2giz - Revision history

OCA at 08:49, 25 October 2023

OCA — Wed, 25 Oct 2023 08:49:12 GMT

←Older revision		Revision as of 08:49, 25 October 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2giz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GIZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2giz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GIZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2giz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giz OCA], [https://pdbe.org/2giz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2giz RCSB], [https://www.ebi.ac.uk/pdbsum/2giz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2giz ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.68Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2giz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giz OCA], [https://pdbe.org/2giz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2giz RCSB], [https://www.ebi.ac.uk/pdbsum/2giz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2giz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CRVP1_NAJAT CRVP1_NAJAT]] Inhibits calcium-activated potassium channels (KCa1.1/KCNMA1), voltage-gated potassium channel Kv1.3/KCNA3, and the calcium release channel/ryanodine receptor (RyR). Binds specifically to type 1 RyR (RyR1) from skeletal muscle. Inhibit both the binding of ryanodine to RyR1, and RyR1's calcium-channel activity. Inhibits carbachol-induced muscle contraction and weakly blocks muscle contraction evoked by potassium.<ref>PMID:15581679</ref> <ref>PMID:17070778</ref> <ref>PMID:18658224</ref> <ref>PMID:16042391</ref>	+	[https://www.uniprot.org/uniprot/CRVP1_NAJAT CRVP1_NAJAT] Inhibits calcium-activated potassium channels (KCa1.1/KCNMA1), voltage-gated potassium channel Kv1.3/KCNA3, and the calcium release channel/ryanodine receptor (RyR). Binds specifically to type 1 RyR (RyR1) from skeletal muscle. Inhibit both the binding of ryanodine to RyR1, and RyR1's calcium-channel activity. Inhibits carbachol-induced muscle contraction and weakly blocks muscle contraction evoked by potassium.<ref>PMID:15581679</ref> <ref>PMID:17070778</ref> <ref>PMID:18658224</ref> <ref>PMID:16042391</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 34:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Naja atra]]		[[Category: Naja atra]]
-	[[Category: Jiang, T]]	+	[[Category: Jiang T]]
-	[[Category: Li, H]]	+	[[Category: Li H]]
-	[[Category: Lin, Z]]	+	[[Category: Lin Z]]
-	[[Category: Qi, Z]]	+	[[Category: Qi Z]]
-	[[Category: Shu, Y]]	+	[[Category: Shu Y]]
-	[[Category: Wang, F]]	+	[[Category: Wang F]]
-	[[Category: Yin, C]]	+	[[Category: Yin C]]
-	[[Category: Zhou, Y]]	+	[[Category: Zhou Y]]
-	~~[[Category: Blocker]]~~	+
-	~~[[Category: Crisp]]~~	+
-	~~[[Category: Docking]]~~	+
-	~~[[Category: Electrophysiology]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 14:44, 29 December 2021

OCA — Wed, 29 Dec 2021 14:44:31 GMT

←Older revision		Revision as of 14:44, 29 December 2021
Line 3:		Line 3:
	<StructureSection load='2giz' size='340' side='right'caption='[[2giz]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='2giz' size='340' side='right'caption='[[2giz]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2giz]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2GIZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2giz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GIZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2giz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giz OCA], [~~http~~://pdbe.org/2giz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2giz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2giz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2giz ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2giz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giz OCA], [https://pdbe.org/2giz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2giz RCSB], [https://www.ebi.ac.uk/pdbsum/2giz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2giz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CRVP1_NAJAT CRVP1_NAJAT]] Inhibits calcium-activated potassium channels (KCa1.1/KCNMA1), voltage-gated potassium channel Kv1.3/KCNA3, and the calcium release channel/ryanodine receptor (RyR). Binds specifically to type 1 RyR (RyR1) from skeletal muscle. Inhibit both the binding of ryanodine to RyR1, and RyR1's calcium-channel activity. Inhibits carbachol-induced muscle contraction and weakly blocks muscle contraction evoked by potassium.<ref>PMID:15581679</ref> <ref>PMID:17070778</ref> <ref>PMID:18658224</ref> <ref>PMID:16042391</ref>	+	[[https://www.uniprot.org/uniprot/CRVP1_NAJAT CRVP1_NAJAT]] Inhibits calcium-activated potassium channels (KCa1.1/KCNMA1), voltage-gated potassium channel Kv1.3/KCNA3, and the calcium release channel/ryanodine receptor (RyR). Binds specifically to type 1 RyR (RyR1) from skeletal muscle. Inhibit both the binding of ryanodine to RyR1, and RyR1's calcium-channel activity. Inhibits carbachol-induced muscle contraction and weakly blocks muscle contraction evoked by potassium.<ref>PMID:15581679</ref> <ref>PMID:17070778</ref> <ref>PMID:18658224</ref> <ref>PMID:16042391</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:14, 27 March 2020

