2hez - Revision history

OCA at 09:57, 30 August 2023

OCA — Wed, 30 Aug 2023 09:57:21 GMT

←Older revision		Revision as of 09:57, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2hez' size='340' side='right'caption='[[2hez]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2hez' size='340' side='right'caption='[[2hez]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2hez]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~As_1.2186 As 1.2186~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HEZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2hez]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HEZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[2hf0\|2hf0]]~~</~~div></td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bsh ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216816 AS 1.2186])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Choloylglycine_hydrolase Choloylglycine hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.24 3.5.1.24] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hez OCA], [https://pdbe.org/2hez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hez RCSB], [https://www.ebi.ac.uk/pdbsum/2hez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hez ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hez OCA], [https://pdbe.org/2hez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hez RCSB], [https://www.ebi.ac.uk/pdbsum/2hez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hez ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CBH_BIFLN CBH_BIFLN] Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids). Can hydrolyze the amid bond in all six major human bile salts, namely glycocholate (GCA), glycodeoxycholate (GDCA), glycochenodeoxycholate (GCDCA), taurocholate (TCA), taurodeoxycholate (TDCA) and taurochenodeoxycholate (TCDCA). Shows a slight preference for glycine-conjugated bile acids as substrates (PubMed:10831430, PubMed:16905539). Is totally inactive toward penicillin V (PubMed:16905539).<ref>PMID:10831430</ref> <ref>PMID:16905539</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~As 1 2186]]~~	+	[[Category: Bifidobacterium longum]]
-	~~[[Category: Choloylglycine hydrolase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brannigan~~, J A~~]]	+	[[Category: Brannigan JA]]
-	[[Category: Kumar~~, R S~~]]	+	[[Category: Kumar RS]]
-	[[Category: Suresh~~, C G]]~~	+	[[Category: Suresh CG]]
-	~~[[Category: Alpha]]~~	+
-	~~[[Category: Beta]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:38, 17 March 2021

OCA — Wed, 17 Mar 2021 07:38:33 GMT

←Older revision		Revision as of 07:38, 17 March 2021
Line 1:		Line 1:

	==Bifidobacterium longum bile salt hydrolase==		==Bifidobacterium longum bile salt hydrolase==
-	<StructureSection load='2hez' size='340' side='right' caption='[[2hez]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2hez' size='340' side='right'caption='[[2hez]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2hez]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/As_1.2186 As 1.2186]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2HEZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2hez]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/As_1.2186 As 1.2186]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HEZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hf0\|2hf0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hf0\|2hf0]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bsh ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216816 AS 1.2186])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bsh ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216816 AS 1.2186])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Choloylglycine_hydrolase Choloylglycine hydrolase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.24 3.5.1.24] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Choloylglycine_hydrolase Choloylglycine hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.24 3.5.1.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2hez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hez OCA], [~~http~~://pdbe.org/2hez PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2hez RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2hez PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2hez ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hez OCA], [https://pdbe.org/2hez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hez RCSB], [https://www.ebi.ac.uk/pdbsum/2hez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hez ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 36:		Line 36:
	[[Category: As 1 2186]]		[[Category: As 1 2186]]
	[[Category: Choloylglycine hydrolase]]		[[Category: Choloylglycine hydrolase]]
		+	[[Category: Large Structures]]
	[[Category: Brannigan, J A]]		[[Category: Brannigan, J A]]
	[[Category: Kumar, R S]]		[[Category: Kumar, R S]]

OCA at 06:48, 27 June 2018

OCA — Wed, 27 Jun 2018 06:48:23 GMT

←Older revision		Revision as of 06:48, 27 June 2018
Line 1:		Line 1:
		+
	==Bifidobacterium longum bile salt hydrolase==		==Bifidobacterium longum bile salt hydrolase==
	<StructureSection load='2hez' size='340' side='right' caption='[[2hez]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2hez' size='340' side='right' caption='[[2hez]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 8:		Line 9:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bsh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216816 AS 1.2186])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bsh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216816 AS 1.2186])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choloylglycine_hydrolase Choloylglycine hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.24 3.5.1.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choloylglycine_hydrolase Choloylglycine hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.24 3.5.1.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hez OCA], [http://pdbe.org/2hez PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hez RCSB], [http://www.ebi.ac.uk/pdbsum/2hez PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hez OCA], [http://pdbe.org/2hez PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hez RCSB], [http://www.ebi.ac.uk/pdbsum/2hez PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2hez ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2hez_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2hez_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hez ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:58, 11 September 2015

