2i69 - Revision history

OCA at 10:06, 30 August 2023

OCA — Wed, 30 Aug 2023 10:06:49 GMT

←Older revision		Revision as of 10:06, 30 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2i69]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/West_Nile_virus West Nile virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I69 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2i69]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/West_Nile_virus West Nile virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I69 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.11Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i69 OCA], [https://pdbe.org/2i69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i69 RCSB], [https://www.ebi.ac.uk/pdbsum/2i69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i69 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i69 OCA], [https://pdbe.org/2i69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i69 RCSB], [https://www.ebi.ac.uk/pdbsum/2i69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i69 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:35, 28 December 2022

OCA — Wed, 28 Dec 2022 09:35:13 GMT

←Older revision		Revision as of 09:35, 28 December 2022
Line 3:		Line 3:
	<StructureSection load='2i69' size='340' side='right'caption='[[2i69]], [[Resolution\|resolution]] 3.11Å' scene=''>		<StructureSection load='2i69' size='340' side='right'caption='[[2i69]], [[Resolution\|resolution]] 3.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i69]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Wnv Wnv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I69 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i69]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/West_Nile_virus West Nile virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I69 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Envelope protein ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11082 WNV])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i69 OCA], [https://pdbe.org/2i69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i69 RCSB], [https://www.ebi.ac.uk/pdbsum/2i69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i69 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i69 OCA], [https://pdbe.org/2i69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i69 RCSB], [https://www.ebi.ac.uk/pdbsum/2i69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i69 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q80QJ9_WNV Q80QJ9_WNV]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Wnv~~]]	+	[[Category: West Nile virus]]
-	[[Category: Kanai, R]]	+	[[Category: Kanai R]]
-	[[Category: Modis, Y]]	+	[[Category: Modis Y]]
-	~~[[Category: Antibody epitope]]~~	+
-	~~[[Category: Beta sandwich]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Igc]]~~	+
-	~~[[Category: Receptor binding]]~~	+
-	~~[[Category: Viral membrane fusion protein]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 07:29, 24 March 2021

OCA — Wed, 24 Mar 2021 07:29:01 GMT

←Older revision		Revision as of 07:29, 24 March 2021
Line 1:		Line 1:

	==Crystal structure of the West Nile virus envelope glycoprotein==		==Crystal structure of the West Nile virus envelope glycoprotein==
-	<StructureSection load='2i69' size='340' side='right' caption='[[2i69]], [[Resolution\|resolution]] 3.11Å' scene=''>	+	<StructureSection load='2i69' size='340' side='right'caption='[[2i69]], [[Resolution\|resolution]] 3.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i69]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Wnv Wnv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I69 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2I69 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i69]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Wnv Wnv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I69 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Envelope protein ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11082 WNV])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Envelope protein ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11082 WNV])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2i69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i69 OCA], [~~http~~://pdbe.org/2i69 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2i69 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2i69 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2i69 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i69 OCA], [https://pdbe.org/2i69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i69 RCSB], [https://www.ebi.ac.uk/pdbsum/2i69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i69 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Wnv]]		[[Category: Wnv]]
	[[Category: Kanai, R]]		[[Category: Kanai, R]]

OCA at 08:13, 4 July 2018

OCA — Wed, 04 Jul 2018 08:13:13 GMT

←Older revision		Revision as of 08:13, 4 July 2018
Line 1:		Line 1:
		+
	==Crystal structure of the West Nile virus envelope glycoprotein==		==Crystal structure of the West Nile virus envelope glycoprotein==
	<StructureSection load='2i69' size='340' side='right' caption='[[2i69]], [[Resolution\|resolution]] 3.11Å' scene=''>		<StructureSection load='2i69' size='340' side='right' caption='[[2i69]], [[Resolution\|resolution]] 3.11Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Envelope protein ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11082 WNV])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Envelope protein ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11082 WNV])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i69 OCA], [http://pdbe.org/2i69 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i69 RCSB], [http://www.ebi.ac.uk/pdbsum/2i69 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i69 OCA], [http://pdbe.org/2i69 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i69 RCSB], [http://www.ebi.ac.uk/pdbsum/2i69 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i69 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:56, 11 September 2015

