2i1e - Revision history

OCA at 12:37, 10 January 2024

OCA — Wed, 10 Jan 2024 12:37:36 GMT

←Older revision		Revision as of 12:37, 10 January 2024
Line 1:		Line 1:

	==DPC micelle-bound NMR structures of Tritrp2==		==DPC micelle-bound NMR structures of Tritrp2==
-	<StructureSection load='2i1e' size='340' side='right'caption='[[2i1e~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2i1e' size='340' side='right'caption='[[2i1e]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i1e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i1e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1E FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2i1d\|2i1d]], [[2i1f\|2i1f]], [[2i1g\|2i1g]], [[2i1h\|2i1h]], [[2i1i\|2i1i]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1e OCA], [https://pdbe.org/2i1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1e RCSB], [https://www.ebi.ac.uk/pdbsum/2i1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1e OCA], [https://pdbe.org/2i1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1e RCSB], [https://www.ebi.ac.uk/pdbsum/2i1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1e ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Nguyen, L T~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Schibli, D J~~]]	+	[[Category: Nguyen LT]]
-	[[Category: ~~Antimicrobial peptide]]~~	+	[[Category: Schibli DJ]]
-	~~[[Category: Antimicrobial protein]]~~	+
-	~~[[Category: Micelle-bound peptide]]~~	+
-	~~[[Category: Turn~~]]	+

OCA at 10:55, 6 April 2022

OCA — Wed, 06 Apr 2022 10:55:06 GMT

←Older revision		Revision as of 10:55, 6 April 2022
Line 3:		Line 3:
	<StructureSection load='2i1e' size='340' side='right'caption='[[2i1e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2i1e' size='340' side='right'caption='[[2i1e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i1e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2I1E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i1e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1E FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i1d\|2i1d]], [[2i1f\|2i1f]], [[2i1g\|2i1g]], [[2i1h\|2i1h]], [[2i1i\|2i1i]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2i1d\|2i1d]], [[2i1f\|2i1f]], [[2i1g\|2i1g]], [[2i1h\|2i1h]], [[2i1i\|2i1i]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2i1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1e OCA], [~~http~~://pdbe.org/2i1e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2i1e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2i1e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1e ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1e OCA], [https://pdbe.org/2i1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1e RCSB], [https://www.ebi.ac.uk/pdbsum/2i1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1e ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:41, 8 April 2020

OCA — Wed, 08 Apr 2020 07:41:12 GMT

←Older revision		Revision as of 07:41, 8 April 2020
Line 1:		Line 1:

	==DPC micelle-bound NMR structures of Tritrp2==		==DPC micelle-bound NMR structures of Tritrp2==
-	<StructureSection load='2i1e' size='340' side='right' caption='[[2i1e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2i1e' size='340' side='right'caption='[[2i1e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i1e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1E OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2I1E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i1e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2I1E FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i1d\|2i1d]], [[2i1f\|2i1f]], [[2i1g\|2i1g]], [[2i1h\|2i1h]], [[2i1i\|2i1i]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i1d\|2i1d]], [[2i1f\|2i1f]], [[2i1g\|2i1g]], [[2i1h\|2i1h]], [[2i1i\|2i1i]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2i1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1e OCA], [http://pdbe.org/2i1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i1e RCSB], [http://www.ebi.ac.uk/pdbsum/2i1e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1e ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2i1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1e OCA], [http://pdbe.org/2i1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i1e RCSB], [http://www.ebi.ac.uk/pdbsum/2i1e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1e ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Nguyen, L T]]		[[Category: Nguyen, L T]]
	[[Category: Schibli, D J]]		[[Category: Schibli, D J]]

OCA at 08:19, 4 July 2018

OCA — Wed, 04 Jul 2018 08:19:38 GMT

←Older revision		Revision as of 08:19, 4 July 2018
Line 1:		Line 1:
		+
	==DPC micelle-bound NMR structures of Tritrp2==		==DPC micelle-bound NMR structures of Tritrp2==
	<StructureSection load='2i1e' size='340' side='right' caption='[[2i1e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2i1e' size='340' side='right' caption='[[2i1e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i1d\|2i1d]], [[2i1f\|2i1f]], [[2i1g\|2i1g]], [[2i1h\|2i1h]], [[2i1i\|2i1i]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i1d\|2i1d]], [[2i1f\|2i1f]], [[2i1g\|2i1g]], [[2i1h\|2i1h]], [[2i1i\|2i1i]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1e OCA], [http://pdbe.org/2i1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i1e RCSB], [http://www.ebi.ac.uk/pdbsum/2i1e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1e OCA], [http://pdbe.org/2i1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i1e RCSB], [http://www.ebi.ac.uk/pdbsum/2i1e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1e ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:51, 11 September 2015

