2iop - Revision history

OCA at 09:03, 21 February 2024

OCA — Wed, 21 Feb 2024 09:03:50 GMT

←Older revision		Revision as of 09:03, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='2iop' size='340' side='right'caption='[[2iop]], [[Resolution\|resolution]] 3.55Å' scene=''>		<StructureSection load='2iop' size='340' side='right'caption='[[2iop]], [[Resolution\|resolution]] 3.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iop]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IOP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IOP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iop]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IOP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IOP FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE~~-~~5-DIPHOSPHATE'>ADP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.55Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1y4u\|1y4u]], [[1y4s\|1y4s]], [[2ioq\|2ioq]], [[2ior\|2ior]]~~</~~div~~>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">htpG ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iop OCA], [https://pdbe.org/2iop PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iop RCSB], [https://www.ebi.ac.uk/pdbsum/2iop PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iop ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iop OCA], [https://pdbe.org/2iop PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iop RCSB], [https://www.ebi.ac.uk/pdbsum/2iop PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iop ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HTPG_ECOLI HTPG_ECOLI]] Molecular chaperone. Has ATPase activity.[HAMAP-Rule:MF_00505]	+	[https://www.uniprot.org/uniprot/HTPG_ECOLI HTPG_ECOLI] Molecular chaperone. Has ATPase activity.[HAMAP-Rule:MF_00505]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iop ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iop ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	In eukaryotes, the ubiquitous and abundant members of the 90 kilodalton heat-shock protein (hsp90) chaperone family facilitate the folding and conformational changes of a broad array of proteins important in cell signaling, proliferation, and survival. Here we describe the effects of nucleotides on the structure of full-length HtpG, the Escherichia coli hsp90 ortholog. By electron microscopy, the nucleotide-free, AMPPNP bound, and ADP bound states of HtpG adopt completely distinct conformations. Structural characterization of nucleotide-free and ADP bound HtpG was extended to higher resolution by X-ray crystallography. In the absence of nucleotide, HtpG exhibits an "open" conformation in which the three domains of each monomer present hydrophobic elements into the large cleft formed by the dimer. By contrast, ADP binding drives dramatic conformational changes that allow these hydrophobic elements to converge and shield each other from solvent, suggesting a mechanism by which nucleotides could control client protein binding and release.
-
-	Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.,Shiau AK, Harris SF, Southworth DR, Agard DA Cell. 2006 Oct 20;127(2):329-40. PMID:17055434<ref>PMID:17055434</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2iop" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]		*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Agard~~, D A~~]]	+	[[Category: Agard DA]]
-	[[Category: Harris~~, S F~~]]	+	[[Category: Harris SF]]
-	[[Category: Shiau~~, A K]]~~	+	[[Category: Shiau AK]]
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Heat shock protein]]~~	+
-	~~[[Category: Hsp90~~]]	+

OCA at 11:20, 31 March 2021

OCA — Wed, 31 Mar 2021 11:20:07 GMT

←Older revision		Revision as of 11:20, 31 March 2021
Line 1:		Line 1:

	==Crystal Structure of Full-length HtpG, the Escherichia coli Hsp90, Bound to ADP==		==Crystal Structure of Full-length HtpG, the Escherichia coli Hsp90, Bound to ADP==
-	<StructureSection load='2iop' size='340' side='right' caption='[[2iop]], [[Resolution\|resolution]] 3.55Å' scene=''>	+	<StructureSection load='2iop' size='340' side='right'caption='[[2iop]], [[Resolution\|resolution]] 3.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iop]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IOP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IOP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iop]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IOP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IOP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y4u\|1y4u]], [[1y4s\|1y4s]], [[2ioq\|2ioq]], [[2ior\|2ior]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1y4u\|1y4u]], [[1y4s\|1y4s]], [[2ioq\|2ioq]], [[2ior\|2ior]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">htpG ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">htpG ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2iop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iop OCA], [~~http~~://pdbe.org/2iop PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2iop RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2iop PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2iop ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iop OCA], [https://pdbe.org/2iop PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iop RCSB], [https://www.ebi.ac.uk/pdbsum/2iop PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iop ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HTPG_ECOLI HTPG_ECOLI]] Molecular chaperone. Has ATPase activity.[HAMAP-Rule:MF_00505]	+	[[https://www.uniprot.org/uniprot/HTPG_ECOLI HTPG_ECOLI]] Molecular chaperone. Has ATPase activity.[HAMAP-Rule:MF_00505]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Agard, D A]]		[[Category: Agard, D A]]
	[[Category: Harris, S F]]		[[Category: Harris, S F]]

