2i1k - Revision history

OCA at 09:01, 21 February 2024

OCA — Wed, 21 Feb 2024 09:01:11 GMT

←Older revision		Revision as of 09:01, 21 February 2024
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	<StructureSection load='2i1k' size='340' side='right'caption='[[2i1k]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2i1k' size='340' side='right'caption='[[2i1k]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i1k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Fall_armyworm Fall armyworm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i1k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1K FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height~~: ~~3em;~~'>~~[[1isn\|1isn]]~~, ~~[[1j19\|1j19]], [[1e5w\|1e5w]], [[1sgh\|1sgh]], [[1ef1\|1ef1]], [[1gc6\|1gc6]], [[2i1j\|2i1j]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1k OCA], [https://pdbe.org/2i1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1k RCSB], [https://www.ebi.ac.uk/pdbsum/2i1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1k OCA], [https://pdbe.org/2i1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1k RCSB], [https://www.ebi.ac.uk/pdbsum/2i1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1k ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0T1L9_SPOFR A0T1L9_SPOFR]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i1k ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i1k ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Ezrin/radixin/moesin (ERM) family members provide a regulated link between the cortical actin cytoskeleton and the plasma membrane to govern membrane structure and organization. Here, we report the crystal structure of intact insect moesin, revealing that its essential yet previously uncharacterized alpha-helical domain forms extensive interactions with conserved surfaces of the band four-point-one/ezrin/radixin/moesin (FERM) domain. These interdomain contacts provide a functional explanation for how PIP(2) binding and tyrosine phosphorylation of ezrin lead to activation, and provide an understanding of previously enigmatic loss-of-function missense mutations in the tumor suppressor merlin. Sequence conservation and biochemical results indicate that this structure represents a complete model for the closed state of all ERM-merlin proteins, wherein the central alpha-helical domain is an active participant in an extensive set of inhibitory interactions that can be unmasked, in a rheostat-like manner, by coincident regulatory factors that help determine cell polarity and membrane structure.
-
-	Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain.,Li Q, Nance MR, Kulikauskas R, Nyberg K, Fehon R, Karplus PA, Bretscher A, Tesmer JJ J Mol Biol. 2007 Feb 2;365(5):1446-59. Epub 2006 Oct 26. PMID:17134719<ref>PMID:17134719</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2i1k" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Moesin\|Moesin]]		*[[Moesin\|Moesin]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Fall armyworm]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Nance, M R~~]]	+	[[Category: Spodoptera frugiperda]]
-	[[Category: ~~Tesmer, J J.G~~]]	+	[[Category: Nance MR]]
-	[[Category: ~~Actin binding]]~~	+	[[Category: Tesmer JJG]]
-	~~[[Category: C-ermad]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Coiled-coil]]~~	+
-	~~[[Category: Erm]]~~	+
-	~~[[Category: Ezrin]]~~	+
-	~~[[Category: Ferm]]~~	+
-	~~[[Category: Masking]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Merlin]]~~	+
-	~~[[Category: Moesin]]~~	+
-	~~[[Category: Radixin]]~~	+
-	~~[[Category: Regulation]]~~	+
-	~~[[Category: Self-inhibition~~]]	+

OCA at 10:04, 12 May 2021

OCA — Wed, 12 May 2021 10:04:10 GMT

←Older revision		Revision as of 10:04, 12 May 2021
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	<StructureSection load='2i1k' size='340' side='right'caption='[[2i1k]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2i1k' size='340' side='right'caption='[[2i1k]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i1k]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Fall_armyworm Fall armyworm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2I1K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i1k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fall_armyworm Fall armyworm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1isn\|1isn]], [[1j19\|1j19]], [[1e5w\|1e5w]], [[1sgh\|1sgh]], [[1ef1\|1ef1]], [[1gc6\|1gc6]], [[2i1j\|2i1j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1isn\|1isn]], [[1j19\|1j19]], [[1e5w\|1e5w]], [[1sgh\|1sgh]], [[1ef1\|1ef1]], [[1gc6\|1gc6]], [[2i1j\|2i1j]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2i1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1k OCA], [~~http~~://pdbe.org/2i1k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2i1k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2i1k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1k OCA], [https://pdbe.org/2i1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1k RCSB], [https://www.ebi.ac.uk/pdbsum/2i1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1k ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 2i1k" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2i1k" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Moesin\|Moesin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:04, 24 July 2019

OCA — Wed, 24 Jul 2019 09:04:12 GMT

←Older revision		Revision as of 09:04, 24 July 2019
Line 1:		Line 1:

