2hfr - Revision history

OCA at 16:37, 13 December 2023

OCA — Wed, 13 Dec 2023 16:37:33 GMT

←Older revision		Revision as of 16:37, 13 December 2023
Line 1:		Line 1:

	==solution structure of antimicrobial peptide Fowlicidin 3==		==solution structure of antimicrobial peptide Fowlicidin 3==
-	<StructureSection load='2hfr' size='340' side='right'caption='[[2hfr~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2hfr' size='340' side='right'caption='[[2hfr]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2hfr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HFR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2hfr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HFR FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[2amn\|2amn]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfr OCA], [https://pdbe.org/2hfr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hfr RCSB], [https://www.ebi.ac.uk/pdbsum/2hfr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hfr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfr OCA], [https://pdbe.org/2hfr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hfr RCSB], [https://www.ebi.ac.uk/pdbsum/2hfr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hfr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CTHL3_CHICK CTHL3_CHICK]] May bind bacterial lipopolysaccharide (LPS). May have antimicrobial activity and play a role in the innate immune response (By similarity).	+	[https://www.uniprot.org/uniprot/CTHL3_CHICK CTHL3_CHICK] May bind bacterial lipopolysaccharide (LPS). May have antimicrobial activity and play a role in the innate immune response (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bommineni~~, Y R~~]]	+	[[Category: Bommineni YR]]
-	[[Category: Dai, H]]	+	[[Category: Dai H]]
-	[[Category: Gong, Y]]	+	[[Category: Gong Y]]
-	[[Category: Prakash, O]]	+	[[Category: Prakash O]]
-	[[Category: Zhang, G]]	+	[[Category: Zhang G]]
-	~~[[Category: Alpha helix]]~~	+
-	~~[[Category: Antimicrobial protein~~]]	+

OCA at 11:08, 5 January 2022

OCA — Wed, 05 Jan 2022 11:08:27 GMT

←Older revision		Revision as of 11:08, 5 January 2022
Line 3:		Line 3:
	<StructureSection load='2hfr' size='340' side='right'caption='[[2hfr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2hfr' size='340' side='right'caption='[[2hfr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2hfr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2HFR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2hfr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HFR FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2amn\|2amn]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2amn\|2amn]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2hfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfr OCA], [~~http~~://pdbe.org/2hfr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2hfr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2hfr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2hfr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfr OCA], [https://pdbe.org/2hfr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hfr RCSB], [https://www.ebi.ac.uk/pdbsum/2hfr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hfr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CTHL3_CHICK CTHL3_CHICK]] May bind bacterial lipopolysaccharide (LPS). May have antimicrobial activity and play a role in the innate immune response (By similarity).	+	[[https://www.uniprot.org/uniprot/CTHL3_CHICK CTHL3_CHICK]] May bind bacterial lipopolysaccharide (LPS). May have antimicrobial activity and play a role in the innate immune response (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:09, 1 April 2020

OCA — Wed, 01 Apr 2020 10:09:16 GMT

←Older revision		Revision as of 10:09, 1 April 2020
Line 1:		Line 1:

	==solution structure of antimicrobial peptide Fowlicidin 3==		==solution structure of antimicrobial peptide Fowlicidin 3==
-	<StructureSection load='2hfr' size='340' side='right' caption='[[2hfr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2hfr' size='340' side='right'caption='[[2hfr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hfr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HFR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hfr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HFR FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bommineni, Y R]]		[[Category: Bommineni, Y R]]
	[[Category: Dai, H]]		[[Category: Dai, H]]

OCA at 06:17, 27 June 2018

OCA — Wed, 27 Jun 2018 06:17:53 GMT

←Older revision		Revision as of 06:17, 27 June 2018
Line 1:		Line 1:
		+
	==solution structure of antimicrobial peptide Fowlicidin 3==		==solution structure of antimicrobial peptide Fowlicidin 3==
	<StructureSection load='2hfr' size='340' side='right' caption='[[2hfr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2hfr' size='340' side='right' caption='[[2hfr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2hfr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HFR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hfr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HFR FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2amn\|2amn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2amn\|2amn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfr OCA], [http://pdbe.org/2hfr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hfr RCSB], [http://www.ebi.ac.uk/pdbsum/2hfr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfr OCA], [http://pdbe.org/2hfr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hfr RCSB], [http://www.ebi.ac.uk/pdbsum/2hfr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2hfr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 14:23, 11 September 2015

