2iau - Revision history

OCA at 10:08, 30 August 2023

OCA — Wed, 30 Aug 2023 10:08:21 GMT

←Older revision		Revision as of 10:08, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2iau' size='340' side='right'caption='[[2iau]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2iau' size='340' side='right'caption='[[2iau]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iau]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Common_european_squid Common european squid~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IAU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iau]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Loligo_vulgaris Loligo vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IAU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e1a\|1e1a]], [[1pjx\|1pjx]], [[2iao\|2iao]], [[2iap\|2iap]], [[2iaq\|2iaq]], [[2iar\|2iar]], [[2ias\|2ias]], [[2iat\|2iat]], [[2iav\|2iav]], [[2iaw\|2iaw]], [[2iax\|2iax]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Diisopropyl-fluorophosphatase Diisopropyl-fluorophosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.2 3.1.8.2]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iau OCA], [https://pdbe.org/2iau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iau RCSB], [https://www.ebi.ac.uk/pdbsum/2iau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iau ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iau OCA], [https://pdbe.org/2iau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iau RCSB], [https://www.ebi.ac.uk/pdbsum/2iau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iau ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DFPA_LOLVU DFPA_LOLVU]] Biological function and substrate unknown. However, it is capable of acting on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including nerve gases).<ref>PMID:15966726</ref>	+	[https://www.uniprot.org/uniprot/DFPA_LOLVU DFPA_LOLVU] Biological function and substrate unknown. However, it is capable of acting on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including nerve gases).<ref>PMID:15966726</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Common european squid]]
-	[[Category: Diisopropyl-fluorophosphatase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fritzsch, G]]	+	[[Category: Loligo vulgaris]]
-	[[Category: Koepke, J]]	+	[[Category: Fritzsch G]]
-	[[Category: Luecke, C]]	+	[[Category: Koepke J]]
-	[[Category: Rueterjans, H]]	+	[[Category: Luecke C]]
-	[[Category: Scharff~~, E I]]~~	+	[[Category: Rueterjans H]]
-	~~[[Category: Beta-propeller]]~~	+	[[Category: Scharff EI]]
-	~~[[Category: Calcium-binding site]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Phosphotriesterase~~]]	+

OCA at 17:50, 20 October 2021

OCA — Wed, 20 Oct 2021 17:50:59 GMT

←Older revision		Revision as of 17:50, 20 October 2021
Line 3:		Line 3:
	<StructureSection load='2iau' size='340' side='right'caption='[[2iau]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2iau' size='340' side='right'caption='[[2iau]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iau]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Common_european_squid Common european squid]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2IAU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iau]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Common_european_squid Common european squid]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IAU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e1a\|1e1a]], [[1pjx\|1pjx]], [[2iao\|2iao]], [[2iap\|2iap]], [[2iaq\|2iaq]], [[2iar\|2iar]], [[2ias\|2ias]], [[2iat\|2iat]], [[2iav\|2iav]], [[2iaw\|2iaw]], [[2iax\|2iax]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e1a\|1e1a]], [[1pjx\|1pjx]], [[2iao\|2iao]], [[2iap\|2iap]], [[2iaq\|2iaq]], [[2iar\|2iar]], [[2ias\|2ias]], [[2iat\|2iat]], [[2iav\|2iav]], [[2iaw\|2iaw]], [[2iax\|2iax]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Diisopropyl-fluorophosphatase Diisopropyl-fluorophosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.2 3.1.8.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Diisopropyl-fluorophosphatase Diisopropyl-fluorophosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.2 3.1.8.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2iau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iau OCA], [~~http~~://pdbe.org/2iau PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2iau RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2iau PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2iau ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iau OCA], [https://pdbe.org/2iau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iau RCSB], [https://www.ebi.ac.uk/pdbsum/2iau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iau ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DFPA_LOLVU DFPA_LOLVU]] Biological function and substrate unknown. However, it is capable of acting on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including nerve gases).<ref>PMID:15966726</ref>	+	[[https://www.uniprot.org/uniprot/DFPA_LOLVU DFPA_LOLVU]] Biological function and substrate unknown. However, it is capable of acting on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including nerve gases).<ref>PMID:15966726</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:43, 8 April 2020

OCA — Wed, 08 Apr 2020 07:43:59 GMT

←Older revision		Revision as of 07:43, 8 April 2020
Line 1:		Line 1:

