2gwx - Revision history

OCA at 00:07, 28 December 2023

OCA — Thu, 28 Dec 2023 00:07:34 GMT

←Older revision		Revision as of 00:07, 28 December 2023
Line 3:		Line 3:
	<StructureSection load='2gwx' size='340' side='right'caption='[[2gwx]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2gwx' size='340' side='right'caption='[[2gwx]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gwx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GWX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gwx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GWX FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PPARD (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gwx OCA], [https://pdbe.org/2gwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gwx RCSB], [https://www.ebi.ac.uk/pdbsum/2gwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gwx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gwx OCA], [https://pdbe.org/2gwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gwx RCSB], [https://www.ebi.ac.uk/pdbsum/2gwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gwx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>	+	[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blanchard, S]]	+	[[Category: Blanchard S]]
-	[[Category: Brown, P]]	+	[[Category: Brown P]]
-	[[Category: Bruce~~, G W~~]]	+	[[Category: Bruce GW]]
-	[[Category: Kliewer~~, S A~~]]	+	[[Category: Kliewer SA]]
-	[[Category: Lambert~~, M H~~]]	+	[[Category: Lambert MH]]
-	[[Category: Lehmann, J]]	+	[[Category: Lehmann J]]
-	[[Category: Milburn~~, M V~~]]	+	[[Category: Milburn MV]]
-	[[Category: Montana~~, V G~~]]	+	[[Category: Montana VG]]
-	[[Category: Park~~, D J~~]]	+	[[Category: Park DJ]]
-	[[Category: Sternbach, D]]	+	[[Category: Sternbach D]]
-	[[Category: Willson~~, T M~~]]	+	[[Category: Willson TM]]
-	[[Category: Xu~~, H E]]~~	+	[[Category: Xu HE]]
-	~~[[Category: Fatty acid]]~~	+
-	~~[[Category: Nuclear receptor fold]]~~	+
-	~~[[Category: Ppar]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 07:26, 17 March 2021

OCA — Wed, 17 Mar 2021 07:26:12 GMT

←Older revision		Revision as of 07:26, 17 March 2021
Line 1:		Line 1:

	==MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS==		==MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS==
-	<StructureSection load='2gwx' size='340' side='right' caption='[[2gwx]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2gwx' size='340' side='right'caption='[[2gwx]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gwx]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2GWX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gwx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GWX FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARD ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2gwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gwx OCA], [~~http~~://pdbe.org/2gwx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2gwx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2gwx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2gwx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gwx OCA], [https://pdbe.org/2gwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gwx RCSB], [https://www.ebi.ac.uk/pdbsum/2gwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gwx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>	+	[[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Peroxisome ~~Proliferator~~-~~Activated Receptors~~\|Peroxisome ~~Proliferator~~-~~Activated Receptors~~]]	+	*[[Peroxisome proliferator-activated receptor 3D structures\|Peroxisome proliferator-activated receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Blanchard, S]]		[[Category: Blanchard, S]]
	[[Category: Brown, P]]		[[Category: Brown, P]]

OCA at 06:12, 27 June 2018

OCA — Wed, 27 Jun 2018 06:12:04 GMT

←Older revision		Revision as of 06:12, 27 June 2018
Line 1:		Line 1:
		+
	==MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS==		==MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS==
	<StructureSection load='2gwx' size='340' side='right' caption='[[2gwx]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2gwx' size='340' side='right' caption='[[2gwx]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2gwx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GWX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gwx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GWX FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gwx OCA], [http://pdbe.org/2gwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gwx RCSB], [http://www.ebi.ac.uk/pdbsum/2gwx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gwx OCA], [http://pdbe.org/2gwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gwx RCSB], [http://www.ebi.ac.uk/pdbsum/2gwx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2gwx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/2gwx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/2gwx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:16, 7 February 2016

OCA — Sun, 07 Feb 2016 12:16:17 GMT

←Older revision		Revision as of 12:16, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gwx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:25, 10 September 2015

OCA — Thu, 10 Sep 2015 01:25:35 GMT

←Older revision		Revision as of 01:25, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2gwx' size='340' side='right' caption='[[2gwx]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2gwx' size='340' side='right' caption='[[2gwx]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gwx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GWX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gwx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GWX FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gwx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gwx RCSB], [http://www.ebi.ac.uk/pdbsum/2gwx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gwx OCA], [http://pdbe.org/2gwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gwx RCSB], [http://www.ebi.ac.uk/pdbsum/2gwx PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2gwx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Blanchard, S]]		[[Category: Blanchard, S]]
	[[Category: Brown, P]]		[[Category: Brown, P]]

