2h3u - Revision history

OCA at 09:30, 14 February 2024

OCA — Wed, 14 Feb 2024 09:30:56 GMT

←Older revision		Revision as of 09:30, 14 February 2024
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	<StructureSection load='2h3u' size='340' side='right'caption='[[2h3u]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2h3u' size='340' side='right'caption='[[2h3u]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2h3u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H3U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2h3u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H3U FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=152:CARNITINE'>152</scene>~~, ~~<scene name='pdbligand=COA:COENZYME+A'>COA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1ndf\|1ndf]], [[1ndi\|1ndi]], [[1ndb\|1ndb]], [[1t7q\|1t7q]], [[1t7n\|1t7n]], [[1t7o\|1t7o]], [[2h3p\|2h3p]], [[2h3w\|2h3w]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=152:CARNITINE'>152</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Crat ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3u OCA], [https://pdbe.org/2h3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h3u RCSB], [https://www.ebi.ac.uk/pdbsum/2h3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h3u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3u OCA], [https://pdbe.org/2h3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h3u RCSB], [https://www.ebi.ac.uk/pdbsum/2h3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h3u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CACP_MOUSE CACP_MOUSE]] Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.	+	[https://www.uniprot.org/uniprot/CACP_MOUSE CACP_MOUSE] Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h3u ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h3u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Carnitine acyltransferases catalyze the reversible exchange of acyl groups between coenzyme A (CoA) and carnitine. They have important roles in many cellular processes, especially the oxidation of long-chain fatty acids in the mitochondria for energy production, and are attractive targets for drug discovery against diabetes and obesity. To help define in molecular detail the catalytic mechanism of these enzymes, we report here the high resolution crystal structure of wild-type murine carnitine acetyltransferase (CrAT) in a ternary complex with its substrates acetyl-CoA and carnitine, and the structure of the S554A/M564G double mutant in a ternary complex with the substrates CoA and hexanoylcarnitine. Detailed analyses suggest that these structures may be good mimics for the Michaelis complexes for the forward and reverse reactions of the enzyme, representing the first time that such complexes of CrAT have been studied in molecular detail. The structural information provides significant new insights into the catalytic mechanism of CrAT and possibly carnitine acyltransferases in general.
-
-	Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates.,Hsiao YS, Jogl G, Tong L J Biol Chem. 2006 Sep 22;281(38):28480-7. Epub 2006 Jul 26. PMID:16870616<ref>PMID:16870616</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2h3u" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Carnitine acetyltransferase\|Carnitine acetyltransferase]]		*[[Carnitine acetyltransferase\|Carnitine acetyltransferase]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Hsiao~~, Y S~~]]	+	[[Category: Hsiao YS]]
-	[[Category: Jogl, G]]	+	[[Category: Jogl G]]
-	[[Category: Tong, L]]	+	[[Category: Tong L]]
-	~~[[Category: Carnitine acyltransferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:30, 17 March 2021

OCA — Wed, 17 Mar 2021 07:30:48 GMT

←Older revision		Revision as of 07:30, 17 March 2021
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	==Crystal structure of murine carnitine acetyltransferase in complex with carnitine and CoA==		==Crystal structure of murine carnitine acetyltransferase in complex with carnitine and CoA==
-	<StructureSection load='2h3u' size='340' side='right' caption='[[2h3u]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2h3u' size='340' side='right'caption='[[2h3u]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2h3u]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2H3U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2h3u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H3U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=152:CARNITINE'>152</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=152:CARNITINE'>152</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ndf\|1ndf]], [[1ndi\|1ndi]], [[1ndb\|1ndb]], [[1t7q\|1t7q]], [[1t7n\|1t7n]], [[1t7o\|1t7o]], [[2h3p\|2h3p]], [[2h3w\|2h3w]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ndf\|1ndf]], [[1ndi\|1ndi]], [[1ndb\|1ndb]], [[1t7q\|1t7q]], [[1t7n\|1t7n]], [[1t7o\|1t7o]], [[2h3p\|2h3p]], [[2h3w\|2h3w]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crat ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crat ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2h3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3u OCA], [~~http~~://pdbe.org/2h3u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2h3u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2h3u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2h3u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3u OCA], [https://pdbe.org/2h3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h3u RCSB], [https://www.ebi.ac.uk/pdbsum/2h3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h3u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CACP_MOUSE CACP_MOUSE]] Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.	+	[[https://www.uniprot.org/uniprot/CACP_MOUSE CACP_MOUSE]] Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/2h3u_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/2h3u_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2h3u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2h3u" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carnitine acetyltransferase\|Carnitine acetyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Hsiao, Y S]]		[[Category: Hsiao, Y S]]

