2iqy - Revision history

OCA at 10:15, 30 August 2023

OCA — Wed, 30 Aug 2023 10:15:10 GMT

←Older revision		Revision as of 10:15, 30 August 2023
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	<StructureSection load='2iqy' size='340' side='right'caption='[[2iqy]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='2iqy' size='340' side='right'caption='[[2iqy]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iqy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IQY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iqy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IQY FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height~~: ~~3em;~~'>~~[[2iqx\|2iqx]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iqy OCA], [https://pdbe.org/2iqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iqy RCSB], [https://www.ebi.ac.uk/pdbsum/2iqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iqy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iqy OCA], [https://pdbe.org/2iqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iqy RCSB], [https://www.ebi.ac.uk/pdbsum/2iqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iqy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PEBP1_RAT PEBP1_RAT]] Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.	+	[https://www.uniprot.org/uniprot/PEBP1_RAT PEBP1_RAT] Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Heil~~, G L~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Joachimiak, A]]	+	[[Category: Heil GL]]
-	[[Category: Joachimiak, G]]	+	[[Category: Joachimiak A]]
-	[[Category: Kim, Y]]	+	[[Category: Joachimiak G]]
-	[[Category: Koide, S]]	+	[[Category: Kim Y]]
-	~~[[Category: Alpha-beta]]~~	+	[[Category: Koide S]]
-	~~[[Category: Hydrolase inhibitor~~]]	+

OCA at 10:05, 12 May 2021

OCA — Wed, 12 May 2021 10:05:38 GMT

←Older revision		Revision as of 10:05, 12 May 2021
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	<StructureSection load='2iqy' size='340' side='right'caption='[[2iqy]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='2iqy' size='340' side='right'caption='[[2iqy]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iqy]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IQY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iqy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IQY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iqx\|2iqx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2iqx\|2iqx]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2iqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iqy OCA], [~~http~~://pdbe.org/2iqy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2iqy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2iqy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2iqy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iqy OCA], [https://pdbe.org/2iqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iqy RCSB], [https://www.ebi.ac.uk/pdbsum/2iqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iqy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PEBP1_RAT PEBP1_RAT]] Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.	+	[[https://www.uniprot.org/uniprot/PEBP1_RAT PEBP1_RAT]] Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:03, 24 July 2019

OCA — Wed, 24 Jul 2019 09:03:50 GMT

←Older revision		Revision as of 09:03, 24 July 2019
Line 1:		Line 1:

	==Rat Phosphatidylethanolamine-Binding Protein==		==Rat Phosphatidylethanolamine-Binding Protein==
-	<StructureSection load='2iqy' size='340' side='right' caption='[[2iqy]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='2iqy' size='340' side='right'caption='[[2iqy]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2iqy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IQY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2iqy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IQY FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iq/2iqy_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iq/2iqy_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Heil, G L]]		[[Category: Heil, G L]]
	[[Category: Joachimiak, A]]		[[Category: Joachimiak, A]]

OCA at 08:34, 18 October 2017

OCA — Wed, 18 Oct 2017 08:34:32 GMT

←Older revision		Revision as of 08:34, 18 October 2017
Line 1:		Line 1:
		+
	==Rat Phosphatidylethanolamine-Binding Protein==		==Rat Phosphatidylethanolamine-Binding Protein==
	<StructureSection load='2iqy' size='340' side='right' caption='[[2iqy]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='2iqy' size='340' side='right' caption='[[2iqy]], [[Resolution\|resolution]] 1.40Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iqx\|2iqx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iqx\|2iqx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iqy OCA], [http://pdbe.org/2iqy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iqy RCSB], [http://www.ebi.ac.uk/pdbsum/2iqy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iqy OCA], [http://pdbe.org/2iqy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iqy RCSB], [http://www.ebi.ac.uk/pdbsum/2iqy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iqy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iqy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	__TOC__		__TOC__

OCA at 12:47, 11 September 2015

OCA — Fri, 11 Sep 2015 12:47:35 GMT

←Older revision		Revision as of 12:47, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2iqy' size='340' side='right' caption='[[2iqy]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='2iqy' size='340' side='right' caption='[[2iqy]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iqy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IQY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iqy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IQY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iqx\|2iqx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iqx\|2iqx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iqy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iqy RCSB], [http://www.ebi.ac.uk/pdbsum/2iqy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iqy OCA], [http://pdbe.org/2iqy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iqy RCSB], [http://www.ebi.ac.uk/pdbsum/2iqy PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Heil, G L]]		[[Category: Heil, G L]]
	[[Category: Joachimiak, A]]		[[Category: Joachimiak, A]]

