2i7n - Revision history

OCA at 09:01, 21 February 2024

OCA — Wed, 21 Feb 2024 09:01:59 GMT

←Older revision		Revision as of 09:01, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='2i7n' size='340' side='right'caption='[[2i7n]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2i7n' size='340' side='right'caption='[[2i7n]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i7n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I7N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i7n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I7N FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[2i7p\|2i7p]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PANK1, PANK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7n OCA], [https://pdbe.org/2i7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i7n RCSB], [https://www.ebi.ac.uk/pdbsum/2i7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i7n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7n OCA], [https://pdbe.org/2i7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i7n RCSB], [https://www.ebi.ac.uk/pdbsum/2i7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i7n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PANK1_HUMAN PANK1_HUMAN]] Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).	+	[https://www.uniprot.org/uniprot/PANK1_HUMAN PANK1_HUMAN] Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i7n ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i7n ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Pantothenate kinase (PanK) catalyzes the first step in CoA biosynthesis and there are three human genes that express four isoforms with highly conserved catalytic core domains. Here we report the homodimeric structures of the catalytic cores of PanK1alpha and PanK3 in complex with acetyl-CoA, a feedback inhibitor. Each monomer adopts a fold of the actin kinase superfamily and the inhibitor-bound structures explain the basis for the allosteric regulation by CoA thioesters. These structures also provide an opportunity to investigate the structural effects of the PanK2 mutations that have been implicated in neurodegeneration. Biochemical and thermodynamic analyses of the PanK3 mutant proteins corresponding to PanK2 mutations show that mutant proteins with compromised activities and/or stabilities correlate with a higher incidence of the early onset of disease.
-
-	Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.,Hong BS, Senisterra G, Rabeh WM, Vedadi M, Leonardi R, Zhang YM, Rock CO, Jackowski S, Park HW J Biol Chem. 2007 Sep 21;282(38):27984-93. Epub 2007 Jul 13. PMID:17631502<ref>PMID:17631502</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2i7n" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Pantothenate kinase 3D structures\|Pantothenate kinase 3D structures]]		*[[Pantothenate kinase 3D structures\|Pantothenate kinase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Pantothenate kinase]]~~	+	[[Category: Allali-Hassani A]]
-	[[Category: Allali-Hassani, A]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Bochkarev A]]
-	[[Category: Bochkarev, A]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Hong BS]]
-	[[Category: Hong~~, B S~~]]	+	[[Category: Loppnau P]]
-	[[Category: Loppnau, P]]	+	[[Category: Park HW]]
-	[[Category: Park~~, H W~~]]	+	[[Category: Sundstrom M]]
-	[[Category: Sundstrom, M]]	+	[[Category: Tempel W]]
-	[[Category: Tempel, W]]	+	[[Category: Wang L]]
-	[[Category: Wang, L]]	+	[[Category: Weigelt J]]
-	[[Category: Weigelt, J]]	+
-	~~[[Category: Pank]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:29, 24 March 2021

OCA — Wed, 24 Mar 2021 07:29:49 GMT

←Older revision		Revision as of 07:29, 24 March 2021
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	==Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA==		==Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA==
-	<StructureSection load='2i7n' size='340' side='right' caption='[[2i7n]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2i7n' size='340' side='right'caption='[[2i7n]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i7n]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2I7N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i7n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I7N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i7p\|2i7p]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2i7p\|2i7p]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PANK1, PANK ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PANK1, PANK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2i7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7n OCA], [~~http~~://pdbe.org/2i7n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2i7n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2i7n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2i7n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7n OCA], [https://pdbe.org/2i7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i7n RCSB], [https://www.ebi.ac.uk/pdbsum/2i7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i7n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PANK1_HUMAN PANK1_HUMAN]] Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).	+	[[https://www.uniprot.org/uniprot/PANK1_HUMAN PANK1_HUMAN]] Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Pantothenate kinase\|Pantothenate kinase]]	+	*[[Pantothenate kinase 3D structures\|Pantothenate kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
	[[Category: Allali-Hassani, A]]		[[Category: Allali-Hassani, A]]

