2hgu - Revision history

OCA: Redirecting to 4v4z

OCA — Wed, 10 Dec 2014 15:10:43 GMT

Redirecting to 4v4z

←Older revision		Revision as of 15:10, 10 December 2014
Line 1:		Line 1:
-	~~==70S T.Th. ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A. This entry 2HGU contains 50S ribosomal subunit. The 30S ribosomal subunit can be found in PDB entry 2HGR.==~~	+	#REDIRECT [[4v4z]] This PDB entry is obsolete and replaced by 4v4z
-	~~<StructureSection load='2hgu' size='340' side='right' caption='~~[[~~2hgu]], [[Resolution\|resolution]] 4.51Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	~~<table><tr><td colspan='2'>[[2hgu~~]] is a 32 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HGU FirstGlance]. <br>	+
-	~~</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hgr\|2hgr]]</td></tr>~~	+
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hgu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hgu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hgu RCSB], [http://www.ebi.ac.uk/pdbsum/2hgu PDBsum]</span></td></tr>	+
-	~~<table>~~	+
-	~~== Evolutionary Conservation ==~~	+
-	~~[[Image:Consurf_key_small.gif\|200px\|right]]~~	+
-	~~Check<jmol>~~	+
-	~~<jmolCheckbox>~~	+
-	~~<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hg/2hgu_consurf.spt"</scriptWhenChecked>~~	+
-	~~<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>~~	+
-	~~<text>to colour the structure~~ by ~~Evolutionary Conservation</text>~~	+
-	~~</jmolCheckbox>~~	+
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].	+
-	~~<div style="clear:both"></div>~~	+
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Translation initiation is a major determinant of the overall expression level of a gene. The translation of functionally active protein requires the messenger RNA to be positioned on the ribosome such that the start/initiation codon will be read first and in the correct frame. Little is known about the molecular basis for the interaction of mRNA with the ribosome at different states of translation. Recent crystal structures of the ribosomal subunits, the empty 70S ribosome and the 70S ribosome containing functional ligands have provided information about the general organization of the ribosome and its functional centres. Here we compare the X-ray structures of eight ribosome complexes modelling the translation initiation, post-initiation and elongation states. In the initiation and post-initiation complexes, the presence of the Shine-Dalgarno (SD) duplex causes strong anchoring of the 5'-end of mRNA onto the platform of the 30S subunit, with numerous interactions between mRNA and the ribosome. Conversely, the 5' end of the 'elongator' mRNA lacking SD interactions is flexible, suggesting a different exit path for mRNA during elongation. After the initiation of translation, but while an SD interaction is still present, mRNA moves in the 3'-->5' direction with simultaneous clockwise rotation and lengthening of the SD duplex, bringing it into contact with ribosomal protein S2.	+
-		+
-	Structural basis for messenger RNA movement on the ribosome.,Yusupova G, Jenner L, Rees B, Moras D, Yusupov M Nature. 2006 Nov 16;444(7117):391-4. Epub 2006 Oct 18. PMID:17051149<ref>PMID:17051149</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-		+
-	~~==See Also==~~	+
-	*[[Ribosome 3D structures\|Ribosome 3D structures]]	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Thermus thermophilus]]~~	+
-	~~[[Category: Jenner, L.]]~~	+
-	~~[[Category: Moras, D.]]~~	+
-	~~[[Category: Rees, B.]]~~	+
-	~~[[Category: Yusupov, M.]]~~	+
-	~~[[Category: Yusupova, G.]]~~	+
-	~~[[Category: Initiation]]~~	+
-	~~[[Category: Ribosome]]~~	+
-	~~[[Category: Ribosome functional complex]]~~	+

