2hg4 - Revision history

OCA at 07:39, 17 March 2021

OCA — Wed, 17 Mar 2021 07:39:18 GMT

←Older revision		Revision as of 07:39, 17 March 2021
Line 1:		Line 1:

	==Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS.==		==Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS.==
-	<StructureSection load='2hg4' size='340' side='right' caption='[[2hg4]], [[Resolution\|resolution]] 2.73Å' scene=''>	+	<StructureSection load='2hg4' size='340' side='right'caption='[[2hg4]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2hg4]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HG4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2HG4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2hg4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HG4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 "Actinomyces erythreus" (sic) Waksman 1923])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 "Actinomyces erythreus" (sic) Waksman 1923])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2hg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hg4 OCA], [~~http~~://pdbe.org/2hg4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2hg4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2hg4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2hg4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hg4 OCA], [https://pdbe.org/2hg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hg4 RCSB], [https://www.ebi.ac.uk/pdbsum/2hg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hg4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 32:		Line 32:
	==See Also==		==See Also==
	*[[6-deoxyerythronolide B synthase (DEBS)\|6-deoxyerythronolide B synthase (DEBS)]]		*[[6-deoxyerythronolide B synthase (DEBS)\|6-deoxyerythronolide B synthase (DEBS)]]
		+	*[[6-deoxyerythronolide B synthase 3D structures\|6-deoxyerythronolide B synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: 6-deoxyerythronolide-B synthase]]		[[Category: 6-deoxyerythronolide-B synthase]]
		+	[[Category: Large Structures]]
	[[Category: Cane, D E]]		[[Category: Cane, D E]]
	[[Category: Khosla, C]]		[[Category: Khosla, C]]

OCA at 06:27, 27 June 2018

OCA — Wed, 27 Jun 2018 06:27:10 GMT

←Older revision		Revision as of 06:27, 27 June 2018
Line 1:		Line 1:
		+
	==Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS.==		==Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS.==
	<StructureSection load='2hg4' size='340' side='right' caption='[[2hg4]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='2hg4' size='340' side='right' caption='[[2hg4]], [[Resolution\|resolution]] 2.73Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 "Actinomyces erythreus" (sic) Waksman 1923])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 "Actinomyces erythreus" (sic) Waksman 1923])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hg4 OCA], [http://pdbe.org/2hg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2hg4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hg4 OCA], [http://pdbe.org/2hg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2hg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2hg4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hg/2hg4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hg/2hg4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:10, 8 February 2016

OCA — Mon, 08 Feb 2016 04:10:28 GMT

←Older revision		Revision as of 04:10, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hg4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:43, 10 September 2015

OCA — Thu, 10 Sep 2015 07:43:25 GMT

←Older revision		Revision as of 07:43, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2hg4' size='340' side='right' caption='[[2hg4]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='2hg4' size='340' side='right' caption='[[2hg4]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2hg4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharopolyspora_erythraea Saccharopolyspora erythraea~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HG4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2hg4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HG4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 ~~Saccharopolyspora erythraea~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 "Actinomyces erythreus" (sic) Waksman 1923])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hg4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2hg4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hg4 OCA], [http://pdbe.org/2hg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2hg4 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2hg4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: 6-deoxyerythronolide-B synthase]]		[[Category: 6-deoxyerythronolide-B synthase]]
-	[[Category: Saccharopolyspora erythraea]]
	[[Category: Cane, D E]]		[[Category: Cane, D E]]
	[[Category: Khosla, C]]		[[Category: Khosla, C]]

OCA at 09:02, 16 January 2015

OCA — Fri, 16 Jan 2015 09:02:58 GMT

←Older revision		Revision as of 09:02, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hg4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HG4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hg4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HG4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 Saccharopolyspora erythraea])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 Saccharopolyspora erythraea])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hg4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2hg4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hg4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2hg4 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: 6-deoxyerythronolide-B synthase]]		[[Category: 6-deoxyerythronolide-B synthase]]
	[[Category: Saccharopolyspora erythraea]]		[[Category: Saccharopolyspora erythraea]]
-	[[Category: Cane, D E.]]	+	[[Category: Cane, D E]]
-	[[Category: Khosla, C.]]	+	[[Category: Khosla, C]]
-	[[Category: Kim, C Y.]]	+	[[Category: Kim, C Y]]
-	[[Category: Mathews, I I.]]	+	[[Category: Mathews, I I]]
-	[[Category: Tang, Y.]]	+	[[Category: Tang, Y]]
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Deb]]		[[Category: Deb]]

OCA at 05:06, 29 September 2014

OCA — Mon, 29 Sep 2014 05:06:54 GMT

←Older revision		Revision as of 05:06, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2hg4.~~png~~\|~~left~~\|200px]]	+	==Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS.==
		+	<StructureSection load='2hg4' size='340' side='right' caption='[[2hg4]], [[Resolution\|resolution]] 2.73Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2hg4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HG4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">eryA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1836 Saccharopolyspora erythraea])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-deoxyerythronolide-B_synthase 6-deoxyerythronolide-B synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.94 2.3.1.94] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hg4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2hg4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hg/2hg4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The x-ray crystal structure of a 194-kDa fragment from module 5 of the 6-deoxyerythronolide B synthase has been solved at 2.7 Angstrom resolution. Each subunit of the homodimeric protein contains a full-length ketosynthase (KS) and acyl transferase (AT) domain as well as three flanking "linkers." The linkers are structurally well defined and contribute extensively to intersubunit or interdomain interactions, frequently by means of multiple highly conserved residues. The crystal structure also reveals that the active site residue Cys-199 of the KS domain is separated from the active site residue Ser-642 of the AT domain by approximately 80 Angstrom. This distance is too large to be covered simply by alternative positioning of a statically anchored, fully extended phosphopantetheine arm of the acyl carrier protein domain from module 5. Thus, substantial domain reorganization appears necessary for the acyl carrier protein to interact successively with both the AT and the KS domains of this prototypical polyketide synthase module. The 2.7-Angstrom KS-AT structure is fully consistent with a recently reported lower resolution, 4.5-Angstrom model of fatty acid synthase structure, and emphasizes the close biochemical and structural similarity between polyketide synthase and fatty acid synthase enzymology.

