2gee - Revision history

OCA at 09:39, 30 August 2023

OCA — Wed, 30 Aug 2023 09:39:30 GMT

←Older revision		Revision as of 09:39, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2gee' size='340' side='right'caption='[[2gee]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='2gee' size='340' side='right'caption='[[2gee]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gee]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GEE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gee]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GEE FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2fnb\|2fnb]], [[1fnf\|1fnf]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.01Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">DKFZp686O1166 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gee OCA], [https://pdbe.org/2gee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gee RCSB], [https://www.ebi.ac.uk/pdbsum/2gee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gee ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gee OCA], [https://pdbe.org/2gee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gee RCSB], [https://www.ebi.ac.uk/pdbsum/2gee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gee ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:[https://omim.org/entry/601894 601894]]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.<ref>PMID:18268355</ref>	+	[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN] Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:[https://omim.org/entry/601894 601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.<ref>PMID:18268355</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref> Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>	+	[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref> Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aukhil, I]]	+	[[Category: Aukhil I]]
-	[[Category: Bencharit, S]]	+	[[Category: Bencharit S]]
-	[[Category: Cui~~, C B~~]]	+	[[Category: Cui CB]]
-	[[Category: Howard-Williams~~, E L~~]]	+	[[Category: Howard-Williams EL]]
-	[[Category: Siddiqui, A]]	+	[[Category: Siddiqui A]]
-	~~[[Category: Cancer]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Eiiib]]~~	+
-	~~[[Category: Fibronectin]]~~	+
-	~~[[Category: Neovascularization]]~~	+
-	~~[[Category: Oncoprotein]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 18:58, 10 March 2021

OCA — Wed, 10 Mar 2021 18:58:58 GMT

←Older revision		Revision as of 18:58, 10 March 2021
Line 1:		Line 1:

	==Crystal Structure of Human Type III Fibronectin Extradomain B and Domain 8==		==Crystal Structure of Human Type III Fibronectin Extradomain B and Domain 8==
-	<StructureSection load='2gee' size='340' side='right' caption='[[2gee]], [[Resolution\|resolution]] 2.01Å' scene=''>	+	<StructureSection load='2gee' size='340' side='right'caption='[[2gee]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gee]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2GEE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gee]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GEE FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fnb\|2fnb]], [[1fnf\|1fnf]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fnb\|2fnb]], [[1fnf\|1fnf]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp686O1166 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp686O1166 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2gee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gee OCA], [~~http~~://pdbe.org/2gee PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2gee RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2gee PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2gee ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gee OCA], [https://pdbe.org/2gee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gee RCSB], [https://www.ebi.ac.uk/pdbsum/2gee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gee ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:[~~http~~://omim.org/entry/601894 601894]]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.<ref>PMID:18268355</ref>	+	[[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:[https://omim.org/entry/601894 601894]]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.<ref>PMID:18268355</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref> Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>	+	[[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref> Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Aukhil, I]]		[[Category: Aukhil, I]]
	[[Category: Bencharit, S]]		[[Category: Bencharit, S]]

OCA at 07:20, 20 June 2018

OCA — Wed, 20 Jun 2018 07:20:41 GMT

←Older revision		Revision as of 07:20, 20 June 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Human Type III Fibronectin Extradomain B and Domain 8==		==Crystal Structure of Human Type III Fibronectin Extradomain B and Domain 8==
	<StructureSection load='2gee' size='340' side='right' caption='[[2gee]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='2gee' size='340' side='right' caption='[[2gee]], [[Resolution\|resolution]] 2.01Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fnb\|2fnb]], [[1fnf\|1fnf]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fnb\|2fnb]], [[1fnf\|1fnf]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp686O1166 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp686O1166 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gee OCA], [http://pdbe.org/2gee PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gee RCSB], [http://www.ebi.ac.uk/pdbsum/2gee PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gee OCA], [http://pdbe.org/2gee PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gee RCSB], [http://www.ebi.ac.uk/pdbsum/2gee PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2gee ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ge/2gee_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ge/2gee_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 00:25, 10 February 2016

OCA — Wed, 10 Feb 2016 00:25:08 GMT

←Older revision		Revision as of 00:25, 10 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gee ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:32, 11 September 2015

OCA — Fri, 11 Sep 2015 03:32:04 GMT

←Older revision		Revision as of 03:32, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2gee' size='340' side='right' caption='[[2gee]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='2gee' size='340' side='right' caption='[[2gee]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gee]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GEE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gee]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GEE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fnb\|2fnb]], [[1fnf\|1fnf]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fnb\|2fnb]], [[1fnf\|1fnf]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp686O1166 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp686O1166 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gee OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gee RCSB], [http://www.ebi.ac.uk/pdbsum/2gee PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gee OCA], [http://pdbe.org/2gee PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gee RCSB], [http://www.ebi.ac.uk/pdbsum/2gee PDBsum]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:[http://omim.org/entry/601894 601894]]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.<ref>PMID:18268355</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref> Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2gee" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Aukhil, I]]		[[Category: Aukhil, I]]
	[[Category: Bencharit, S]]		[[Category: Bencharit, S]]

