2i1p - Revision history

OCA at 08:27, 14 June 2023

OCA — Wed, 14 Jun 2023 08:27:02 GMT

←Older revision		Revision as of 08:27, 14 June 2023
Line 1:		Line 1:

	==Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin==		==Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin==
-	<StructureSection load='2i1p' size='340' side='right'caption='[[2i1p~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2i1p' size='340' side='right'caption='[[2i1p]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1p OCA], [https://pdbe.org/2i1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1p RCSB], [https://www.ebi.ac.uk/pdbsum/2i1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1p OCA], [https://pdbe.org/2i1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1p RCSB], [https://www.ebi.ac.uk/pdbsum/2i1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LRP2_RAT LRP2_RAT]] Acts together with cubilin to mediate HDL endocytosis (By similarity). Receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B.<ref>PMID:7544804</ref>	+	[https://www.uniprot.org/uniprot/LRP2_RAT LRP2_RAT] Acts together with cubilin to mediate HDL endocytosis (By similarity). Receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B.<ref>PMID:7544804</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bade-Noskova, V]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Dancea, F]]	+	[[Category: Bade-Noskova V]]
-	[[Category: Kerjaschki, D]]	+	[[Category: Dancea F]]
-	[[Category: Luecke, C]]	+	[[Category: Kerjaschki D]]
-	[[Category: Rueterjans, H]]	+	[[Category: Luecke C]]
-	[[Category: Shi, M]]	+	[[Category: Rueterjans H]]
-	[[Category: Wolf~~, C A]]~~	+	[[Category: Shi M]]
-	~~[[Category: Calcium cage]]~~	+	[[Category: Wolf CA]]
-	~~[[Category: Cysteine-rich repeat]]~~	+
-	~~[[Category: Ligand binding domain]]~~	+
-	~~[[Category: Ligand binding protein]]~~	+
-	~~[[Category: Low density lipoprotein receptor~~]]	+

OCA at 13:23, 24 November 2021

OCA — Wed, 24 Nov 2021 13:23:30 GMT

←Older revision		Revision as of 13:23, 24 November 2021
Line 3:		Line 3:
	<StructureSection load='2i1p' size='340' side='right'caption='[[2i1p]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2i1p' size='340' side='right'caption='[[2i1p]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i1p]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2I1P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2i1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1p OCA], [~~http~~://pdbe.org/2i1p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2i1p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2i1p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1p OCA], [https://pdbe.org/2i1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1p RCSB], [https://www.ebi.ac.uk/pdbsum/2i1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LRP2_RAT LRP2_RAT]] Acts together with cubilin to mediate HDL endocytosis (By similarity). Receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B.<ref>PMID:7544804</ref>	+	[[https://www.uniprot.org/uniprot/LRP2_RAT LRP2_RAT]] Acts together with cubilin to mediate HDL endocytosis (By similarity). Receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B.<ref>PMID:7544804</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:47, 19 February 2020

OCA — Wed, 19 Feb 2020 06:47:14 GMT

←Older revision		Revision as of 06:47, 19 February 2020
Line 1:		Line 1:

	==Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin==		==Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin==
-	<StructureSection load='2i1p' size='340' side='right' caption='[[2i1p]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2i1p' size='340' side='right'caption='[[2i1p]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2i1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1P FirstGlance]. <br>		<table><tr><td colspan='2'>[[2i1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1P FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Bade-Noskova, V]]		[[Category: Bade-Noskova, V]]
	[[Category: Dancea, F]]		[[Category: Dancea, F]]

OCA at 07:54, 4 July 2018

OCA — Wed, 04 Jul 2018 07:54:25 GMT

←Older revision		Revision as of 07:54, 4 July 2018
Line 1:		Line 1:
		+
	==Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin==		==Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin==
	<StructureSection load='2i1p' size='340' side='right' caption='[[2i1p]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2i1p' size='340' side='right' caption='[[2i1p]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2i1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1P FirstGlance]. <br>		<table><tr><td colspan='2'>[[2i1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1p OCA], [http://pdbe.org/2i1p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i1p RCSB], [http://www.ebi.ac.uk/pdbsum/2i1p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1p OCA], [http://pdbe.org/2i1p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i1p RCSB], [http://www.ebi.ac.uk/pdbsum/2i1p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i1p_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i1p_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:34, 9 February 2016

OCA — Tue, 09 Feb 2016 05:34:31 GMT

←Older revision		Revision as of 05:34, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i1p ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:07, 10 September 2015

