2go2 - Revision history

OCA at 09:28, 14 February 2024

OCA — Wed, 14 Feb 2024 09:28:50 GMT

←Older revision		Revision as of 09:28, 14 February 2024
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	<StructureSection load='2go2' size='340' side='right'caption='[[2go2]], [[Resolution\|resolution]] 1.87Å' scene=''>		<StructureSection load='2go2' size='340' side='right'caption='[[2go2]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2go2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bauba Bauba~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GO2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2go2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bauhinia_bauhinioides Bauhinia bauhinioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GO2 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDO:~~1~~,2-ETHANEDIOL'>EDO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.87Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~BbKI ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=166014 BAUBA])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2go2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go2 OCA], [https://pdbe.org/2go2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2go2 RCSB], [https://www.ebi.ac.uk/pdbsum/2go2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2go2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2go2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go2 OCA], [https://pdbe.org/2go2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2go2 RCSB], [https://www.ebi.ac.uk/pdbsum/2go2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2go2 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6VEQ7_BAUBA Q6VEQ7_BAUBA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2go2 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2go2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	A Kunitz-type protease inhibitor (BbKI) found in Bauhinia bauhinioides seeds has been overexpressed in Escherichia coli and crystallized at 293 K using PEG 4000 as the precipitant. X-ray diffraction data have been collected to 1.87 A resolution using an in-house X-ray generator. The crystals of the recombinant protein (rBbKI) belong to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 46.70, b = 64.14, c = 59.24 A. Calculation of the Matthews coefficient suggests the presence of one monomer of rBbKI in the asymmetric unit, with a corresponding solvent content of 51% (VM = 2.5 A3 Da(-1)). Iodinated crystals were prepared and a derivative data set was also collected at 2.1 A resolution. Crystals soaked for a few seconds in a cryogenic solution containing 0.5 M NaI were found to be reasonably isomorphous to the native crystals. Furthermore, the presence of iodide anions could be confirmed in the NaI-derivatized crystal. Data sets from native and derivative crystals are being evaluated for use in crystal structure determination by means of the SIRAS (single isomorphous replacement with anomalous scattering) method.
-
-	Crystallization and preliminary X-ray analysis of a novel Kunitz-type kallikrein inhibitor from Bauhinia bauhinioides.,Navarro MV, Vierira DF, Nagem RA, de Araujo AP, Oliva ML, Garratt RC Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Oct 1;61(Pt, 10):910-3. Epub 2005 Sep 30. PMID:16511193<ref>PMID:16511193</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2go2" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bauba~~]]	+	[[Category: Bauhinia bauhinioides]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Garratt~~, R C~~]]	+	[[Category: Garratt RC]]
-	[[Category: Navarro~~, M V.A S]]~~	+	[[Category: Navarro MVAS]]
-	~~[[Category: Beta-trefoil fold]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 19:11, 10 March 2021

OCA — Wed, 10 Mar 2021 19:11:14 GMT

←Older revision		Revision as of 19:11, 10 March 2021
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	==Crystal structure of BbKI, a Kunitz-type kallikrein inhibitor==		==Crystal structure of BbKI, a Kunitz-type kallikrein inhibitor==
-	<StructureSection load='2go2' size='340' side='right' caption='[[2go2]], [[Resolution\|resolution]] 1.87Å' scene=''>	+	<StructureSection load='2go2' size='340' side='right'caption='[[2go2]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2go2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bauba Bauba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2GO2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2go2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bauba Bauba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GO2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BbKI ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=166014 BAUBA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BbKI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=166014 BAUBA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2go2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go2 OCA], [~~http~~://pdbe.org/2go2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2go2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2go2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2go2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2go2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go2 OCA], [https://pdbe.org/2go2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2go2 RCSB], [https://www.ebi.ac.uk/pdbsum/2go2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2go2 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Bauba]]		[[Category: Bauba]]
		+	[[Category: Large Structures]]
	[[Category: Garratt, R C]]		[[Category: Garratt, R C]]
	[[Category: Navarro, M V.A S]]		[[Category: Navarro, M V.A S]]
	[[Category: Beta-trefoil fold]]		[[Category: Beta-trefoil fold]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 07:21, 20 June 2018

