2gh6 - Revision history

OCA at 09:40, 30 August 2023

OCA — Wed, 30 Aug 2023 09:40:45 GMT

←Older revision		Revision as of 09:40, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2gh6' size='340' side='right'caption='[[2gh6]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2gh6' size='340' side='right'caption='[[2gh6]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gh6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Alcsd Alcsd~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GH6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gh6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Alcaligenaceae_bacterium_FB188 Alcaligenaceae bacterium FB188]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GH6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CF3:9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE'>CF3</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.203Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zz0\|1zz0]], [[1zz1\|1zz1]], [[1zz3\|1zz3]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CF3:9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE'>CF3</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hdaH, hdaH1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242601 ALCSD])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gh6 OCA], [https://pdbe.org/2gh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gh6 RCSB], [https://www.ebi.ac.uk/pdbsum/2gh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gh6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gh6 OCA], [https://pdbe.org/2gh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gh6 RCSB], [https://www.ebi.ac.uk/pdbsum/2gh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gh6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HDAH_ALCSD HDAH_ALCSD]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 2gh6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2gh6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Histone deacetylase 3D structures\|Histone deacetylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Alcsd~~]]	+	[[Category: Alcaligenaceae bacterium FB188]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ficner, R]]	+	[[Category: Ficner R]]
-	[[Category: Hildmann, C]]	+	[[Category: Hildmann C]]
-	[[Category: Nielsen~~, T K~~]]	+	[[Category: Nielsen TK]]
-	[[Category: Riester, D]]	+	[[Category: Riester D]]
-	[[Category: Schwienhorst, A]]	+	[[Category: Schwienhorst A]]
-	[[Category: Wegener, D]]	+	[[Category: Wegener D]]
-	~~[[Category: Histone deacetylase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Trifluoromethyl ketone]]~~	+
-	~~[[Category: Zinc-ion~~]]	+

OCA at 19:03, 10 March 2021

OCA — Wed, 10 Mar 2021 19:03:21 GMT

←Older revision		Revision as of 19:03, 10 March 2021
Line 1:		Line 1:

	==Crystal structure of a HDAC-like protein with 9,9,9-trifluoro-8-oxo-N-phenylnonan amide bound==		==Crystal structure of a HDAC-like protein with 9,9,9-trifluoro-8-oxo-N-phenylnonan amide bound==
-	<StructureSection load='2gh6' size='340' side='right' caption='[[2gh6]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2gh6' size='340' side='right'caption='[[2gh6]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gh6]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Alcsd Alcsd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GH6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2GH6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gh6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Alcsd Alcsd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GH6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF3:9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE'>CF3</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CF3:9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE'>CF3</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz0\|1zz0]], [[1zz1\|1zz1]], [[1zz3\|1zz3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zz0\|1zz0]], [[1zz1\|1zz1]], [[1zz3\|1zz3]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hdaH, hdaH1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242601 ALCSD])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hdaH, hdaH1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242601 ALCSD])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2gh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gh6 OCA], [~~http~~://pdbe.org/2gh6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2gh6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2gh6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2gh6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gh6 OCA], [https://pdbe.org/2gh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gh6 RCSB], [https://www.ebi.ac.uk/pdbsum/2gh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gh6 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Alcsd]]		[[Category: Alcsd]]
		+	[[Category: Large Structures]]
	[[Category: Ficner, R]]		[[Category: Ficner, R]]
	[[Category: Hildmann, C]]		[[Category: Hildmann, C]]

OCA at 07:27, 20 June 2018

OCA — Wed, 20 Jun 2018 07:27:51 GMT

←Older revision		Revision as of 07:27, 20 June 2018
Line 1:		Line 1:
		+
	==Crystal structure of a HDAC-like protein with 9,9,9-trifluoro-8-oxo-N-phenylnonan amide bound==		==Crystal structure of a HDAC-like protein with 9,9,9-trifluoro-8-oxo-N-phenylnonan amide bound==
	<StructureSection load='2gh6' size='340' side='right' caption='[[2gh6]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2gh6' size='340' side='right' caption='[[2gh6]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz0\|1zz0]], [[1zz1\|1zz1]], [[1zz3\|1zz3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz0\|1zz0]], [[1zz1\|1zz1]], [[1zz3\|1zz3]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hdaH, hdaH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242601 ALCSD])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hdaH, hdaH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242601 ALCSD])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gh6 OCA], [http://pdbe.org/2gh6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gh6 RCSB], [http://www.ebi.ac.uk/pdbsum/2gh6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gh6 OCA], [http://pdbe.org/2gh6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gh6 RCSB], [http://www.ebi.ac.uk/pdbsum/2gh6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2gh6 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gh/2gh6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gh/2gh6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:37, 8 February 2016