OCA — Fri, 11 Sep 2015 14:23:16 GMT

←Older revision		Revision as of 14:23, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2hfr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HFR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hfr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HFR FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2amn\|2amn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2amn\|2amn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hfr RCSB], [http://www.ebi.ac.uk/pdbsum/2hfr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfr OCA], [http://pdbe.org/2hfr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hfr RCSB], [http://www.ebi.ac.uk/pdbsum/2hfr PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CTHL3_CHICK CTHL3_CHICK]] May bind bacterial lipopolysaccharide (LPS). May have antimicrobial activity and play a role in the innate immune response (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2hfr" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:42, 3 January 2015

OCA — Sat, 03 Jan 2015 22:42:53 GMT

←Older revision		Revision as of 22:42, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hfr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HFR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hfr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HFR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2amn\|2amn]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2amn\|2amn]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hfr RCSB], [http://www.ebi.ac.uk/pdbsum/2hfr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hfr RCSB], [http://www.ebi.ac.uk/pdbsum/2hfr PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bommineni, Y R.]]	+	[[Category: Bommineni, Y R]]
-	[[Category: Dai, H.]]	+	[[Category: Dai, H]]
-	[[Category: Gong, Y.]]	+	[[Category: Gong, Y]]
-	[[Category: Prakash, O.]]	+	[[Category: Prakash, O]]
-	[[Category: Zhang, G.]]	+	[[Category: Zhang, G]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]

OCA at 06:51, 9 June 2014

OCA — Mon, 09 Jun 2014 06:51:06 GMT

←Older revision		Revision as of 06:51, 9 June 2014
Line 1:		Line 1:
-	[[~~Image:~~2hfr.~~png~~\|~~left~~\|~~200px~~]]	+	==solution structure of antimicrobial peptide Fowlicidin 3==
		+	<StructureSection load='2hfr' size='340' side='right' caption='[[2hfr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2hfr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HFR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2amn\|2amn]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hfr RCSB], [http://www.ebi.ac.uk/pdbsum/2hfr PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cathelicidins are an important family of cationic host defense peptides in vertebrates with both antimicrobial and immunomodulatory activities. Fowlicidin-1 and fowlicidin-2 are two newly identified chicken cathelicidins with potent antibacterial activities. Here we report structural and functional characterization of the putatively mature form of the third chicken cathelicidin, fowlicidin-3, for exploration of its therapeutic potential. NMR spectroscopy revealed that fowlicidin-3 comprises 27 amino-acid residues and adopts a predominantly alpha-helical structure extending from residue 9 to 25 with a slight kink induced by a glycine at position 17. It is highly potent against a broad range of Gram-negative and Gram-positive bacteria in vitro, including antibiotic-resistant strains, with minimum inhibitory concentrations in the range 1-2 microM. It kills bacteria quickly, permeabilizing cytoplasmic membranes immediately on coming into contact with them. Unlike many other host defense peptides with antimicrobial activities that are diminished by serum or salt, fowlicidin-3 retains bacteria-killing activities in the presence of 50% serum or physiological concentrations of salt. Furthermore, it is capable of suppressing lipopolysaccharide-induced expression of proinflammatory genes in mouse macrophage RAW264.7 cells, with nearly complete blockage at 10 microM. Fowlicidin-3 appears to be an excellent candidate for future development as a novel antimicrobial and antisepsis agent, particularly against antibiotic-resistant pathogens.

-	~~{{STRUCTURE_2hfr\| PDB=2hfr \| SCENE= }}~~	+	Fowlicidin-3 is an alpha-helical cationic host defense peptide with potent antibacterial and lipopolysaccharide-neutralizing activities.,Bommineni YR, Dai H, Gong YX, Soulages JL, Fernando SC, Desilva U, Prakash O, Zhang G FEBS J. 2007 Jan;274(2):418-28. PMID:17229147<ref>PMID:17229147</ref>

-	~~===solution structure~~ of ~~antimicrobial peptide Fowlicidin 3===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17229147}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2hfr]] is a 1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2HFR OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017229147<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bommineni, Y R.]]		[[Category: Bommineni, Y R.]]
	[[Category: Dai, H.]]		[[Category: Dai, H.]]

