2iq1 - Revision history

OCA at 09:03, 21 February 2024

OCA — Wed, 21 Feb 2024 09:03:56 GMT

←Older revision		Revision as of 09:03, 21 February 2024
Line 1:		Line 1:

	==Crystal structure of human PPM1K==		==Crystal structure of human PPM1K==
-	<StructureSection load='2iq1' size='340' side='right'caption='[[2iq1]]' scene=''>	+	<StructureSection load='2iq1' size='340' side='right'caption='[[2iq1]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IQ1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iq1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IQ1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [https://pdbe.org/2iq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB], [https://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iq1 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2iq1 TOPSAN]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [https://pdbe.org/2iq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB], [https://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iq1 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2iq1 TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN] Intermediate maple syrup urine disease.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN] Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.<ref>PMID:17374715</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 25:
	==See Also==		==See Also==
	*[[Protein phosphatase 3D structures\|Protein phosphatase 3D structures]]		*[[Protein phosphatase 3D structures\|Protein phosphatase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Adams J]]		[[Category: Adams J]]

OCA at 11:20, 31 March 2021

OCA — Wed, 31 Mar 2021 11:20:52 GMT

←Older revision		Revision as of 11:20, 31 March 2021
Line 1:		Line 1:

	==Crystal structure of human PPM1K==		==Crystal structure of human PPM1K==
-	<StructureSection load='2iq1' size='340' side='right' caption='[[2iq1]]~~, [[Resolution\|resolution]] 2.25Å~~' scene=''>	+	<StructureSection load='2iq1' size='340' side='right'caption='[[2iq1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[2iq1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IQ1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IQ1 FirstGlance]. <br>
-	</td></tr>~~<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [https://pdbe.org/2iq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB], [https://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iq1 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2iq1 TOPSAN]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp761G058 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [~~http~~://pdbe.org/2iq1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2iq1 ProSAT], [~~http~~://www.topsan.org/Proteins/NYSGXRC/2iq1 TOPSAN]</span></td></tr>	+
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN]] Intermediate maple syrup urine disease.
-	== Function ==
-	[[http://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN]] Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.<ref>PMID:17374715</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 22:		Line 16:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iq1 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iq1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.
-
-	Structural genomics of protein phosphatases.,Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:18058037<ref>PMID:18058037</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2iq1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Protein phosphatase\|Protein phosphatase]]	+	*[[Protein phosphatase 3D structures\|Protein phosphatase 3D structures]]
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Adams, J]]	+	[[Category: Adams J]]
-	[[Category: Almo~~, S C~~]]	+	[[Category: Almo SC]]
-	[[Category: Bain~~, K T~~]]	+	[[Category: Bain KT]]
-	[[Category: Bonanno~~, J B~~]]	+	[[Category: Bonanno JB]]
-	[[Category: Burley~~, S K~~]]	+	[[Category: Burley SK]]
-	[[Category: Freeman, J]]	+	[[Category: Freeman J]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Pelletier L]]
-	[[Category: Pelletier, L]]	+	[[Category: Russell M]]
-	[[Category: Russell, M]]	+	[[Category: Sauder JM]]
-	[[Category: Sauder~~, J M~~]]	+	[[Category: Wasserman S]]
-	[[Category: Wasserman, S]]	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]~~	+
-	~~[[Category: Protein phosphatase 2c kappa]]~~	+
-	~~[[Category: PSI, Protein structure initiative~~]]	+

OCA at 08:27, 14 November 2018

OCA — Wed, 14 Nov 2018 08:27:11 GMT

←Older revision		Revision as of 08:27, 14 November 2018
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iq/2iq1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iq/2iq1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 2iq1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2iq1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Protein phosphatase\|Protein phosphatase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:34, 18 October 2017

OCA — Wed, 18 Oct 2017 08:34:06 GMT

←Older revision		Revision as of 08:34, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of human PPM1K==		==Crystal structure of human PPM1K==
	<StructureSection load='2iq1' size='340' side='right' caption='[[2iq1]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='2iq1' size='340' side='right' caption='[[2iq1]], [[Resolution\|resolution]] 2.25Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp761G058 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp761G058 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [http://pdbe.org/2iq1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB], [http://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2iq1 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [http://pdbe.org/2iq1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB], [http://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iq1 ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/2iq1 TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iq1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 2iq1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2iq1" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Protein phosphatase\|Protein phosphatase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:48, 11 September 2015

OCA — Fri, 11 Sep 2015 07:48:32 GMT

←Older revision		Revision as of 07:48, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2iq1' size='340' side='right' caption='[[2iq1]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='2iq1' size='340' side='right' caption='[[2iq1]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iq1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IQ1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iq1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IQ1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp761G058 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp761G058 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB], [http://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2iq1 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [http://pdbe.org/2iq1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB], [http://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2iq1 TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN]] Intermediate maple syrup urine disease.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN]] Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.<ref>PMID:17374715</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2iq1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Adams, J]]		[[Category: Adams, J]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]

