2icc - Revision history

OCA at 11:13, 31 March 2021

OCA — Wed, 31 Mar 2021 11:13:09 GMT

←Older revision		Revision as of 11:13, 31 March 2021
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	==Extracellular Domain of CRIg==		==Extracellular Domain of CRIg==
-	<StructureSection load='2icc' size='340' side='right' caption='[[2icc]], [[Resolution\|resolution]] 1.20Å' scene=''>	+	<StructureSection load='2icc' size='340' side='right'caption='[[2icc]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2icc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ICC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2icc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ICC FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2icf\|2icf]], [[2ice\|2ice]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2icf\|2icf]], [[2ice\|2ice]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VSIG4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VSIG4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2icc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2icc OCA], [~~http~~://pdbe.org/2icc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2icc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2icc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2icc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2icc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2icc OCA], [https://pdbe.org/2icc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2icc RCSB], [https://www.ebi.ac.uk/pdbsum/2icc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2icc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/VSIG4_HUMAN VSIG4_HUMAN]] Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.<ref>PMID:17016562</ref> <ref>PMID:17051150</ref>	+	[[https://www.uniprot.org/uniprot/VSIG4_HUMAN VSIG4_HUMAN]] Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.<ref>PMID:17016562</ref> <ref>PMID:17051150</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/2icc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/2icc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Wiesmann, C]]		[[Category: Wiesmann, C]]
	[[Category: Alternative pathway]]		[[Category: Alternative pathway]]

OCA at 08:27, 18 October 2017

OCA — Wed, 18 Oct 2017 08:27:35 GMT

←Older revision		Revision as of 08:27, 18 October 2017
Line 1:		Line 1:
		+
	==Extracellular Domain of CRIg==		==Extracellular Domain of CRIg==
	<StructureSection load='2icc' size='340' side='right' caption='[[2icc]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='2icc' size='340' side='right' caption='[[2icc]], [[Resolution\|resolution]] 1.20Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2icf\|2icf]], [[2ice\|2ice]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2icf\|2icf]], [[2ice\|2ice]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VSIG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VSIG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2icc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2icc OCA], [http://pdbe.org/2icc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2icc RCSB], [http://www.ebi.ac.uk/pdbsum/2icc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2icc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2icc OCA], [http://pdbe.org/2icc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2icc RCSB], [http://www.ebi.ac.uk/pdbsum/2icc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2icc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 05:18, 9 February 2016

OCA — Tue, 09 Feb 2016 05:18:23 GMT

←Older revision		Revision as of 05:18, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2icc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:00, 10 September 2015

OCA — Thu, 10 Sep 2015 19:00:22 GMT

←Older revision		Revision as of 19:00, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2icc' size='340' side='right' caption='[[2icc]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='2icc' size='340' side='right' caption='[[2icc]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2icc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ICC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2icc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ICC FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2icf\|2icf]], [[2ice\|2ice]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2icf\|2icf]], [[2ice\|2ice]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VSIG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VSIG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2icc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2icc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2icc RCSB], [http://www.ebi.ac.uk/pdbsum/2icc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2icc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2icc OCA], [http://pdbe.org/2icc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2icc RCSB], [http://www.ebi.ac.uk/pdbsum/2icc PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2icc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Wiesmann, C]]		[[Category: Wiesmann, C]]
	[[Category: Alternative pathway]]		[[Category: Alternative pathway]]

OCA at 04:42, 25 December 2014

OCA — Thu, 25 Dec 2014 04:42:10 GMT

←Older revision		Revision as of 04:42, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2icc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ICC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2icc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ICC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2icf\|2icf]], [[2ice\|2ice]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2icf\|2icf]], [[2ice\|2ice]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VSIG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VSIG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2icc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2icc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2icc RCSB], [http://www.ebi.ac.uk/pdbsum/2icc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2icc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2icc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2icc RCSB], [http://www.ebi.ac.uk/pdbsum/2icc PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VSIG4_HUMAN VSIG4_HUMAN]] Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.<ref>PMID:17016562</ref> <ref>PMID:17051150</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Wiesmann, C.]]	+	[[Category: Wiesmann, C]]
	[[Category: Alternative pathway]]		[[Category: Alternative pathway]]
	[[Category: Complement receptor]]		[[Category: Complement receptor]]
	[[Category: Ig like domain]]		[[Category: Ig like domain]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 10:57, 30 September 2014

OCA — Tue, 30 Sep 2014 10:57:26 GMT

←Older revision		Revision as of 10:57, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2icc.~~png~~\|~~left~~\|200px]]	+	==Extracellular Domain of CRIg==
		+	<StructureSection load='2icc' size='340' side='right' caption='[[2icc]], [[Resolution\|resolution]] 1.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2icc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ICC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2icf\|2icf]], [[2ice\|2ice]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VSIG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2icc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2icc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2icc RCSB], [http://www.ebi.ac.uk/pdbsum/2icc PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/2icc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The complement system is a key part of the innate immune system, and is required for clearance of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles, but it is unknown how CRIg selectively recognizes proteolytic C3-fragments and whether binding of CRIg to C3b inhibits convertase activation. Here we present the crystal structure of C3b in complex with CRIg and, using CRIg mutants, provide evidence that CRIg acts as an inhibitor of the alternative pathway of complement. The structure shows that activation of C3 induces major structural rearrangements, including a dramatic movement (>80 A) of the thioester-bond-containing domain through which C3b attaches to pathogen surfaces. We show that CRIg is not only a phagocytic receptor, but also a potent inhibitor of the alternative pathway convertases. The structure provides insights into the complex macromolecular structural rearrangements that occur during complement activation and inhibition. Moreover, our structure-function studies relating the structural basis of complement activation and the means by which CRIg inhibits the convertases provide important clues to the development of therapeutics that target complement.

