2i83 - Revision history

OCA at 10:25, 12 January 2022

OCA — Wed, 12 Jan 2022 10:25:24 GMT

←Older revision		Revision as of 10:25, 12 January 2022
Line 3:		Line 3:
	<StructureSection load='2i83' size='340' side='right'caption='[[2i83]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2i83' size='340' side='right'caption='[[2i83]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i83]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2I83 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i83]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I83 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2i83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i83 OCA], [~~http~~://pdbe.org/2i83 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2i83 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2i83 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2i83 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i83 OCA], [https://pdbe.org/2i83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i83 RCSB], [https://www.ebi.ac.uk/pdbsum/2i83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i83 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CD44_HUMAN CD44_HUMAN]] Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.	+	[[https://www.uniprot.org/uniprot/CD44_HUMAN CD44_HUMAN]] Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:42, 8 April 2020

OCA — Wed, 08 Apr 2020 07:42:59 GMT

←Older revision		Revision as of 07:42, 8 April 2020
Line 1:		Line 1:

	==hyaluronan-binding domain of CD44 in its ligand-bound form==		==hyaluronan-binding domain of CD44 in its ligand-bound form==
-	<StructureSection load='2i83' size='340' side='right' caption='[[2i83]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2i83' size='340' side='right'caption='[[2i83]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i83]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2I83 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i83]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2I83 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2i83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i83 OCA], [http://pdbe.org/2i83 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i83 RCSB], [http://www.ebi.ac.uk/pdbsum/2i83 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i83 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2i83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i83 OCA], [http://pdbe.org/2i83 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i83 RCSB], [http://www.ebi.ac.uk/pdbsum/2i83 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i83 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hayasaka, H]]		[[Category: Hayasaka, H]]
	[[Category: Kajiwara, M]]		[[Category: Kajiwara, M]]

OCA at 07:57, 4 July 2018

OCA — Wed, 04 Jul 2018 07:57:22 GMT

←Older revision		Revision as of 07:57, 4 July 2018
Line 1:		Line 1:
		+
	==hyaluronan-binding domain of CD44 in its ligand-bound form==		==hyaluronan-binding domain of CD44 in its ligand-bound form==
	<StructureSection load='2i83' size='340' side='right' caption='[[2i83]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2i83' size='340' side='right' caption='[[2i83]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2i83]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I83 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2i83]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I83 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i83 OCA], [http://pdbe.org/2i83 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i83 RCSB], [http://www.ebi.ac.uk/pdbsum/2i83 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i83 OCA], [http://pdbe.org/2i83 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i83 RCSB], [http://www.ebi.ac.uk/pdbsum/2i83 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i83 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i8/2i83_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i8/2i83_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i83 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:02, 11 September 2015

OCA — Fri, 11 Sep 2015 09:02:44 GMT

←Older revision		Revision as of 09:02, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2i83' size='340' side='right' caption='[[2i83]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2i83' size='340' side='right' caption='[[2i83]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i83]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I83 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i83]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I83 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i83 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i83 RCSB], [http://www.ebi.ac.uk/pdbsum/2i83 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i83 OCA], [http://pdbe.org/2i83 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i83 RCSB], [http://www.ebi.ac.uk/pdbsum/2i83 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2i83" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hayasaka, H]]		[[Category: Hayasaka, H]]
	[[Category: Kajiwara, M]]		[[Category: Kajiwara, M]]

OCA at 14:13, 25 December 2014

OCA — Thu, 25 Dec 2014 14:13:11 GMT

←Older revision		Revision as of 14:13, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2i83]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I83 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2i83]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I83 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i83 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i83 RCSB], [http://www.ebi.ac.uk/pdbsum/2i83 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i83 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i83 RCSB], [http://www.ebi.ac.uk/pdbsum/2i83 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CD44_HUMAN CD44_HUMAN]] Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hayasaka, H.]]	+	[[Category: Hayasaka, H]]
-	[[Category: Kajiwara, M.]]	+	[[Category: Kajiwara, M]]
-	[[Category: Miyasaka, M.]]	+	[[Category: Miyasaka, M]]
-	[[Category: Ogino, S.]]	+	[[Category: Ogino, S]]
-	[[Category: Sakakura, M.]]	+	[[Category: Sakakura, M]]
-	[[Category: Shimada, I.]]	+	[[Category: Shimada, I]]
-	[[Category: Sugahara, K N.]]	+	[[Category: Sugahara, K N]]
-	[[Category: Takeda, M.]]	+	[[Category: Takeda, M]]
-	[[Category: Terasawa, H.]]	+	[[Category: Terasawa, H]]
-	[[Category: Umemoto, R.]]	+	[[Category: Umemoto, R]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Link module]]		[[Category: Link module]]

OCA at 09:16, 30 September 2014

OCA — Tue, 30 Sep 2014 09:16:38 GMT

←Older revision		Revision as of 09:16, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2i83.~~png\|left~~\|200px]]	+	==hyaluronan-binding domain of CD44 in its ligand-bound form==
		+	<StructureSection load='2i83' size='340' side='right' caption='[[2i83]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2i83]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I83 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i83 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i83 RCSB], [http://www.ebi.ac.uk/pdbsum/2i83 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i8/2i83_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CD44, a major cell surface receptor for hyaluronan (HA), contains a functional domain responsible for HA binding at its N terminus (residues 21-178). Accumulating evidence indicates that proteolytic cleavage of CD44 in its extracellular region (residues 21-268) leads to enhanced tumor cell migration and invasion. Hence, understanding the mechanisms underlying the CD44 proteolytic cleavage is important for understanding the mechanism of CD44-mediated tumor progression. Here we present the NMR structure of the HA-binding domain of CD44 in its HA-bound state. The structure is composed of the Link module (residues 32-124) and an extended lobe (residues 21-31 and 125-152). Interestingly, a comparison of its unbound and HA-bound structures revealed that rearrangement of the beta-strands in the extended lobe (residues 143-148) and disorder of the structure in the following C-terminal region (residues 153-169) occurred upon HA binding, which is consistent with the results of trypsin proteolysis studies of the CD44 HA-binding domain. The order-to-disorder transition of the C-terminal region by HA binding may be involved in the CD44-mediated cell migration.

