2gib - Revision history

OCA at 09:28, 14 February 2024

OCA — Wed, 14 Feb 2024 09:28:07 GMT

←Older revision		Revision as of 09:28, 14 February 2024
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	<StructureSection load='2gib' size='340' side='right'caption='[[2gib]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2gib' size='340' side='right'caption='[[2gib]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gib]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Cvhsa Cvhsa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GIB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gib]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome-related_coronavirus Severe acute respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GIB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~N ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=227859 CVHSA])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gib OCA], [https://pdbe.org/2gib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gib RCSB], [https://www.ebi.ac.uk/pdbsum/2gib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gib ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gib OCA], [https://pdbe.org/2gib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gib RCSB], [https://www.ebi.ac.uk/pdbsum/2gib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gib ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~NCAP_CVHSA NCAP_CVHSA~~]~~] Major structural component of virions that associates with genomic~~ RNA ~~to form~~ a ~~long, flexible,~~ helical ~~nucleocapsid~~ (~~By similarity~~).	+	[https://www.uniprot.org/uniprot/NCAP_SARS NCAP_SARS] Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (PubMed:17210170). May modulate transforming growth factor-beta signaling by binding host SMAD3 (PubMed:18055455).[HAMAP-Rule:MF_04096]<ref>PMID:17210170</ref> <ref>PMID:18055455</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gib ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gib ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The causative agent of severe acute respiratory syndrome (SARS) is the SARS-associated coronavirus, SARS-CoV. The nucleocapsid (N) protein plays an essential role in SARS-CoV genome packaging and virion assembly. We have previously shown that SARS-CoV N protein forms a dimer in solution through its C-terminal domain. In this study, the crystal structure of the dimerization domain, consisting of residues 270-370, is determined to 1.75A resolution. The structure shows a dimer with extensive interactions between the two subunits, suggesting that the dimeric form of the N protein is the functional unit in vivo. Although lacking significant sequence similarity, the dimerization domain of SARS-CoV N protein has a fold similar to that of the nucleocapsid protein of the porcine reproductive and respiratory syndrome virus. This finding provides structural evidence of the evolutionary link between Coronaviridae and Arteriviridae, suggesting that the N proteins of both viruses have a common origin.
-
-	Crystal structure of the severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein dimerization domain reveals evolutionary linkage between corona- and arteriviridae.,Yu IM, Oldham ML, Zhang J, Chen J J Biol Chem. 2006 Jun 23;281(25):17134-9. Epub 2006 Apr 20. PMID:16627473<ref>PMID:16627473</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2gib" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cvhsa]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chen, J~~]]	+	[[Category: Severe acute respiratory syndrome-related coronavirus]]
-	[[Category: ~~Oldham, M L]]~~	+	[[Category: Chen J]]
-	~~[[Category: Yu, I M]]~~	+	[[Category: Oldham ML]]
-	~~[[Category: Zhang,~~ J]]	+	[[Category: Yu IM]]
-	[[Category: ~~Dimer~~]]	+	[[Category: Zhang J]]
-	[[Category: ~~Nucleocapsid~~]]	+
-	[[Category: ~~Sar]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 19:05, 10 March 2021

OCA — Wed, 10 Mar 2021 19:05:06 GMT

←Older revision		Revision as of 19:05, 10 March 2021
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	==Crystal structure of the SARS coronavirus nucleocapsid protein dimerization domain==		==Crystal structure of the SARS coronavirus nucleocapsid protein dimerization domain==
-	<StructureSection load='2gib' size='340' side='right' caption='[[2gib]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='2gib' size='340' side='right'caption='[[2gib]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gib]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cvhsa Cvhsa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2GIB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gib]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cvhsa Cvhsa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GIB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">N ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 CVHSA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">N ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 CVHSA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2gib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gib OCA], [~~http~~://pdbe.org/2gib PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2gib RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2gib PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2gib ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gib OCA], [https://pdbe.org/2gib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gib RCSB], [https://www.ebi.ac.uk/pdbsum/2gib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gib ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NCAP_CVHSA NCAP_CVHSA]] Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid (By similarity).	+	[[https://www.uniprot.org/uniprot/NCAP_CVHSA NCAP_CVHSA]] Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Nucleoprotein\|Nucleoprotein]]	+	*[[Nucleoprotein 3D structures\|Nucleoprotein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Cvhsa]]		[[Category: Cvhsa]]
		+	[[Category: Large Structures]]
	[[Category: Chen, J]]		[[Category: Chen, J]]
	[[Category: Oldham, M L]]		[[Category: Oldham, M L]]