OCA — Wed, 20 Jun 2018 07:21:51 GMT

←Older revision		Revision as of 07:21, 20 June 2018
Line 1:		Line 1:
		+
	==Crystal structure of BbKI, a Kunitz-type kallikrein inhibitor==		==Crystal structure of BbKI, a Kunitz-type kallikrein inhibitor==
	<StructureSection load='2go2' size='340' side='right' caption='[[2go2]], [[Resolution\|resolution]] 1.87Å' scene=''>		<StructureSection load='2go2' size='340' side='right' caption='[[2go2]], [[Resolution\|resolution]] 1.87Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BbKI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=166014 BAUBA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BbKI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=166014 BAUBA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2go2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go2 OCA], [http://pdbe.org/2go2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2go2 RCSB], [http://www.ebi.ac.uk/pdbsum/2go2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2go2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go2 OCA], [http://pdbe.org/2go2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2go2 RCSB], [http://www.ebi.ac.uk/pdbsum/2go2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2go2 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/go/2go2_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/go/2go2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:56, 8 February 2016

OCA — Mon, 08 Feb 2016 04:56:05 GMT

←Older revision		Revision as of 04:56, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2go2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:05, 10 September 2015

OCA — Thu, 10 Sep 2015 08:05:14 GMT

←Older revision		Revision as of 08:05, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2go2' size='340' side='right' caption='[[2go2]], [[Resolution\|resolution]] 1.87Å' scene=''>		<StructureSection load='2go2' size='340' side='right' caption='[[2go2]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2go2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bauhinia_bauhinioides Bauhinia bauhinioides~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GO2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2go2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bauba Bauba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GO2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BbKI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=166014 ~~Bauhinia bauhinioides~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BbKI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=166014 BAUBA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2go2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2go2 RCSB], [http://www.ebi.ac.uk/pdbsum/2go2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2go2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go2 OCA], [http://pdbe.org/2go2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2go2 RCSB], [http://www.ebi.ac.uk/pdbsum/2go2 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2go2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bauhinia bauhinioides~~]]	+	[[Category: Bauba]]
	[[Category: Garratt, R C]]		[[Category: Garratt, R C]]
	[[Category: Navarro, M V.A S]]		[[Category: Navarro, M V.A S]]
	[[Category: Beta-trefoil fold]]		[[Category: Beta-trefoil fold]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 09:25, 16 January 2015

OCA — Fri, 16 Jan 2015 09:25:02 GMT

←Older revision		Revision as of 09:25, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2go2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bauhinia_bauhinioides Bauhinia bauhinioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GO2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2go2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bauhinia_bauhinioides Bauhinia bauhinioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GO2 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BbKI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=166014 Bauhinia bauhinioides])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BbKI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=166014 Bauhinia bauhinioides])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2go2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2go2 RCSB], [http://www.ebi.ac.uk/pdbsum/2go2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2go2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2go2 RCSB], [http://www.ebi.ac.uk/pdbsum/2go2 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Bauhinia bauhinioides]]		[[Category: Bauhinia bauhinioides]]
-	[[Category: Garratt, R C.]]	+	[[Category: Garratt, R C]]
-	[[Category: Navarro, M V.A S.]]	+	[[Category: Navarro, M V.A S]]
	[[Category: Beta-trefoil fold]]		[[Category: Beta-trefoil fold]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 09:01, 30 September 2014