OCA — Fri, 27 Mar 2020 11:14:52 GMT

←Older revision		Revision as of 11:14, 27 March 2020
Line 1:		Line 1:

	==Structural and functional analysis of Natrin, a member of crisp-3 family blocks a variety of ion channels==		==Structural and functional analysis of Natrin, a member of crisp-3 family blocks a variety of ion channels==
-	<StructureSection load='2giz' size='340' side='right' caption='[[2giz]], [[Resolution\|resolution]] 1.68Å' scene=''>	+	<StructureSection load='2giz' size='340' side='right'caption='[[2giz]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2giz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GIZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2giz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GIZ FirstGlance]. <br>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Naja atra]]		[[Category: Naja atra]]
	[[Category: Jiang, T]]		[[Category: Jiang, T]]

OCA at 07:17, 20 June 2018

OCA — Wed, 20 Jun 2018 07:17:46 GMT

←Older revision		Revision as of 07:17, 20 June 2018
Line 1:		Line 1:
		+
	==Structural and functional analysis of Natrin, a member of crisp-3 family blocks a variety of ion channels==		==Structural and functional analysis of Natrin, a member of crisp-3 family blocks a variety of ion channels==
	<StructureSection load='2giz' size='340' side='right' caption='[[2giz]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='2giz' size='340' side='right' caption='[[2giz]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2giz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GIZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2giz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GIZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2giz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giz OCA], [http://pdbe.org/2giz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2giz RCSB], [http://www.ebi.ac.uk/pdbsum/2giz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2giz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giz OCA], [http://pdbe.org/2giz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2giz RCSB], [http://www.ebi.ac.uk/pdbsum/2giz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2giz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/2giz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/2giz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:32, 10 February 2016

OCA — Wed, 10 Feb 2016 03:32:17 GMT

←Older revision		Revision as of 03:32, 10 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2giz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:57, 11 September 2015

OCA — Fri, 11 Sep 2015 04:57:30 GMT

←Older revision		Revision as of 04:57, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2giz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GIZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2giz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GIZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2giz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2giz RCSB], [http://www.ebi.ac.uk/pdbsum/2giz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2giz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giz OCA], [http://pdbe.org/2giz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2giz RCSB], [http://www.ebi.ac.uk/pdbsum/2giz PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2giz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:29, 25 December 2014

OCA — Thu, 25 Dec 2014 11:29:50 GMT

←Older revision		Revision as of 11:29, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2giz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GIZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2giz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GIZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2giz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2giz RCSB], [http://www.ebi.ac.uk/pdbsum/2giz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2giz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2giz RCSB], [http://www.ebi.ac.uk/pdbsum/2giz PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CRVP1_NAJAT CRVP1_NAJAT]] Inhibits calcium-activated potassium channels (KCa1.1/KCNMA1), voltage-gated potassium channel Kv1.3/KCNA3, and the calcium release channel/ryanodine receptor (RyR). Binds specifically to type 1 RyR (RyR1) from skeletal muscle. Inhibit both the binding of ryanodine to RyR1, and RyR1's calcium-channel activity. Inhibits carbachol-induced muscle contraction and weakly blocks muscle contraction evoked by potassium.<ref>PMID:15581679</ref> <ref>PMID:17070778</ref> <ref>PMID:18658224</ref> <ref>PMID:16042391</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Naja atra]]		[[Category: Naja atra]]
-	[[Category: Jiang, T.]]	+	[[Category: Jiang, T]]
-	[[Category: Li, H.]]	+	[[Category: Li, H]]
-	[[Category: Lin, Z.]]	+	[[Category: Lin, Z]]
-	[[Category: Qi, Z.]]	+	[[Category: Qi, Z]]
-	[[Category: Shu, Y.]]	+	[[Category: Shu, Y]]
-	[[Category: Wang, F.]]	+	[[Category: Wang, F]]
-	[[Category: Yin, C.]]	+	[[Category: Yin, C]]
-	[[Category: Zhou, Y.]]	+	[[Category: Zhou, Y]]
	[[Category: Blocker]]		[[Category: Blocker]]
	[[Category: Crisp]]		[[Category: Crisp]]

