2ghi - Revision history

OCA at 09:40, 30 August 2023

OCA — Wed, 30 Aug 2023 09:40:53 GMT

←Older revision		Revision as of 09:40, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2ghi' size='340' side='right'caption='[[2ghi]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2ghi' size='340' side='right'caption='[[2ghi]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ghi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plasmodium_yoelii_yoelii_17xnl~~ Plasmodium yoelii yoelii ~~17xnl~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GHI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ghi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii_17XNL Plasmodium yoelii yoelii 17XNL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GHI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ghi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ghi OCA], [https://pdbe.org/2ghi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ghi RCSB], [https://www.ebi.ac.uk/pdbsum/2ghi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ghi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ghi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ghi OCA], [https://pdbe.org/2ghi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ghi RCSB], [https://www.ebi.ac.uk/pdbsum/2ghi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ghi ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q7RBT4_PLAYO Q7RBT4_PLAYO]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Plasmodium yoelii yoelii ~~17xnl~~]]	+	[[Category: Plasmodium yoelii yoelii 17XNL]]
-	[[Category: Alam, Z]]	+	[[Category: Alam Z]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Artz~~, J D~~]]	+	[[Category: Artz JD]]
-	[[Category: Bochkarev, A]]	+	[[Category: Bochkarev A]]
-	[[Category: Choe, J]]	+	[[Category: Choe J]]
-	[[Category: Dong, A]]	+	[[Category: Dong A]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Edwards AM]]
-	[[Category: Gao, M]]	+	[[Category: Gao M]]
-	[[Category: Hui, R]]	+	[[Category: Hui R]]
-	[[Category: Kozieradzki, I]]	+	[[Category: Kozieradzki I]]
-	[[Category: Lew, J]]	+	[[Category: Lew J]]
-	[[Category: Melone, M]]	+	[[Category: Melone M]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Sundstrom M]]
-	[[Category: Sundstrom, M]]	+	[[Category: Vedadi M]]
-	[[Category: Vedadi, M]]	+	[[Category: Wasney G]]
-	[[Category: Wasney, G]]	+	[[Category: Weigelt J]]
-	[[Category: Weigelt, J]]	+	[[Category: Zhao Y]]
-	[[Category: Zhao, Y]]	+
-	~~[[Category: Mdr]]~~	+
-	~~[[Category: Multidrug resistance protein]]~~	+
-	~~[[Category: Plasmodium yoelii]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 09:58, 5 May 2021

OCA — Wed, 05 May 2021 09:58:10 GMT

←Older revision		Revision as of 09:58, 5 May 2021
Line 3:		Line 3:
	<StructureSection load='2ghi' size='340' side='right'caption='[[2ghi]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2ghi' size='340' side='right'caption='[[2ghi]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ghi]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii_17xnl Plasmodium yoelii yoelii 17xnl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2GHI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ghi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii_17xnl Plasmodium yoelii yoelii 17xnl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GHI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ghi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ghi OCA], [~~http~~://pdbe.org/2ghi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ghi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ghi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ghi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ghi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ghi OCA], [https://pdbe.org/2ghi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ghi RCSB], [https://www.ebi.ac.uk/pdbsum/2ghi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ghi ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:37, 24 July 2019

OCA — Wed, 24 Jul 2019 09:37:35 GMT

←Older revision		Revision as of 09:37, 24 July 2019
Line 1:		Line 1:

	==Crystal Structure of Plasmodium yoelii Multidrug Resistance Protein 2==		==Crystal Structure of Plasmodium yoelii Multidrug Resistance Protein 2==
-	<StructureSection load='2ghi' size='340' side='right' caption='[[2ghi]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2ghi' size='340' side='right'caption='[[2ghi]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ghi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii_17xnl Plasmodium yoelii yoelii 17xnl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GHI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ghi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii_17xnl Plasmodium yoelii yoelii 17xnl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GHI FirstGlance]. <br>
Line 11:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gh/2ghi_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gh/2ghi_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Plasmodium yoelii yoelii 17xnl]]		[[Category: Plasmodium yoelii yoelii 17xnl]]
	[[Category: Alam, Z]]		[[Category: Alam, Z]]

