2g9a - Revision history

OCA at 08:48, 25 October 2023

OCA — Wed, 25 Oct 2023 08:48:27 GMT

←Older revision		Revision as of 08:48, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='2g9a' size='340' side='right'caption='[[2g9a]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2g9a' size='340' side='right'caption='[[2g9a]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2g9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2g9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G9A FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=MLY:N~~-~~DIMETHYL-LYSINE'>MLY</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2g99\|2g99]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9a OCA], [https://pdbe.org/2g9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g9a RCSB], [https://www.ebi.ac.uk/pdbsum/2g9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g9a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9a OCA], [https://pdbe.org/2g9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g9a RCSB], [https://www.ebi.ac.uk/pdbsum/2g9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g9a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>	+	[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g9a ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g9a ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The WD40 repeat protein WDR5 specifically associates with the K4-methylated histone H3 in human cells. To investigate the structural basis for this specific recognition, we have determined the structure of WDR5 in complex with a dimethylated H3-K4 peptide at 1.9 A resolution. Unlike the chromodomain that recognizes the methylated H3-K4 through a hydrophobic cage, the specificity of WDR5 for methylated H3-K4 is conferred by the nonconventional hydrogen bonds between the two zeta-methyl groups of the dimethylated Lys4 and the carboxylate oxygen of Glu322 in WDR5. The three amino acids Ala-Arg-Thr preceding Lys4 form most of the specific contacts with WDR5, with Ala1 forming intermolecular hydrogen bonds and salt bridges, and the side chain of Arg2 inserting into the central channel of WDR5. Both structural and biochemical studies presented here suggest another mode of recognition for the methylated histone tail.
		+
		+	Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5.,Han Z, Guo L, Wang H, Shen Y, Deng XW, Chai J Mol Cell. 2006 Apr 7;22(1):137-44. PMID:16600877<ref>PMID:16600877</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 2g9a" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chai, J]]	+	[[Category: Chai J]]
-	[[Category: Han, Z]]	+	[[Category: Han Z]]
-	[[Category: Shen, Y]]	+	[[Category: Shen Y]]
-	[[Category: Wang, H]]	+	[[Category: Wang H]]
-	~~[[Category: Structural protein-dna binding protein complex]]~~	+
-	~~[[Category: Wd40 repeat protein~~]]	+

OCA at 14:42, 29 December 2021

OCA — Wed, 29 Dec 2021 14:42:08 GMT

←Older revision		Revision as of 14:42, 29 December 2021
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	<StructureSection load='2g9a' size='340' side='right'caption='[[2g9a]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2g9a' size='340' side='right'caption='[[2g9a]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2g9a]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2G9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2g9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G9A FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g99\|2g99]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2g99\|2g99]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2g9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9a OCA], [~~http~~://pdbe.org/2g9a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2g9a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2g9a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2g9a ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9a OCA], [https://pdbe.org/2g9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g9a RCSB], [https://www.ebi.ac.uk/pdbsum/2g9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g9a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>	+	[[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[~~Histone~~ 3D structures\|~~Histone 3D structures]]~~	+	*[[WD-repeat protein 3D structures\|WD-repeat protein 3D structures]]
-	*[[WD ~~repeat~~-~~containing protein\|WD~~ repeat~~-containing~~ protein]]	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:11, 27 March 2020

OCA — Fri, 27 Mar 2020 11:11:21 GMT

←Older revision		Revision as of 11:11, 27 March 2020
Line 1:		Line 1:

	==Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5==		==Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5==
-	<StructureSection load='2g9a' size='340' side='right' caption='[[2g9a]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='2g9a' size='340' side='right'caption='[[2g9a]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2g9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G9A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2g9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G9A FirstGlance]. <br>
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Histone\|Histone]]	+	*[[Histone 3D structures\|Histone 3D structures]]
	*[[WD repeat-containing protein\|WD repeat-containing protein]]		*[[WD repeat-containing protein\|WD repeat-containing protein]]
	== References ==		== References ==
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chai, J]]		[[Category: Chai, J]]
	[[Category: Han, Z]]		[[Category: Han, Z]]

OCA at 07:14, 20 June 2018

OCA — Wed, 20 Jun 2018 07:14:29 GMT

←Older revision		Revision as of 07:14, 20 June 2018
Line 1:		Line 1:
		+
	==Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5==		==Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5==
	<StructureSection load='2g9a' size='340' side='right' caption='[[2g9a]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2g9a' size='340' side='right' caption='[[2g9a]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g99\|2g99]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g99\|2g99]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9a OCA], [http://pdbe.org/2g9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g9a RCSB], [http://www.ebi.ac.uk/pdbsum/2g9a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9a OCA], [http://pdbe.org/2g9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g9a RCSB], [http://www.ebi.ac.uk/pdbsum/2g9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2g9a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g9/2g9a_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g9/2g9a_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 22:		Line 23:
	==See Also==		==See Also==
	*[[Histone\|Histone]]		*[[Histone\|Histone]]
-	*[[WD-repeat protein 5\|WD-repeat protein 5]]	+	*[[WD repeat-containing protein\|WD repeat-containing protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:51, 10 February 2016