OCA at 08:09, 4 July 2018

OCA — Wed, 04 Jul 2018 08:09:29 GMT

←Older revision		Revision as of 08:09, 4 July 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Full-length HtpG, the Escherichia coli Hsp90, Bound to ADP==		==Crystal Structure of Full-length HtpG, the Escherichia coli Hsp90, Bound to ADP==
	<StructureSection load='2iop' size='340' side='right' caption='[[2iop]], [[Resolution\|resolution]] 3.55Å' scene=''>		<StructureSection load='2iop' size='340' side='right' caption='[[2iop]], [[Resolution\|resolution]] 3.55Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y4u\|1y4u]], [[1y4s\|1y4s]], [[2ioq\|2ioq]], [[2ior\|2ior]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y4u\|1y4u]], [[1y4s\|1y4s]], [[2ioq\|2ioq]], [[2ior\|2ior]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">htpG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">htpG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iop OCA], [http://pdbe.org/2iop PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iop RCSB], [http://www.ebi.ac.uk/pdbsum/2iop PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iop OCA], [http://pdbe.org/2iop PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iop RCSB], [http://www.ebi.ac.uk/pdbsum/2iop PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iop ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/io/2iop_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/io/2iop_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iop ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:14, 12 September 2015

OCA — Sat, 12 Sep 2015 02:14:48 GMT

←Older revision		Revision as of 02:14, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2iop' size='340' side='right' caption='[[2iop]], [[Resolution\|resolution]] 3.55Å' scene=''>		<StructureSection load='2iop' size='340' side='right' caption='[[2iop]], [[Resolution\|resolution]] 3.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iop]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IOP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IOP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iop]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IOP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IOP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y4u\|1y4u]], [[1y4s\|1y4s]], [[2ioq\|2ioq]], [[2ior\|2ior]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y4u\|1y4u]], [[1y4s\|1y4s]], [[2ioq\|2ioq]], [[2ior\|2ior]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">htpG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">htpG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iop OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iop RCSB], [http://www.ebi.ac.uk/pdbsum/2iop PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iop OCA], [http://pdbe.org/2iop PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iop RCSB], [http://www.ebi.ac.uk/pdbsum/2iop PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2iop" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Agard, D A]]		[[Category: Agard, D A]]
	[[Category: Harris, S F]]		[[Category: Harris, S F]]

OCA at 22:33, 25 December 2014

OCA — Thu, 25 Dec 2014 22:33:14 GMT

←Older revision		Revision as of 22:33, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2iop]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IOP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IOP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2iop]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IOP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IOP FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y4u\|1y4u]], [[1y4s\|1y4s]], [[2ioq\|2ioq]], [[2ior\|2ior]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y4u\|1y4u]], [[1y4s\|1y4s]], [[2ioq\|2ioq]], [[2ior\|2ior]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">htpG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">htpG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iop OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iop RCSB], [http://www.ebi.ac.uk/pdbsum/2iop PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iop OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iop RCSB], [http://www.ebi.ac.uk/pdbsum/2iop PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HTPG_ECOLI HTPG_ECOLI]] Molecular chaperone. Has ATPase activity.[HAMAP-Rule:MF_00505]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Agard, D A.]]	+	[[Category: Agard, D A]]
-	[[Category: Harris, S F.]]	+	[[Category: Harris, S F]]
-	[[Category: Shiau, A K.]]	+	[[Category: Shiau, A K]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Heat shock protein]]		[[Category: Heat shock protein]]
	[[Category: Hsp90]]		[[Category: Hsp90]]