OCA at 08:35, 16 January 2015

OCA — Fri, 16 Jan 2015 08:35:54 GMT

←Older revision		Revision as of 08:35, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2gee]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GEE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gee]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GEE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fnb\|2fnb]], [[1fnf\|1fnf]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fnb\|2fnb]], [[1fnf\|1fnf]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp686O1166 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp686O1166 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gee OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gee RCSB], [http://www.ebi.ac.uk/pdbsum/2gee PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gee OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gee RCSB], [http://www.ebi.ac.uk/pdbsum/2gee PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Aukhil, I.]]	+	[[Category: Aukhil, I]]
-	[[Category: Bencharit, S.]]	+	[[Category: Bencharit, S]]
-	[[Category: Cui, C B.]]	+	[[Category: Cui, C B]]
-	[[Category: Howard-Williams, E L.]]	+	[[Category: Howard-Williams, E L]]
-	[[Category: Siddiqui, A.]]	+	[[Category: Siddiqui, A]]
	[[Category: Cancer]]		[[Category: Cancer]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 10:09, 30 September 2014

OCA — Tue, 30 Sep 2014 10:09:16 GMT

←Older revision		Revision as of 10:09, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2gee\| PDB=2gee \| SCENE= }}~~	+	==Crystal Structure of Human Type III Fibronectin Extradomain B and Domain 8==
-	===Crystal Structure of Human Type III Fibronectin Extradomain B and Domain 8===	+	<StructureSection load='2gee' size='340' side='right' caption='[[2gee]], [[Resolution\|resolution]] 2.01Å' scene=''>
-	~~{{ABSTRACT_PUBMED_17261313}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2gee]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GEE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fnb\|2fnb]], [[1fnf\|1fnf]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp686O1166 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gee OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gee RCSB], [http://www.ebi.ac.uk/pdbsum/2gee PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ge/2gee_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The alternatively spliced type III extradomain B (EIIIB) of fibronectin (FN) is expressed only during embryogenesis, wound healing and tumorigenesis. The biological function of this domain is unclear. We describe here the first crystal structure of the interface between alternatively spliced EIIIB and its adjacent FN type III domain 8 (FN B-8). The opened CC' loop of EIIIB, and the rotation and tilt of EIIIB allow good access to the FG loop of FN-8, which is normally hindered by the CC' loop of FN-7. In addition, the AGEGIP sequence of the CC'' loop of EIIIB replaces the NGQQGN sequence of the CC' loop of FN-7. Finally, the CC'' loop of EIIIB forms an acidic groove with FN-8. These structural findings warrant future studies directed at identifying potential binding partners for FN B-8 interface, linking EIIIB to skeletal and cartilaginous development, wound healing, and tumorigenesis, respectively.

-	~~==About this Structure==~~	+	Structural insights into fibronectin type III domain-mediated signaling.,Bencharit S, Cui CB, Siddiqui A, Howard-Williams EL, Sondek J, Zuobi-Hasona K, Aukhil I J Mol Biol. 2007 Mar 23;367(2):303-9. Epub 2006 Oct 11. PMID:17261313<ref>PMID:17261313</ref>
-	~~[[2gee]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2GEE OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:017261313</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Aukhil, I.]]		[[Category: Aukhil, I.]]

OCA at 21:20, 24 March 2013

OCA — Sun, 24 Mar 2013 21:20:40 GMT

←Older revision		Revision as of 21:20, 24 March 2013
Line 1:		Line 1:
-	[[Image:2gee.png\|left\|200px]]
-
	{{STRUCTURE_2gee\| PDB=2gee \| SCENE= }}		{{STRUCTURE_2gee\| PDB=2gee \| SCENE= }}
-
	===Crystal Structure of Human Type III Fibronectin Extradomain B and Domain 8===		===Crystal Structure of Human Type III Fibronectin Extradomain B and Domain 8===
-
	{{ABSTRACT_PUBMED_17261313}}		{{ABSTRACT_PUBMED_17261313}}

Line 11:		Line 7:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:017261313</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017261313</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Aukhil, I.]]		[[Category: Aukhil, I.]]

OCA: Protected "2gee" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:38:09 GMT

Protected "2gee" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:38, 7 January 2013

OCA at 14:38, 7 January 2013

OCA — Mon, 07 Jan 2013 14:38:06 GMT

←Older revision		Revision as of 14:38, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2gee.png\|left\|200px]]		[[Image:2gee.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2gee", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2gee\| PDB=2gee \| SCENE= }}		{{STRUCTURE_2gee\| PDB=2gee \| SCENE= }}

	===Crystal Structure of Human Type III Fibronectin Extradomain B and Domain 8===		===Crystal Structure of Human Type III Fibronectin Extradomain B and Domain 8===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17261313}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17261313 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17261313}}		{{ABSTRACT_PUBMED_17261313}}

	==About this Structure==		==About this Structure==
-	~~2GEE~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEE OCA].	+	[[2gee]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEE OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17261313~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017261313</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Aukhil, I.]]		[[Category: Aukhil, I.]]
Line 37:		Line 25:
	[[Category: Oncoprotein]]		[[Category: Oncoprotein]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 31 12:32:04 2010''