2hi3 - Revision history

OCA at 19:02, 29 May 2024

OCA — Wed, 29 May 2024 19:02:10 GMT

←Older revision		Revision as of 19:02, 29 May 2024
Line 1:		Line 1:

	==Solution structure of the homeodomain-only protein HOP==		==Solution structure of the homeodomain-only protein HOP==
-	<StructureSection load='2hi3' size='340' side='right'caption='[[2hi3~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2hi3' size='340' side='right'caption='[[2hi3]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2hi3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HI3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2hi3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HI3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi3 OCA], [https://pdbe.org/2hi3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hi3 RCSB], [https://www.ebi.ac.uk/pdbsum/2hi3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hi3 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi3 OCA], [https://pdbe.org/2hi3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hi3 RCSB], [https://www.ebi.ac.uk/pdbsum/2hi3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hi3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HOP_MOUSE HOP_MOUSE]] Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy.<ref>PMID:12297045</ref> <ref>PMID:12297046</ref>	+	[https://www.uniprot.org/uniprot/HOP_MOUSE HOP_MOUSE] Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy.<ref>PMID:12297045</ref> <ref>PMID:12297046</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Epstein~~, J A~~]]	+	[[Category: Epstein JA]]
-	[[Category: Kook, H]]	+	[[Category: Kook H]]
-	[[Category: Mackay~~, J P~~]]	+	[[Category: Mackay JP]]
-	[[Category: Simpson~~, R J~~]]	+	[[Category: Simpson RJ]]
-	[[Category: Yung~~, W W]]~~	+	[[Category: Yung WW]]
-	~~[[Category: Homeodomain]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 11:09, 5 January 2022

OCA — Wed, 05 Jan 2022 11:09:08 GMT

←Older revision		Revision as of 11:09, 5 January 2022
Line 3:		Line 3:
	<StructureSection load='2hi3' size='340' side='right'caption='[[2hi3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2hi3' size='340' side='right'caption='[[2hi3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2hi3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2HI3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2hi3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HI3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2hi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi3 OCA], [~~http~~://pdbe.org/2hi3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2hi3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2hi3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2hi3 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi3 OCA], [https://pdbe.org/2hi3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hi3 RCSB], [https://www.ebi.ac.uk/pdbsum/2hi3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hi3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HOP_MOUSE HOP_MOUSE]] Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy.<ref>PMID:12297045</ref> <ref>PMID:12297046</ref>	+	[[https://www.uniprot.org/uniprot/HOP_MOUSE HOP_MOUSE]] Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy.<ref>PMID:12297045</ref> <ref>PMID:12297046</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 2hi3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2hi3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[HOP protein\|HOP protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:09, 1 April 2020

OCA — Wed, 01 Apr 2020 10:09:58 GMT

←Older revision		Revision as of 10:09, 1 April 2020
Line 1:		Line 1:

	==Solution structure of the homeodomain-only protein HOP==		==Solution structure of the homeodomain-only protein HOP==
-	<StructureSection load='2hi3' size='340' side='right' caption='[[2hi3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2hi3' size='340' side='right'caption='[[2hi3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hi3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hi3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI3 FirstGlance]. <br>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Epstein, J A]]		[[Category: Epstein, J A]]

OCA at 06:13, 27 June 2018

OCA — Wed, 27 Jun 2018 06:13:42 GMT

←Older revision		Revision as of 06:13, 27 June 2018
Line 1:		Line 1:
		+
	==Solution structure of the homeodomain-only protein HOP==		==Solution structure of the homeodomain-only protein HOP==
	<StructureSection load='2hi3' size='340' side='right' caption='[[2hi3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2hi3' size='340' side='right' caption='[[2hi3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hi3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hi3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi3 OCA], [http://pdbe.org/2hi3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hi3 RCSB], [http://www.ebi.ac.uk/pdbsum/2hi3 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi3 OCA], [http://pdbe.org/2hi3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hi3 RCSB], [http://www.ebi.ac.uk/pdbsum/2hi3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2hi3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/2hi3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/2hi3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hi3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:18, 12 September 2015

OCA — Sat, 12 Sep 2015 01:18:50 GMT

←Older revision		Revision as of 01:18, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2hi3' size='340' side='right' caption='[[2hi3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2hi3' size='340' side='right' caption='[[2hi3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2hi3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2hi3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hi3 RCSB], [http://www.ebi.ac.uk/pdbsum/2hi3 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi3 OCA], [http://pdbe.org/2hi3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hi3 RCSB], [http://www.ebi.ac.uk/pdbsum/2hi3 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2hi3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Epstein, J A]]		[[Category: Epstein, J A]]
	[[Category: Kook, H]]		[[Category: Kook, H]]