-	~~{{STRUCTURE_2i83\| PDB=2i83 \| SCENE= }}~~	+	Ligand-induced structural changes of the CD44 hyaluronan-binding domain revealed by NMR.,Takeda M, Ogino S, Umemoto R, Sakakura M, Kajiwara M, Sugahara KN, Hayasaka H, Miyasaka M, Terasawa H, Shimada I J Biol Chem. 2006 Dec 29;281(52):40089-95. Epub 2006 Nov 2. PMID:17085435<ref>PMID:17085435</ref>

-	~~===hyaluronan-binding domain~~ of ~~CD44 in its ligand-bound form===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17085435}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2i83]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA].~~	+

	==See Also==		==See Also==
	*[[CD44\|CD44]]		*[[CD44\|CD44]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017085435<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayasaka, H.]]		[[Category: Hayasaka, H.]]

OCA: Protected "2i83" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 14:11:09 GMT

Protected "2i83" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:11, 7 January 2013

OCA at 14:11, 7 January 2013

OCA — Mon, 07 Jan 2013 14:11:06 GMT

←Older revision		Revision as of 14:11, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2i83.png\|left\|200px]]		[[Image:2i83.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2i83", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2i83\| PDB=2i83 \| SCENE= }}		{{STRUCTURE_2i83\| PDB=2i83 \| SCENE= }}

	===hyaluronan-binding domain of CD44 in its ligand-bound form===		===hyaluronan-binding domain of CD44 in its ligand-bound form===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17085435}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17085435 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17085435}}		{{ABSTRACT_PUBMED_17085435}}

	==About this Structure==		==About this Structure==
-	~~2I83~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA].	+	[[2i83]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA].
		+
		+	==See Also==
		+	*[[CD44\|CD44]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17085435~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017085435</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayasaka, H.]]		[[Category: Hayasaka, H.]]
Line 35:		Line 26:
	[[Category: Terasawa, H.]]		[[Category: Terasawa, H.]]
	[[Category: Umemoto, R.]]		[[Category: Umemoto, R.]]
		+	[[Category: Cell adhesion]]
	[[Category: Link module]]		[[Category: Link module]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:23:33 2009''

OCA at 16:23, 17 February 2009

OCA — Tue, 17 Feb 2009 16:23:36 GMT

←Older revision		Revision as of 16:23, 17 February 2009
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	==About this Structure==		==About this Structure==
-	2I83 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA].	+	2I83 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA].

	==Reference==		==Reference==
-	Ligand-induced structural changes of the CD44 hyaluronan-binding domain revealed by NMR., Takeda M, Ogino S, Umemoto R, Sakakura M, Kajiwara M, Sugahara KN, Hayasaka H, Miyasaka M, Terasawa H, Shimada I, J Biol Chem. 2006 Dec 29;281(52):40089-95. Epub 2006 Nov 2. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17085435 17085435]~~	+	<ref group="xtra">PMID:17085435</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Hayasaka, H.]]		[[Category: Hayasaka, H.]]
	[[Category: Kajiwara, M.]]		[[Category: Kajiwara, M.]]
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	[[Category: Link module]]		[[Category: Link module]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 02:20~~:23 ~~2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:23:33 2009''

OCA at 23:20, 28 July 2008

OCA — Mon, 28 Jul 2008 23:20:29 GMT

←Older revision		Revision as of 23:20, 28 July 2008
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-	[[Image:2i83.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2i83.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2i83\| PDB=2i83 \| SCENE= }}		{{STRUCTURE_2i83\| PDB=2i83 \| SCENE= }}

-	~~'''~~hyaluronan-binding domain of CD44 in its ligand-bound form~~'''~~	+	===hyaluronan-binding domain of CD44 in its ligand-bound form===


-	~~==Overview==~~	+	<!--
-	~~CD44~~, ~~a major cell surface receptor for hyaluronan (HA)~~, contains a functional domain responsible for HA binding at its N terminus (residues 21-178). Accumulating evidence indicates that proteolytic cleavage of CD44 in its extracellular region (residues 21-268) leads to ~~enhanced tumor cell migration and invasion. Hence, understanding~~ the ~~mechanisms underlying the CD44 proteolytic cleavage is important for understanding the mechanism of CD44-mediated tumor progression~~. ~~Here we present the NMR structure of the HA-binding domain of CD44 in its HA-bound state~~. ~~The structure is composed of the Link module (residues 32-124~~) and an extended lobe (residues 21-31 and 125-152). Interestingly, a comparison of its unbound and HA-bound structures revealed that rearrangement of the beta-strands in the extended lobe (residues 143-148) and disorder of the structure in the following C-terminal region (residues 153-169) occurred upon HA binding, ~~which~~ is ~~consistent with~~ the ~~results of trypsin proteolysis studies of the CD44 HA-binding domain~~. ~~The order~~-to-~~disorder transition of the C-terminal region by HA binding may be involved in the CD44-mediated cell migration.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_17085435}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17085435 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17085435}}

	==About this Structure==		==About this Structure==
-	2I83 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA].	+	2I83 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I83 OCA].

	==Reference==		==Reference==
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	[[Category: Umemoto, R.]]		[[Category: Umemoto, R.]]
	[[Category: Link module]]		[[Category: Link module]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 07~~:11:42 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:20:23 2008''