OCA — Wed, 10 Feb 2016 01:51:01 GMT

←Older revision		Revision as of 01:51, 10 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g9a ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 04:11, 11 September 2015

OCA — Fri, 11 Sep 2015 04:11:12 GMT

←Older revision		Revision as of 04:11, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2g9a' size='340' side='right' caption='[[2g9a]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2g9a' size='340' side='right' caption='[[2g9a]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2g9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2g9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G9A FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g99\|2g99]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g99\|2g99]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g9a RCSB], [http://www.ebi.ac.uk/pdbsum/2g9a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9a OCA], [http://pdbe.org/2g9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g9a RCSB], [http://www.ebi.ac.uk/pdbsum/2g9a PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:
	==See Also==		==See Also==
	*[[Histone\|Histone]]		*[[Histone\|Histone]]
		+	*[[WD-repeat protein 5\|WD-repeat protein 5]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chai, J]]		[[Category: Chai, J]]
	[[Category: Han, Z]]		[[Category: Han, Z]]

OCA at 10:58, 25 December 2014

OCA — Thu, 25 Dec 2014 10:58:17 GMT

←Older revision		Revision as of 10:58, 25 December 2014
Line 1:		Line 1:
-	~~[[Image:2g9a.png\|left\|200px]]~~	+	==Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5==
-		+	<StructureSection load='2g9a' size='340' side='right' caption='[[2g9a]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~{{STRUCTURE_2g9a\| PDB=2g9a \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2g9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G9A FirstGlance]. <br>
-	===Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5===	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g99\|2g99]]</td></tr>
-	~~{{ABSTRACT_PUBMED_016600877}}~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g9a RCSB], [http://www.ebi.ac.uk/pdbsum/2g9a PDBsum]</span></td></tr>
-		+	</table>
-	==~~About this Structure~~==	+	== Function ==
-	[[2g9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9A OCA].	+	[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g9/2g9a_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Histone\|Histone]]		*[[Histone\|Histone]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016600877<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chai, J.]]	+	[[Category: Chai, J]]
-	[[Category: Han, Z.]]	+	[[Category: Han, Z]]
-	[[Category: Shen, Y.]]	+	[[Category: Shen, Y]]
-	[[Category: Wang, H.]]	+	[[Category: Wang, H]]
	[[Category: Structural protein-dna binding protein complex]]		[[Category: Structural protein-dna binding protein complex]]
	[[Category: Wd40 repeat protein]]		[[Category: Wd40 repeat protein]]

OCA at 15:54, 20 October 2012

OCA — Sat, 20 Oct 2012 15:54:08 GMT

←Older revision		Revision as of 15:54, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2g9a]] is a 2 chain structure ~~of [[Histone]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9A OCA].	+	[[2g9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9A OCA].

	==See Also==		==See Also==

OCA: Protected "2g9a" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 19:51:34 GMT

Protected "2g9a" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:51, 26 July 2012

OCA at 19:51, 26 July 2012

OCA — Thu, 26 Jul 2012 19:51:33 GMT

←Older revision		Revision as of 19:51, 26 July 2012
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-	{{Seed}}
	[[Image:2g9a.png\|left\|200px]]		[[Image:2g9a.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2g9a", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2g9a\| PDB=2g9a \| SCENE= }}		{{STRUCTURE_2g9a\| PDB=2g9a \| SCENE= }}

	===Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5===		===Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5===

		+	{{ABSTRACT_PUBMED_016600877}}

	==About this Structure==		==About this Structure==
-	~~2G9A~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9A OCA].	+	[[2g9a]] is a 2 chain structure of [[Histone]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9A OCA].
		+
		+	==See Also==
		+	*[[Histone\|Histone]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:016600877</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chai, J.]]		[[Category: Chai, J.]]
Line 20:		Line 20:
	[[Category: Shen, Y.]]		[[Category: Shen, Y.]]
	[[Category: Wang, H.]]		[[Category: Wang, H.]]
		+	[[Category: Structural protein-dna binding protein complex]]
	[[Category: Wd40 repeat protein]]		[[Category: Wd40 repeat protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:27:17 2009''