OCA — Fri, 11 Sep 2015 07:51:13 GMT

←Older revision		Revision as of 07:51, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i1d\|2i1d]], [[2i1f\|2i1f]], [[2i1g\|2i1g]], [[2i1h\|2i1h]], [[2i1i\|2i1i]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i1d\|2i1d]], [[2i1f\|2i1f]], [[2i1g\|2i1g]], [[2i1h\|2i1h]], [[2i1i\|2i1i]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i1e RCSB], [http://www.ebi.ac.uk/pdbsum/2i1e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1e OCA], [http://pdbe.org/2i1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i1e RCSB], [http://www.ebi.ac.uk/pdbsum/2i1e PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2i1e" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:35, 22 December 2014

OCA — Mon, 22 Dec 2014 05:35:22 GMT

←Older revision		Revision as of 05:35, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2i1e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2i1e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1E FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i1d\|2i1d]], [[2i1f\|2i1f]], [[2i1g\|2i1g]], [[2i1h\|2i1h]], [[2i1i\|2i1i]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i1d\|2i1d]], [[2i1f\|2i1f]], [[2i1g\|2i1g]], [[2i1h\|2i1h]], [[2i1i\|2i1i]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i1e RCSB], [http://www.ebi.ac.uk/pdbsum/2i1e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i1e RCSB], [http://www.ebi.ac.uk/pdbsum/2i1e PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Nguyen, L T.]]	+	[[Category: Nguyen, L T]]
-	[[Category: Schibli, D J.]]	+	[[Category: Schibli, D J]]
	[[Category: Antimicrobial peptide]]		[[Category: Antimicrobial peptide]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]
	[[Category: Micelle-bound peptide]]		[[Category: Micelle-bound peptide]]
	[[Category: Turn]]		[[Category: Turn]]

OCA at 07:01, 9 June 2014

OCA — Mon, 09 Jun 2014 07:01:56 GMT

←Older revision		Revision as of 07:01, 9 June 2014
Line 1:		Line 1:
-	[[~~Image:~~2i1e.~~png~~\|~~left~~\|~~200px~~]]	+	==DPC micelle-bound NMR structures of Tritrp2==
		+	<StructureSection load='2i1e' size='340' side='right' caption='[[2i1e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2i1e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1E FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i1d\|2i1d]], [[2i1f\|2i1f]], [[2i1g\|2i1g]], [[2i1h\|2i1h]], [[2i1i\|2i1i]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i1e RCSB], [http://www.ebi.ac.uk/pdbsum/2i1e PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tritrpticin is a member of the cathelicidin family of antimicrobial peptides. Starting from its native sequence (VRRFPWWWPFLRR), eight synthetic peptide analogs were studied to investigate the roles of specific residues in its biological and structural properties. This included amidation of the C-terminus paired with substitutions of its cationic and Phe residues, as well as the Pro residues that are important for its two-turn micelle-bound structure. These analogs were determined to have a significant antimicrobial potency. In contrast, two other peptide analogs, those with the three Trp residues substituted with either Phe or Tyr residues are not highly membrane perturbing, as determined by leakage and flip-flop assays using fluorescence spectroscopy. Nevertheless the Phe analog has a high activity; this suggests an intracellular mechanism for antimicrobial activity that may be part of the overall mechanism of action of native tritrpticin as a complement to membrane perturbation. NMR experiments of these two Trp-substituted peptides showed the presence of multiple conformers. The structures of the six remaining Trp-containing analogs bound to dodecylphosphocholine micelles showed major, well-defined conformations. These peptides are membrane disruptive and show a wide range in hemolytic activity. Their micelle-bound structures either retain the typical turn-turn structure of native tritrpticin or have an extended alpha-helix. This work demonstrates that closely related antimicrobial peptides can often have remarkably altered properties with complex influences on their biological activities.

-	~~{{STRUCTURE_2i1e\| PDB=2i1e \| SCENE= }}~~	+	Structure-function analysis of tritrpticin analogs: potential relationships between antimicrobial activities, model membrane interactions, and their micelle-bound NMR structures.,Schibli DJ, Nguyen LT, Kernaghan SD, Rekdal O, Vogel HJ Biophys J. 2006 Dec 15;91(12):4413-26. Epub 2006 Sep 22. PMID:16997878<ref>PMID:16997878</ref>

-	~~===DPC micelle-bound NMR structures~~ of ~~Tritrp2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16997878}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2i1e]] is a 1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2I1E OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016997878<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Nguyen, L T.]]		[[Category: Nguyen, L T.]]
	[[Category: Schibli, D J.]]		[[Category: Schibli, D J.]]

