2i96 - Revision history

OCA at 19:03, 29 May 2024

OCA — Wed, 29 May 2024 19:03:52 GMT

←Older revision		Revision as of 19:03, 29 May 2024
Line 1:		Line 1:

	==Solution structure of the oxidized microsomal human cytochrome b5==		==Solution structure of the oxidized microsomal human cytochrome b5==
-	<StructureSection load='2i96' size='340' side='right'caption='[[2i96~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2i96' size='340' side='right'caption='[[2i96]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i96]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I96 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i96]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I96 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1hko\|1hko]], [[1aw3\|1aw3]], [[1do9\|1do9]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i96 OCA], [https://pdbe.org/2i96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i96 RCSB], [https://www.ebi.ac.uk/pdbsum/2i96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i96 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i96 OCA], [https://pdbe.org/2i96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i96 RCSB], [https://www.ebi.ac.uk/pdbsum/2i96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i96 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN]] Defects in CYB5A are the cause of methemoglobinemia CYB5A-related (METHB-CYB5A) [MIM:[https://omim.org/entry/250790 250790]]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia.<ref>PMID:8168836</ref>	+	[https://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN] Defects in CYB5A are the cause of methemoglobinemia CYB5A-related (METHB-CYB5A) [MIM:[https://omim.org/entry/250790 250790]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia.<ref>PMID:8168836</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN]] Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.	+	[https://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN] Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Heijenoort, C Van]]~~	+	[[Category: Nunez-Quintana M]]
-	[[Category: Nunez-Quintana, M]]	+	[[Category: Truan G]]
-	[[Category: Truan, G]]	+	[[Category: Van Heijenoort C]]
-	[[Category: ~~B5 fold]]~~	+
-	~~[[Category: Electron transport~~]]	+

OCA at 10:25, 12 January 2022

OCA — Wed, 12 Jan 2022 10:25:52 GMT

OCA at 07:43, 8 April 2020

OCA — Wed, 08 Apr 2020 07:43:32 GMT

←Older revision		Revision as of 07:43, 8 April 2020
Line 1:		Line 1:

	==Solution structure of the oxidized microsomal human cytochrome b5==		==Solution structure of the oxidized microsomal human cytochrome b5==
-	<StructureSection load='2i96' size='340' side='right' caption='[[2i96]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2i96' size='340' side='right'caption='[[2i96]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i96]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I96 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2I96 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i96]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I96 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2I96 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hko\|1hko]], [[1aw3\|1aw3]], [[1do9\|1do9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hko\|1hko]], [[1aw3\|1aw3]], [[1do9\|1do9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2i96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i96 OCA], [http://pdbe.org/2i96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i96 RCSB], [http://www.ebi.ac.uk/pdbsum/2i96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i96 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2i96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i96 OCA], [http://pdbe.org/2i96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i96 RCSB], [http://www.ebi.ac.uk/pdbsum/2i96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i96 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 24:

	==See Also==		==See Also==
-	*[[Cytochrome b5\|Cytochrome b5]]	+	*[[Cytochrome b5 3D structures\|Cytochrome b5 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Heijenoort, C Van]]		[[Category: Heijenoort, C Van]]
	[[Category: Nunez-Quintana, M]]		[[Category: Nunez-Quintana, M]]

OCA at 08:33, 4 July 2018

OCA — Wed, 04 Jul 2018 08:33:37 GMT

←Older revision		Revision as of 08:33, 4 July 2018
Line 1:		Line 1:
		+
	==Solution structure of the oxidized microsomal human cytochrome b5==		==Solution structure of the oxidized microsomal human cytochrome b5==
	<StructureSection load='2i96' size='340' side='right' caption='[[2i96]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2i96' size='340' side='right' caption='[[2i96]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hko\|1hko]], [[1aw3\|1aw3]], [[1do9\|1do9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hko\|1hko]], [[1aw3\|1aw3]], [[1do9\|1do9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i96 OCA], [http://pdbe.org/2i96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i96 RCSB], [http://www.ebi.ac.uk/pdbsum/2i96 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i96 OCA], [http://pdbe.org/2i96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i96 RCSB], [http://www.ebi.ac.uk/pdbsum/2i96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i96 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i9/2i96_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i9/2i96_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i96 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 09:30, 11 September 2015

OCA — Fri, 11 Sep 2015 09:30:26 GMT

←Older revision		Revision as of 09:30, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2i96' size='340' side='right' caption='[[2i96]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2i96' size='340' side='right' caption='[[2i96]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i96]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I96 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i96]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I96 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hko\|1hko]], [[1aw3\|1aw3]], [[1do9\|1do9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hko\|1hko]], [[1aw3\|1aw3]], [[1do9\|1do9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i96 RCSB], [http://www.ebi.ac.uk/pdbsum/2i96 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i96 OCA], [http://pdbe.org/2i96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i96 RCSB], [http://www.ebi.ac.uk/pdbsum/2i96 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Heijenoort, C Van]]		[[Category: Heijenoort, C Van]]
	[[Category: Nunez-Quintana, M]]		[[Category: Nunez-Quintana, M]]