OCA at 07:54, 18 October 2017

OCA — Wed, 18 Oct 2017 07:54:27 GMT

←Older revision		Revision as of 07:54, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Plasmodium yoelii Multidrug Resistance Protein 2==		==Crystal Structure of Plasmodium yoelii Multidrug Resistance Protein 2==
	<StructureSection load='2ghi' size='340' side='right' caption='[[2ghi]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2ghi' size='340' side='right' caption='[[2ghi]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2ghi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii_17xnl Plasmodium yoelii yoelii 17xnl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GHI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ghi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii_17xnl Plasmodium yoelii yoelii 17xnl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GHI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ghi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ghi OCA], [http://pdbe.org/2ghi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ghi RCSB], [http://www.ebi.ac.uk/pdbsum/2ghi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ghi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ghi OCA], [http://pdbe.org/2ghi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ghi RCSB], [http://www.ebi.ac.uk/pdbsum/2ghi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ghi ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 05:50, 7 February 2016

OCA — Sun, 07 Feb 2016 05:50:09 GMT

←Older revision		Revision as of 05:50, 7 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ghi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:27, 9 September 2015

OCA — Wed, 09 Sep 2015 22:27:52 GMT

←Older revision		Revision as of 22:27, 9 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2ghi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii_17xnl Plasmodium yoelii yoelii 17xnl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GHI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ghi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii_17xnl Plasmodium yoelii yoelii 17xnl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GHI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ghi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ghi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ghi RCSB], [http://www.ebi.ac.uk/pdbsum/2ghi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ghi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ghi OCA], [http://pdbe.org/2ghi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ghi RCSB], [http://www.ebi.ac.uk/pdbsum/2ghi PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ghi" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:31, 16 January 2015

OCA — Fri, 16 Jan 2015 09:31:31 GMT

←Older revision		Revision as of 09:31, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ghi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii_17xnl Plasmodium yoelii yoelii 17xnl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GHI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ghi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii_17xnl Plasmodium yoelii yoelii 17xnl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GHI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ghi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ghi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ghi RCSB], [http://www.ebi.ac.uk/pdbsum/2ghi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ghi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ghi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ghi RCSB], [http://www.ebi.ac.uk/pdbsum/2ghi PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Plasmodium yoelii yoelii 17xnl]]		[[Category: Plasmodium yoelii yoelii 17xnl]]
-	[[Category: Alam, Z.]]	+	[[Category: Alam, Z]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Artz, J D.]]	+	[[Category: Artz, J D]]
-	[[Category: Bochkarev, A.]]	+	[[Category: Bochkarev, A]]
-	[[Category: Choe, J.]]	+	[[Category: Choe, J]]
-	[[Category: Dong, A.]]	+	[[Category: Dong, A]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Gao, M.]]	+	[[Category: Gao, M]]
-	[[Category: Hui, R.]]	+	[[Category: Hui, R]]
-	[[Category: Kozieradzki, I.]]	+	[[Category: Kozieradzki, I]]
-	[[Category: Lew, J.]]	+	[[Category: Lew, J]]
-	[[Category: Melone, M.]]	+	[[Category: Melone, M]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Sundstrom, M.]]	+	[[Category: Sundstrom, M]]
-	[[Category: Vedadi, M.]]	+	[[Category: Vedadi, M]]
-	[[Category: Wasney, G.]]	+	[[Category: Wasney, G]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Zhao, Y.]]	+	[[Category: Zhao, Y]]
	[[Category: Mdr]]		[[Category: Mdr]]
	[[Category: Multidrug resistance protein]]		[[Category: Multidrug resistance protein]]
	[[Category: Plasmodium yoelii]]		[[Category: Plasmodium yoelii]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 09:06, 30 September 2014