	==Moesin from Spodoptera frugiperda reveals the coiled-coil domain at 3.0 angstrom resolution==		==Moesin from Spodoptera frugiperda reveals the coiled-coil domain at 3.0 angstrom resolution==
-	<StructureSection load='2i1k' size='340' side='right' caption='[[2i1k]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='2i1k' size='340' side='right'caption='[[2i1k]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2i1k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fall_armyworm Fall armyworm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1K FirstGlance]. <br>		<table><tr><td colspan='2'>[[2i1k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fall_armyworm Fall armyworm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1K FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i1k_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i1k_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Fall armyworm]]		[[Category: Fall armyworm]]
		+	[[Category: Large Structures]]
	[[Category: Nance, M R]]		[[Category: Nance, M R]]
	[[Category: Tesmer, J J.G]]		[[Category: Tesmer, J J.G]]

OCA at 08:21, 18 October 2017

OCA — Wed, 18 Oct 2017 08:21:37 GMT

←Older revision		Revision as of 08:21, 18 October 2017
Line 1:		Line 1:
		+
	==Moesin from Spodoptera frugiperda reveals the coiled-coil domain at 3.0 angstrom resolution==		==Moesin from Spodoptera frugiperda reveals the coiled-coil domain at 3.0 angstrom resolution==
	<StructureSection load='2i1k' size='340' side='right' caption='[[2i1k]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2i1k' size='340' side='right' caption='[[2i1k]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i1k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Spodoptera_frugiperda Spodoptera frugiperda~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i1k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fall_armyworm Fall armyworm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1isn\|1isn]], [[1j19\|1j19]], [[1e5w\|1e5w]], [[1sgh\|1sgh]], [[1ef1\|1ef1]], [[1gc6\|1gc6]], [[2i1j\|2i1j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1isn\|1isn]], [[1j19\|1j19]], [[1e5w\|1e5w]], [[1sgh\|1sgh]], [[1ef1\|1ef1]], [[1gc6\|1gc6]], [[2i1j\|2i1j]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1k OCA], [http://pdbe.org/2i1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i1k RCSB], [http://www.ebi.ac.uk/pdbsum/2i1k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1k OCA], [http://pdbe.org/2i1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i1k RCSB], [http://www.ebi.ac.uk/pdbsum/2i1k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1k ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Spodoptera frugiperda~~]]	+	[[Category: Fall armyworm]]
	[[Category: Nance, M R]]		[[Category: Nance, M R]]
	[[Category: Tesmer, J J.G]]		[[Category: Tesmer, J J.G]]

OCA at 18:04, 8 February 2016

OCA — Mon, 08 Feb 2016 18:04:39 GMT

←Older revision		Revision as of 18:04, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i1k ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:04, 10 September 2015

OCA — Thu, 10 Sep 2015 14:04:59 GMT

←Older revision		Revision as of 14:04, 10 September 2015
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1isn\|1isn]], [[1j19\|1j19]], [[1e5w\|1e5w]], [[1sgh\|1sgh]], [[1ef1\|1ef1]], [[1gc6\|1gc6]], [[2i1j\|2i1j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1isn\|1isn]], [[1j19\|1j19]], [[1e5w\|1e5w]], [[1sgh\|1sgh]], [[1ef1\|1ef1]], [[1gc6\|1gc6]], [[2i1j\|2i1j]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i1k RCSB], [http://www.ebi.ac.uk/pdbsum/2i1k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1k OCA], [http://pdbe.org/2i1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i1k RCSB], [http://www.ebi.ac.uk/pdbsum/2i1k PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2i1k" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:56, 16 January 2015

OCA — Fri, 16 Jan 2015 08:56:16 GMT

←Older revision		Revision as of 08:56, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2i1k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1K FirstGlance]. <br>		<table><tr><td colspan='2'>[[2i1k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1K FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1isn\|1isn]], [[1j19\|1j19]], [[1e5w\|1e5w]], [[1sgh\|1sgh]], [[1ef1\|1ef1]], [[1gc6\|1gc6]], [[2i1j\|2i1j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1isn\|1isn]], [[1j19\|1j19]], [[1e5w\|1e5w]], [[1sgh\|1sgh]], [[1ef1\|1ef1]], [[1gc6\|1gc6]], [[2i1j\|2i1j]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i1k RCSB], [http://www.ebi.ac.uk/pdbsum/2i1k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i1k RCSB], [http://www.ebi.ac.uk/pdbsum/2i1k PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Spodoptera frugiperda]]		[[Category: Spodoptera frugiperda]]
-	[[Category: Nance, M R.]]	+	[[Category: Nance, M R]]
-	[[Category: Tesmer, J J.G.]]	+	[[Category: Tesmer, J J.G]]
	[[Category: Actin binding]]		[[Category: Actin binding]]
	[[Category: C-ermad]]		[[Category: C-ermad]]