OCA at 08:49, 16 January 2015

OCA — Fri, 16 Jan 2015 08:49:59 GMT

←Older revision		Revision as of 08:49, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2gwx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GWX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gwx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GWX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gwx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gwx RCSB], [http://www.ebi.ac.uk/pdbsum/2gwx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gwx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gwx RCSB], [http://www.ebi.ac.uk/pdbsum/2gwx PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Blanchard, S.]]	+	[[Category: Blanchard, S]]
-	[[Category: Brown, P.]]	+	[[Category: Brown, P]]
-	[[Category: Bruce, G W.]]	+	[[Category: Bruce, G W]]
-	[[Category: Kliewer, S A.]]	+	[[Category: Kliewer, S A]]
-	[[Category: Lambert, M H.]]	+	[[Category: Lambert, M H]]
-	[[Category: Lehmann, J.]]	+	[[Category: Lehmann, J]]
-	[[Category: Milburn, M V.]]	+	[[Category: Milburn, M V]]
-	[[Category: Montana, V G.]]	+	[[Category: Montana, V G]]
-	[[Category: Park, D J.]]	+	[[Category: Park, D J]]
-	[[Category: Sternbach, D.]]	+	[[Category: Sternbach, D]]
-	[[Category: Willson, T M.]]	+	[[Category: Willson, T M]]
-	[[Category: Xu, H E.]]	+	[[Category: Xu, H E]]
	[[Category: Fatty acid]]		[[Category: Fatty acid]]
	[[Category: Nuclear receptor fold]]		[[Category: Nuclear receptor fold]]
	[[Category: Ppar]]		[[Category: Ppar]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 04:59, 29 September 2014

OCA — Mon, 29 Sep 2014 04:59:05 GMT

←Older revision		Revision as of 04:59, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2gwx.~~png\|left~~\|200px]]	+	==MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS==
		+	<StructureSection load='2gwx' size='340' side='right' caption='[[2gwx]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2gwx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GWX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPARD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gwx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gwx RCSB], [http://www.ebi.ac.uk/pdbsum/2gwx PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/2gwx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors for fatty acids (FAs) that regulate glucose and lipid homeostasis. We report the crystal structure of the PPAR delta ligand-binding domain (LBD) bound to either the FA eicosapentaenoic acid (EPA) or the synthetic fibrate GW2433. The carboxylic acids of EPA and GW2433 interact directly with the activation function 2 (AF-2) helix. The hydrophobic tail of EPA adopts two distinct conformations within the large hydrophobic cavity. GW2433 occupies essentially the same space as EPA bound in both conformations. These structures provide molecular insight into the propensity for PPARs to interact with a variety of synthetic and natural compounds, including FAs that vary in both chain length and degree of saturation.

-	~~{{STRUCTURE_2gwx\| PDB=2gwx \| SCENE= }}~~	+	Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.,Xu HE, Lambert MH, Montana VG, Parks DJ, Blanchard SG, Brown PJ, Sternbach DD, Lehmann JM, Wisely GB, Willson TM, Kliewer SA, Milburn MV Mol Cell. 1999 Mar;3(3):397-403. PMID:10198642<ref>PMID:10198642</ref>

-	~~===MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10198642}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2gwx]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2GWX OCA].~~	+

	==See Also==		==See Also==
	*[[Peroxisome Proliferator-Activated Receptors\|Peroxisome Proliferator-Activated Receptors]]		*[[Peroxisome Proliferator-Activated Receptors\|Peroxisome Proliferator-Activated Receptors]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010198642<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blanchard, S.]]		[[Category: Blanchard, S.]]

OCA at 06:36, 20 October 2012

OCA — Sat, 20 Oct 2012 06:36:41 GMT

←Older revision		Revision as of 06:36, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2gwx]] is a 2 chain structure ~~of [[Peroxisome Proliferator-Activated Receptors]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWX OCA].	+	[[2gwx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWX OCA].

	==See Also==		==See Also==

OCA at 13:43, 25 July 2012

OCA — Wed, 25 Jul 2012 13:43:58 GMT

←Older revision		Revision as of 13:43, 25 July 2012
Line 1:		Line 1:
	[[Image:2gwx.png\|left\|200px]]		[[Image:2gwx.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2gwx", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2gwx\| PDB=2gwx \| SCENE= }}		{{STRUCTURE_2gwx\| PDB=2gwx \| SCENE= }}

	===MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS===		===MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10198642}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10198642 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10198642}}		{{ABSTRACT_PUBMED_10198642}}

OCA: Protected "2gwx" [edit=sysop:move=sysop]

OCA — Sat, 02 Jun 2012 15:26:15 GMT

Protected "2gwx" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:26, 2 June 2012