2idj - Revision history

OCA at 10:09, 30 August 2023

OCA — Wed, 30 Aug 2023 10:09:24 GMT

←Older revision		Revision as of 10:09, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2idj' size='340' side='right'caption='[[2idj]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='2idj' size='340' side='right'caption='[[2idj]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2idj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IDJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2idj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IDJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[1bhj\|1bhj]]~~, [[~~1nbh~~\|~~1nbh~~]]~~, [[1nbi\|1nbi]], [[1r74\|1r74]], [[1r8x\|1r8x]], [[2idk\|2idk]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Gnmt ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10116 Buffalo rat])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Glycine_N-methyltransferase Glycine N-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.20 2.1.1.20]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2idj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2idj OCA], [https://pdbe.org/2idj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2idj RCSB], [https://www.ebi.ac.uk/pdbsum/2idj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2idj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2idj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2idj OCA], [https://pdbe.org/2idj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2idj RCSB], [https://www.ebi.ac.uk/pdbsum/2idj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2idj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GNMT_RAT GNMT_RAT]] Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.	+	[https://www.uniprot.org/uniprot/GNMT_RAT GNMT_RAT] Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
-	[[Category: Glycine N-methyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Egli, M]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Loukachevitch~~, L V~~]]	+	[[Category: Egli M]]
-	[[Category: Luka, Z]]	+	[[Category: Loukachevitch LV]]
-	[[Category: Newcomer~~, M E~~]]	+	[[Category: Luka Z]]
-	[[Category: Pakhomova, S]]	+	[[Category: Newcomer ME]]
-	[[Category: Wagner, C]]	+	[[Category: Pakhomova S]]
-	~~[[Category: Apoprotein]]~~	+	[[Category: Wagner C]]
-	~~[[Category: Glycine n-methyltransferase]]~~	+
-	~~[[Category: Rat]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:13, 31 March 2021

OCA — Wed, 31 Mar 2021 11:13:54 GMT

←Older revision		Revision as of 11:13, 31 March 2021
Line 1:		Line 1:

	==Crystal Structure of Rat Glycine N-Methyltransferase Apoprotein, Monoclinic Form==		==Crystal Structure of Rat Glycine N-Methyltransferase Apoprotein, Monoclinic Form==
-	<StructureSection load='2idj' size='340' side='right' caption='[[2idj]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='2idj' size='340' side='right'caption='[[2idj]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2idj]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IDJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2idj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IDJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bhj\|1bhj]], [[1nbh\|1nbh]], [[1nbi\|1nbi]], [[1r74\|1r74]], [[1r8x\|1r8x]], [[2idk\|2idk]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bhj\|1bhj]], [[1nbh\|1nbh]], [[1nbi\|1nbi]], [[1r74\|1r74]], [[1r8x\|1r8x]], [[2idk\|2idk]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gnmt ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gnmt ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glycine_N-methyltransferase Glycine N-methyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.20 2.1.1.20] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycine_N-methyltransferase Glycine N-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.20 2.1.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2idj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2idj OCA], [~~http~~://pdbe.org/2idj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2idj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2idj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2idj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2idj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2idj OCA], [https://pdbe.org/2idj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2idj RCSB], [https://www.ebi.ac.uk/pdbsum/2idj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2idj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GNMT_RAT GNMT_RAT]] Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.	+	[[https://www.uniprot.org/uniprot/GNMT_RAT GNMT_RAT]] Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/id/2idj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/id/2idj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 37:		Line 37:
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
	[[Category: Glycine N-methyltransferase]]		[[Category: Glycine N-methyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Egli, M]]		[[Category: Egli, M]]
	[[Category: Loukachevitch, L V]]		[[Category: Loukachevitch, L V]]

OCA at 08:28, 18 October 2017

OCA — Wed, 18 Oct 2017 08:28:23 GMT

←Older revision		Revision as of 08:28, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Rat Glycine N-Methyltransferase Apoprotein, Monoclinic Form==		==Crystal Structure of Rat Glycine N-Methyltransferase Apoprotein, Monoclinic Form==
	<StructureSection load='2idj' size='340' side='right' caption='[[2idj]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='2idj' size='340' side='right' caption='[[2idj]], [[Resolution\|resolution]] 2.35Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gnmt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gnmt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_N-methyltransferase Glycine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.20 2.1.1.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_N-methyltransferase Glycine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.20 2.1.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2idj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2idj OCA], [http://pdbe.org/2idj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2idj RCSB], [http://www.ebi.ac.uk/pdbsum/2idj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2idj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2idj OCA], [http://pdbe.org/2idj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2idj RCSB], [http://www.ebi.ac.uk/pdbsum/2idj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2idj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 17:33, 8 February 2016