OCA — Mon, 08 Feb 2016 22:37:59 GMT

←Older revision		Revision as of 22:37, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gh6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:01, 10 September 2015

OCA — Thu, 10 Sep 2015 16:01:20 GMT

←Older revision		Revision as of 16:01, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2gh6' size='340' side='right' caption='[[2gh6]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2gh6' size='340' side='right' caption='[[2gh6]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gh6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Alcaligenaceae_bacterium_fb188 Alcaligenaceae bacterium fb188~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GH6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gh6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcsd Alcsd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GH6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF3:9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE'>CF3</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF3:9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE'>CF3</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz0\|1zz0]], [[1zz1\|1zz1]], [[1zz3\|1zz3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz0\|1zz0]], [[1zz1\|1zz1]], [[1zz3\|1zz3]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hdaH, hdaH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242601 ~~Alcaligenaceae bacterium FB188~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hdaH, hdaH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242601 ALCSD])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gh6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gh6 RCSB], [http://www.ebi.ac.uk/pdbsum/2gh6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gh6 OCA], [http://pdbe.org/2gh6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gh6 RCSB], [http://www.ebi.ac.uk/pdbsum/2gh6 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2gh6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Alcaligenaceae bacterium fb188~~]]	+	[[Category: Alcsd]]
	[[Category: Ficner, R]]		[[Category: Ficner, R]]
	[[Category: Hildmann, C]]		[[Category: Hildmann, C]]

OCA at 02:36, 25 December 2014

OCA — Thu, 25 Dec 2014 02:36:34 GMT

←Older revision		Revision as of 02:36, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2gh6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcaligenaceae_bacterium_fb188 Alcaligenaceae bacterium fb188]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GH6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gh6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcaligenaceae_bacterium_fb188 Alcaligenaceae bacterium fb188]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GH6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF3:9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE'>CF3</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF3:9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE'>CF3</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz0\|1zz0]], [[1zz1\|1zz1]], [[1zz3\|1zz3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz0\|1zz0]], [[1zz1\|1zz1]], [[1zz3\|1zz3]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hdaH, hdaH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242601 Alcaligenaceae bacterium FB188])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hdaH, hdaH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242601 Alcaligenaceae bacterium FB188])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gh6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gh6 RCSB], [http://www.ebi.ac.uk/pdbsum/2gh6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gh6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gh6 RCSB], [http://www.ebi.ac.uk/pdbsum/2gh6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Alcaligenaceae bacterium fb188]]		[[Category: Alcaligenaceae bacterium fb188]]
-	[[Category: Ficner, R.]]	+	[[Category: Ficner, R]]
-	[[Category: Hildmann, C.]]	+	[[Category: Hildmann, C]]
-	[[Category: Nielsen, T K.]]	+	[[Category: Nielsen, T K]]
-	[[Category: Riester, D.]]	+	[[Category: Riester, D]]
-	[[Category: Schwienhorst, A.]]	+	[[Category: Schwienhorst, A]]
-	[[Category: Wegener, D.]]	+	[[Category: Wegener, D]]
	[[Category: Histone deacetylase]]		[[Category: Histone deacetylase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Trifluoromethyl ketone]]		[[Category: Trifluoromethyl ketone]]
	[[Category: Zinc-ion]]		[[Category: Zinc-ion]]

OCA at 10:57, 30 September 2014

OCA — Tue, 30 Sep 2014 10:57:08 GMT

←Older revision		Revision as of 10:57, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2gh6.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of a HDAC-like protein with 9,9,9-trifluoro-8-oxo-N-phenylnonan amide bound==
		+	<StructureSection load='2gh6' size='340' side='right' caption='[[2gh6]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2gh6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcaligenaceae_bacterium_fb188 Alcaligenaceae bacterium fb188]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GH6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF3:9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE'>CF3</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz0\|1zz0]], [[1zz1\|1zz1]], [[1zz3\|1zz3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hdaH, hdaH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242601 Alcaligenaceae bacterium FB188])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gh6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gh6 RCSB], [http://www.ebi.ac.uk/pdbsum/2gh6 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gh/2gh6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Histone deacetylases (HDACs) have emerged as attractive targets in anticancer drug development. To date, a number of HDAC inhibitors have been developed and most of them are hydroxamic acid derivatives, typified by suberoylanilide hydroxamic acid (SAHA). Not surprisingly, structural information that can greatly enhance the design of novel HDAC inhibitors is so far only available for hydroxamic acids in complex with HDAC or HDAC-like enzymes. Here, the first structure of an enzyme complex with a nonhydroxamate HDAC inhibitor is presented. The structure of the trifluoromethyl ketone inhibitor 9,9,9-trifluoro-8-oxo-N-phenylnonanamide in complex with bacterial FB188 HDAH (histone deacetylase-like amidohydrolase from Bordetella/Alcaligenes strain FB188) has been determined. HDAH reveals high sequential and functional homology to human class 2 HDACs and a high structural homology to human class 1 HDACs. Comparison with the structure of HDAH in complex with SAHA reveals that the two inhibitors superimpose well. However, significant differences in binding to the active site of HDAH were observed. In the presented structure the O atom of the trifluoromethyl ketone moiety is within binding distance of the Zn atom of the enzyme and the F atoms participate in interactions with the enzyme, thereby involving more amino acids in enzyme-inhibitor binding.

