2i38 - Revision history

OCA at 19:03, 29 May 2024

OCA — Wed, 29 May 2024 19:03:36 GMT

←Older revision		Revision as of 19:03, 29 May 2024
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	==Solution structure of the RRM of SRp20==		==Solution structure of the RRM of SRp20==
-	<StructureSection load='2i38' size='340' side='right'caption='[[2i38~~]], [[NMR_Ensembles_of_Models \| 19 NMR models~~]]' scene=''>	+	<StructureSection load='2i38' size='340' side='right'caption='[[2i38]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i38]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I38 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i38]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I38 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2i2y\|2i2y]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i38 OCA], [https://pdbe.org/2i38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i38 RCSB], [https://www.ebi.ac.uk/pdbsum/2i38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i38 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i38 OCA], [https://pdbe.org/2i38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i38 RCSB], [https://www.ebi.ac.uk/pdbsum/2i38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i38 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SRSF3_HUMAN SRSF3_HUMAN] Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).<ref>PMID:11336712</ref> <ref>PMID:17036044</ref> <ref>PMID:18364396</ref> <ref>PMID:26876937</ref> <ref>PMID:28984244</ref> <ref>PMID:32440474</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Allain~~, F H.T~~]]	+	[[Category: Allain FHT]]
-	[[Category: Hargous~~, Y F]]~~	+	[[Category: Hargous YF]]
-	~~[[Category: Alpha-beta sandwich]]~~	+
-	~~[[Category: Beta1-alpha1-beta2-beta3-alpha2-beta4]]~~	+
-	~~[[Category: Rna binding protein-chimera complex]]~~	+
-	~~[[Category: Rrm~~]]	+

OCA at 07:26, 24 March 2021

OCA — Wed, 24 Mar 2021 07:26:55 GMT

←Older revision		Revision as of 07:26, 24 March 2021
Line 1:		Line 1:

	==Solution structure of the RRM of SRp20==		==Solution structure of the RRM of SRp20==
-	<StructureSection load='2i38' size='340' side='right' caption='[[2i38]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>	+	<StructureSection load='2i38' size='340' side='right'caption='[[2i38]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i38]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2I38 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i38]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I38 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i2y\|2i2y]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2i2y\|2i2y]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2i38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i38 OCA], [~~http~~://pdbe.org/2i38 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2i38 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2i38 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2i38 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i38 OCA], [https://pdbe.org/2i38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i38 RCSB], [https://www.ebi.ac.uk/pdbsum/2i38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i38 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 2i38" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2i38" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Pre-mRNA splicing factors 3D structures\|Pre-mRNA splicing factors 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]
	[[Category: Hargous, Y F]]		[[Category: Hargous, Y F]]

OCA at 06:38, 31 January 2018

OCA — Wed, 31 Jan 2018 06:38:53 GMT

←Older revision		Revision as of 06:38, 31 January 2018
Line 1:		Line 1:
		+
	==Solution structure of the RRM of SRp20==		==Solution structure of the RRM of SRp20==
	<StructureSection load='2i38' size='340' side='right' caption='[[2i38]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>		<StructureSection load='2i38' size='340' side='right' caption='[[2i38]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i2y\|2i2y]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i2y\|2i2y]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i38 OCA], [http://pdbe.org/2i38 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i38 RCSB], [http://www.ebi.ac.uk/pdbsum/2i38 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i38 OCA], [http://pdbe.org/2i38 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i38 RCSB], [http://www.ebi.ac.uk/pdbsum/2i38 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i38 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i3/2i38_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i3/2i38_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i38 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 2i38" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2i38" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:42, 12 September 2015

OCA — Sat, 12 Sep 2015 02:42:15 GMT

←Older revision		Revision as of 02:42, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2i38' size='340' side='right' caption='[[2i38]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>		<StructureSection load='2i38' size='340' side='right' caption='[[2i38]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i38]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I38 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i38]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I38 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i2y\|2i2y]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i2y\|2i2y]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i38 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i38 RCSB], [http://www.ebi.ac.uk/pdbsum/2i38 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i38 OCA], [http://pdbe.org/2i38 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i38 RCSB], [http://www.ebi.ac.uk/pdbsum/2i38 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2i38" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]
	[[Category: Hargous, Y F]]		[[Category: Hargous, Y F]]

OCA at 09:32, 16 January 2015

OCA — Fri, 16 Jan 2015 09:32:43 GMT

←Older revision		Revision as of 09:32, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2i38]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I38 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2i38]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I38 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i2y\|2i2y]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i2y\|2i2y]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i38 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i38 RCSB], [http://www.ebi.ac.uk/pdbsum/2i38 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i38 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i38 RCSB], [http://www.ebi.ac.uk/pdbsum/2i38 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]
-	[[Category: Hargous, Y F.]]	+	[[Category: Hargous, Y F]]
	[[Category: Alpha-beta sandwich]]		[[Category: Alpha-beta sandwich]]
	[[Category: Beta1-alpha1-beta2-beta3-alpha2-beta4]]		[[Category: Beta1-alpha1-beta2-beta3-alpha2-beta4]]
	[[Category: Rna binding protein-chimera complex]]		[[Category: Rna binding protein-chimera complex]]
	[[Category: Rrm]]		[[Category: Rrm]]