OCA — Thu, 10 Sep 2015 19:07:47 GMT

←Older revision		Revision as of 19:07, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2i1p' size='340' side='right' caption='[[2i1p]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2i1p' size='340' side='right' caption='[[2i1p]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i1p RCSB], [http://www.ebi.ac.uk/pdbsum/2i1p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1p OCA], [http://pdbe.org/2i1p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i1p RCSB], [http://www.ebi.ac.uk/pdbsum/2i1p PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2i1p" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Bade-Noskova, V]]		[[Category: Bade-Noskova, V]]
	[[Category: Dancea, F]]		[[Category: Dancea, F]]

OCA at 04:46, 25 December 2014

OCA — Thu, 25 Dec 2014 04:46:30 GMT

←Older revision		Revision as of 04:46, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2i1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1P FirstGlance]. <br>		<table><tr><td colspan='2'>[[2i1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1P FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i1p RCSB], [http://www.ebi.ac.uk/pdbsum/2i1p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i1p RCSB], [http://www.ebi.ac.uk/pdbsum/2i1p PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LRP2_RAT LRP2_RAT]] Acts together with cubilin to mediate HDL endocytosis (By similarity). Receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B.<ref>PMID:7544804</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Bade-Noskova, V.]]	+	[[Category: Bade-Noskova, V]]
-	[[Category: Dancea, F.]]	+	[[Category: Dancea, F]]
-	[[Category: Kerjaschki, D.]]	+	[[Category: Kerjaschki, D]]
-	[[Category: Luecke, C.]]	+	[[Category: Luecke, C]]
-	[[Category: Rueterjans, H.]]	+	[[Category: Rueterjans, H]]
-	[[Category: Shi, M.]]	+	[[Category: Shi, M]]
-	[[Category: Wolf, C A.]]	+	[[Category: Wolf, C A]]
	[[Category: Calcium cage]]		[[Category: Calcium cage]]
	[[Category: Cysteine-rich repeat]]		[[Category: Cysteine-rich repeat]]

OCA at 07:41, 30 September 2014

OCA — Tue, 30 Sep 2014 07:41:58 GMT

←Older revision		Revision as of 07:41, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2i1p.~~png\|left~~\|200px]]	+	==Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin==
		+	<StructureSection load='2i1p' size='340' side='right' caption='[[2i1p]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2i1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1P FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i1p RCSB], [http://www.ebi.ac.uk/pdbsum/2i1p PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i1p_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Megalin, an approx. 600 kDa transmembrane glycoprotein that acts as multi-ligand transporter, is a member of the low density lipoprotein receptor gene family. Several cysteine-rich repeats, each consisting of about 40 residues, are responsible for the multispecific binding of ligands. The solution structure of the twelfth cysteine-rich ligand-binding repeat with class A motif found in megalin features two short beta-strands and two helical turns, yielding the typical fold with a I-III, II-V and IV-VI disulfide bridge connectivity pattern and a calcium coordination site at the C-terminal end. The resulting differences in electrostatic surface potential compared to other ligand-binding modules of this gene family, however, may be responsible for the functional divergence.

-	~~{{STRUCTURE_2i1p\| PDB=2i1p \| SCENE= }}~~	+	Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin.,Wolf CA, Dancea F, Shi M, Bade-Noskova V, Ruterjans H, Kerjaschki D, Lucke C J Biomol NMR. 2007 Apr;37(4):321-8. Epub 2007 Jan 24. PMID:17245526<ref>PMID:17245526</ref>

-	~~===Solution structure~~ of the ~~twelfth cysteine-rich ligand-binding repeat in rat megalin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17245526}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2i1p]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017245526<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Bade-Noskova, V.]]		[[Category: Bade-Noskova, V.]]

OCA: Protected "2i1p" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 12:51:14 GMT

Protected "2i1p" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:51, 7 January 2013

OCA at 12:51, 7 January 2013

OCA — Mon, 07 Jan 2013 12:51:11 GMT

←Older revision		Revision as of 12:51, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2i1p.png\|left\|200px]]		[[Image:2i1p.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2i1p", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2i1p\| PDB=2i1p \| SCENE= }}		{{STRUCTURE_2i1p\| PDB=2i1p \| SCENE= }}

	===Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin===		===Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17245526}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17245526 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17245526}}		{{ABSTRACT_PUBMED_17245526}}

	==About this Structure==		==About this Structure==
-	~~2I1P~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA].	+	[[2i1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17245526~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017245526</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Bade-Noskova, V.]]		[[Category: Bade-Noskova, V.]]
Line 35:		Line 23:
	[[Category: Cysteine-rich repeat]]		[[Category: Cysteine-rich repeat]]
	[[Category: Ligand binding domain]]		[[Category: Ligand binding domain]]
		+	[[Category: Ligand binding protein]]
	[[Category: Low density lipoprotein receptor]]		[[Category: Low density lipoprotein receptor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:52:53 2009''