2hke - Revision history

OCA at 08:51, 25 October 2023

OCA — Wed, 25 Oct 2023 08:51:11 GMT

←Older revision		Revision as of 08:51, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='2hke' size='340' side='right'caption='[[2hke]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2hke' size='340' side='right'caption='[[2hke]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2hke]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Trypanosoma_(trypanozoon)_brucei~~ Trypanosoma ~~(trypanozoon)~~ brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HKE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2hke]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HKE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[2hk2\|2hk2]]~~, [[~~2hk3~~\|~~2hk3~~]]~~</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>mdd (CDS:Tb10.05.0010) ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~5691 Trypanosoma (Trypanozoon) brucei])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Diphosphomevalonate_decarboxylase Diphosphomevalonate decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.33 4.1.1.33]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hke OCA], [https://pdbe.org/2hke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hke RCSB], [https://www.ebi.ac.uk/pdbsum/2hke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hke ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hke OCA], [https://pdbe.org/2hke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hke RCSB], [https://www.ebi.ac.uk/pdbsum/2hke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hke ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q388P2_TRYB2 Q388P2_TRYB2]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Diphosphomevalonate decarboxylase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Alphey, M S~~]]	+	[[Category: Trypanosoma brucei]]
-	[[Category: ~~Byres, E~~]]	+	[[Category: Alphey MS]]
-	[[Category: ~~Hunter, W N~~]]	+	[[Category: Byres E]]
-	[[Category: ~~Decarboxylase]]~~	+	[[Category: Hunter WN]]
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Mevalonate diphosphate decarboxylase~~]]	+

OCA at 07:17, 24 March 2021

OCA — Wed, 24 Mar 2021 07:17:16 GMT

←Older revision		Revision as of 07:17, 24 March 2021
Line 1:		Line 1:

	==Mevalonate diphosphate decarboxylase from Trypanosoma brucei==		==Mevalonate diphosphate decarboxylase from Trypanosoma brucei==
-	<StructureSection load='2hke' size='340' side='right' caption='[[2hke]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2hke' size='340' side='right'caption='[[2hke]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2hke]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HKE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2HKE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2hke]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HKE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hk2\|2hk2]], [[2hk3\|2hk3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hk2\|2hk2]], [[2hk3\|2hk3]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mdd (CDS:Tb10.05.0010) ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mdd (CDS:Tb10.05.0010) ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Diphosphomevalonate_decarboxylase Diphosphomevalonate decarboxylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.33 4.1.1.33] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Diphosphomevalonate_decarboxylase Diphosphomevalonate decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.33 4.1.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hke OCA], [~~http~~://pdbe.org/2hke PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2hke RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2hke PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2hke ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hke OCA], [https://pdbe.org/2hke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hke RCSB], [https://www.ebi.ac.uk/pdbsum/2hke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hke ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Diphosphomevalonate decarboxylase]]		[[Category: Diphosphomevalonate decarboxylase]]
		+	[[Category: Large Structures]]
	[[Category: Alphey, M S]]		[[Category: Alphey, M S]]
	[[Category: Byres, E]]		[[Category: Byres, E]]

OCA at 06:41, 27 June 2018

OCA — Wed, 27 Jun 2018 06:41:32 GMT

←Older revision		Revision as of 06:41, 27 June 2018
Line 1:		Line 1:
		+
	==Mevalonate diphosphate decarboxylase from Trypanosoma brucei==		==Mevalonate diphosphate decarboxylase from Trypanosoma brucei==
	<StructureSection load='2hke' size='340' side='right' caption='[[2hke]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2hke' size='340' side='right' caption='[[2hke]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mdd (CDS:Tb10.05.0010) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mdd (CDS:Tb10.05.0010) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diphosphomevalonate_decarboxylase Diphosphomevalonate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.33 4.1.1.33] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diphosphomevalonate_decarboxylase Diphosphomevalonate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.33 4.1.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hke OCA], [http://pdbe.org/2hke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hke RCSB], [http://www.ebi.ac.uk/pdbsum/2hke PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hke OCA], [http://pdbe.org/2hke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hke RCSB], [http://www.ebi.ac.uk/pdbsum/2hke PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2hke ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/2hke_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/2hke_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hke ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:14, 11 September 2015

OCA — Fri, 11 Sep 2015 16:14:37 GMT

←Older revision		Revision as of 16:14, 11 September 2015
Line 7:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mdd (CDS:Tb10.05.0010) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mdd (CDS:Tb10.05.0010) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diphosphomevalonate_decarboxylase Diphosphomevalonate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.33 4.1.1.33] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diphosphomevalonate_decarboxylase Diphosphomevalonate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.33 4.1.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hke RCSB], [http://www.ebi.ac.uk/pdbsum/2hke PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hke OCA], [http://pdbe.org/2hke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hke RCSB], [http://www.ebi.ac.uk/pdbsum/2hke PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2hke" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:17, 16 January 2015