	==Crystal structure of squid ganglion DFPase W244Y mutant==		==Crystal structure of squid ganglion DFPase W244Y mutant==
-	<StructureSection load='2iau' size='340' side='right' caption='[[2iau]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2iau' size='340' side='right'caption='[[2iau]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iau]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Common_european_squid Common european squid]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IAU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iau]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Common_european_squid Common european squid]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2IAU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e1a\|1e1a]], [[1pjx\|1pjx]], [[2iao\|2iao]], [[2iap\|2iap]], [[2iaq\|2iaq]], [[2iar\|2iar]], [[2ias\|2ias]], [[2iat\|2iat]], [[2iav\|2iav]], [[2iaw\|2iaw]], [[2iax\|2iax]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e1a\|1e1a]], [[1pjx\|1pjx]], [[2iao\|2iao]], [[2iap\|2iap]], [[2iaq\|2iaq]], [[2iar\|2iar]], [[2ias\|2ias]], [[2iat\|2iat]], [[2iav\|2iav]], [[2iaw\|2iaw]], [[2iax\|2iax]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diisopropyl-fluorophosphatase Diisopropyl-fluorophosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.2 3.1.8.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diisopropyl-fluorophosphatase Diisopropyl-fluorophosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.2 3.1.8.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2iau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iau OCA], [http://pdbe.org/2iau PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iau RCSB], [http://www.ebi.ac.uk/pdbsum/2iau PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iau ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2iau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iau OCA], [http://pdbe.org/2iau PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iau RCSB], [http://www.ebi.ac.uk/pdbsum/2iau PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iau ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 36:		Line 36:
	[[Category: Common european squid]]		[[Category: Common european squid]]
	[[Category: Diisopropyl-fluorophosphatase]]		[[Category: Diisopropyl-fluorophosphatase]]
		+	[[Category: Large Structures]]
	[[Category: Fritzsch, G]]		[[Category: Fritzsch, G]]
	[[Category: Koepke, J]]		[[Category: Koepke, J]]

OCA at 08:26, 4 July 2018

OCA — Wed, 04 Jul 2018 08:26:16 GMT

←Older revision		Revision as of 08:26, 4 July 2018
Line 1:		Line 1:
		+
	==Crystal structure of squid ganglion DFPase W244Y mutant==		==Crystal structure of squid ganglion DFPase W244Y mutant==
	<StructureSection load='2iau' size='340' side='right' caption='[[2iau]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2iau' size='340' side='right' caption='[[2iau]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e1a\|1e1a]], [[1pjx\|1pjx]], [[2iao\|2iao]], [[2iap\|2iap]], [[2iaq\|2iaq]], [[2iar\|2iar]], [[2ias\|2ias]], [[2iat\|2iat]], [[2iav\|2iav]], [[2iaw\|2iaw]], [[2iax\|2iax]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e1a\|1e1a]], [[1pjx\|1pjx]], [[2iao\|2iao]], [[2iap\|2iap]], [[2iaq\|2iaq]], [[2iar\|2iar]], [[2ias\|2ias]], [[2iat\|2iat]], [[2iav\|2iav]], [[2iaw\|2iaw]], [[2iax\|2iax]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diisopropyl-fluorophosphatase Diisopropyl-fluorophosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.2 3.1.8.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diisopropyl-fluorophosphatase Diisopropyl-fluorophosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.2 3.1.8.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iau OCA], [http://pdbe.org/2iau PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iau RCSB], [http://www.ebi.ac.uk/pdbsum/2iau PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iau OCA], [http://pdbe.org/2iau PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iau RCSB], [http://www.ebi.ac.uk/pdbsum/2iau PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iau ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/2iau_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/2iau_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iau ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:53, 11 September 2015

OCA — Fri, 11 Sep 2015 10:53:39 GMT

←Older revision		Revision as of 10:53, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2iau' size='340' side='right' caption='[[2iau]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2iau' size='340' side='right' caption='[[2iau]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iau]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Loligo_vulgaris Loligo vulgaris~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IAU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iau]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Common_european_squid Common european squid]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IAU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e1a\|1e1a]], [[1pjx\|1pjx]], [[2iao\|2iao]], [[2iap\|2iap]], [[2iaq\|2iaq]], [[2iar\|2iar]], [[2ias\|2ias]], [[2iat\|2iat]], [[2iav\|2iav]], [[2iaw\|2iaw]], [[2iax\|2iax]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e1a\|1e1a]], [[1pjx\|1pjx]], [[2iao\|2iao]], [[2iap\|2iap]], [[2iaq\|2iaq]], [[2iar\|2iar]], [[2ias\|2ias]], [[2iat\|2iat]], [[2iav\|2iav]], [[2iaw\|2iaw]], [[2iax\|2iax]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diisopropyl-fluorophosphatase Diisopropyl-fluorophosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.2 3.1.8.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diisopropyl-fluorophosphatase Diisopropyl-fluorophosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.2 3.1.8.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iau OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iau RCSB], [http://www.ebi.ac.uk/pdbsum/2iau PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iau OCA], [http://pdbe.org/2iau PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iau RCSB], [http://www.ebi.ac.uk/pdbsum/2iau PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2iau" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Common european squid]]
	[[Category: Diisopropyl-fluorophosphatase]]		[[Category: Diisopropyl-fluorophosphatase]]
-	[[Category: Loligo vulgaris]]
	[[Category: Fritzsch, G]]		[[Category: Fritzsch, G]]
	[[Category: Koepke, J]]		[[Category: Koepke, J]]