OCA at 10:34, 30 September 2014

OCA — Tue, 30 Sep 2014 10:34:52 GMT

←Older revision		Revision as of 10:34, 30 September 2014
Line 1:		Line 1:
-	~~{{Large structure}}~~	+	==70S T.Th. ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A. This entry 2HGU contains 50S ribosomal subunit. The 30S ribosomal subunit can be found in PDB entry 2HGR.==
-	~~{{STRUCTURE_2hgu\| PDB=2hgu \| SCENE= }}~~	+	<StructureSection load='2hgu' size='340' side='right' caption='[[2hgu]], [[Resolution\|resolution]] 4.51Å' scene=''>
-	===70S T.Th. ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A. This entry 2HGU contains 50S ribosomal subunit. The 30S ribosomal subunit can be found in PDB entry 2HGR.===	+	== Structural highlights ==
-	~~{{ABSTRACT_PUBMED_17051149}}~~	+	<table><tr><td colspan='2'>[[2hgu]] is a 32 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HGU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hgr\|2hgr]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hgu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hgu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hgu RCSB], [http://www.ebi.ac.uk/pdbsum/2hgu PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hg/2hgu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Translation initiation is a major determinant of the overall expression level of a gene. The translation of functionally active protein requires the messenger RNA to be positioned on the ribosome such that the start/initiation codon will be read first and in the correct frame. Little is known about the molecular basis for the interaction of mRNA with the ribosome at different states of translation. Recent crystal structures of the ribosomal subunits, the empty 70S ribosome and the 70S ribosome containing functional ligands have provided information about the general organization of the ribosome and its functional centres. Here we compare the X-ray structures of eight ribosome complexes modelling the translation initiation, post-initiation and elongation states. In the initiation and post-initiation complexes, the presence of the Shine-Dalgarno (SD) duplex causes strong anchoring of the 5'-end of mRNA onto the platform of the 30S subunit, with numerous interactions between mRNA and the ribosome. Conversely, the 5' end of the 'elongator' mRNA lacking SD interactions is flexible, suggesting a different exit path for mRNA during elongation. After the initiation of translation, but while an SD interaction is still present, mRNA moves in the 3'-->5' direction with simultaneous clockwise rotation and lengthening of the SD duplex, bringing it into contact with ribosomal protein S2.

-	~~==About this Structure==~~	+	Structural basis for messenger RNA movement on the ribosome.,Yusupova G, Jenner L, Rees B, Moras D, Yusupov M Nature. 2006 Nov 16;444(7117):391-4. Epub 2006 Oct 18. PMID:17051149<ref>PMID:17051149</ref>
-	~~[[2hgu]] is a 32 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2HGU OCA].~~	+

-	~~==See Also==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	*[[Ribosomal protein L1\|Ribosomal protein L1]]	+	</div>
-	*[[Ribosomal protein L11\|Ribosomal protein L11]]	+
-	*[[Ribosomal protein L13\|Ribosomal protein L13]]	+
-	*[[Ribosomal protein L14\|Ribosomal protein L14]]	+
-	*[[Ribosomal protein L15\|Ribosomal protein L15]]	+
-	*[[Ribosomal protein L16\|Ribosomal protein L16]]	+
-	*[[Ribosomal protein L17\|Ribosomal protein L17]]	+
-	*[[Ribosomal protein L18\|Ribosomal protein L18]]	+
-	*[[Ribosomal protein L19\|Ribosomal protein L19]]	+
-	*[[Ribosomal protein L2\|Ribosomal protein L2]]	+
-	*[[Ribosomal protein L20\|Ribosomal protein L20]]	+
-	*[[Ribosomal protein L21\|Ribosomal protein L21]]	+
-	*[[Ribosomal protein L22\|Ribosomal protein L22]]	+
-	*[[Ribosomal protein L23\|Ribosomal protein L23]]	+
-	*[[Ribosomal protein L24\|Ribosomal protein L24]]	+
-	*[[Ribosomal protein L25\|Ribosomal protein L25]]	+
-	*[[Ribosomal protein L27\|Ribosomal protein L27]]	+
-	*[[Ribosomal protein L29\|Ribosomal protein L29]]	+
-	*[[Ribosomal protein L3\|Ribosomal protein L3]]	+
-	*[[Ribosomal protein L30\|Ribosomal protein L30]]	+
-	*[[Ribosomal protein L31\|Ribosomal protein L31]]	+
-	*[[Ribosomal protein L32\|Ribosomal protein L32]]	+
-	*[[Ribosomal protein L33\|Ribosomal protein L33]]	+
-	*[[Ribosomal protein L34\|Ribosomal protein L34]]	+
-	*[[Ribosomal protein L35\|Ribosomal protein L35]]	+
-	*[[Ribosomal protein L36\|Ribosomal protein L36]]	+
-	*[[Ribosomal protein L4\|Ribosomal protein L4]]	+
-	*[[Ribosomal protein L5\|Ribosomal protein L5]]	+
-	*[[Ribosomal protein L6\|Ribosomal protein L6]]	+
-	*[[Ribosomal protein L9\|Ribosomal protein L9]]	+