OCA at 10:32, 29 September 2014

OCA — Mon, 29 Sep 2014 10:32:31 GMT

←Older revision		Revision as of 10:32, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2i38.~~png~~\|~~left~~\|200px]]	+	==Solution structure of the RRM of SRp20==
		+	<StructureSection load='2i38' size='340' side='right' caption='[[2i38]], [[NMR_Ensembles_of_Models \| 19 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2i38]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I38 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i2y\|2i2y]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i38 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i38 RCSB], [http://www.ebi.ac.uk/pdbsum/2i38 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i3/2i38_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The sequence-specific RNA-binding proteins SRp20 and 9G8 are the smallest members of the serine- and arginine-rich (SR) protein family, well known for their role in splicing. They also play a role in mRNA export, in particular of histone mRNAs. We present the solution structures of the free 9G8 and SRp20 RNA recognition motifs (RRMs) and of SRp20 RRM in complex with the RNA sequence 5'CAUC3'. The SRp20-RNA structure reveals that although all 4 nt are contacted by the RRM, only the 5' cytosine is primarily recognized in a specific way. This might explain the numerous consensus sequences found by SELEX (systematic evolution of ligands by exponential enrichment) for the RRM of 9G8 and SRp20. Furthermore, we identify a short arginine-rich peptide adjacent to the SRp20 and 9G8 RRMs, which does not contact RNA but is necessary and sufficient for interaction with the export factor Tip-associated protein (TAP). Together, these results provide a molecular description for mRNA and TAP recognition by SRp20 and 9G8.

-	~~{{STRUCTURE_2i38\| PDB=2i38 \| SCENE= }}~~	+	Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8.,Hargous Y, Hautbergue GM, Tintaru AM, Skrisovska L, Golovanov AP, Stevenin J, Lian LY, Wilson SA, Allain FH EMBO J. 2006 Nov 1;25(21):5126-37. Epub 2006 Oct 12. PMID:17036044<ref>PMID:17036044</ref>

-	~~===Solution structure~~ of the ~~RRM of SRp20===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17036044}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2i38]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA].~~	+

	==See Also==		==See Also==
	*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]		*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017036044<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]

OCA at 22:36, 20 October 2012

OCA — Sat, 20 Oct 2012 22:36:21 GMT

←Older revision		Revision as of 22:36, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2i38]] is a 1 chain structure ~~of [[Pre-mRNA-splicing factor]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA].	+	[[2i38]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA].

	==See Also==		==See Also==

OCA: Protected "2i38" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 16:52:45 GMT

Protected "2i38" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:52, 27 July 2012

OCA at 16:52, 27 July 2012

OCA — Fri, 27 Jul 2012 16:52:44 GMT

←Older revision		Revision as of 16:52, 27 July 2012
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-	{{Seed}}
	[[Image:2i38.png\|left\|200px]]		[[Image:2i38.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2i38", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2i38\| PDB=2i38 \| SCENE= }}		{{STRUCTURE_2i38\| PDB=2i38 \| SCENE= }}

	===Solution structure of the RRM of SRp20===		===Solution structure of the RRM of SRp20===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17036044}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17036044 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17036044}}		{{ABSTRACT_PUBMED_17036044}}

	==About this Structure==		==About this Structure==
-	~~2I38~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA].	+	[[2i38]] is a 1 chain structure of [[Pre-mRNA-splicing factor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA].
		+
		+	==See Also==
		+	*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17036044~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017036044</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]
Line 29:		Line 20:
	[[Category: Alpha-beta sandwich]]		[[Category: Alpha-beta sandwich]]
	[[Category: Beta1-alpha1-beta2-beta3-alpha2-beta4]]		[[Category: Beta1-alpha1-beta2-beta3-alpha2-beta4]]
		+	[[Category: Rna binding protein-chimera complex]]
	[[Category: Rrm]]		[[Category: Rrm]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:12:20 2009''

OCA at 08:12, 18 February 2009

OCA — Wed, 18 Feb 2009 08:12:21 GMT

←Older revision		Revision as of 08:12, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2I38 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA].	+	2I38 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I38 OCA].

	==Reference==		==Reference==
-	Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8., Hargous Y, Hautbergue GM, Tintaru AM, Skrisovska L, Golovanov AP, Stevenin J, Lian LY, Wilson SA, Allain FH, EMBO J. 2006 Nov 1;25(21):5126-37. Epub 2006 Oct 12. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17036044 17036044]~~	+	<ref group="xtra">PMID:17036044</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Allain, F H.T]]		[[Category: Allain, F H.T]]
	[[Category: Hargous, Y F.]]		[[Category: Hargous, Y F.]]
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	[[Category: Rrm]]		[[Category: Rrm]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 16~~:38:~~29 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:12:20 2009''