OCA at 08:05, 4 July 2018

OCA — Wed, 04 Jul 2018 08:05:52 GMT

←Older revision		Revision as of 08:05, 4 July 2018
Line 1:		Line 1:
		+
	==Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA==		==Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA==
	<StructureSection load='2i7n' size='340' side='right' caption='[[2i7n]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2i7n' size='340' side='right' caption='[[2i7n]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PANK1, PANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PANK1, PANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7n OCA], [http://pdbe.org/2i7n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i7n RCSB], [http://www.ebi.ac.uk/pdbsum/2i7n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7n OCA], [http://pdbe.org/2i7n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i7n RCSB], [http://www.ebi.ac.uk/pdbsum/2i7n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i7n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i7/2i7n_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i7/2i7n_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i7n ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:51, 11 September 2015

OCA — Fri, 11 Sep 2015 09:51:35 GMT

←Older revision		Revision as of 09:51, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2i7n' size='340' side='right' caption='[[2i7n]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2i7n' size='340' side='right' caption='[[2i7n]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i7n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I7N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i7n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I7N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i7p\|2i7p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i7p\|2i7p]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PANK1, PANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PANK1, PANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i7n RCSB], [http://www.ebi.ac.uk/pdbsum/2i7n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7n OCA], [http://pdbe.org/2i7n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i7n RCSB], [http://www.ebi.ac.uk/pdbsum/2i7n PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2i7n" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
	[[Category: Allali-Hassani, A]]		[[Category: Allali-Hassani, A]]

OCA at 14:45, 25 December 2014

OCA — Thu, 25 Dec 2014 14:45:38 GMT

←Older revision		Revision as of 14:45, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2i7n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I7N FirstGlance]. <br>		<table><tr><td colspan='2'>[[2i7n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I7N FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i7p\|2i7p]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i7p\|2i7p]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PANK1, PANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PANK1, PANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i7n RCSB], [http://www.ebi.ac.uk/pdbsum/2i7n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i7n RCSB], [http://www.ebi.ac.uk/pdbsum/2i7n PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PANK1_HUMAN PANK1_HUMAN]] Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
-	[[Category: Allali-Hassani, A.]]	+	[[Category: Allali-Hassani, A]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bochkarev, A.]]	+	[[Category: Bochkarev, A]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Hong, B S.]]	+	[[Category: Hong, B S]]
-	[[Category: Loppnau, P.]]	+	[[Category: Loppnau, P]]
-	[[Category: Park, H W.]]	+	[[Category: Park, H W]]
-	[[Category: Sundstrom, M.]]	+	[[Category: Sundstrom, M]]
-	[[Category: Tempel, W.]]	+	[[Category: Tempel, W]]
-	[[Category: Wang, L.]]	+	[[Category: Wang, L]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
	[[Category: Pank]]		[[Category: Pank]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:30, 30 September 2014

OCA — Tue, 30 Sep 2014 10:30:52 GMT

←Older revision		Revision as of 10:30, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2i7n.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA==
		+	<StructureSection load='2i7n' size='340' side='right' caption='[[2i7n]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2i7n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I7N FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i7p\|2i7p]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PANK1, PANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i7n RCSB], [http://www.ebi.ac.uk/pdbsum/2i7n PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i7/2i7n_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pantothenate kinase (PanK) catalyzes the first step in CoA biosynthesis and there are three human genes that express four isoforms with highly conserved catalytic core domains. Here we report the homodimeric structures of the catalytic cores of PanK1alpha and PanK3 in complex with acetyl-CoA, a feedback inhibitor. Each monomer adopts a fold of the actin kinase superfamily and the inhibitor-bound structures explain the basis for the allosteric regulation by CoA thioesters. These structures also provide an opportunity to investigate the structural effects of the PanK2 mutations that have been implicated in neurodegeneration. Biochemical and thermodynamic analyses of the PanK3 mutant proteins corresponding to PanK2 mutations show that mutant proteins with compromised activities and/or stabilities correlate with a higher incidence of the early onset of disease.