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:017051149</ref><ref group~~=~~"xtra">PMID:017721443~~</~~ref~~><~~references group="xtra"~~/>	+	*[[Ribosome 3D structures\|Ribosome 3D structures]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Jenner, L.]]		[[Category: Jenner, L.]]

OCA at 08:04, 11 March 2013

OCA — Mon, 11 Mar 2013 08:04:17 GMT

←Older revision		Revision as of 08:04, 11 March 2013
Line 1:		Line 1:
-	~~[[Image:2hgu.png\|left\|200px]]~~	+	{{Large structure}}
-		+
	{{STRUCTURE_2hgu\| PDB=2hgu \| SCENE= }}		{{STRUCTURE_2hgu\| PDB=2hgu \| SCENE= }}
-
	===70S T.Th. ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A. This entry 2HGU contains 50S ribosomal subunit. The 30S ribosomal subunit can be found in PDB entry 2HGR.===		===70S T.Th. ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A. This entry 2HGU contains 50S ribosomal subunit. The 30S ribosomal subunit can be found in PDB entry 2HGR.===
-
	{{ABSTRACT_PUBMED_17051149}}		{{ABSTRACT_PUBMED_17051149}}

OCA at 16:53, 20 October 2012

OCA — Sat, 20 Oct 2012 16:53:33 GMT

←Older revision		Revision as of 16:53, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2hgu]] is a 32 chain structure of [[Ribosomal protein L1]], [[Ribosomal protein L11]], [[Ribosomal protein L13]], [[Ribosomal protein L14]], [[Ribosomal protein L15]], [[Ribosomal protein L16]], [[Ribosomal protein L17]], [[Ribosomal protein L18]], [[Ribosomal protein L19]], [[Ribosomal protein L2]], [[Ribosomal protein L20]], [[Ribosomal protein L21]], [[Ribosomal protein L22]], [[Ribosomal protein L23]], [[Ribosomal protein L24]], [[Ribosomal protein L25]], [[Ribosomal protein L27]], [[Ribosomal protein L29]], [[Ribosomal protein L3]], [[Ribosomal protein L30]], [[Ribosomal protein L31]], [[Ribosomal protein L32]], [[Ribosomal protein L33]], [[Ribosomal protein L34]], [[Ribosomal protein L35]], [[Ribosomal protein L36]], [[Ribosomal protein L4]], [[Ribosomal protein L5]], [[Ribosomal protein L6]] and [[Ribosomal protein L9]] with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGU OCA].	+	[[2hgu]] is a 32 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGU OCA].