OCA — Fri, 16 Jan 2015 09:17:09 GMT

←Older revision		Revision as of 09:17, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hke]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HKE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hke]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HKE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hk2\|2hk2]], [[2hk3\|2hk3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hk2\|2hk2]], [[2hk3\|2hk3]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mdd (CDS:Tb10.05.0010) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mdd (CDS:Tb10.05.0010) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diphosphomevalonate_decarboxylase Diphosphomevalonate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.33 4.1.1.33] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diphosphomevalonate_decarboxylase Diphosphomevalonate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.33 4.1.1.33] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hke RCSB], [http://www.ebi.ac.uk/pdbsum/2hke PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hke RCSB], [http://www.ebi.ac.uk/pdbsum/2hke PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Diphosphomevalonate decarboxylase]]		[[Category: Diphosphomevalonate decarboxylase]]
-	[[Category: Alphey, M S.]]	+	[[Category: Alphey, M S]]
-	[[Category: Byres, E.]]	+	[[Category: Byres, E]]
-	[[Category: Hunter, W N.]]	+	[[Category: Hunter, W N]]
	[[Category: Decarboxylase]]		[[Category: Decarboxylase]]
-	[[Category: Diphosphomevalonate decarboxylase]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Mevalonate diphosphate decarboxylase]]		[[Category: Mevalonate diphosphate decarboxylase]]

OCA at 11:46, 3 October 2014

OCA — Fri, 03 Oct 2014 11:46:13 GMT

←Older revision		Revision as of 11:46, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2hke\| PDB~~=2hke \| ~~SCENE~~= }}	+	==Mevalonate diphosphate decarboxylase from Trypanosoma brucei==
-	===~~Mevalonate diphosphate decarboxylase~~ from Trypanosoma brucei===	+	<StructureSection load='2hke' size='340' side='right' caption='[[2hke]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_17583736}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2hke]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HKE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hk2\|2hk2]], [[2hk3\|2hk3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mdd (CDS:Tb10.05.0010) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diphosphomevalonate_decarboxylase Diphosphomevalonate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.33 4.1.1.33] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hke RCSB], [http://www.ebi.ac.uk/pdbsum/2hke PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/2hke_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mevalonate diphosphate decarboxylase (MDD) catalyzes the ATP-dependent decarboxylation of mevalonate 5-diphosphate (MDP) to form isopentenyl pyrophosphate, a ubiquitous precursor for isoprenoid biosynthesis. MDD is a poorly understood component of this important metabolic pathway. Complementation of a temperature-sensitive yeast mutant by the putative mdd genes of Trypanosoma brucei and Staphylococcus aureus provides proof-of-function. Crystal structures of MDD from T. brucei (TbMDD, at 1.8 A resolution) and S. aureus (SaMDD, in two distinct crystal forms, each diffracting to 2.3 A resolution) have been determined. Gel-filtration chromatography and analytical ultracentrifugation experiments indicate that TbMDD is predominantly monomeric in solution while SaMDD is dimeric. The new crystal structures and comparison with that of the yeast Saccharomyces cerevisiae enzyme (ScMDD) reveal the structural basis for this variance in quaternary structure. The presence of an ordered sulfate in the structure of TbMDD reveals for the first time details of a ligand binding in the MDD active site and, in conjunction with well-ordered water molecules, comparisons with the related enzyme mevalonate kinase, structural and biochemical data derived on ScMDD and SaMDD, allows us to model a ternary complex with MDP and ATP. This model facilitates discussion of the molecular determinants of substrate recognition and contributions made by specific residues to the enzyme mechanism.

-	~~==About this Structure==~~	+	Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity.,Byres E, Alphey MS, Smith TK, Hunter WN J Mol Biol. 2007 Aug 10;371(2):540-53. Epub 2007 Jun 4. PMID:17583736<ref>PMID:17583736</ref>
-	~~[[2hke]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Trypanosoma_~~(~~trypanozoon~~)~~_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2HKE OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:017583736</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Diphosphomevalonate decarboxylase]]		[[Category: Diphosphomevalonate decarboxylase]]
	[[Category: Alphey, M S.]]		[[Category: Alphey, M S.]]

OCA at 08:26, 23 April 2014

OCA — Wed, 23 Apr 2014 08:26:32 GMT

←Older revision		Revision as of 08:26, 23 April 2014
Line 1:		Line 1:
-	[[Image:2hke.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2hke", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2hke\| PDB=2hke \| SCENE= }}		{{STRUCTURE_2hke\| PDB=2hke \| SCENE= }}
-
	===Mevalonate diphosphate decarboxylase from Trypanosoma brucei===		===Mevalonate diphosphate decarboxylase from Trypanosoma brucei===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17583736}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17583736 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17583736}}		{{ABSTRACT_PUBMED_17583736}}

	==About this Structure==		==About this Structure==
-	[[2hke]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_brucei~~ Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HKE OCA].	+	[[2hke]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HKE OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:017583736</ref><~~ref~~ group="xtra"~~>PMID:016511101<~~/~~ref~~><references ~~group="xtra"~~/>	+	<ref group="xtra">PMID:017583736</ref><references group="xtra"/><references/>
	[[Category: Diphosphomevalonate decarboxylase]]		[[Category: Diphosphomevalonate decarboxylase]]
-	[[Category: Trypanosoma brucei]]
	[[Category: Alphey, M S.]]		[[Category: Alphey, M S.]]
	[[Category: Byres, E.]]		[[Category: Byres, E.]]

OCA: Protected "2hke" [edit=sysop:move=sysop]

OCA — Sat, 02 Jun 2012 09:17:29 GMT

Protected "2hke" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:17, 2 June 2012