OCA — Tue, 30 Sep 2014 09:01:15 GMT

←Older revision		Revision as of 09:01, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2go2.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of BbKI, a Kunitz-type kallikrein inhibitor==
		+	<StructureSection load='2go2' size='340' side='right' caption='[[2go2]], [[Resolution\|resolution]] 1.87Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2go2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bauhinia_bauhinioides Bauhinia bauhinioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GO2 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BbKI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=166014 Bauhinia bauhinioides])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2go2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2go2 RCSB], [http://www.ebi.ac.uk/pdbsum/2go2 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/go/2go2_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A Kunitz-type protease inhibitor (BbKI) found in Bauhinia bauhinioides seeds has been overexpressed in Escherichia coli and crystallized at 293 K using PEG 4000 as the precipitant. X-ray diffraction data have been collected to 1.87 A resolution using an in-house X-ray generator. The crystals of the recombinant protein (rBbKI) belong to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 46.70, b = 64.14, c = 59.24 A. Calculation of the Matthews coefficient suggests the presence of one monomer of rBbKI in the asymmetric unit, with a corresponding solvent content of 51% (VM = 2.5 A3 Da(-1)). Iodinated crystals were prepared and a derivative data set was also collected at 2.1 A resolution. Crystals soaked for a few seconds in a cryogenic solution containing 0.5 M NaI were found to be reasonably isomorphous to the native crystals. Furthermore, the presence of iodide anions could be confirmed in the NaI-derivatized crystal. Data sets from native and derivative crystals are being evaluated for use in crystal structure determination by means of the SIRAS (single isomorphous replacement with anomalous scattering) method.

-	~~{{STRUCTURE_2go2\| PDB=2go2 \| SCENE= }}~~	+	Crystallization and preliminary X-ray analysis of a novel Kunitz-type kallikrein inhibitor from Bauhinia bauhinioides.,Navarro MV, Vierira DF, Nagem RA, de Araujo AP, Oliva ML, Garratt RC Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Oct 1;61(Pt, 10):910-3. Epub 2005 Sep 30. PMID:16511193<ref>PMID:16511193</ref>

-	~~===Crystal structure of BbKI~~, a ~~Kunitz-type kallikrein inhibitor===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16511193}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2go2]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bauhinia_bauhinioides Bauhinia bauhinioides]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2GO2 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016511193<~~/~~ref~~><~~ref group="xtra">PMID:016041066</ref><references group="xtra"~~/>	+
	[[Category: Bauhinia bauhinioides]]		[[Category: Bauhinia bauhinioides]]
	[[Category: Garratt, R C.]]		[[Category: Garratt, R C.]]

OCA at 12:28, 23 January 2013

OCA — Wed, 23 Jan 2013 12:28:34 GMT

←Older revision		Revision as of 12:28, 23 January 2013
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	[[Image:2go2.png\|left\|200px]]		[[Image:2go2.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2go2", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2go2\| PDB=2go2 \| SCENE= }}		{{STRUCTURE_2go2\| PDB=2go2 \| SCENE= }}

	===Crystal structure of BbKI, a Kunitz-type kallikrein inhibitor===		===Crystal structure of BbKI, a Kunitz-type kallikrein inhibitor===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16511193}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16511193 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16511193}}		{{ABSTRACT_PUBMED_16511193}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16511193~~</ref><ref group="xtra">PMID:~~16041066~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016511193</ref><ref group="xtra">PMID:016041066</ref><references group="xtra"/>
	[[Category: Bauhinia bauhinioides]]		[[Category: Bauhinia bauhinioides]]
	[[Category: Garratt, R C.]]		[[Category: Garratt, R C.]]

OCA: Protected "2go2" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 20:57:50 GMT

Protected "2go2" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:57, 14 March 2011

OCA at 20:57, 14 March 2011

OCA — Mon, 14 Mar 2011 20:57:48 GMT

←Older revision		Revision as of 20:57, 14 March 2011
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-	{{Seed}}
	[[Image:2go2.png\|left\|200px]]		[[Image:2go2.png\|left\|200px]]

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	===Crystal structure of BbKI, a Kunitz-type kallikrein inhibitor===		===Crystal structure of BbKI, a Kunitz-type kallikrein inhibitor===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_16511193}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16511193 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16511193}}

	==About this Structure==		==About this Structure==
-	~~2GO2~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bauhinia_bauhinioides Bauhinia bauhinioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO2 OCA].	+	[[2go2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bauhinia_bauhinioides Bauhinia bauhinioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO2 OCA].

	==Reference==		==Reference==
Line 22:		Line 27:
	[[Category: Navarro, M V.A S.]]		[[Category: Navarro, M V.A S.]]
	[[Category: Beta-trefoil fold]]		[[Category: Beta-trefoil fold]]
-		+	[[Category: Protein binding]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 18:57:50 2009''~~	+