. Docking of a peptidoglycan molecule into the structure of NgMltA reveals a number of conserved residues that are likely involved in substrate binding, including a potential binding pocket for the peptidyl moieties. This structure supports the assignment of Asp405 as the acid catalyst responsible for cleavage of the glycosidic bond. In EcMltA, the equivalent residue is Asp328, which has been identified previously. The structures also suggest a catalytic role for Asp393 (Asp317 in EcMltA) in activating the C6 hydroxyl group during formation of the 1,6-anhydro linkage. Finally, in comparison to EcMltA, NgMltA contains a unique third domain that is an insertion within domain 2. The domain is beta in structure and may mediate protein-protein interactions that are specific to peptidoglycan metabolism in N.gonorrhoeae.

-	~~{{STRUCTURE_2g6g\| PDB=2g6g \| SCENE= }}~~	+	Crystal structures of the lytic transglycosylase MltA from N.gonorrhoeae and E.coli: insights into interdomain movements and substrate binding.,Powell AJ, Liu ZJ, Nicholas RA, Davies C J Mol Biol. 2006 May 26;359(1):122-36. Epub 2006 Mar 29. PMID:16618494<ref>PMID:16618494</ref>

-	~~===Crystal structure~~ of ~~MltA from Neisseria gonorrhoeae===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16618494}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2g6g]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Neisseria_gonorrhoeae_fa_1090 Neisseria gonorrhoeae fa 1090]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2G6G OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016618494<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Neisseria gonorrhoeae fa 1090]]		[[Category: Neisseria gonorrhoeae fa 1090]]
	[[Category: Davies, C.]]		[[Category: Davies, C.]]

OCA: Protected "2g6g" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:29:53 GMT

Protected "2g6g" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:29, 7 January 2013

OCA at 14:29, 7 January 2013

OCA — Mon, 07 Jan 2013 14:29:49 GMT

←Older revision		Revision as of 14:29, 7 January 2013
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-	{{Seed}}
	[[Image:2g6g.png\|left\|200px]]		[[Image:2g6g.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2g6g", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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	{{STRUCTURE_2g6g\| PDB=2g6g \| SCENE= }}		{{STRUCTURE_2g6g\| PDB=2g6g \| SCENE= }}

	===Crystal structure of MltA from Neisseria gonorrhoeae===		===Crystal structure of MltA from Neisseria gonorrhoeae===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16618494}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16618494 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16618494}}		{{ABSTRACT_PUBMED_16618494}}

	==About this Structure==		==About this Structure==
-	~~2G6G~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Neisseria_gonorrhoeae~~ Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6G OCA].	+	[[2g6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae_fa_1090 Neisseria gonorrhoeae fa 1090]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6G OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16618494~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016618494</ref><references group="xtra"/>
-	[[Category: Neisseria gonorrhoeae]]	+	[[Category: Neisseria gonorrhoeae fa 1090]]
	[[Category: Davies, C.]]		[[Category: Davies, C.]]
	[[Category: Liu, Z J.]]		[[Category: Liu, Z J.]]
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	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-
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OCA at 17:43, 16 February 2009

OCA — Mon, 16 Feb 2009 17:43:47 GMT

←Older revision		Revision as of 17:43, 16 February 2009
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	==About this Structure==		==About this Structure==
-	2G6G is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6G OCA].	+	2G6G is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6G OCA].

	==Reference==		==Reference==
-	Crystal structures of the lytic transglycosylase MltA from N.gonorrhoeae and E.coli: insights into interdomain movements and substrate binding., Powell AJ, Liu ZJ, Nicholas RA, Davies C, J Mol Biol. 2006 May 26;359(1):122-36. Epub 2006 Mar 29. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16618494 16618494]~~	+	<ref group="xtra">PMID:16618494</ref><references group="xtra"/>
	[[Category: Neisseria gonorrhoeae]]		[[Category: Neisseria gonorrhoeae]]
-	[[Category: Single protein]]
	[[Category: Davies, C.]]		[[Category: Davies, C.]]
	[[Category: Liu, Z J.]]		[[Category: Liu, Z J.]]
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	[[Category: Hydrolase]]		[[Category: Hydrolase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 23~~:50:~~01 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:43:45 2009''

OCA at 20:50, 27 July 2008

OCA — Sun, 27 Jul 2008 20:50:06 GMT

←Older revision		Revision as of 20:50, 27 July 2008
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-	[[Image:2g6g.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2g6g.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2g6g\| PDB=2g6g \| SCENE= }}		{{STRUCTURE_2g6g\| PDB=2g6g \| SCENE= }}

-	~~'''~~Crystal structure of MltA from Neisseria gonorrhoeae~~'''~~	+	===Crystal structure of MltA from Neisseria gonorrhoeae===


-	~~==Overview==~~	+	<!--
-	~~MltA is a lytic transglycosylase of Gram~~-~~negative bacteria that cleaves the beta~~-1,4 glycosidic linkages between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) in peptidoglycan. We have determined the crystal structures of MltA from Neisseria gonorrhoeae and Escherichia coli (NgMltA and EcMltA), ~~which have only 21.5% sequence identity. Both proteins have two main domains separated by a deep groove. Domain 1 shows structural similarity with~~ the so-called double-psi barrel family of proteins. Comparison of the two structures reveals substantial differences in the relative positions of domains 1 and 2 such that the active site groove in NgMltA is much wider and appears more able to ~~accommodate peptidoglycan substrate than EcMltA, suggesting that domain closure occurs after substrate binding. Docking of a peptidoglycan molecule into~~ the structure of NgMltA reveals a number of conserved residues that are likely involved in substrate binding, including a potential binding pocket for the peptidyl moieties. This structure supports the assignment of Asp405 as ~~the acid catalyst responsible for cleavage of the glycosidic bond~~. ~~In EcMltA, the equivalent residue is Asp328, which has been identified previously~~. ~~The structures also suggest a catalytic role for Asp393 (Asp317 in EcMltA~~) ~~in activating the C6 hydroxyl group during formation of the 1~~,~~6-anhydro linkage. Finally, in comparison to EcMltA, NgMltA contains a unique third domain that~~ is ~~an insertion within domain 2~~. ~~The domain is beta in structure and may mediate protein~~-~~protein interactions that are specific to peptidoglycan metabolism in N.gonorrhoeae.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_16618494}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16618494 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16618494}}

	==About this Structure==		==About this Structure==
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	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
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