OCA: Protected "2i1e" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 15:53:23 GMT

Protected "2i1e" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:53, 14 August 2012

OCA at 15:53, 14 August 2012

OCA — Tue, 14 Aug 2012 15:53:21 GMT

←Older revision		Revision as of 15:53, 14 August 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2i1e.png\|left\|200px]]		[[Image:2i1e.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2i1e", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2i1e\| PDB=2i1e \| SCENE= }}		{{STRUCTURE_2i1e\| PDB=2i1e \| SCENE= }}

	===DPC micelle-bound NMR structures of Tritrp2===		===DPC micelle-bound NMR structures of Tritrp2===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16997878}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16997878 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16997878}}		{{ABSTRACT_PUBMED_16997878}}

	==About this Structure==		==About this Structure==
-	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1E OCA].	+	[[2i1e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1E OCA].

	==Reference==		==Reference==
-	Structure-function analysis of tritrpticin analogs: potential relationships between antimicrobial activities, model membrane interactions, and their micelle-bound NMR structures., Schibli DJ, Nguyen LT, Kernaghan SD, Rekdal O, Vogel HJ, Biophys J. 2006 Dec 15;91(12):4413-26. Epub 2006 Sep 22. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~16997878 16997878]~~	+	<ref group="xtra">PMID:016997878</ref><references group="xtra"/>
	[[Category: Nguyen, L T.]]		[[Category: Nguyen, L T.]]
	[[Category: Schibli, D J.]]		[[Category: Schibli, D J.]]
	[[Category: Antimicrobial peptide]]		[[Category: Antimicrobial peptide]]
		+	[[Category: Antimicrobial protein]]
	[[Category: Micelle-bound peptide]]		[[Category: Micelle-bound peptide]]
	[[Category: Turn]]		[[Category: Turn]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:24:04 2008''

OCA at 21:24, 28 July 2008

OCA — Mon, 28 Jul 2008 21:24:06 GMT

←Older revision		Revision as of 21:24, 28 July 2008
Line 1:		Line 1:
-	[[Image:2i1e.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2i1e.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2i1e\| PDB=2i1e \| SCENE= }}		{{STRUCTURE_2i1e\| PDB=2i1e \| SCENE= }}

-	~~'''~~DPC micelle-bound NMR structures of Tritrp2~~'''~~	+	===DPC micelle-bound NMR structures of Tritrp2===


-	~~==Overview==~~	+	<!--
-	~~Tritrpticin is a member of the cathelicidin family of antimicrobial peptides. Starting from its native sequence (VRRFPWWWPFLRR)~~, eight synthetic peptide analogs were studied to investigate the roles of specific residues in its biological and structural properties. This included amidation of the C-terminus paired with substitutions of its cationic and Phe residues, ~~as well as~~ the ~~Pro residues that are important for its two-turn micelle-bound structure. These analogs were determined~~ to ~~have a significant antimicrobial potency. In contrast, two other peptide analogs, those with~~ the ~~three Trp residues substituted with either Phe or Tyr residues are not highly membrane perturbing,~~ as ~~determined by leakage and flip-flop assays using fluorescence spectroscopy~~. Nevertheless the Phe analog has a high activity; this suggests an intracellular mechanism for antimicrobial activity that may be part of the overall mechanism of action of native tritrpticin as a complement to membrane perturbation. ~~NMR experiments of these two Trp-substituted peptides showed~~ the ~~presence of multiple conformers~~. ~~The structures of the six remaining Trp~~-~~containing analogs bound to dodecylphosphocholine micelles showed major, well~~-defined conformations. These peptides are membrane disruptive and show a wide range in hemolytic activity. Their micelle-bound structures either retain the typical turn-turn structure of native tritrpticin or have an extended alpha-helix. This work demonstrates that closely related antimicrobial peptides can often have remarkably altered properties with complex influences on their biological activities.	+	The line below this paragraph, {{ABSTRACT_PUBMED_16997878}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16997878 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16997878}}

	==About this Structure==		==About this Structure==
-	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1E OCA].	+	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1E OCA].

	==Reference==		==Reference==
Line 25:		Line 29:
	[[Category: Micelle-bound peptide]]		[[Category: Micelle-bound peptide]]
	[[Category: Turn]]		[[Category: Turn]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 06~~:57:34 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:24:04 2008''