OCA — Mon, 08 Feb 2016 17:33:52 GMT

←Older revision		Revision as of 17:33, 8 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2idj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:51, 10 September 2015

OCA — Thu, 10 Sep 2015 13:51:51 GMT

←Older revision		Revision as of 13:51, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2idj' size='340' side='right' caption='[[2idj]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='2idj' size='340' side='right' caption='[[2idj]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2idj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IDJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2idj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IDJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bhj\|1bhj]], [[1nbh\|1nbh]], [[1nbi\|1nbi]], [[1r74\|1r74]], [[1r8x\|1r8x]], [[2idk\|2idk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bhj\|1bhj]], [[1nbh\|1nbh]], [[1nbi\|1nbi]], [[1r74\|1r74]], [[1r8x\|1r8x]], [[2idk\|2idk]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gnmt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gnmt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_N-methyltransferase Glycine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.20 2.1.1.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_N-methyltransferase Glycine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.20 2.1.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2idj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2idj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2idj RCSB], [http://www.ebi.ac.uk/pdbsum/2idj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2idj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2idj OCA], [http://pdbe.org/2idj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2idj RCSB], [http://www.ebi.ac.uk/pdbsum/2idj PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2idj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Glycine N-methyltransferase]]		[[Category: Glycine N-methyltransferase]]
-	[[Category: Rattus norvegicus]]
	[[Category: Egli, M]]		[[Category: Egli, M]]
	[[Category: Loukachevitch, L V]]		[[Category: Loukachevitch, L V]]

OCA at 01:00, 25 December 2014

OCA — Thu, 25 Dec 2014 01:00:50 GMT

←Older revision		Revision as of 01:00, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2idj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IDJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2idj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IDJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bhj\|1bhj]], [[1nbh\|1nbh]], [[1nbi\|1nbi]], [[1r74\|1r74]], [[1r8x\|1r8x]], [[2idk\|2idk]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bhj\|1bhj]], [[1nbh\|1nbh]], [[1nbi\|1nbi]], [[1r74\|1r74]], [[1r8x\|1r8x]], [[2idk\|2idk]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gnmt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gnmt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_N-methyltransferase Glycine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.20 2.1.1.20] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_N-methyltransferase Glycine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.20 2.1.1.20] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2idj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2idj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2idj RCSB], [http://www.ebi.ac.uk/pdbsum/2idj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2idj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2idj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2idj RCSB], [http://www.ebi.ac.uk/pdbsum/2idj PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GNMT_RAT GNMT_RAT]] Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	[[Category: Glycine N-methyltransferase]]		[[Category: Glycine N-methyltransferase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Egli, M.]]	+	[[Category: Egli, M]]
-	[[Category: Loukachevitch, L V.]]	+	[[Category: Loukachevitch, L V]]
-	[[Category: Luka, Z.]]	+	[[Category: Luka, Z]]
-	[[Category: Newcomer, M E.]]	+	[[Category: Newcomer, M E]]
-	[[Category: Pakhomova, S.]]	+	[[Category: Pakhomova, S]]
-	[[Category: Wagner, C.]]	+	[[Category: Wagner, C]]
-	[[Category: Apoprotein.]]	+	[[Category: Apoprotein]]
	[[Category: Glycine n-methyltransferase]]		[[Category: Glycine n-methyltransferase]]
	[[Category: Rat]]		[[Category: Rat]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:18, 30 September 2014