OCA at 21:54, 25 December 2014

OCA — Thu, 25 Dec 2014 21:54:33 GMT

←Older revision		Revision as of 21:54, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hi3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hi3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hi3 RCSB], [http://www.ebi.ac.uk/pdbsum/2hi3 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hi3 RCSB], [http://www.ebi.ac.uk/pdbsum/2hi3 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HOP_MOUSE HOP_MOUSE]] Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy.<ref>PMID:12297045</ref> <ref>PMID:12297046</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Epstein, J A.]]	+	[[Category: Epstein, J A]]
-	[[Category: Kook, H.]]	+	[[Category: Kook, H]]
-	[[Category: Mackay, J P.]]	+	[[Category: Mackay, J P]]
-	[[Category: Simpson, R J.]]	+	[[Category: Simpson, R J]]
-	[[Category: Yung, W W.]]	+	[[Category: Yung, W W]]
	[[Category: Homeodomain]]		[[Category: Homeodomain]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 09:15, 30 September 2014

OCA — Tue, 30 Sep 2014 09:15:12 GMT

←Older revision		Revision as of 09:15, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2hi3.~~png\|left~~\|200px]]	+	==Solution structure of the homeodomain-only protein HOP==
		+	<StructureSection load='2hi3' size='340' side='right' caption='[[2hi3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2hi3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hi3 RCSB], [http://www.ebi.ac.uk/pdbsum/2hi3 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/2hi3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Homeodomain-only protein (HOP) is an 8-kDa transcriptional corepressor that is essential for the normal development of the mammalian heart. Previous studies have shown that HOP, which consists entirely of a putative homeodomain, acts downstream of Nkx2.5 and associates with the serum response factor (SRF), repressing transcription from SRF-responsive genes. HOP is also able to recruit histone deacetylase (HDAC) activity, consistent with its ability to repress transcription. Unlike other classic homeodomain proteins, HOP does not appear to interact with DNA, although it has been unclear if this is because of an overall divergent structure or because of specific amino acid differences between HOP and other homeodomains. To work toward an understanding of HOP function, we have determined the 3D structure of full-length HOP and used a range of biochemical assays to define the parts of the protein that are functionally important for its repression activity. We show that HOP forms a classical homeodomain fold but that it cannot recognize double stranded DNA, a result that emphasizes the importance of caution in predicting protein function from sequence homology alone. We also demonstrate that two distinct regions on the surface of HOP are required for its ability to repress an SRF-driven reporter gene, and it is likely that these motifs direct interactions between HOP and partner proteins such as SRF- and HDAC-containing complexes. Our results demonstrate that the homeodomain fold has been co-opted during evolution for functions other than sequence-specific DNA binding and suggest that HOP functions as an adaptor protein to mediate transcriptional repression.

-	~~{{STRUCTURE_2hi3\| PDB=2hi3 \| SCENE= }}~~	+	Analysis of the structure and function of the transcriptional coregulator HOP.,Kook H, Yung WW, Simpson RJ, Kee HJ, Shin S, Lowry JA, Loughlin FE, Yin Z, Epstein JA, Mackay JP Biochemistry. 2006 Sep 5;45(35):10584-90. PMID:16939210<ref>PMID:16939210</ref>

-	~~===Solution structure~~ of the ~~homeodomain-only protein HOP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16939210}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2hi3]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016939210<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Epstein, J A.]]		[[Category: Epstein, J A.]]

OCA: Protected "2hi3" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:09:57 GMT

Protected "2hi3" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:09, 7 January 2013

OCA at 14:09, 7 January 2013

OCA — Mon, 07 Jan 2013 14:09:54 GMT

←Older revision		Revision as of 14:09, 7 January 2013
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-	{{Seed}}
	[[Image:2hi3.png\|left\|200px]]		[[Image:2hi3.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2hi3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2hi3\| PDB=2hi3 \| SCENE= }}		{{STRUCTURE_2hi3\| PDB=2hi3 \| SCENE= }}

	===Solution structure of the homeodomain-only protein HOP===		===Solution structure of the homeodomain-only protein HOP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16939210}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16939210 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16939210}}		{{ABSTRACT_PUBMED_16939210}}

	==About this Structure==		==About this Structure==
-	~~2HI3~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA].	+	[[2hi3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16939210~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016939210</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Epstein, J A.]]		[[Category: Epstein, J A.]]
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	[[Category: Yung, W W.]]		[[Category: Yung, W W.]]
	[[Category: Homeodomain]]		[[Category: Homeodomain]]
-		+	[[Category: Transcription]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 09:02:39 2009''~~	+

OCA at 07:02, 18 February 2009

OCA — Wed, 18 Feb 2009 07:02:41 GMT

←Older revision		Revision as of 07:02, 18 February 2009
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	==About this Structure==		==About this Structure==
-	2HI3 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA].	+	2HI3 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI3 OCA].

	==Reference==		==Reference==
-	Analysis of the structure and function of the transcriptional coregulator HOP., Kook H, Yung WW, Simpson RJ, Kee HJ, Shin S, Lowry JA, Loughlin FE, Yin Z, Epstein JA, Mackay JP, Biochemistry. 2006 Sep 5;45(35):10584-90. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16939210 16939210]~~	+	<ref group="xtra">PMID:16939210</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Single protein]]
	[[Category: Epstein, J A.]]		[[Category: Epstein, J A.]]
	[[Category: Kook, H.]]		[[Category: Kook, H.]]
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	[[Category: Homeodomain]]		[[Category: Homeodomain]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 15~~:15:~~53 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:02:39 2009''