	==See Also==		==See Also==

OCA at 23:12, 26 July 2012

OCA — Thu, 26 Jul 2012 23:12:35 GMT

←Older revision		Revision as of 23:12, 26 July 2012
Line 1:		Line 1:
	[[Image:2hgu.png\|left\|200px]]		[[Image:2hgu.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2hgu", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2hgu\| PDB=2hgu \| SCENE= }}		{{STRUCTURE_2hgu\| PDB=2hgu \| SCENE= }}

	===70S T.Th. ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A. This entry 2HGU contains 50S ribosomal subunit. The 30S ribosomal subunit can be found in PDB entry 2HGR.===		===70S T.Th. ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A. This entry 2HGU contains 50S ribosomal subunit. The 30S ribosomal subunit can be found in PDB entry 2HGR.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17051149}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17051149 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17051149}}		{{ABSTRACT_PUBMED_17051149}}

	==About this Structure==		==About this Structure==
-	[[2hgu]] is a 32 chain structure of [[Ribosomal protein L1]], [[Ribosomal protein L2]], [[Ribosomal protein L3]], [[Ribosomal protein L4]], [[Ribosomal protein L5]] ~~and~~ [[Ribosomal protein L6]] with sequence from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus_hb8~~ Thermus thermophilus ~~hb8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGU OCA].	+	[[2hgu]] is a 32 chain structure of [[Ribosomal protein L1]], [[Ribosomal protein L11]], [[Ribosomal protein L13]], [[Ribosomal protein L14]], [[Ribosomal protein L15]], [[Ribosomal protein L16]], [[Ribosomal protein L17]], [[Ribosomal protein L18]], [[Ribosomal protein L19]], [[Ribosomal protein L2]], [[Ribosomal protein L20]], [[Ribosomal protein L21]], [[Ribosomal protein L22]], [[Ribosomal protein L23]], [[Ribosomal protein L24]], [[Ribosomal protein L25]], [[Ribosomal protein L27]], [[Ribosomal protein L29]], [[Ribosomal protein L3]], [[Ribosomal protein L30]], [[Ribosomal protein L31]], [[Ribosomal protein L32]], [[Ribosomal protein L33]], [[Ribosomal protein L34]], [[Ribosomal protein L35]], [[Ribosomal protein L36]], [[Ribosomal protein L4]], [[Ribosomal protein L5]], [[Ribosomal protein L6]] and [[Ribosomal protein L9]] with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGU OCA].

	==See Also==		==See Also==
-	*[[Ribosomal protein L1]]	+	*[[Ribosomal protein L1\|Ribosomal protein L1]]
-	*[[Ribosomal protein L2]]	+	*[[Ribosomal protein L11\|Ribosomal protein L11]]
-	*[[Ribosomal protein L3]]	+	*[[Ribosomal protein L13\|Ribosomal protein L13]]
-	*[[Ribosomal protein L4]]	+	*[[Ribosomal protein L14\|Ribosomal protein L14]]
-	*[[Ribosomal protein L5]]	+	*[[Ribosomal protein L15\|Ribosomal protein L15]]
-	*[[Ribosomal protein L6]]	+	*[[Ribosomal protein L16\|Ribosomal protein L16]]
		+	*[[Ribosomal protein L17\|Ribosomal protein L17]]
		+	*[[Ribosomal protein L18\|Ribosomal protein L18]]
		+	*[[Ribosomal protein L19\|Ribosomal protein L19]]
		+	*[[Ribosomal protein L2\|Ribosomal protein L2]]
		+	*[[Ribosomal protein L20\|Ribosomal protein L20]]
		+	*[[Ribosomal protein L21\|Ribosomal protein L21]]
		+	*[[Ribosomal protein L22\|Ribosomal protein L22]]
		+	*[[Ribosomal protein L23\|Ribosomal protein L23]]
		+	*[[Ribosomal protein L24\|Ribosomal protein L24]]
		+	*[[Ribosomal protein L25\|Ribosomal protein L25]]
		+	*[[Ribosomal protein L27\|Ribosomal protein L27]]
		+	*[[Ribosomal protein L29\|Ribosomal protein L29]]
		+	*[[Ribosomal protein L3\|Ribosomal protein L3]]
		+	*[[Ribosomal protein L30\|Ribosomal protein L30]]
		+	*[[Ribosomal protein L31\|Ribosomal protein L31]]
		+	*[[Ribosomal protein L32\|Ribosomal protein L32]]
		+	*[[Ribosomal protein L33\|Ribosomal protein L33]]
		+	*[[Ribosomal protein L34\|Ribosomal protein L34]]
		+	*[[Ribosomal protein L35\|Ribosomal protein L35]]
		+	*[[Ribosomal protein L36\|Ribosomal protein L36]]
		+	*[[Ribosomal protein L4\|Ribosomal protein L4]]
		+	*[[Ribosomal protein L5\|Ribosomal protein L5]]
		+	*[[Ribosomal protein L6\|Ribosomal protein L6]]
		+	*[[Ribosomal protein L9\|Ribosomal protein L9]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17051149~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017051149</ref><ref group="xtra">PMID:017721443</ref><references group="xtra"/>
-	[[Category: Thermus thermophilus ~~hb8~~]]	+	[[Category: Thermus thermophilus]]
	[[Category: Jenner, L.]]		[[Category: Jenner, L.]]
	[[Category: Moras, D.]]		[[Category: Moras, D.]]
Line 38:		Line 51:
	[[Category: Yusupova, G.]]		[[Category: Yusupova, G.]]
	[[Category: Initiation]]		[[Category: Initiation]]
		+	[[Category: Ribosome]]
	[[Category: Ribosome functional complex]]		[[Category: Ribosome functional complex]]

