2haz - Revision history

OCA at 09:54, 30 August 2023

OCA — Wed, 30 Aug 2023 09:54:42 GMT

←Older revision		Revision as of 09:54, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2haz' size='340' side='right'caption='[[2haz]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2haz' size='340' side='right'caption='[[2haz]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2haz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HAZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2haz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HAZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~NCAM1 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2haz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2haz OCA], [https://pdbe.org/2haz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2haz RCSB], [https://www.ebi.ac.uk/pdbsum/2haz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2haz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2haz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2haz OCA], [https://pdbe.org/2haz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2haz RCSB], [https://www.ebi.ac.uk/pdbsum/2haz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2haz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NCAM1_HUMAN NCAM1_HUMAN] This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lavie, A]]	+	[[Category: Lavie A]]
-	[[Category: Sekulic, N]]	+	[[Category: Sekulic N]]
-	~~[[Category: Beta sandwich]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Fibronectin type iii repeat]]~~	+
-	~~[[Category: Fn1]]~~	+
-	~~[[Category: Ncam~~]]	+

OCA at 07:35, 17 March 2021

OCA — Wed, 17 Mar 2021 07:35:34 GMT

←Older revision		Revision as of 07:35, 17 March 2021
Line 1:		Line 1:

	==Crystal structure of the first fibronectin domain of human NCAM1==		==Crystal structure of the first fibronectin domain of human NCAM1==
-	<StructureSection load='2haz' size='340' side='right' caption='[[2haz]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='2haz' size='340' side='right'caption='[[2haz]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2haz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2HAZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2haz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HAZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCAM1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCAM1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2haz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2haz OCA], [~~http~~://pdbe.org/2haz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2haz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2haz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2haz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2haz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2haz OCA], [https://pdbe.org/2haz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2haz RCSB], [https://www.ebi.ac.uk/pdbsum/2haz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2haz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lavie, A]]		[[Category: Lavie, A]]
	[[Category: Sekulic, N]]		[[Category: Sekulic, N]]

OCA at 06:53, 27 June 2018

OCA — Wed, 27 Jun 2018 06:53:57 GMT

←Older revision		Revision as of 06:53, 27 June 2018
Line 1:		Line 1:
		+
	==Crystal structure of the first fibronectin domain of human NCAM1==		==Crystal structure of the first fibronectin domain of human NCAM1==
	<StructureSection load='2haz' size='340' side='right' caption='[[2haz]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2haz' size='340' side='right' caption='[[2haz]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2haz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2haz OCA], [http://pdbe.org/2haz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2haz RCSB], [http://www.ebi.ac.uk/pdbsum/2haz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2haz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2haz OCA], [http://pdbe.org/2haz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2haz RCSB], [http://www.ebi.ac.uk/pdbsum/2haz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2haz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/2haz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/2haz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:48, 7 February 2016

OCA — Sun, 07 Feb 2016 15:48:31 GMT

←Older revision		Revision as of 15:48, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2haz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:56, 10 September 2015

OCA — Thu, 10 Sep 2015 02:56:02 GMT

←Older revision		Revision as of 02:56, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2haz' size='340' side='right' caption='[[2haz]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2haz' size='340' side='right' caption='[[2haz]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2haz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HAZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2haz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HAZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2haz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2haz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2haz RCSB], [http://www.ebi.ac.uk/pdbsum/2haz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2haz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2haz OCA], [http://pdbe.org/2haz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2haz RCSB], [http://www.ebi.ac.uk/pdbsum/2haz PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2haz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Lavie, A]]		[[Category: Lavie, A]]
	[[Category: Sekulic, N]]		[[Category: Sekulic, N]]

OCA at 08:40, 16 January 2015

OCA — Fri, 16 Jan 2015 08:40:47 GMT

←Older revision		Revision as of 08:40, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2haz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HAZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2haz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HAZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2haz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2haz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2haz RCSB], [http://www.ebi.ac.uk/pdbsum/2haz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2haz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2haz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2haz RCSB], [http://www.ebi.ac.uk/pdbsum/2haz PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Lavie, A.]]	+	[[Category: Lavie, A]]
-	[[Category: Sekulic, N.]]	+	[[Category: Sekulic, N]]
	[[Category: Beta sandwich]]		[[Category: Beta sandwich]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 10:14, 30 September 2014