OCA at 08:06, 18 October 2017

OCA — Wed, 18 Oct 2017 08:06:01 GMT

←Older revision		Revision as of 08:06, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of murine carnitine acetyltransferase in complex with carnitine and CoA==		==Crystal structure of murine carnitine acetyltransferase in complex with carnitine and CoA==
	<StructureSection load='2h3u' size='340' side='right' caption='[[2h3u]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2h3u' size='340' side='right' caption='[[2h3u]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ndf\|1ndf]], [[1ndi\|1ndi]], [[1ndb\|1ndb]], [[1t7q\|1t7q]], [[1t7n\|1t7n]], [[1t7o\|1t7o]], [[2h3p\|2h3p]], [[2h3w\|2h3w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ndf\|1ndf]], [[1ndi\|1ndi]], [[1ndb\|1ndb]], [[1t7q\|1t7q]], [[1t7n\|1t7n]], [[1t7o\|1t7o]], [[2h3p\|2h3p]], [[2h3w\|2h3w]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crat ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crat ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3u OCA], [http://pdbe.org/2h3u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2h3u RCSB], [http://www.ebi.ac.uk/pdbsum/2h3u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3u OCA], [http://pdbe.org/2h3u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2h3u RCSB], [http://www.ebi.ac.uk/pdbsum/2h3u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2h3u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 2h3u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2h3u" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Carnitine acetyltransferase\|Carnitine acetyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:07, 9 February 2016

OCA — Tue, 09 Feb 2016 21:07:31 GMT

←Older revision		Revision as of 21:07, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h3u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:02, 11 September 2015

OCA — Fri, 11 Sep 2015 02:02:29 GMT

←Older revision		Revision as of 02:02, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2h3u' size='340' side='right' caption='[[2h3u]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2h3u' size='340' side='right' caption='[[2h3u]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2h3u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H3U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2h3u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H3U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=152:CARNITINE'>152</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=152:CARNITINE'>152</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ndf\|1ndf]], [[1ndi\|1ndi]], [[1ndb\|1ndb]], [[1t7q\|1t7q]], [[1t7n\|1t7n]], [[1t7o\|1t7o]], [[2h3p\|2h3p]], [[2h3w\|2h3w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ndf\|1ndf]], [[1ndi\|1ndi]], [[1ndb\|1ndb]], [[1t7q\|1t7q]], [[1t7n\|1t7n]], [[1t7o\|1t7o]], [[2h3p\|2h3p]], [[2h3w\|2h3w]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crat ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crat ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h3u RCSB], [http://www.ebi.ac.uk/pdbsum/2h3u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3u OCA], [http://pdbe.org/2h3u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2h3u RCSB], [http://www.ebi.ac.uk/pdbsum/2h3u PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CACP_MOUSE CACP_MOUSE]] Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2h3u" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Hsiao, Y S]]		[[Category: Hsiao, Y S]]
	[[Category: Jogl, G]]		[[Category: Jogl, G]]

OCA at 08:36, 16 January 2015

OCA — Fri, 16 Jan 2015 08:36:17 GMT

←Older revision		Revision as of 08:36, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2h3u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H3U FirstGlance]. <br>		<table><tr><td colspan='2'>[[2h3u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H3U FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=152:CARNITINE'>152</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=152:CARNITINE'>152</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ndf\|1ndf]], [[1ndi\|1ndi]], [[1ndb\|1ndb]], [[1t7q\|1t7q]], [[1t7n\|1t7n]], [[1t7o\|1t7o]], [[2h3p\|2h3p]], [[2h3w\|2h3w]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ndf\|1ndf]], [[1ndi\|1ndi]], [[1ndb\|1ndb]], [[1t7q\|1t7q]], [[1t7n\|1t7n]], [[1t7o\|1t7o]], [[2h3p\|2h3p]], [[2h3w\|2h3w]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crat ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crat ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h3u RCSB], [http://www.ebi.ac.uk/pdbsum/2h3u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h3u RCSB], [http://www.ebi.ac.uk/pdbsum/2h3u PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Hsiao, Y S.]]	+	[[Category: Hsiao, Y S]]
-	[[Category: Jogl, G.]]	+	[[Category: Jogl, G]]
-	[[Category: Tong, L.]]	+	[[Category: Tong, L]]
	[[Category: Carnitine acyltransferase]]		[[Category: Carnitine acyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:15, 30 September 2014