OCA at 12:42, 6 November 2014

OCA — Thu, 06 Nov 2014 12:42:20 GMT

←Older revision		Revision as of 12:42, 6 November 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2iq1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IQ1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2iq1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IQ1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp761G058 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp761G058 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB], [http://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2iq1 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB], [http://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2iq1 TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Adams, J.]]	+	[[Category: Adams, J]]
-	[[Category: Almo, S C.]]	+	[[Category: Almo, S C]]
-	[[Category: Bain, K T.]]	+	[[Category: Bain, K T]]
-	[[Category: Bonanno, J B.]]	+	[[Category: Bonanno, J B]]
-	[[Category: Burley, S K.]]	+	[[Category: Burley, S K]]
-	[[Category: Freeman, J.]]	+	[[Category: Freeman, J]]
-	[[Category: ~~NYSGXRC, New York SGX Research Center for~~ Structural ~~Genomics.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Pelletier, L.]]	+	[[Category: Pelletier, L]]
-	[[Category: Russell, M.]]	+	[[Category: Russell, M]]
-	[[Category: Sauder, J M.]]	+	[[Category: Sauder, J M]]
-	[[Category: Wasserman, S.]]	+	[[Category: Wasserman, S]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: New ~~york sgx research center~~ for ~~structural genomic]]~~	+	[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
-	~~[[Category: Nysgxrc~~]]	+
	[[Category: Protein phosphatase 2c kappa]]		[[Category: Protein phosphatase 2c kappa]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category: Psi-2]]~~	+
-	~~[[Category: Structural genomic~~]]	+

OCA at 08:02, 30 September 2014

OCA — Tue, 30 Sep 2014 08:02:04 GMT

←Older revision		Revision as of 08:02, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2iq1.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of human PPM1K==
		+	<StructureSection load='2iq1' size='340' side='right' caption='[[2iq1]], [[Resolution\|resolution]] 2.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2iq1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IQ1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DKFZp761G058 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB], [http://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2iq1 TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iq/2iq1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.

-	~~{{STRUCTURE_2iq1\| PDB=2iq1 \| SCENE= }}~~	+	Structural genomics of protein phosphatases.,Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:18058037<ref>PMID:18058037</ref>

-	~~===Crystal structure~~ of ~~human PPM1K===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_18058037}}~~	+	==See Also==
-		+	*[[Protein phosphatase\|Protein phosphatase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2iq1~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:018058037<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Adams, J.]]		[[Category: Adams, J.]]

OCA: Protected "2iq1" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 13:06:56 GMT

Protected "2iq1" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:06, 7 January 2013

OCA at 13:06, 7 January 2013

OCA — Mon, 07 Jan 2013 13:06:53 GMT

←Older revision		Revision as of 13:06, 7 January 2013
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-	{{Seed}}
	[[Image:2iq1.png\|left\|200px]]		[[Image:2iq1.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2iq1", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2iq1\| PDB=2iq1 \| SCENE= }}		{{STRUCTURE_2iq1\| PDB=2iq1 \| SCENE= }}

	===Crystal structure of human PPM1K===		===Crystal structure of human PPM1K===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18058037}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18058037 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18058037}}		{{ABSTRACT_PUBMED_18058037}}

	==About this Structure==		==About this Structure==
-	~~2IQ1~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA].	+	[[2iq1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18058037~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018058037</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Adams, J.]]		[[Category: Adams, J.]]
Line 31:		Line 19:
	[[Category: Burley, S K.]]		[[Category: Burley, S K.]]
	[[Category: Freeman, J.]]		[[Category: Freeman, J.]]
-	[[Category: NYSGXRC, New York ~~Structural GenomiX~~ Research ~~Consortium~~.]]	+	[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
	[[Category: Pelletier, L.]]		[[Category: Pelletier, L.]]
	[[Category: Russell, M.]]		[[Category: Russell, M.]]
Line 37:		Line 25:
	[[Category: Wasserman, S.]]		[[Category: Wasserman, S.]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: New york ~~structural genomix~~ research ~~consortium~~]]	+	[[Category: New york sgx research center for structural genomic]]
	[[Category: Nysgxrc]]		[[Category: Nysgxrc]]
	[[Category: Protein phosphatase 2c kappa]]		[[Category: Protein phosphatase 2c kappa]]
Line 43:		Line 31:
	[[Category: Psi-2]]		[[Category: Psi-2]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:23:37 2009''

OCA at 15:23, 17 February 2009

OCA — Tue, 17 Feb 2009 15:23:39 GMT

←Older revision		Revision as of 15:23, 17 February 2009
Line 23:		Line 23:

	==Reference==		==Reference==
-	Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18058037 18058037]~~	+	<ref group="xtra">PMID:18058037</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Adams, J.]]		[[Category: Adams, J.]]
Line 44:		Line 44:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Nov 16 15~~:14:~~03 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:23:37 2009''