OCA at 09:48, 29 September 2014

OCA — Mon, 29 Sep 2014 09:48:49 GMT

←Older revision		Revision as of 09:48, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2iop.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Full-length HtpG, the Escherichia coli Hsp90, Bound to ADP==
		+	<StructureSection load='2iop' size='340' side='right' caption='[[2iop]], [[Resolution\|resolution]] 3.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2iop]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IOP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IOP FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y4u\|1y4u]], [[1y4s\|1y4s]], [[2ioq\|2ioq]], [[2ior\|2ior]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">htpG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iop OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iop RCSB], [http://www.ebi.ac.uk/pdbsum/2iop PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/io/2iop_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In eukaryotes, the ubiquitous and abundant members of the 90 kilodalton heat-shock protein (hsp90) chaperone family facilitate the folding and conformational changes of a broad array of proteins important in cell signaling, proliferation, and survival. Here we describe the effects of nucleotides on the structure of full-length HtpG, the Escherichia coli hsp90 ortholog. By electron microscopy, the nucleotide-free, AMPPNP bound, and ADP bound states of HtpG adopt completely distinct conformations. Structural characterization of nucleotide-free and ADP bound HtpG was extended to higher resolution by X-ray crystallography. In the absence of nucleotide, HtpG exhibits an "open" conformation in which the three domains of each monomer present hydrophobic elements into the large cleft formed by the dimer. By contrast, ADP binding drives dramatic conformational changes that allow these hydrophobic elements to converge and shield each other from solvent, suggesting a mechanism by which nucleotides could control client protein binding and release.

-	~~{{STRUCTURE_2iop\| PDB=2iop \| SCENE= }}~~	+	Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.,Shiau AK, Harris SF, Southworth DR, Agard DA Cell. 2006 Oct 20;127(2):329-40. PMID:17055434<ref>PMID:17055434</ref>

-	~~===Crystal Structure~~ of ~~Full-length HtpG,~~ the ~~Escherichia coli Hsp90, Bound to ADP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17055434}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2iop]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2IOP OCA].~~	+

	==See Also==		==See Also==
	*[[Heat Shock Proteins\|Heat Shock Proteins]]		*[[Heat Shock Proteins\|Heat Shock Proteins]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017055434<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Agard, D A.]]		[[Category: Agard, D A.]]

OCA at 22:26, 20 October 2012

OCA — Sat, 20 Oct 2012 22:26:00 GMT

←Older revision		Revision as of 22:26, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2iop]] is a 4 chain structure ~~of [[Heat Shock Proteins]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IOP OCA].	+	[[2iop]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IOP OCA].

	==See Also==		==See Also==

OCA: Protected "2iop" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 16:16:49 GMT

Protected "2iop" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:16, 27 July 2012

OCA at 16:16, 27 July 2012

OCA — Fri, 27 Jul 2012 16:16:48 GMT

←Older revision		Revision as of 16:16, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2iop.png\|left\|200px]]		[[Image:2iop.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2iop", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2iop\| PDB=2iop \| SCENE= }}		{{STRUCTURE_2iop\| PDB=2iop \| SCENE= }}

	===Crystal Structure of Full-length HtpG, the Escherichia coli Hsp90, Bound to ADP===		===Crystal Structure of Full-length HtpG, the Escherichia coli Hsp90, Bound to ADP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17055434}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17055434 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17055434}}		{{ABSTRACT_PUBMED_17055434}}

	==About this Structure==		==About this Structure==
-	~~2IOP~~ is a 4 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IOP OCA].	+	[[2iop]] is a 4 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IOP OCA].
		+
		+	==See Also==
		+	*[[Heat Shock Proteins\|Heat Shock Proteins]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17055434~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017055434</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Agard, D A.]]		[[Category: Agard, D A.]]
Line 31:		Line 22:
	[[Category: Heat shock protein]]		[[Category: Heat shock protein]]
	[[Category: Hsp90]]		[[Category: Hsp90]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:50:19 2009''

OCA at 07:50, 18 February 2009

OCA — Wed, 18 Feb 2009 07:50:19 GMT

←Older revision		Revision as of 07:50, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2IOP is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IOP OCA].	+	2IOP is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IOP OCA].

	==Reference==		==Reference==
-	~~Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements., Shiau AK, Harris SF, Southworth DR, Agard DA, Cell. 2006 Oct 20;127(2):329-40.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17055434 17055434]~~	+	<ref group="xtra">PMID:17055434</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Single protein]]
	[[Category: Agard, D A.]]		[[Category: Agard, D A.]]
	[[Category: Harris, S F.]]		[[Category: Harris, S F.]]
Line 33:		Line 32:
	[[Category: Hsp90]]		[[Category: Hsp90]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 16~~:10:~~37 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:50:19 2009''