OCA at 08:33, 30 September 2014

OCA — Tue, 30 Sep 2014 08:33:43 GMT

←Older revision		Revision as of 08:33, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2i1k.~~png~~\|~~left~~\|200px]]	+	==Moesin from Spodoptera frugiperda reveals the coiled-coil domain at 3.0 angstrom resolution==
		+	<StructureSection load='2i1k' size='340' side='right' caption='[[2i1k]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2i1k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1K FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1isn\|1isn]], [[1j19\|1j19]], [[1e5w\|1e5w]], [[1sgh\|1sgh]], [[1ef1\|1ef1]], [[1gc6\|1gc6]], [[2i1j\|2i1j]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i1k RCSB], [http://www.ebi.ac.uk/pdbsum/2i1k PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i1k_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ezrin/radixin/moesin (ERM) family members provide a regulated link between the cortical actin cytoskeleton and the plasma membrane to govern membrane structure and organization. Here, we report the crystal structure of intact insect moesin, revealing that its essential yet previously uncharacterized alpha-helical domain forms extensive interactions with conserved surfaces of the band four-point-one/ezrin/radixin/moesin (FERM) domain. These interdomain contacts provide a functional explanation for how PIP(2) binding and tyrosine phosphorylation of ezrin lead to activation, and provide an understanding of previously enigmatic loss-of-function missense mutations in the tumor suppressor merlin. Sequence conservation and biochemical results indicate that this structure represents a complete model for the closed state of all ERM-merlin proteins, wherein the central alpha-helical domain is an active participant in an extensive set of inhibitory interactions that can be unmasked, in a rheostat-like manner, by coincident regulatory factors that help determine cell polarity and membrane structure.

-	~~{{STRUCTURE_2i1k\| PDB=2i1k \| SCENE= }}~~	+	Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain.,Li Q, Nance MR, Kulikauskas R, Nyberg K, Fehon R, Karplus PA, Bretscher A, Tesmer JJ J Mol Biol. 2007 Feb 2;365(5):1446-59. Epub 2006 Oct 26. PMID:17134719<ref>PMID:17134719</ref>

-	~~===Moesin from Spodoptera frugiperda reveals~~ the ~~coiled-coil domain at 3~~.~~0 angstrom resolution===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17134719}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2i1k]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1K OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017134719<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Spodoptera frugiperda]]		[[Category: Spodoptera frugiperda]]
	[[Category: Nance, M R.]]		[[Category: Nance, M R.]]

OCA: Protected "2i1k" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 13:33:31 GMT

Protected "2i1k" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:33, 7 January 2013

OCA at 13:33, 7 January 2013

OCA — Mon, 07 Jan 2013 13:33:29 GMT

←Older revision		Revision as of 13:33, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2i1k.png\|left\|200px]]		[[Image:2i1k.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2i1k", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2i1k\| PDB=2i1k \| SCENE= }}		{{STRUCTURE_2i1k\| PDB=2i1k \| SCENE= }}

	===Moesin from Spodoptera frugiperda reveals the coiled-coil domain at 3.0 angstrom resolution===		===Moesin from Spodoptera frugiperda reveals the coiled-coil domain at 3.0 angstrom resolution===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17134719}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17134719 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17134719}}		{{ABSTRACT_PUBMED_17134719}}

	==About this Structure==		==About this Structure==
-	~~2I1K~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1K OCA].	+	[[2i1k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1K OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17134719~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017134719</ref><references group="xtra"/>
	[[Category: Spodoptera frugiperda]]		[[Category: Spodoptera frugiperda]]
	[[Category: Nance, M R.]]		[[Category: Nance, M R.]]
Line 29:		Line 17:
	[[Category: Actin binding]]		[[Category: Actin binding]]
	[[Category: C-ermad]]		[[Category: C-ermad]]
		+	[[Category: Cell adhesion]]
	[[Category: Coiled-coil]]		[[Category: Coiled-coil]]
	[[Category: Erm]]		[[Category: Erm]]
Line 34:		Line 23:
	[[Category: Ferm]]		[[Category: Ferm]]
	[[Category: Masking]]		[[Category: Masking]]
		+	[[Category: Membrane protein]]
	[[Category: Merlin]]		[[Category: Merlin]]
	[[Category: Moesin]]		[[Category: Moesin]]
Line 39:		Line 29:
	[[Category: Regulation]]		[[Category: Regulation]]
	[[Category: Self-inhibition]]		[[Category: Self-inhibition]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:59:38 2009''