-	~~{{STRUCTURE_2gh6\| PDB=2gh6 \| SCENE= }}~~	+	Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor.,Nielsen TK, Hildmann C, Riester D, Wegener D, Schwienhorst A, Ficner R Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 1;63(Pt, 4):270-3. Epub 2007 Mar 23. PMID:17401192<ref>PMID:17401192</ref>

-	~~===Crystal structure of a HDAC-like protein with 9~~,~~9,9-trifluoro-8-oxo-N-phenylnonan amide bound===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17401192}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2gh6]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Alcaligenaceae_bacterium_fb188 Alcaligenaceae bacterium fb188]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2GH6 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017401192<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Alcaligenaceae bacterium fb188]]		[[Category: Alcaligenaceae bacterium fb188]]
	[[Category: Ficner, R.]]		[[Category: Ficner, R.]]

OCA: Protected "2gh6" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 15:24:23 GMT

Protected "2gh6" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:24, 7 January 2013

OCA at 15:24, 7 January 2013

OCA — Mon, 07 Jan 2013 15:24:21 GMT

←Older revision		Revision as of 15:24, 7 January 2013
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-	{{Seed}}
	[[Image:2gh6.png\|left\|200px]]		[[Image:2gh6.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2gh6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2gh6\| PDB=2gh6 \| SCENE= }}		{{STRUCTURE_2gh6\| PDB=2gh6 \| SCENE= }}

	===Crystal structure of a HDAC-like protein with 9,9,9-trifluoro-8-oxo-N-phenylnonan amide bound===		===Crystal structure of a HDAC-like protein with 9,9,9-trifluoro-8-oxo-N-phenylnonan amide bound===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17401192}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17401192 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17401192}}		{{ABSTRACT_PUBMED_17401192}}

	==About this Structure==		==About this Structure==
-	~~2GH6~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Alcaligenaceae_bacterium_fb188 Alcaligenaceae bacterium fb188]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GH6 OCA].	+	[[2gh6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcaligenaceae_bacterium_fb188 Alcaligenaceae bacterium fb188]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GH6 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17401192~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017401192</ref><references group="xtra"/>
	[[Category: Alcaligenaceae bacterium fb188]]		[[Category: Alcaligenaceae bacterium fb188]]
	[[Category: Ficner, R.]]		[[Category: Ficner, R.]]
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	[[Category: Trifluoromethyl ketone]]		[[Category: Trifluoromethyl ketone]]
	[[Category: Zinc-ion]]		[[Category: Zinc-ion]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 20:30:38 2009''

OCA at 18:30, 18 November 2009

OCA — Wed, 18 Nov 2009 18:30:40 GMT

←Older revision		Revision as of 18:30, 18 November 2009
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	===Crystal structure of a HDAC-like protein with 9,9,9-trifluoro-8-oxo-N-phenylnonan amide bound===		===Crystal structure of a HDAC-like protein with 9,9,9-trifluoro-8-oxo-N-phenylnonan amide bound===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_17401192}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17401192 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17401192}}

	==About this Structure==		==About this Structure==
	2GH6 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Alcaligenaceae_bacterium_fb188 Alcaligenaceae bacterium fb188]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GH6 OCA].		2GH6 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Alcaligenaceae_bacterium_fb188 Alcaligenaceae bacterium fb188]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GH6 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:17401192</ref><references group="xtra"/>
	[[Category: Alcaligenaceae bacterium fb188]]		[[Category: Alcaligenaceae bacterium fb188]]
	[[Category: Ficner, R.]]		[[Category: Ficner, R.]]
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	[[Category: Zinc-ion]]		[[Category: Zinc-ion]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 20:22:21 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 20:30:38 2009''