OCA at 15:29, 25 December 2014

OCA — Thu, 25 Dec 2014 15:29:14 GMT

←Older revision		Revision as of 15:29, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2iau]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Loligo_vulgaris Loligo vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IAU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2iau]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Loligo_vulgaris Loligo vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IAU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e1a\|1e1a]], [[1pjx\|1pjx]], [[2iao\|2iao]], [[2iap\|2iap]], [[2iaq\|2iaq]], [[2iar\|2iar]], [[2ias\|2ias]], [[2iat\|2iat]], [[2iav\|2iav]], [[2iaw\|2iaw]], [[2iax\|2iax]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e1a\|1e1a]], [[1pjx\|1pjx]], [[2iao\|2iao]], [[2iap\|2iap]], [[2iaq\|2iaq]], [[2iar\|2iar]], [[2ias\|2ias]], [[2iat\|2iat]], [[2iav\|2iav]], [[2iaw\|2iaw]], [[2iax\|2iax]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diisopropyl-fluorophosphatase Diisopropyl-fluorophosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.2 3.1.8.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diisopropyl-fluorophosphatase Diisopropyl-fluorophosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.2 3.1.8.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iau OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iau RCSB], [http://www.ebi.ac.uk/pdbsum/2iau PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iau OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iau RCSB], [http://www.ebi.ac.uk/pdbsum/2iau PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DFPA_LOLVU DFPA_LOLVU]] Biological function and substrate unknown. However, it is capable of acting on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including nerve gases).<ref>PMID:15966726</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	[[Category: Diisopropyl-fluorophosphatase]]		[[Category: Diisopropyl-fluorophosphatase]]
	[[Category: Loligo vulgaris]]		[[Category: Loligo vulgaris]]
-	[[Category: Fritzsch, G.]]	+	[[Category: Fritzsch, G]]
-	[[Category: Koepke, J.]]	+	[[Category: Koepke, J]]
-	[[Category: Luecke, C.]]	+	[[Category: Luecke, C]]
-	[[Category: Rueterjans, H.]]	+	[[Category: Rueterjans, H]]
-	[[Category: Scharff, E I.]]	+	[[Category: Scharff, E I]]
	[[Category: Beta-propeller]]		[[Category: Beta-propeller]]
	[[Category: Calcium-binding site]]		[[Category: Calcium-binding site]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Phosphotriesterase]]		[[Category: Phosphotriesterase]]

OCA at 08:10, 30 September 2014

OCA — Tue, 30 Sep 2014 08:10:23 GMT

←Older revision		Revision as of 08:10, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2iau.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of squid ganglion DFPase W244Y mutant==
		+	<StructureSection load='2iau' size='340' side='right' caption='[[2iau]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2iau]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Loligo_vulgaris Loligo vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IAU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e1a\|1e1a]], [[1pjx\|1pjx]], [[2iao\|2iao]], [[2iap\|2iap]], [[2iaq\|2iaq]], [[2iar\|2iar]], [[2ias\|2ias]], [[2iat\|2iat]], [[2iav\|2iav]], [[2iaw\|2iaw]], [[2iax\|2iax]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diisopropyl-fluorophosphatase Diisopropyl-fluorophosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.2 3.1.8.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iau OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iau RCSB], [http://www.ebi.ac.uk/pdbsum/2iau PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/2iau_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Phosphotriesterases (PTE) are enzymes capable of detoxifying organophosphate-based chemical warfare agents by hydrolysis. One subclass of these enzymes comprises the family of diisopropylfluorophosphatases (DFPases). The DFPase reported here was originally isolated from squid head ganglion of Loligo vulgaris and can be characterized as squid-type DFPase. It is capable of hydrolyzing the organophosphates diisopropylfluorophosphate, soman, sarin, tabun, and cyclosarin. RESULTS: Crystals were grown of both the native and the selenomethionine-labeled enzyme. The X-ray crystal structure of the DFPase from Loligo vulgaris has been solved by MAD phasing and refined to a crystallographic R value of 17.6% at a final resolution of 1.8 A. Using site-directed mutagenesis, we have structurally and functionally characterized essential residues in the active site of the enzyme. CONCLUSIONS: The crystal structure of the DFPase from Loligo vulgaris is the first example of a structural characterization of a squid-type DFPase and the second crystal structure of a PTE determined to date. Therefore, it may serve as a structural model for squid-type DFPases in general. The overall structure of this protein represents a six-fold beta propeller with two calcium ions bound in a central water-filled tunnel. The consensus motif found in the blades of this beta propeller has not yet been observed in other beta propeller structures. Based on the results obtained from mutants of active-site residues, a mechanistic model for the DFP hydrolysis has been developed.