OCA: Protected "2hfr" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 17:34:57 GMT

Protected "2hfr" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:34, 14 August 2012

OCA at 17:34, 14 August 2012

OCA — Tue, 14 Aug 2012 17:34:55 GMT

←Older revision		Revision as of 17:34, 14 August 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2hfr.png\|left\|200px]]		[[Image:2hfr.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2hfr", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2hfr\| PDB=2hfr \| SCENE= }}		{{STRUCTURE_2hfr\| PDB=2hfr \| SCENE= }}

	===solution structure of antimicrobial peptide Fowlicidin 3===		===solution structure of antimicrobial peptide Fowlicidin 3===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17229147}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17229147 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17229147}}		{{ABSTRACT_PUBMED_17229147}}

	==About this Structure==		==About this Structure==
-	~~2HFR is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA].	+	[[2hfr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA].

	==Reference==		==Reference==
-	Fowlicidin-3 is an alpha-helical cationic host defense peptide with potent antibacterial and lipopolysaccharide-neutralizing activities., Bommineni YR, Dai H, Gong YX, Soulages JL, Fernando SC, Desilva U, Prakash O, Zhang G, FEBS J. 2007 Jan;274(2):418-28. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17229147 17229147]~~	+	<ref group="xtra">PMID:017229147</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Bommineni, Y R.]]		[[Category: Bommineni, Y R.]]
	[[Category: Dai, H.]]		[[Category: Dai, H.]]
Line 31:		Line 18:
	[[Category: Zhang, G.]]		[[Category: Zhang, G.]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]
-		+	[[Category: Antimicrobial protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Jul 29 07:51:47 2008''~~	+

OCA at 04:51, 29 July 2008

OCA — Tue, 29 Jul 2008 04:51:55 GMT

←Older revision		Revision as of 04:51, 29 July 2008
Line 1:		Line 1:
-	[[Image:2hfr.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2hfr.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2hfr\| PDB=2hfr \| SCENE= }}		{{STRUCTURE_2hfr\| PDB=2hfr \| SCENE= }}

-	~~'''~~solution structure of antimicrobial peptide Fowlicidin 3~~'''~~	+	===solution structure of antimicrobial peptide Fowlicidin 3===


-	~~==Overview==~~	+	<!--
-	~~Cathelicidins are an important family of cationic host defense peptides in vertebrates with both antimicrobial and immunomodulatory activities. Fowlicidin~~-~~1 and fowlicidin~~-2 are two newly identified chicken cathelicidins with potent antibacterial activities. Here we report structural and functional characterization of the putatively mature form of the third chicken cathelicidin, ~~fowlicidin-3~~, ~~for exploration of its therapeutic potential. NMR spectroscopy revealed that fowlicidin-3 comprises 27 amino-acid residues and adopts a predominantly alpha-helical structure extending from residue 9~~ to 25 with a slight kink induced by a glycine at position 17. It is highly potent against a broad range of Gram-negative and Gram-positive bacteria in vitro, including antibiotic-resistant strains, with minimum inhibitory concentrations in the ~~range 1-2 microM. It kills bacteria quickly, permeabilizing cytoplasmic membranes immediately~~ on ~~coming into contact with them~~. Unlike many other host defense peptides with antimicrobial activities that are diminished by serum or salt, fowlicidin-3 retains bacteria-killing activities in the presence of 50% serum or physiological concentrations of salt. ~~Furthermore~~, it is ~~capable of suppressing lipopolysaccharide-induced expression of proinflammatory genes in mouse macrophage RAW264~~.~~7 cells, with nearly complete blockage at 10 microM. Fowlicidin~~-~~3 appears to be an excellent candidate for future development as a novel antimicrobial and antisepsis agent, particularly against antibiotic~~-~~resistant pathogens.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_17229147}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17229147 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17229147}}

	==About this Structure==		==About this Structure==
-	2HFR is a [[Single protein]] structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA].	+	2HFR is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFR OCA].

	==Reference==		==Reference==
Line 27:		Line 31:
	[[Category: Zhang, G.]]		[[Category: Zhang, G.]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 06~~:14:22 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:51:47 2008''