OCA: Protected "2hgu" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 22:45:59 GMT

Protected "2hgu" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:45, 26 December 2010

OCA at 22:45, 26 December 2010

OCA — Sun, 26 Dec 2010 22:45:58 GMT

←Older revision		Revision as of 22:45, 26 December 2010
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2hgu.png\|left\|200px]]		[[Image:2hgu.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~2HGU~~ is a 32 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus~~ Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGU OCA].	+	[[2hgu]] is a 32 chain structure of [[Ribosomal protein L1]], [[Ribosomal protein L2]], [[Ribosomal protein L3]], [[Ribosomal protein L4]], [[Ribosomal protein L5]] and [[Ribosomal protein L6]] with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGU OCA].
		+
		+	==See Also==
		+	*[[Ribosomal protein L1]]
		+	*[[Ribosomal protein L2]]
		+	*[[Ribosomal protein L3]]
		+	*[[Ribosomal protein L4]]
		+	*[[Ribosomal protein L5]]
		+	*[[Ribosomal protein L6]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:17051149</ref><references group="xtra"/>		<ref group="xtra">PMID:17051149</ref><references group="xtra"/>
-	[[Category: Thermus thermophilus]]	+	[[Category: Thermus thermophilus hb8]]
	[[Category: Jenner, L.]]		[[Category: Jenner, L.]]
	[[Category: Moras, D.]]		[[Category: Moras, D.]]
Line 32:		Line 39:
	[[Category: Initiation]]		[[Category: Initiation]]
	[[Category: Ribosome functional complex]]		[[Category: Ribosome functional complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:40:53 2009''

OCA at 14:40, 17 February 2009

OCA — Tue, 17 Feb 2009 14:40:55 GMT

←Older revision		Revision as of 14:40, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2HGU is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGU OCA].	+	2HGU is a 32 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGU OCA].

	==Reference==		==Reference==
-	~~Structural basis for messenger RNA movement on the ribosome., Yusupova G, Jenner L, Rees B, Moras D, Yusupov M, Nature. 2006 Nov 16;444(7117):391-4. Epub 2006 Oct 18.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17051149 17051149]~~	+	<ref group="xtra">PMID:17051149</ref><references group="xtra"/>
-	~~[[Category: Protein complex]]~~	+
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Jenner, L.]]		[[Category: Jenner, L.]]
Line 34:		Line 33:
	[[Category: Ribosome functional complex]]		[[Category: Ribosome functional complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 23~~:24:~~55 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:40:53 2009''

OCA at 20:24, 28 July 2008

OCA — Mon, 28 Jul 2008 20:24:59 GMT

←Older revision		Revision as of 20:24, 28 July 2008
Line 1:		Line 1:
-	[[Image:2hgu.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2hgu.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2hgu\| PDB=2hgu \| SCENE= }}		{{STRUCTURE_2hgu\| PDB=2hgu \| SCENE= }}