-	~~{{STRUCTURE_2iau\| PDB=2iau \| SCENE= }}~~	+	Crystal structure of diisopropylfluorophosphatase from Loligo vulgaris.,Scharff EI, Koepke J, Fritzsch G, Lucke C, Ruterjans H Structure. 2001 Jun;9(6):493-502. PMID:11435114<ref>PMID:11435114</ref>

-	~~===Crystal structure~~ of ~~squid ganglion DFPase W244Y mutant===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11435114}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2iau]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Loligo_vulgaris Loligo vulgaris]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2IAU OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011435114<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Diisopropyl-fluorophosphatase]]		[[Category: Diisopropyl-fluorophosphatase]]
	[[Category: Loligo vulgaris]]		[[Category: Loligo vulgaris]]

OCA: Protected "2iau" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 10:37:18 GMT

Protected "2iau" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:37, 7 January 2013

OCA at 10:37, 7 January 2013

OCA — Mon, 07 Jan 2013 10:37:15 GMT

←Older revision		Revision as of 10:37, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2iau.png\|left\|200px]]		[[Image:2iau.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2iau", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2iau\| PDB=2iau \| SCENE= }}		{{STRUCTURE_2iau\| PDB=2iau \| SCENE= }}

	===Crystal structure of squid ganglion DFPase W244Y mutant===		===Crystal structure of squid ganglion DFPase W244Y mutant===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11435114}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11435114 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11435114}}		{{ABSTRACT_PUBMED_11435114}}

	==About this Structure==		==About this Structure==
-	~~2IAU~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Loligo_vulgaris Loligo vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAU OCA].	+	[[2iau]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Loligo_vulgaris Loligo vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAU OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11435114~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011435114</ref><references group="xtra"/>
	[[Category: Diisopropyl-fluorophosphatase]]		[[Category: Diisopropyl-fluorophosphatase]]
	[[Category: Loligo vulgaris]]		[[Category: Loligo vulgaris]]
Line 33:		Line 21:
	[[Category: Beta-propeller]]		[[Category: Beta-propeller]]
	[[Category: Calcium-binding site]]		[[Category: Calcium-binding site]]
		+	[[Category: Hydrolase]]
	[[Category: Phosphotriesterase]]		[[Category: Phosphotriesterase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:22:23 2009''

OCA at 18:22, 17 February 2009

OCA — Tue, 17 Feb 2009 18:22:24 GMT

←Older revision		Revision as of 18:22, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2IAU is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Loligo_vulgaris Loligo vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAU OCA].	+	2IAU is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Loligo_vulgaris Loligo vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IAU OCA].

	==Reference==		==Reference==
-	~~Crystal structure of diisopropylfluorophosphatase from Loligo vulgaris., Scharff EI, Koepke J, Fritzsch G, Lucke C, Ruterjans H, Structure. 2001 Jun;9(6):493-502.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11435114 11435114]~~	+	<ref group="xtra">PMID:11435114</ref><references group="xtra"/>
	[[Category: Diisopropyl-fluorophosphatase]]		[[Category: Diisopropyl-fluorophosphatase]]
	[[Category: Loligo vulgaris]]		[[Category: Loligo vulgaris]]
-	[[Category: Single protein]]
	[[Category: Fritzsch, G.]]		[[Category: Fritzsch, G.]]
	[[Category: Koepke, J.]]		[[Category: Koepke, J.]]
Line 36:		Line 35:
	[[Category: Phosphotriesterase]]		[[Category: Phosphotriesterase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 04~~:15:~~12 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:22:23 2009''