OCA — Fri, 11 Sep 2015 09:56:59 GMT

←Older revision		Revision as of 09:56, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2i69' size='340' side='right' caption='[[2i69]], [[Resolution\|resolution]] 3.11Å' scene=''>		<StructureSection load='2i69' size='340' side='right' caption='[[2i69]], [[Resolution\|resolution]] 3.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i69]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~West_nile_virus West nile virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I69 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I69 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i69]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Wnv Wnv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I69 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I69 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Envelope protein ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11082 ~~West Nile virus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Envelope protein ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11082 WNV])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i69 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i69 RCSB], [http://www.ebi.ac.uk/pdbsum/2i69 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i69 OCA], [http://pdbe.org/2i69 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i69 RCSB], [http://www.ebi.ac.uk/pdbsum/2i69 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2i69" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~West nile virus~~]]	+	[[Category: Wnv]]
	[[Category: Kanai, R]]		[[Category: Kanai, R]]
	[[Category: Modis, Y]]		[[Category: Modis, Y]]

OCA at 09:06, 16 January 2015

OCA — Fri, 16 Jan 2015 09:06:36 GMT

←Older revision		Revision as of 09:06, 16 January 2015
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: West nile virus]]		[[Category: West nile virus]]
-	[[Category: Kanai, R.]]	+	[[Category: Kanai, R]]
-	[[Category: Modis, Y.]]	+	[[Category: Modis, Y]]
	[[Category: Antibody epitope]]		[[Category: Antibody epitope]]
	[[Category: Beta sandwich]]		[[Category: Beta sandwich]]

OCA at 15:38, 12 October 2014

OCA — Sun, 12 Oct 2014 15:38:56 GMT

←Older revision		Revision as of 15:38, 12 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2i69.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of the West Nile virus envelope glycoprotein==
		+	<StructureSection load='2i69' size='340' side='right' caption='[[2i69]], [[Resolution\|resolution]] 3.11Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2i69]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I69 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I69 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Envelope protein ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11082 West Nile virus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i69 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i69 RCSB], [http://www.ebi.ac.uk/pdbsum/2i69 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	West Nile virus, a member of the Flavivirus genus, causes fever that can progress to life-threatening encephalitis. The major envelope glycoprotein, E, of these viruses mediates viral attachment and entry by membrane fusion. We have determined the crystal structure of a soluble fragment of West Nile virus E. The structure adopts the same overall fold as that of the E proteins from dengue and tick-borne encephalitis viruses. The conformation of domain II is different from that in other prefusion E structures, however, and resembles the conformation of domain II in postfusion E structures. The epitopes of neutralizing West Nile virus-specific antibodies map to a region of domain III that is exposed on the viral surface and has been implicated in receptor binding. In contrast, we show that certain recombinant therapeutic antibodies, which cross-neutralize West Nile and dengue viruses, bind a peptide from domain I that is exposed only during the membrane fusion transition. By revealing the details of the molecular landscape of the West Nile virus surface, our structure will assist the design of antiviral vaccines and therapeutics.

-	~~{{STRUCTURE_2i69\| PDB=2i69 \| SCENE= }}~~	+	Crystal structure of west nile virus envelope glycoprotein reveals viral surface epitopes.,Kanai R, Kar K, Anthony K, Gould LH, Ledizet M, Fikrig E, Marasco WA, Koski RA, Modis Y J Virol. 2006 Nov;80(22):11000-8. Epub 2006 Aug 30. PMID:16943291<ref>PMID:16943291</ref>

-	~~===Crystal structure~~ of the ~~West Nile virus envelope glycoprotein===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16943291}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[2i69]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I69 OCA].~~	+	</StructureSection>
	[[Category: West nile virus]]		[[Category: West nile virus]]
	[[Category: Kanai, R.]]		[[Category: Kanai, R.]]