OCA at 06:58, 20 June 2018

OCA — Wed, 20 Jun 2018 06:58:38 GMT

←Older revision		Revision as of 06:58, 20 June 2018
Line 1:		Line 1:
		+
	==Crystal structure of the SARS coronavirus nucleocapsid protein dimerization domain==		==Crystal structure of the SARS coronavirus nucleocapsid protein dimerization domain==
	<StructureSection load='2gib' size='340' side='right' caption='[[2gib]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2gib' size='340' side='right' caption='[[2gib]], [[Resolution\|resolution]] 1.75Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 CVHSA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 CVHSA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gib OCA], [http://pdbe.org/2gib PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gib RCSB], [http://www.ebi.ac.uk/pdbsum/2gib PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gib OCA], [http://pdbe.org/2gib PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gib RCSB], [http://www.ebi.ac.uk/pdbsum/2gib PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2gib ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/2gib_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/2gib_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gib ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:13, 11 September 2015

OCA — Fri, 11 Sep 2015 15:13:23 GMT

←Older revision		Revision as of 15:13, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2gib' size='340' side='right' caption='[[2gib]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2gib' size='340' side='right' caption='[[2gib]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gib]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sars_coronavirus Sars coronavirus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GIB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gib]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cvhsa Cvhsa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GIB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 ~~SARS coronavirus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 CVHSA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gib OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gib RCSB], [http://www.ebi.ac.uk/pdbsum/2gib PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gib OCA], [http://pdbe.org/2gib PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gib RCSB], [http://www.ebi.ac.uk/pdbsum/2gib PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2gib" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Sars coronavirus~~]]	+	[[Category: Cvhsa]]
	[[Category: Chen, J]]		[[Category: Chen, J]]
	[[Category: Oldham, M L]]		[[Category: Oldham, M L]]

OCA at 18:13, 25 December 2014

OCA — Thu, 25 Dec 2014 18:13:57 GMT

←Older revision		Revision as of 18:13, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2gib]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GIB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gib]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GIB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 SARS coronavirus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 SARS coronavirus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gib OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gib RCSB], [http://www.ebi.ac.uk/pdbsum/2gib PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gib OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gib RCSB], [http://www.ebi.ac.uk/pdbsum/2gib PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NCAP_CVHSA NCAP_CVHSA]] Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Sars coronavirus]]		[[Category: Sars coronavirus]]
-	[[Category: Chen, J.]]	+	[[Category: Chen, J]]
-	[[Category: Oldham, M L.]]	+	[[Category: Oldham, M L]]
-	[[Category: Yu, I M.]]	+	[[Category: Yu, I M]]
-	[[Category: Zhang, J.]]	+	[[Category: Zhang, J]]
	[[Category: Dimer]]		[[Category: Dimer]]
	[[Category: Nucleocapsid]]		[[Category: Nucleocapsid]]
	[[Category: Sar]]		[[Category: Sar]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 05:40, 29 September 2014

OCA — Mon, 29 Sep 2014 05:40:16 GMT

←Older revision		Revision as of 05:40, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2gib.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the SARS coronavirus nucleocapsid protein dimerization domain==
		+	<StructureSection load='2gib' size='340' side='right' caption='[[2gib]], [[Resolution\|resolution]] 1.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2gib]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GIB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 SARS coronavirus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gib OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gib RCSB], [http://www.ebi.ac.uk/pdbsum/2gib PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/2gib_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The causative agent of severe acute respiratory syndrome (SARS) is the SARS-associated coronavirus, SARS-CoV. The nucleocapsid (N) protein plays an essential role in SARS-CoV genome packaging and virion assembly. We have previously shown that SARS-CoV N protein forms a dimer in solution through its C-terminal domain. In this study, the crystal structure of the dimerization domain, consisting of residues 270-370, is determined to 1.75A resolution. The structure shows a dimer with extensive interactions between the two subunits, suggesting that the dimeric form of the N protein is the functional unit in vivo. Although lacking significant sequence similarity, the dimerization domain of SARS-CoV N protein has a fold similar to that of the nucleocapsid protein of the porcine reproductive and respiratory syndrome virus. This finding provides structural evidence of the evolutionary link between Coronaviridae and Arteriviridae, suggesting that the N proteins of both viruses have a common origin.