OCA at 08:12, 30 September 2014

OCA — Tue, 30 Sep 2014 08:12:11 GMT

←Older revision		Revision as of 08:12, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2giz.~~png\|left~~\|200px]]	+	==Structural and functional analysis of Natrin, a member of crisp-3 family blocks a variety of ion channels==
		+	<StructureSection load='2giz' size='340' side='right' caption='[[2giz]], [[Resolution\|resolution]] 1.68Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2giz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GIZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2giz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2giz RCSB], [http://www.ebi.ac.uk/pdbsum/2giz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/2giz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cysteine-rich secretory proteins (CRISPs) are secreted single-chain proteins found in different sources. Natrin is a member of the CRISP family purified from the snake venom of Naja naja atra, which has been reported as a BKca channel blocker. In our study, crystals of natrin were obtained in two different crystal forms and the structure of one of them was solved at a resolution of 1.68A. Our electrophysiological experiments indicated that natrin can block the ion channel currents of the voltage-gated potassium channel Kv1.3. Docking analyses of the interaction between natrin and Kv1.3 revealed a novel interaction pattern different from the two previously reported K(+) channel inhibition models termed "functional dyad" and "basic ring". These findings offered new insights into the function of natrin and how the specific interactions between CRISPs and different ion channels can be achieved.

-	~~{{STRUCTURE_2giz\| PDB=2giz \| SCENE= }}~~	+	Structural and functional analysis of natrin, a venom protein that targets various ion channels.,Wang F, Li H, Liu MN, Song H, Han HM, Wang QL, Yin CC, Zhou YC, Qi Z, Shu YY, Lin ZJ, Jiang T Biochem Biophys Res Commun. 2006 Dec 15;351(2):443-8. Epub 2006 Oct 20. PMID:17070778<ref>PMID:17070778</ref>

-	~~===Structural and functional analysis of Natrin~~, a ~~member~~ of ~~crisp-3 family blocks a variety of ion channels===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17070778}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2giz]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Naja_atra Naja atra]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017070778<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Naja atra]]		[[Category: Naja atra]]
	[[Category: Jiang, T.]]		[[Category: Jiang, T.]]

OCA: Protected "2giz" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 10:39:11 GMT

Protected "2giz" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:39, 7 January 2013

OCA at 10:39, 7 January 2013

OCA — Mon, 07 Jan 2013 10:39:06 GMT

←Older revision		Revision as of 10:39, 7 January 2013
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-	{{Seed}}
	[[Image:2giz.png\|left\|200px]]		[[Image:2giz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2giz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2giz\| PDB=2giz \| SCENE= }}		{{STRUCTURE_2giz\| PDB=2giz \| SCENE= }}

	===Structural and functional analysis of Natrin, a member of crisp-3 family blocks a variety of ion channels===		===Structural and functional analysis of Natrin, a member of crisp-3 family blocks a variety of ion channels===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17070778}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17070778 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_17070778}}		{{ABSTRACT_PUBMED_17070778}}

	==About this Structure==		==About this Structure==
-	~~2GIZ~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA].	+	[[2giz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17070778~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017070778</ref><references group="xtra"/>
	[[Category: Naja atra]]		[[Category: Naja atra]]
	[[Category: Jiang, T.]]		[[Category: Jiang, T.]]
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	[[Category: Blocker]]		[[Category: Blocker]]
	[[Category: Crisp]]		[[Category: Crisp]]
-	[[Category: Crystal structure]]
	[[Category: Docking]]		[[Category: Docking]]
	[[Category: Electrophysiology]]		[[Category: Electrophysiology]]
-		+	[[Category: Toxin]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 15:05:44 2009''~~	+