OCA — Tue, 30 Sep 2014 08:18:49 GMT

←Older revision		Revision as of 08:18, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2idj.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Rat Glycine N-Methyltransferase Apoprotein, Monoclinic Form==
		+	<StructureSection load='2idj' size='340' side='right' caption='[[2idj]], [[Resolution\|resolution]] 2.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2idj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IDJ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bhj\|1bhj]], [[1nbh\|1nbh]], [[1nbi\|1nbi]], [[1r74\|1r74]], [[1r8x\|1r8x]], [[2idk\|2idk]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gnmt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_N-methyltransferase Glycine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.20 2.1.1.20] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2idj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2idj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2idj RCSB], [http://www.ebi.ac.uk/pdbsum/2idj PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/id/2idj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glycine N-methyltransferase (GNMT) is a key regulatory enzyme in methyl group metabolism. It is abundant in the liver, where it uses excess S-adenosylmethionine (AdoMet) to methylate glycine to N-methylglycine (sarcosine) and produces S-adenosylhomocysteine (AdoHcy), thereby controlling the methylating potential of the cell. GNMT also links utilization of preformed methyl groups, in the form of methionine, to their de novo synthesis, because it is inhibited by a specific form of folate, 5-methyltetrahydrofolate. Although the structure of the enzyme has been elucidated by x-ray crystallography of the apoenzyme and in the presence of the substrate, the location of the folate inhibitor in the tetrameric structure has not been identified. We report here for the first time the crystal structure of rat GNMT complexed with 5-methyltetrahydrofolate. In the GNMT-folate complex, two folate binding sites were located in the intersubunit areas of the tetramer. Each folate binding site is formed primarily by two 1-7 N-terminal regions of one pair of subunits and two 205-218 regions of the other pair of subunits. Both the pteridine and p-aminobenzoyl rings are located in the hydrophobic cavities formed by Tyr5, Leu207, and Met215 residues of all subunits. Binding experiments in solution also confirm that one GNMT tetramer binds two folate molecules. For the enzymatic reaction to take place, the N-terminal fragments of GNMT must have a significant degree of conformational freedom to provide access to the active sites. The presence of the folate in this position provides a mechanism for its inhibition.

-	~~{{STRUCTURE_2idj\| PDB=2idj \| SCENE= }}~~	+	5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase.,Luka Z, Pakhomova S, Loukachevitch LV, Egli M, Newcomer ME, Wagner C J Biol Chem. 2007 Feb 9;282(6):4069-75. Epub 2006 Dec 7. PMID:17158459<ref>PMID:17158459</ref>

-	~~===Crystal Structure of Rat Glycine N-Methyltransferase Apoprotein~~, ~~Monoclinic Form===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17158459}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2idj]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2IDJ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017158459<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Glycine N-methyltransferase]]		[[Category: Glycine N-methyltransferase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]

OCA: Protected "2idj" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 13:21:36 GMT

Protected "2idj" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:21, 7 January 2013

OCA at 13:21, 7 January 2013

OCA — Mon, 07 Jan 2013 13:21:33 GMT

←Older revision		Revision as of 13:21, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2idj.png\|left\|200px]]		[[Image:2idj.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2idj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2idj\| PDB=2idj \| SCENE= }}		{{STRUCTURE_2idj\| PDB=2idj \| SCENE= }}

	===Crystal Structure of Rat Glycine N-Methyltransferase Apoprotein, Monoclinic Form===		===Crystal Structure of Rat Glycine N-Methyltransferase Apoprotein, Monoclinic Form===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17158459}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17158459 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17158459}}		{{ABSTRACT_PUBMED_17158459}}

	==About this Structure==		==About this Structure==
-	~~2IDJ~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDJ OCA].	+	[[2idj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDJ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17158459~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017158459</ref><references group="xtra"/>
	[[Category: Glycine N-methyltransferase]]		[[Category: Glycine N-methyltransferase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
Line 35:		Line 23:
	[[Category: Glycine n-methyltransferase]]		[[Category: Glycine n-methyltransferase]]
	[[Category: Rat]]		[[Category: Rat]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 00:49:13 2009''~~	+

OCA at 22:49, 16 February 2009

OCA — Mon, 16 Feb 2009 22:49:15 GMT

←Older revision		Revision as of 22:49, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2IDJ is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDJ OCA].	+	2IDJ is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDJ OCA].

	==Reference==		==Reference==
-	5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase., Luka Z, Pakhomova S, Loukachevitch LV, Egli M, Newcomer ME, Wagner C, J Biol Chem. 2007 Feb 9;282(6):4069-75. Epub 2006 Dec 7. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17158459 17158459]~~	+	<ref group="xtra">PMID:17158459</ref><references group="xtra"/>
	[[Category: Glycine N-methyltransferase]]		[[Category: Glycine N-methyltransferase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Single protein]]
	[[Category: Egli, M.]]		[[Category: Egli, M.]]
	[[Category: Loukachevitch, L V.]]		[[Category: Loukachevitch, L V.]]
Line 37:		Line 36:
	[[Category: Rat]]		[[Category: Rat]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 05~~:19:~~14 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:49:13 2009''