-	~~'''~~70S T.Th. ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A. This entry 2HGU contains 50S ribosomal subunit. The 30S ribosomal subunit can be found in PDB entry 2HGR.~~'''~~	+	===70S T.Th. ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A. This entry 2HGU contains 50S ribosomal subunit. The 30S ribosomal subunit can be found in PDB entry 2HGR.===


-	~~==Overview==~~	+	<!--
-	~~Translation initiation is a major determinant of the overall expression level of a gene.~~ The ~~translation of functionally active protein requires~~ the ~~messenger RNA~~ to ~~be positioned~~ on ~~the ribosome such that the start~~/~~initiation codon will be read first and in the correct frame~~. ~~Little is known about the molecular basis for the interaction of mRNA with the ribosome at different states of translation~~. Recent crystal structures of the ribosomal subunits, the empty 70S ribosome and the 70S ribosome containing functional ligands have provided information about the general organization of the ribosome and its functional centres. Here we compare the X-ray structures of eight ribosome complexes modelling the translation initiation, post-initiation and elongation states. In the initiation and post-initiation complexes, the presence of the Shine-Dalgarno (SD) ~~duplex causes strong anchoring of the 5'-end of mRNA onto the platform of the 30S subunit~~, ~~with numerous interactions between mRNA and~~ the ~~ribosome~~. Conversely, the 5' end of the 'elongator' mRNA lacking SD interactions is flexible, suggesting a different exit path for mRNA during elongation. After the initiation of translation, but while an SD interaction is still present, mRNA moves in the 3'--~~>5' direction with simultaneous clockwise rotation and lengthening of the SD duplex, bringing it into contact with ribosomal protein S2.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_17051149}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17051149 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17051149}}

	==About this Structure==		==About this Structure==
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	[[Category: Initiation]]		[[Category: Initiation]]
	[[Category: Ribosome functional complex]]		[[Category: Ribosome functional complex]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 06~~:16:46 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:24:55 2008''

OCA at 03:16, 4 May 2008

OCA — Sun, 04 May 2008 03:16:47 GMT

←Older revision		Revision as of 03:16, 4 May 2008
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	[[Image:2hgu.gif\|left\|200px]]		[[Image:2hgu.gif\|left\|200px]]

-	{{Structure	+	<!--
-	\|PDB~~= 2hgu \|SIZE=350\|CAPTION= <~~scene ~~name='initialview01'>2hgu</scene>~~, ~~resolution 4~~.~~510Å~~	+	The line below this paragraph, containing "STRUCTURE_2hgu", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <scene name='pdbligand=A:ADENOSINE~~-~~5'~~-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene>	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	\|~~ACTIVITY~~=	+	or leave the SCENE parameter empty for the default display.
-	\|~~GENE~~=	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_2hgu\| PDB=2hgu \| SCENE= }}
-	~~\|RELATEDENTRY=[[2hgr\|2HGR]]~~	+
-	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hgu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hgu OCA], [http://www.ebi.ac.uk/pdbsum/2hgu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hgu RCSB]</span>	+
-	}}	+

	'''70S T.Th. ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A. This entry 2HGU contains 50S ribosomal subunit. The 30S ribosomal subunit can be found in PDB entry 2HGR.'''		'''70S T.Th. ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A. This entry 2HGU contains 50S ribosomal subunit. The 30S ribosomal subunit can be found in PDB entry 2HGR.'''
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	[[Category: Yusupov, M.]]		[[Category: Yusupov, M.]]
	[[Category: Yusupova, G.]]		[[Category: Yusupova, G.]]
-	[[Category: ~~initiation~~]]	+	[[Category: Initiation]]
-	[[Category: ~~ribosome~~ functional complex]]	+	[[Category: Ribosome functional complex]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:16:46 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 03~~:30:18 2008''	+