OCA — Tue, 30 Sep 2014 10:14:30 GMT

←Older revision		Revision as of 10:14, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2haz.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the first fibronectin domain of human NCAM1==
		+	<StructureSection load='2haz' size='340' side='right' caption='[[2haz]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2haz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HAZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2haz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2haz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2haz RCSB], [http://www.ebi.ac.uk/pdbsum/2haz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/2haz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Polysialic acid is a developmentally regulated, anti-adhesive glycan that is added to the neural cell adhesion molecule, NCAM. Polysialylated NCAM is critical for brain development and plays roles in synaptic plasticity, axon guidance, and cell migration. The first fibronectin type III repeat of NCAM, FN1, is necessary for the polysialylation of N-glycans on the adjacent immunoglobulin domain. This repeat cannot be replaced by other fibronectin type III repeats. We solved the crystal structure of human NCAM FN1 and found that, in addition to a unique acidic surface patch, it possesses a novel alpha-helix that links strands 4 and 5 of its beta-sandwich structure. Replacement of the alpha-helix did not eliminate polysialyltransferase recognition, but shifted the addition of polysialic acid from the N-glycans modifying the adjacent immunoglobulin domain to O-glycans modifying FN1. Other experiments demonstrated that replacement of residues in the acidic surface patch alter the polysialylation of both N- and O-glycans in the same way, while the alpha-helix is only required for the polysialylation of N-glycans. Our data are consistent with a model in which the FN1 alpha-helix is involved in an Ig5-FN1 interaction that is critical for the correct positioning of Ig5 N-glycans for polysialylation.

-	~~{{STRUCTURE_2haz\| PDB=2haz \| SCENE= }}~~	+	A novel alpha-helix in the first fibronectin type III repeat of the neural cell adhesion molecule is critical for N-glycan polysialylation.,Mendiratta SS, Sekulic N, Hernandez-Guzman FG, Close BE, Lavie A, Colley KJ J Biol Chem. 2006 Nov 24;281(47):36052-9. Epub 2006 Sep 26. PMID:17003032<ref>PMID:17003032</ref>

-	~~===Crystal structure~~ of the ~~first fibronectin domain of human NCAM1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17003032}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2haz]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2HAZ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017003032<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Lavie, A.]]		[[Category: Lavie, A.]]

OCA: Protected "2haz" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:42:48 GMT

Protected "2haz" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:42, 7 January 2013

OCA at 14:42, 7 January 2013

OCA — Mon, 07 Jan 2013 14:42:44 GMT

←Older revision		Revision as of 14:42, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2haz.png\|left\|200px]]		[[Image:2haz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2haz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2haz\| PDB=2haz \| SCENE= }}		{{STRUCTURE_2haz\| PDB=2haz \| SCENE= }}

	===Crystal structure of the first fibronectin domain of human NCAM1===		===Crystal structure of the first fibronectin domain of human NCAM1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17003032}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17003032 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17003032}}		{{ABSTRACT_PUBMED_17003032}}

	==About this Structure==		==About this Structure==
-	~~2HAZ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAZ OCA].	+	[[2haz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAZ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17003032~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017003032</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Lavie, A.]]		[[Category: Lavie, A.]]
	[[Category: Sekulic, N.]]		[[Category: Sekulic, N.]]
	[[Category: Beta sandwich]]		[[Category: Beta sandwich]]
		+	[[Category: Cell adhesion]]
	[[Category: Fibronectin type iii repeat]]		[[Category: Fibronectin type iii repeat]]
	[[Category: Fn1]]		[[Category: Fn1]]
	[[Category: Ncam]]		[[Category: Ncam]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:53:13 2009''

OCA at 12:53, 16 February 2009

OCA — Mon, 16 Feb 2009 12:53:15 GMT

←Older revision		Revision as of 12:53, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2HAZ is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAZ OCA].	+	2HAZ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAZ OCA].

	==Reference==		==Reference==
-	A novel alpha-helix in the first fibronectin type III repeat of the neural cell adhesion molecule is critical for N-glycan polysialylation., Mendiratta SS, Sekulic N, Hernandez-Guzman FG, Close BE, Lavie A, Colley KJ, J Biol Chem. 2006 Nov 24;281(47):36052-9. Epub 2006 Sep 26. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17003032 17003032]~~	+	<ref group="xtra">PMID:17003032</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Lavie, A.]]		[[Category: Lavie, A.]]
	[[Category: Sekulic, N.]]		[[Category: Sekulic, N.]]
Line 33:		Line 32:
	[[Category: Ncam]]		[[Category: Ncam]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 17~~:38:~~35 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:53:13 2009''