OCA at 08:38, 16 January 2015

OCA — Fri, 16 Jan 2015 08:38:03 GMT

←Older revision		Revision as of 08:38, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2i96]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I96 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2i96]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I96 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hko\|1hko]], [[1aw3\|1aw3]], [[1do9\|1do9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hko\|1hko]], [[1aw3\|1aw3]], [[1do9\|1do9]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i96 RCSB], [http://www.ebi.ac.uk/pdbsum/2i96 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i96 RCSB], [http://www.ebi.ac.uk/pdbsum/2i96 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN]] Defects in CYB5A are the cause of methemoglobinemia CYB5A-related (METHB-CYB5A) [MIM:[http://omim.org/entry/250790 250790]]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia.<ref>PMID:8168836</ref>		[[http://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN]] Defects in CYB5A are the cause of methemoglobinemia CYB5A-related (METHB-CYB5A) [MIM:[http://omim.org/entry/250790 250790]]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia.<ref>PMID:8168836</ref>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Heijenoort, C Van.]]	+	[[Category: Heijenoort, C Van]]
-	[[Category: Nunez-Quintana, M.]]	+	[[Category: Nunez-Quintana, M]]
-	[[Category: Truan, G.]]	+	[[Category: Truan, G]]
	[[Category: B5 fold]]		[[Category: B5 fold]]
	[[Category: Electron transport]]		[[Category: Electron transport]]

OCA at 10:11, 30 September 2014

OCA — Tue, 30 Sep 2014 10:11:31 GMT

←Older revision		Revision as of 10:11, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2i96\| PDB=2i96 \| SCENE= }}~~	+	==Solution structure of the oxidized microsomal human cytochrome b5==
-	===Solution structure of the oxidized microsomal human cytochrome b5===	+	<StructureSection load='2i96' size='340' side='right' caption='[[2i96]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[2i96]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I96 FirstGlance]. <br>
-	[[http://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN]] Defects in CYB5A are the cause of methemoglobinemia CYB5A-related (METHB-CYB5A) [MIM:[http://omim.org/entry/250790 250790]]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia.<ref>PMID:8168836</ref>	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hko\|1hko]], [[1aw3\|1aw3]], [[1do9\|1do9]]</td></tr>
-	==Function==	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i96 RCSB], [http://www.ebi.ac.uk/pdbsum/2i96 PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN]] Defects in CYB5A are the cause of methemoglobinemia CYB5A-related (METHB-CYB5A) [MIM:[http://omim.org/entry/250790 250790]]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia.<ref>PMID:8168836</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN]] Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.		[[http://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN]] Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.
-		+	== Evolutionary Conservation ==
-	==~~About this Structure~~==	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-	[[~~2i96~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens~~]. ~~Full experimental information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2I96 OCA~~].	+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i9/2i96_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Cytochrome b5\|Cytochrome b5]]		*[[Cytochrome b5\|Cytochrome b5]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Heijenoort, C Van.]]		[[Category: Heijenoort, C Van.]]

OCA at 06:12, 25 March 2013

OCA — Mon, 25 Mar 2013 06:12:11 GMT

←Older revision		Revision as of 06:12, 25 March 2013
Line 1:		Line 1:
-	[[Image:2i96.png\|left\|200px]]
-
	{{STRUCTURE_2i96\| PDB=2i96 \| SCENE= }}		{{STRUCTURE_2i96\| PDB=2i96 \| SCENE= }}
-
	===Solution structure of the oxidized microsomal human cytochrome b5===		===Solution structure of the oxidized microsomal human cytochrome b5===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN]] Defects in CYB5A are the cause of methemoglobinemia CYB5A-related (METHB-CYB5A) [MIM:[http://omim.org/entry/250790 250790]]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia.<ref>PMID:8168836</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN]] Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.

	==About this Structure==		==About this Structure==
Line 11:		Line 13:
	==See Also==		==See Also==
	*[[Cytochrome b5\|Cytochrome b5]]		*[[Cytochrome b5\|Cytochrome b5]]
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Heijenoort, C Van.]]		[[Category: Heijenoort, C Van.]]

OCA at 17:51, 20 October 2012

OCA — Sat, 20 Oct 2012 17:51:15 GMT

←Older revision		Revision as of 17:51, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2i96]] is a 1 chain structure ~~of [[Cytochrome b5]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I96 OCA].	+	[[2i96]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I96 OCA].

	==See Also==		==See Also==

OCA: Protected "2i96" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 02:13:08 GMT

Protected "2i96" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:13, 27 July 2012

←Older revision		Revision as of 10:25, 12 January 2022
Line 3:		Line 3:
	<StructureSection load='2i96' size='340' side='right'caption='[[2i96]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2i96' size='340' side='right'caption='[[2i96]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i96]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I96 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2I96 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i96]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I96 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hko\|1hko]], [[1aw3\|1aw3]], [[1do9\|1do9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hko\|1hko]], [[1aw3\|1aw3]], [[1do9\|1do9]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2i96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i96 OCA], [~~http~~://pdbe.org/2i96 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2i96 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2i96 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2i96 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i96 OCA], [https://pdbe.org/2i96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i96 RCSB], [https://www.ebi.ac.uk/pdbsum/2i96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i96 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN]] Defects in CYB5A are the cause of methemoglobinemia CYB5A-related (METHB-CYB5A) [MIM:[~~http~~://omim.org/entry/250790 250790]]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia.<ref>PMID:8168836</ref>	+	[[https://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN]] Defects in CYB5A are the cause of methemoglobinemia CYB5A-related (METHB-CYB5A) [MIM:[https://omim.org/entry/250790 250790]]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia.<ref>PMID:8168836</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN]] Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.	+	[[https://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN]] Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]