OCA — Fri, 11 Sep 2015 10:58:37 GMT

←Older revision		Revision as of 10:58, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2hez' size='340' side='right' caption='[[2hez]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2hez' size='340' side='right' caption='[[2hez]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2hez]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bifidobacterium_longum Bifidobacterium longum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HEZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2hez]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/As_1.2186 As 1.2186]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HEZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hf0\|2hf0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hf0\|2hf0]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bsh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216816 ~~Bifidobacterium longum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bsh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216816 AS 1.2186])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choloylglycine_hydrolase Choloylglycine hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.24 3.5.1.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choloylglycine_hydrolase Choloylglycine hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.24 3.5.1.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hez OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hez RCSB], [http://www.ebi.ac.uk/pdbsum/2hez PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hez OCA], [http://pdbe.org/2hez PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hez RCSB], [http://www.ebi.ac.uk/pdbsum/2hez PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2hez" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bifidobacterium longum~~]]	+	[[Category: As 1 2186]]
	[[Category: Choloylglycine hydrolase]]		[[Category: Choloylglycine hydrolase]]
	[[Category: Brannigan, J A]]		[[Category: Brannigan, J A]]

OCA at 08:36, 16 January 2015

OCA — Fri, 16 Jan 2015 08:36:51 GMT

←Older revision		Revision as of 08:36, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hez]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HEZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hez]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HEZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hf0\|2hf0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hf0\|2hf0]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bsh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216816 Bifidobacterium longum])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bsh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216816 Bifidobacterium longum])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choloylglycine_hydrolase Choloylglycine hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.24 3.5.1.24] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choloylglycine_hydrolase Choloylglycine hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.24 3.5.1.24] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hez OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hez RCSB], [http://www.ebi.ac.uk/pdbsum/2hez PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hez OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hez RCSB], [http://www.ebi.ac.uk/pdbsum/2hez PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Bifidobacterium longum]]		[[Category: Bifidobacterium longum]]
	[[Category: Choloylglycine hydrolase]]		[[Category: Choloylglycine hydrolase]]
-	[[Category: Brannigan, J A.]]	+	[[Category: Brannigan, J A]]
-	[[Category: Kumar, R S.]]	+	[[Category: Kumar, R S]]
-	[[Category: Suresh, C G.]]	+	[[Category: Suresh, C G]]
	[[Category: Alpha]]		[[Category: Alpha]]
	[[Category: Beta]]		[[Category: Beta]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 08:15, 30 September 2014

OCA — Tue, 30 Sep 2014 08:15:24 GMT

←Older revision		Revision as of 08:15, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2hez.~~png~~\|~~left~~\|200px]]	+	==Bifidobacterium longum bile salt hydrolase==
		+	<StructureSection load='2hez' size='340' side='right' caption='[[2hez]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2hez]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HEZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hf0\|2hf0]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bsh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216816 Bifidobacterium longum])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choloylglycine_hydrolase Choloylglycine hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.24 3.5.1.24] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hez OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hez RCSB], [http://www.ebi.ac.uk/pdbsum/2hez PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2hez_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bile salt hydrolase (BSH) is an enzyme produced by the intestinal microflora that catalyzes the deconjugation of glycine- or taurine-linked bile salts. The crystal structure of BSH reported here from Bifidobacterium longum reveals that it is a member of N-terminal nucleophil hydrolase structural superfamily possessing the characteristic alphabetabetaalpha tetra-lamellar tertiary structure arrangement. Site-directed mutagenesis of the catalytic nucleophil residue, however, shows that it has no role in zymogen processing into its corresponding active form. Substrate specificity was studied using Michaelis-Menten and inhibition kinetics and fluorescence spectroscopy. These data were compared with the specificity profile of BSH from Clostridium perfrigens and pencillin V acylase from Bacillus sphaericus, for both of which the three-dimensional structures are available. Comparative analysis shows a gradation in activity toward common substrates, throwing light on a possible common route toward the evolution of pencillin V acylase and BSH.

-	~~{{STRUCTURE_2hez\| PDB=2hez \| SCENE= }}~~	+	Structural and functional analysis of a conjugated bile salt hydrolase from Bifidobacterium longum reveals an evolutionary relationship with penicillin V acylase.,Kumar RS, Brannigan JA, Prabhune AA, Pundle AV, Dodson GG, Dodson EJ, Suresh CG J Biol Chem. 2006 Oct 27;281(43):32516-25. Epub 2006 Aug 11. PMID:16905539<ref>PMID:16905539</ref>

-	~~===Bifidobacterium longum bile salt hydrolase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16905539}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2hez]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bifidobacterium_longum Bifidobacterium longum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2HEZ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016905539<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bifidobacterium longum]]		[[Category: Bifidobacterium longum]]
	[[Category: Choloylglycine hydrolase]]		[[Category: Choloylglycine hydrolase]]