-	~~{{STRUCTURE_2hg4\| PDB=2hg4 \| SCENE= }}~~	+	The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.,Tang Y, Kim CY, Mathews II, Cane DE, Khosla C Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11124-9. Epub 2006 Jul 14. PMID:16844787<ref>PMID:16844787</ref>

-	~~===Structure~~ of the ~~ketosynthase-acyltransferase didomain~~ of ~~module 5 from DEBS~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16844787}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2hg4]] is a 6 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HG4 OCA].~~	+

	==See Also==		==See Also==
	*[[6-deoxyerythronolide B synthase (DEBS)\|6-deoxyerythronolide B synthase (DEBS)]]		*[[6-deoxyerythronolide B synthase (DEBS)\|6-deoxyerythronolide B synthase (DEBS)]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016844787<~~/~~ref~~><~~ref group="xtra">PMID:015518537</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: 6-deoxyerythronolide-B synthase]]		[[Category: 6-deoxyerythronolide-B synthase]]
	[[Category: Saccharopolyspora erythraea]]		[[Category: Saccharopolyspora erythraea]]

OCA at 08:52, 20 October 2012

OCA — Sat, 20 Oct 2012 08:52:08 GMT

←Older revision		Revision as of 08:52, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2hg4]] is a 6 chain structure ~~of [[6-deoxyerythronolide B synthase (DEBS)]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HG4 OCA].	+	[[2hg4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HG4 OCA].

	==See Also==		==See Also==
Line 14:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:016844787</ref><ref group="xtra">PMID:015518537~~</ref><ref group="xtra">PMID:009756477~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016844787</ref><ref group="xtra">PMID:015518537</ref><references group="xtra"/>
	[[Category: 6-deoxyerythronolide-B synthase]]		[[Category: 6-deoxyerythronolide-B synthase]]
	[[Category: Saccharopolyspora erythraea]]		[[Category: Saccharopolyspora erythraea]]

OCA at 21:01, 25 July 2012

OCA — Wed, 25 Jul 2012 21:01:39 GMT

←Older revision		Revision as of 21:01, 25 July 2012
Line 1:		Line 1:
	[[Image:2hg4.png\|left\|200px]]		[[Image:2hg4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2hg4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2hg4\| PDB=2hg4 \| SCENE= }}		{{STRUCTURE_2hg4\| PDB=2hg4 \| SCENE= }}

	===Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS.===		===Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16844787}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16844787 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16844787}}		{{ABSTRACT_PUBMED_16844787}}

	==About this Structure==		==About this Structure==
-	[[2hg4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HG4 OCA].	+	[[2hg4]] is a 6 chain structure of [[6-deoxyerythronolide B synthase (DEBS)]] with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HG4 OCA].

	==See Also==		==See Also==
-	*[[6-deoxyerythronolide B synthase (DEBS)]]	+	*[[6-deoxyerythronolide B synthase (DEBS)\|6-deoxyerythronolide B synthase (DEBS)]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16844787~~</ref><ref group="xtra">PMID:~~15518537~~</ref><ref group="xtra">PMID:~~9756477~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016844787</ref><ref group="xtra">PMID:015518537</ref><ref group="xtra">PMID:009756477</ref><references group="xtra"/>
	[[Category: 6-deoxyerythronolide-B synthase]]		[[Category: 6-deoxyerythronolide-B synthase]]
	[[Category: Saccharopolyspora erythraea]]		[[Category: Saccharopolyspora erythraea]]
Line 37:		Line 26:
	[[Category: Ketosynthase]]		[[Category: Ketosynthase]]
	[[Category: Module 5]]		[[Category: Module 5]]
		+	[[Category: Transferase]]

OCA: Protected "2hg4" [edit=sysop:move=sysop]

OCA — Tue, 28 Dec 2010 13:15:15 GMT

Protected "2hg4" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:15, 28 December 2010

OCA at 13:15, 28 December 2010

OCA — Tue, 28 Dec 2010 13:15:14 GMT

←Older revision		Revision as of 13:15, 28 December 2010
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2hg4.png\|left\|200px]]		[[Image:2hg4.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~2HG4~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HG4 OCA].	+	[[2hg4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HG4 OCA].
		+
		+	==See Also==
		+	*[[6-deoxyerythronolide B synthase (DEBS)]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:16844787</ref><ref group="xtra">PMID:15518537</ref><ref group="xtra">PMID:9756477</ref><references group="xtra"/>		<ref group="xtra">PMID:16844787</ref><ref group="xtra">PMID:15518537</ref><ref group="xtra">PMID:9756477</ref><references group="xtra"/>
-	[[Category: ~~Erythronolide~~ synthase]]	+	[[Category: 6-deoxyerythronolide-B synthase]]
	[[Category: Saccharopolyspora erythraea]]		[[Category: Saccharopolyspora erythraea]]
	[[Category: Cane, D E.]]		[[Category: Cane, D E.]]
Line 35:		Line 37:
	[[Category: Ketosynthase]]		[[Category: Ketosynthase]]
	[[Category: Module 5]]		[[Category: Module 5]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:42:44 2009''