-	~~{{STRUCTURE_2icc\| PDB=2icc \| SCENE= }}~~	+	Structure of C3b in complex with CRIg gives insights into regulation of complement activation.,Wiesmann C, Katschke KJ, Yin J, Helmy KY, Steffek M, Fairbrother WJ, McCallum SA, Embuscado L, DeForge L, Hass PE, van Lookeren Campagne M Nature. 2006 Nov 9;444(7116):217-20. Epub 2006 Oct 15. PMID:17051150<ref>PMID:17051150</ref>

-	~~===Extracellular Domain~~ of ~~CRIg===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17051150}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2icc]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ICC OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017051150<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Wiesmann, C.]]		[[Category: Wiesmann, C.]]

OCA: Protected "2icc" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 12:43:57 GMT

Protected "2icc" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:43, 7 January 2013

OCA at 12:43, 7 January 2013

OCA — Mon, 07 Jan 2013 12:43:53 GMT

←Older revision		Revision as of 12:43, 7 January 2013
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-	{{Seed}}
	[[Image:2icc.png\|left\|200px]]		[[Image:2icc.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2icc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2icc\| PDB=2icc \| SCENE= }}		{{STRUCTURE_2icc\| PDB=2icc \| SCENE= }}

	===Extracellular Domain of CRIg===		===Extracellular Domain of CRIg===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17051150}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17051150 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17051150}}		{{ABSTRACT_PUBMED_17051150}}

	==About this Structure==		==About this Structure==
-	~~2ICC~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICC OCA].	+	[[2icc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICC OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17051150~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017051150</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Wiesmann, C.]]		[[Category: Wiesmann, C.]]
Line 30:		Line 18:
	[[Category: Ig like domain]]		[[Category: Ig like domain]]
	[[Category: Immune system]]		[[Category: Immune system]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:46:48 2009''

OCA at 04:46, 17 February 2009

OCA — Tue, 17 Feb 2009 04:46:49 GMT

←Older revision		Revision as of 04:46, 17 February 2009
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	==About this Structure==		==About this Structure==
-	2ICC is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICC OCA].	+	2ICC is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICC OCA].

	==Reference==		==Reference==
-	Structure of C3b in complex with CRIg gives insights into regulation of complement activation., Wiesmann C, Katschke KJ, Yin J, Helmy KY, Steffek M, Fairbrother WJ, McCallum SA, Embuscado L, DeForge L, Hass PE, van Lookeren Campagne M, Nature. 2006 Nov 9;444(7116):217-20. Epub 2006 Oct 15. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17051150 17051150]~~	+	<ref group="xtra">PMID:17051150</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Wiesmann, C.]]		[[Category: Wiesmann, C.]]
	[[Category: Alternative pathway]]		[[Category: Alternative pathway]]
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	[[Category: Immune system]]		[[Category: Immune system]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 10~~:24:~~08 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:46:48 2009''

OCA at 07:24, 28 July 2008

OCA — Mon, 28 Jul 2008 07:24:13 GMT

←Older revision		Revision as of 07:24, 28 July 2008
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-	[[Image:2icc.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2icc.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2icc\| PDB=2icc \| SCENE= }}		{{STRUCTURE_2icc\| PDB=2icc \| SCENE= }}

-	~~'''~~Extracellular Domain of CRIg~~'''~~	+	===Extracellular Domain of CRIg===


-	~~==Overview==~~	+	<!--
-	The ~~complement system is a key part of the innate immune system~~, ~~and is required for clearance of pathogens from the bloodstream. After exposure to pathogens~~, the ~~third component of the complement system, C3, is cleaved~~ to ~~C3b which, after recruitment of factor B, initiates formation of~~ the ~~alternative pathway convertases. CRIg, a complement receptor expressed~~ on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles, but it is unknown how CRIg selectively recognizes proteolytic C3-fragments and whether binding of CRIg to C3b inhibits convertase activation. ~~Here we present the crystal structure of C3b in complex with CRIg and, using CRIg mutants, provide evidence that CRIg acts as an inhibitor of the alternative pathway of complement~~. ~~The structure shows that activation of C3 induces major structural rearrangements~~, ~~including a dramatic movement (>80 A) of the thioester-bond-containing domain through which C3b attaches to pathogen surfaces. We show that CRIg~~ is ~~not only a phagocytic receptor, but also a potent inhibitor of~~ the ~~alternative pathway convertases~~. ~~The structure provides insights into the complex macromolecular structural rearrangements that occur during complement activation and inhibition. Moreover, our structure~~-function studies relating the structural basis of complement activation and the means by which CRIg inhibits the convertases provide important clues to the development of therapeutics that target complement.	+	The line below this paragraph, {{ABSTRACT_PUBMED_17051150}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17051150 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17051150}}

	==About this Structure==		==About this Structure==
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	[[Category: Ig like domain]]		[[Category: Ig like domain]]
	[[Category: Immune system]]		[[Category: Immune system]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 07~~:19:34 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:24:08 2008''