-	~~{{STRUCTURE_2i7n\| PDB=2i7n \| SCENE= }}~~	+	Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.,Hong BS, Senisterra G, Rabeh WM, Vedadi M, Leonardi R, Zhang YM, Rock CO, Jackowski S, Park HW J Biol Chem. 2007 Sep 21;282(38):27984-93. Epub 2007 Jul 13. PMID:17631502<ref>PMID:17631502</ref>

-	~~===Crystal structure~~ of ~~human PANK1 alpha:~~ the ~~catalytic core domain in complex with AcCoA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17631502}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2i7n]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA].~~	+

	==See Also==		==See Also==
	*[[Pantothenate kinase\|Pantothenate kinase]]		*[[Pantothenate kinase\|Pantothenate kinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017631502<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]

OCA: Protected "2i7n" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:58:35 GMT

Protected "2i7n" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:58, 7 January 2013

OCA at 14:58, 7 January 2013

OCA — Mon, 07 Jan 2013 14:58:31 GMT

←Older revision		Revision as of 14:58, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2i7n.png\|left\|200px]]		[[Image:2i7n.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2i7n", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2i7n\| PDB=2i7n \| SCENE= }}		{{STRUCTURE_2i7n\| PDB=2i7n \| SCENE= }}

	===Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA===		===Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17631502}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17631502 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17631502}}		{{ABSTRACT_PUBMED_17631502}}

	==About this Structure==		==About this Structure==
-	~~2I7N~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA].	+	[[2i7n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA].
		+
		+	==See Also==
		+	*[[Pantothenate kinase\|Pantothenate kinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17631502~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017631502</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
Line 39:		Line 30:
	[[Category: Pank]]		[[Category: Pank]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:03:06 2009''

OCA at 17:03, 17 February 2009

OCA — Tue, 17 Feb 2009 17:03:07 GMT

←Older revision		Revision as of 17:03, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2I7N is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA].	+	2I7N is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA].

	==Reference==		==Reference==
-	Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder., Hong BS, Senisterra G, Rabeh WM, Vedadi M, Leonardi R, Zhang YM, Rock CO, Jackowski S, Park HW, J Biol Chem. 2007 Sep 21;282(38):27984-93. Epub 2007 Jul 13. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17631502 17631502]~~	+	<ref group="xtra">PMID:17631502</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
-	[[Category: Single protein]]
	[[Category: Allali-Hassani, A.]]		[[Category: Allali-Hassani, A.]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 41:		Line 40:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Nov 5 10~~:38:~~51 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:03:06 2009''

OCA at 08:38, 5 November 2008

OCA — Wed, 05 Nov 2008 08:38:51 GMT

←Older revision		Revision as of 08:38, 5 November 2008
Line 1:		Line 1:
-	[[Image:2i7n.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2i7n.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2i7n\| PDB=2i7n \| SCENE= }}		{{STRUCTURE_2i7n\| PDB=2i7n \| SCENE= }}

-	~~'''~~Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA~~'''~~	+	===Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_17631502}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17631502 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17631502}}

	==About this Structure==		==About this Structure==
	2I7N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA].		2I7N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA].
		+
		+	==Reference==
		+	Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder., Hong BS, Senisterra G, Rabeh WM, Vedadi M, Leonardi R, Zhang YM, Rock CO, Jackowski S, Park HW, J Biol Chem. 2007 Sep 21;282(38):27984-93. Epub 2007 Jul 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17631502 17631502]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
Line 21:		Line 31:
	[[Category: Bochkarev, A.]]		[[Category: Bochkarev, A.]]
	[[Category: Edwards, A M.]]		[[Category: Edwards, A M.]]
-	[[Category: Hong, B.]]	+	[[Category: Hong, B S.]]
	[[Category: Loppnau, P.]]		[[Category: Loppnau, P.]]
-	[[Category: Park, H.]]	+	[[Category: Park, H W.]]
	[[Category: Sundstrom, M.]]		[[Category: Sundstrom, M.]]
	[[Category: Tempel, W.]]		[[Category: Tempel, W.]]
Line 29:		Line 39:
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J.]]
	[[Category: Pank]]		[[Category: Pank]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 07:~~10:45 2008''	+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 5 10:38:51 2008''