-	~~{{STRUCTURE_2gib\| PDB=2gib \| SCENE= }}~~	+	Crystal structure of the severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein dimerization domain reveals evolutionary linkage between corona- and arteriviridae.,Yu IM, Oldham ML, Zhang J, Chen J J Biol Chem. 2006 Jun 23;281(25):17134-9. Epub 2006 Apr 20. PMID:16627473<ref>PMID:16627473</ref>

-	~~===Crystal structure~~ of the ~~SARS coronavirus nucleocapsid protein dimerization domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16627473}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2gib]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sars_coronavirus Sars coronavirus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA].~~	+

	==See Also==		==See Also==
	*[[Nucleoprotein\|Nucleoprotein]]		*[[Nucleoprotein\|Nucleoprotein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016627473<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Sars coronavirus]]		[[Category: Sars coronavirus]]
	[[Category: Chen, J.]]		[[Category: Chen, J.]]

OCA at 19:51, 20 October 2012

OCA — Sat, 20 Oct 2012 19:51:10 GMT

←Older revision		Revision as of 19:51, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2gib]] is a 2 chain structure ~~of [[Nucleoprotein]]~~ with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA].	+	[[2gib]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA].

	==See Also==		==See Also==

OCA: Protected "2gib" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 08:40:58 GMT

Protected "2gib" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:40, 27 July 2012

OCA at 08:40, 27 July 2012

OCA — Fri, 27 Jul 2012 08:40:57 GMT

←Older revision		Revision as of 08:40, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2gib.png\|left\|200px]]		[[Image:2gib.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2gib", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2gib\| PDB=2gib \| SCENE= }}		{{STRUCTURE_2gib\| PDB=2gib \| SCENE= }}

	===Crystal structure of the SARS coronavirus nucleocapsid protein dimerization domain===		===Crystal structure of the SARS coronavirus nucleocapsid protein dimerization domain===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16627473}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16627473 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16627473}}		{{ABSTRACT_PUBMED_16627473}}

	==About this Structure==		==About this Structure==
-	~~2GIB~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA].	+	[[2gib]] is a 2 chain structure of [[Nucleoprotein]] with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA].
		+
		+	==See Also==
		+	*[[Nucleoprotein\|Nucleoprotein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16627473~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016627473</ref><references group="xtra"/>
	[[Category: Sars coronavirus]]		[[Category: Sars coronavirus]]
	[[Category: Chen, J.]]		[[Category: Chen, J.]]
Line 33:		Line 24:
	[[Category: Sar]]		[[Category: Sar]]
	[[Category: Viral protein]]		[[Category: Viral protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 20:30:50 2009''

OCA at 18:30, 18 November 2009

OCA — Wed, 18 Nov 2009 18:30:51 GMT

←Older revision		Revision as of 18:30, 18 November 2009
Line 12:		Line 12:
	===Crystal structure of the SARS coronavirus nucleocapsid protein dimerization domain===		===Crystal structure of the SARS coronavirus nucleocapsid protein dimerization domain===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_16627473}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16627473 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16627473}}

	==About this Structure==		==About this Structure==
	2GIB is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA].		2GIB is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:16627473</ref><references group="xtra"/>
	[[Category: Sars coronavirus]]		[[Category: Sars coronavirus]]
	[[Category: Chen, J.]]		[[Category: Chen, J.]]
	[[Category: Oldham, M L.]]		[[Category: Oldham, M L.]]
-	[[Category: Yu, I.]]	+	[[Category: Yu, I M.]]
	[[Category: Zhang, J.]]		[[Category: Zhang, J.]]
	[[Category: Dimer]]		[[Category: Dimer]]
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	[[Category: Viral protein]]		[[Category: Viral protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 20:17:46 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 20:30:50 2009''