OCA: Protected "2hez" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 10:41:37 GMT

Protected "2hez" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:41, 7 January 2013

OCA at 10:41, 7 January 2013

OCA — Mon, 07 Jan 2013 10:41:34 GMT

←Older revision		Revision as of 10:41, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2hez.png\|left\|200px]]		[[Image:2hez.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2hez", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2hez\| PDB=2hez \| SCENE= }}		{{STRUCTURE_2hez\| PDB=2hez \| SCENE= }}

	===Bifidobacterium longum bile salt hydrolase===		===Bifidobacterium longum bile salt hydrolase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16905539}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16905539 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16905539}}		{{ABSTRACT_PUBMED_16905539}}

	==About this Structure==		==About this Structure==
-	~~2HEZ~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEZ OCA].	+	[[2hez]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEZ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16905539~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016905539</ref><references group="xtra"/>
	[[Category: Bifidobacterium longum]]		[[Category: Bifidobacterium longum]]
	[[Category: Choloylglycine hydrolase]]		[[Category: Choloylglycine hydrolase]]
Line 31:		Line 19:
	[[Category: Alpha]]		[[Category: Alpha]]
	[[Category: Beta]]		[[Category: Beta]]
-		+	[[Category: Hydrolase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 20:26:48 2009''~~	+

OCA at 18:26, 17 February 2009

OCA — Tue, 17 Feb 2009 18:26:49 GMT

←Older revision		Revision as of 18:26, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2HEZ is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEZ OCA].	+	2HEZ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEZ OCA].

	==Reference==		==Reference==
-	Structural and functional analysis of a conjugated bile salt hydrolase from Bifidobacterium longum reveals an evolutionary relationship with penicillin V acylase., Kumar RS, Brannigan JA, Prabhune AA, Pundle AV, Dodson GG, Dodson EJ, Suresh CG, J Biol Chem. 2006 Oct 27;281(43):32516-25. Epub 2006 Aug 11. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16905539 16905539]~~	+	<ref group="xtra">PMID:16905539</ref><references group="xtra"/>
	[[Category: Bifidobacterium longum]]		[[Category: Bifidobacterium longum]]
	[[Category: Choloylglycine hydrolase]]		[[Category: Choloylglycine hydrolase]]
-	[[Category: Single protein]]
	[[Category: Brannigan, J A.]]		[[Category: Brannigan, J A.]]
	[[Category: Kumar, R S.]]		[[Category: Kumar, R S.]]
Line 33:		Line 32:
	[[Category: Beta]]		[[Category: Beta]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 04:~~20:~~41 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:26:48 2009''

OCA at 01:20, 29 July 2008

OCA — Tue, 29 Jul 2008 01:20:43 GMT

←Older revision		Revision as of 01:20, 29 July 2008
Line 1:		Line 1:
-	[[Image:2hez.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2hez.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2hez\| PDB=2hez \| SCENE= }}		{{STRUCTURE_2hez\| PDB=2hez \| SCENE= }}

-	~~'''~~Bifidobacterium longum bile salt hydrolase~~'''~~	+	===Bifidobacterium longum bile salt hydrolase===


-	~~==Overview==~~	+	<!--
-	~~Bile salt hydrolase (BSH) is an enzyme produced by the intestinal microflora that catalyzes the deconjugation of glycine~~- ~~or taurine~~-~~linked bile salts.~~ The ~~crystal structure of BSH reported here from Bifidobacterium longum reveals that it is a member of N-terminal nucleophil hydrolase structural superfamily possessing~~ the ~~characteristic alphabetabetaalpha tetra-lamellar tertiary structure arrangement. Site-directed mutagenesis of~~ the ~~catalytic nucleophil residue, however, shows that~~ it ~~has no role in zymogen processing into its corresponding active form~~. ~~Substrate specificity was studied using Michaelis-Menten and inhibition kinetics and fluorescence spectroscopy~~. ~~These data were compared with the specificity profile of BSH from Clostridium perfrigens and pencillin V acylase from Bacillus sphaericus~~, ~~for both of which~~ the ~~three~~-dimensional structures are available. Comparative analysis shows a gradation in activity toward common substrates, throwing light on a possible common route toward the evolution of pencillin V acylase and BSH.	+	The line below this paragraph, {{ABSTRACT_PUBMED_16905539}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16905539 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16905539}}

	==About this Structure==		==About this Structure==
Line 28:		Line 32:
	[[Category: Alpha]]		[[Category: Alpha]]
	[[Category: Beta]]		[[Category: Beta]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 06~~:12:46 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:20:41 2008''