OCA — Tue, 30 Sep 2014 09:06:46 GMT

←Older revision		Revision as of 09:06, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2ghi.~~png\|left~~\|200px]]	+	==Crystal Structure of Plasmodium yoelii Multidrug Resistance Protein 2==
		+	<StructureSection load='2ghi' size='340' side='right' caption='[[2ghi]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ghi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii_17xnl Plasmodium yoelii yoelii 17xnl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GHI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ghi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ghi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ghi RCSB], [http://www.ebi.ac.uk/pdbsum/2ghi PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gh/2ghi_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Parasites from the protozoan phylum Apicomplexa are responsible for diseases, such as malaria, toxoplasmosis and cryptosporidiosis, all of which have significantly higher rates of mortality and morbidity in economically underdeveloped regions of the world. Advances in vaccine development and drug discovery are urgently needed to control these diseases and can be facilitated by production of purified recombinant proteins from Apicomplexan genomes and determination of their 3D structures. To date, both heterologous expression and crystallization of Apicomplexan proteins have seen only limited success. In an effort to explore the effectiveness of producing and crystallizing proteins on a genome-scale using a standardized methodology, over 400 distinct Plasmodium falciparum target genes were chosen representing different cellular classes, along with select orthologues from four other Plasmodium species as well as Cryptosporidium parvum and Toxoplasma gondii. From a total of 1008 genes from the seven genomes, 304 (30.2%) produced purified soluble proteins and 97 (9.6%) crystallized, culminating in 36 crystal structures. These results demonstrate that, contrary to previous findings, a standardized platform using Escherichia coli can be effective for genome-scale production and crystallography of Apicomplexan proteins. Predictably, orthologous proteins from different Apicomplexan genomes behaved differently in expression, purification and crystallization, although the overall success rates of Plasmodium orthologues do not differ significantly. Their differences were effectively exploited to elevate the overall productivity to levels comparable to the most successful ongoing structural genomics projects: 229 of the 468 target genes produced purified soluble protein from one or more organisms, with 80 and 32 of the purified targets, respectively, leading to crystals and ultimately structures from one or more orthologues.

-	~~{{STRUCTURE_2ghi\| PDB=2ghi \| SCENE= }}~~	+	Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.,Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney GA, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, Mulichak A, Wernimont A, Bray J, Loppnau P, Plotnikova O, Newberry K, Sundararajan E, Houston S, Walker J, Tempel W, Bochkarev A, Kozieradzki I, Edwards A, Arrowsmith C, Roos D, Kain K, Hui R Mol Biochem Parasitol. 2007 Jan;151(1):100-10. Epub 2006 Nov 13. PMID:17125854<ref>PMID:17125854</ref>

-	~~===Crystal Structure~~ of ~~Plasmodium yoelii Multidrug Resistance Protein 2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17125854}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2ghi]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_yoelii_yoelii_17xnl Plasmodium yoelii yoelii 17xnl]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2GHI OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017125854<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Plasmodium yoelii yoelii 17xnl]]		[[Category: Plasmodium yoelii yoelii 17xnl]]
	[[Category: Alam, Z.]]		[[Category: Alam, Z.]]

OCA: Protected "2ghi" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:24:15 GMT

Protected "2ghi" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:24, 7 January 2013

OCA at 11:24, 7 January 2013

OCA — Mon, 07 Jan 2013 11:24:13 GMT

←Older revision		Revision as of 11:24, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2ghi.png\|left\|200px]]		[[Image:2ghi.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ghi", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2ghi\| PDB=2ghi \| SCENE= }}		{{STRUCTURE_2ghi\| PDB=2ghi \| SCENE= }}

	===Crystal Structure of Plasmodium yoelii Multidrug Resistance Protein 2===		===Crystal Structure of Plasmodium yoelii Multidrug Resistance Protein 2===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17125854}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17125854 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17125854}}		{{ABSTRACT_PUBMED_17125854}}

	==About this Structure==		==About this Structure==
-	~~2GHI~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Plasmodium_yoelii_yoelii_str._17xnl~~ Plasmodium yoelii yoelii ~~str.~~ 17xnl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHI OCA].	+	[[2ghi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii_17xnl Plasmodium yoelii yoelii 17xnl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHI OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17125854~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017125854</ref><references group="xtra"/>
-	[[Category: Plasmodium yoelii yoelii ~~str.~~ 17xnl]]	+	[[Category: Plasmodium yoelii yoelii 17xnl]]
	[[Category: Alam, Z.]]		[[Category: Alam, Z.]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 49:		Line 37:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
-		+	[[Category: Transport protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 11:44:51 2009''~~	+