OCA — Tue, 30 Sep 2014 08:15:03 GMT

←Older revision		Revision as of 08:15, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2h3u~~\| ~~PDB~~=2h3u \| ~~SCENE~~= }}	+	==Crystal structure of murine carnitine acetyltransferase in complex with carnitine and CoA==
-	===~~Crystal~~ structure of murine carnitine acetyltransferase in complex with carnitine and CoA~~===~~	+	<StructureSection load='2h3u' size='340' side='right' caption='[[2h3u]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_16870616}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2h3u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H3U FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=152:CARNITINE'>152</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ndf\|1ndf]], [[1ndi\|1ndi]], [[1ndb\|1ndb]], [[1t7q\|1t7q]], [[1t7n\|1t7n]], [[1t7o\|1t7o]], [[2h3p\|2h3p]], [[2h3w\|2h3w]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Crat ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h3u RCSB], [http://www.ebi.ac.uk/pdbsum/2h3u PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/2h3u_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Carnitine acyltransferases catalyze the reversible exchange of acyl groups between coenzyme A (CoA) and carnitine. They have important roles in many cellular processes, especially the oxidation of long-chain fatty acids in the mitochondria for energy production, and are attractive targets for drug discovery against diabetes and obesity. To help define in molecular detail the catalytic mechanism of these enzymes, we report here the high resolution crystal structure of wild-type murine carnitine acetyltransferase (CrAT) in a ternary complex with its substrates acetyl-CoA and carnitine, and the structure of the S554A/M564G double mutant in a ternary complex with the substrates CoA and hexanoylcarnitine. Detailed analyses suggest that these structures may be good mimics for the Michaelis complexes for the forward and reverse reactions of the enzyme, representing the first time that such complexes of CrAT have been studied in molecular detail. The structural information provides significant new insights into the catalytic mechanism of CrAT and possibly carnitine acyltransferases in general.

-	~~==About this Structure==~~	+	Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates.,Hsiao YS, Jogl G, Tong L J Biol Chem. 2006 Sep 22;281(38):28480-7. Epub 2006 Jul 26. PMID:16870616<ref>PMID:16870616</ref>
-	~~[[2h3u]] is a 2 chain structure~~ with ~~sequence from [http~~:~~//en~~.~~wikipedia.org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2H3U OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Carnitine acetyltransferase\|Carnitine acetyltransferase]]		*[[Carnitine acetyltransferase\|Carnitine acetyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016870616<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hsiao, Y S.]]		[[Category: Hsiao, Y S.]]

OCA at 09:31, 11 March 2013

OCA — Mon, 11 Mar 2013 09:31:45 GMT

←Older revision		Revision as of 09:31, 11 March 2013
Line 1:		Line 1:
-	[[Image:2h3u.png\|left\|200px]]
-
	{{STRUCTURE_2h3u\| PDB=2h3u \| SCENE= }}		{{STRUCTURE_2h3u\| PDB=2h3u \| SCENE= }}
-
	===Crystal structure of murine carnitine acetyltransferase in complex with carnitine and CoA===		===Crystal structure of murine carnitine acetyltransferase in complex with carnitine and CoA===
-
	{{ABSTRACT_PUBMED_16870616}}		{{ABSTRACT_PUBMED_16870616}}

OCA: Protected "2h3u" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 13:17:37 GMT

Protected "2h3u" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:17, 7 January 2013

OCA at 13:17, 7 January 2013

OCA — Mon, 07 Jan 2013 13:17:34 GMT

←Older revision		Revision as of 13:17, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2h3u.png\|left\|200px]]		[[Image:2h3u.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2h3u", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2h3u\| PDB=2h3u \| SCENE= }}		{{STRUCTURE_2h3u\| PDB=2h3u \| SCENE= }}

	===Crystal structure of murine carnitine acetyltransferase in complex with carnitine and CoA===		===Crystal structure of murine carnitine acetyltransferase in complex with carnitine and CoA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16870616}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16870616 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16870616}}		{{ABSTRACT_PUBMED_16870616}}

	==About this Structure==		==About this Structure==
-	~~2H3U~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3U OCA].	+	[[2h3u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3U OCA].
		+
		+	==See Also==
		+	*[[Carnitine acetyltransferase\|Carnitine acetyltransferase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16870616~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016870616</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hsiao, Y S.]]		[[Category: Hsiao, Y S.]]
Line 29:		Line 20:
	[[Category: Tong, L.]]		[[Category: Tong, L.]]
	[[Category: Carnitine acyltransferase]]		[[Category: Carnitine acyltransferase]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 12:45:13 2009''~~	+