OCA at 16:39, 25 December 2014

OCA — Thu, 25 Dec 2014 16:39:29 GMT

←Older revision		Revision as of 16:39, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2iqy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IQY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2iqy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IQY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iqx\|2iqx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iqx\|2iqx]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iqy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iqy RCSB], [http://www.ebi.ac.uk/pdbsum/2iqy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iqy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iqy RCSB], [http://www.ebi.ac.uk/pdbsum/2iqy PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PEBP1_RAT PEBP1_RAT]] Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Heil, G L.]]	+	[[Category: Heil, G L]]
-	[[Category: Joachimiak, A.]]	+	[[Category: Joachimiak, A]]
-	[[Category: Joachimiak, G.]]	+	[[Category: Joachimiak, G]]
-	[[Category: Kim, Y.]]	+	[[Category: Kim, Y]]
-	[[Category: Koide, S.]]	+	[[Category: Koide, S]]
	[[Category: Alpha-beta]]		[[Category: Alpha-beta]]
	[[Category: Hydrolase inhibitor]]		[[Category: Hydrolase inhibitor]]

OCA at 10:27, 30 September 2014

OCA — Tue, 30 Sep 2014 10:27:13 GMT

←Older revision		Revision as of 10:27, 30 September 2014
Line 1:		Line 1:
-	~~[[Image:2iqy.png\|left\|200px]]~~	+	==Rat Phosphatidylethanolamine-Binding Protein==
-		+	<StructureSection load='2iqy' size='340' side='right' caption='[[2iqy]], [[Resolution\|resolution]] 1.40Å' scene=''>
-	~~{{STRUCTURE_2iqy\| PDB=2iqy \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2iqy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IQY FirstGlance]. <br>
-	===Rat Phosphatidylethanolamine-Binding Protein===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iqx\|2iqx]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iqy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iqy RCSB], [http://www.ebi.ac.uk/pdbsum/2iqy PDBsum]</span></td></tr>
-	==~~About this Structure~~==	+	<table>
-	[[2iqy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQY OCA].	+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iq/2iqy_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Heil, G L.]]		[[Category: Heil, G L.]]

OCA: Protected "2iqy" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 12:18:13 GMT

Protected "2iqy" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:18, 7 January 2013

OCA at 12:18, 7 January 2013

OCA — Mon, 07 Jan 2013 12:18:11 GMT

←Older revision		Revision as of 12:18, 7 January 2013
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-	{{Seed}}
	[[Image:2iqy.png\|left\|200px]]		[[Image:2iqy.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2iqy", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2iqy\| PDB=2iqy \| SCENE= }}		{{STRUCTURE_2iqy\| PDB=2iqy \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	~~2IQY~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQY OCA].	+	[[2iqy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQY OCA].
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Heil, G L.]]		[[Category: Heil, G L.]]
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	[[Category: Alpha-beta]]		[[Category: Alpha-beta]]
	[[Category: Hydrolase inhibitor]]		[[Category: Hydrolase inhibitor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:59:35 2009''

OCA at 19:59, 17 February 2009

OCA — Tue, 17 Feb 2009 19:59:36 GMT

←Older revision		Revision as of 19:59, 17 February 2009
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-	[[Image:2iqy.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2iqy.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2iqy\| PDB=2iqy \| SCENE= }}		{{STRUCTURE_2iqy\| PDB=2iqy \| SCENE= }}

-	~~'''~~Rat Phosphatidylethanolamine-Binding Protein~~'''~~	+	===Rat Phosphatidylethanolamine-Binding Protein===


	==About this Structure==		==About this Structure==
-	2IQY is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQY OCA].	+	2IQY is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQY OCA].
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Single protein]]
	[[Category: Heil, G L.]]		[[Category: Heil, G L.]]
	[[Category: Joachimiak, A.]]		[[Category: Joachimiak, A.]]
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	[[Category: Alpha-beta]]		[[Category: Alpha-beta]]
	[[Category: Hydrolase inhibitor]]		[[Category: Hydrolase inhibitor]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 07~~:47:~~03 2008~~''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:59:35 2009''