OCA: Protected "2i69" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 15:05:30 GMT

Protected "2i69" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:05, 7 January 2013

OCA at 15:05, 7 January 2013

OCA — Mon, 07 Jan 2013 15:05:26 GMT

←Older revision		Revision as of 15:05, 7 January 2013
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-	{{Seed}}
	[[Image:2i69.png\|left\|200px]]		[[Image:2i69.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2i69\| PDB=2i69 \| SCENE= }}		{{STRUCTURE_2i69\| PDB=2i69 \| SCENE= }}

	===Crystal structure of the West Nile virus envelope glycoprotein===		===Crystal structure of the West Nile virus envelope glycoprotein===

-
-	<!--
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	{{ABSTRACT_PUBMED_16943291}}		{{ABSTRACT_PUBMED_16943291}}

	==About this Structure==		==About this Structure==
-	~~2I69 is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I69 OCA].	+	[[2i69]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I69 OCA].
-		+
-	~~==Reference==~~	+
-	Crystal structure of west nile virus envelope glycoprotein reveals viral surface epitopes., Kanai R, Kar K, Anthony K, Gould LH, Ledizet M, Fikrig E, Marasco WA, Koski RA, Modis Y, J Virol. 2006 Nov;80(22):11000-8. Epub 2006 Aug 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16943291 16943291]	+
-	~~[[Category: Single protein]]~~	+
	[[Category: West nile virus]]		[[Category: West nile virus]]
	[[Category: Kanai, R.]]		[[Category: Kanai, R.]]
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	[[Category: Receptor binding]]		[[Category: Receptor binding]]
	[[Category: Viral membrane fusion protein]]		[[Category: Viral membrane fusion protein]]
-		+	[[Category: Viral protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Jul 29 03:15:19 2008''~~	+

OCA at 00:15, 29 July 2008

OCA — Tue, 29 Jul 2008 00:15:26 GMT

←Older revision		Revision as of 00:15, 29 July 2008
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-	[[Image:2i69.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2i69.png\|left\|200px]]

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	{{STRUCTURE_2i69\| PDB=2i69 \| SCENE= }}		{{STRUCTURE_2i69\| PDB=2i69 \| SCENE= }}

-	~~'''~~Crystal structure of the West Nile virus envelope glycoprotein~~'''~~	+	===Crystal structure of the West Nile virus envelope glycoprotein===


-	~~==Overview==~~	+	<!--
-	~~West Nile virus, a member of the Flavivirus genus, causes fever that can progress to life-threatening encephalitis.~~ The ~~major envelope glycoprotein~~, E, ~~of these viruses mediates viral attachment and entry by membrane fusion. We have determined~~ the ~~crystal structure of a soluble fragment of West Nile virus E. The structure adopts~~ the ~~same overall fold~~ as ~~that of the E proteins from dengue and tick-borne encephalitis viruses~~. ~~The conformation of domain II is different from that in other prefusion E structures~~, ~~however, and resembles the conformation of domain II in postfusion E structures. The epitopes of neutralizing West Nile virus-specific antibodies map to a region of domain III that~~ is ~~exposed on~~ the ~~viral surface and has been implicated in receptor binding~~. ~~In contrast, we show that certain recombinant therapeutic antibodies, which cross~~-neutralize West Nile and dengue viruses, bind a peptide from domain I that is exposed only during the membrane fusion transition. By revealing the details of the molecular landscape of the West Nile virus surface, our structure will assist the design of antiviral vaccines and therapeutics.	+	The line below this paragraph, {{ABSTRACT_PUBMED_16943291}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16943291 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16943291}}

	==About this Structure==		==About this Structure==
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	[[Category: Receptor binding]]		[[Category: Receptor binding]]
	[[Category: Viral membrane fusion protein]]		[[Category: Viral membrane fusion protein]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 07~~:07:35 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:15:19 2008''