2irf - Revision history

OCA at 00:07, 28 December 2023

OCA — Thu, 28 Dec 2023 00:07:47 GMT

←Older revision		Revision as of 00:07, 28 December 2023
Line 3:		Line 3:
	<StructureSection load='2irf' size='340' side='right'caption='[[2irf]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2irf' size='340' side='right'caption='[[2irf]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2irf]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IRF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2irf]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IRF FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=K:POTASSIUM+ION'>K</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [https://pdbe.org/2irf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [https://www.ebi.ac.uk/pdbsum/2irf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2irf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [https://pdbe.org/2irf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [https://www.ebi.ac.uk/pdbsum/2irf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2irf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IRF2_MOUSE IRF2_MOUSE]] Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.	+	[https://www.uniprot.org/uniprot/IRF2_MOUSE IRF2_MOUSE] Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Fujii, Y]]	+	[[Category: Fujii Y]]
-	[[Category: Hakoshima, T]]	+	[[Category: Hakoshima T]]
-	[[Category: Kusumoto, M]]	+	[[Category: Kusumoto M]]
-	[[Category: Kyogoku, Y]]	+	[[Category: Kyogoku Y]]
-	[[Category: Shimizu, T]]	+	[[Category: Shimizu T]]
-	[[Category: Taniguchi, T]]	+	[[Category: Taniguchi T]]
-	~~[[Category: Gene regulation-dna complex]]~~	+
-	~~[[Category: Ifn induction]]~~	+
-	~~[[Category: Irf family]]~~	+
-	~~[[Category: Transcription factor~~]]	+

OCA at 10:31, 12 January 2022

OCA — Wed, 12 Jan 2022 10:31:08 GMT

←Older revision		Revision as of 10:31, 12 January 2022
Line 3:		Line 3:
	<StructureSection load='2irf' size='340' side='right'caption='[[2irf]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2irf' size='340' side='right'caption='[[2irf]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2irf]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2IRF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2irf]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IRF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [~~http~~://pdbe.org/2irf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2irf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2irf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [https://pdbe.org/2irf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [https://www.ebi.ac.uk/pdbsum/2irf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2irf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IRF2_MOUSE IRF2_MOUSE]] Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.	+	[[https://www.uniprot.org/uniprot/IRF2_MOUSE IRF2_MOUSE]] Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:49, 8 April 2020

OCA — Wed, 08 Apr 2020 07:49:41 GMT

←Older revision		Revision as of 07:49, 8 April 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.==		==CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.==
-	<StructureSection load='2irf' size='340' side='right' caption='[[2irf]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2irf' size='340' side='right'caption='[[2irf]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2irf]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRF OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IRF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2irf]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2IRF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [http://pdbe.org/2irf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [http://www.ebi.ac.uk/pdbsum/2irf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2irf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [http://pdbe.org/2irf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [http://www.ebi.ac.uk/pdbsum/2irf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2irf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Fujii, Y]]		[[Category: Fujii, Y]]

OCA at 08:05, 4 July 2018

OCA — Wed, 04 Jul 2018 08:05:14 GMT

←Older revision		Revision as of 08:05, 4 July 2018
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.==		==CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.==
	<StructureSection load='2irf' size='340' side='right' caption='[[2irf]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2irf' size='340' side='right' caption='[[2irf]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [http://pdbe.org/2irf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [http://www.ebi.ac.uk/pdbsum/2irf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [http://pdbe.org/2irf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [http://www.ebi.ac.uk/pdbsum/2irf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2irf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ir/2irf_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ir/2irf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2irf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:41, 11 September 2015

OCA — Fri, 11 Sep 2015 16:41:35 GMT

←Older revision		Revision as of 16:41, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2irf' size='340' side='right' caption='[[2irf]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2irf' size='340' side='right' caption='[[2irf]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2irf]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IRF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2irf]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IRF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [http://www.ebi.ac.uk/pdbsum/2irf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [http://pdbe.org/2irf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [http://www.ebi.ac.uk/pdbsum/2irf PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2irf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Fujii, Y]]		[[Category: Fujii, Y]]
	[[Category: Hakoshima, T]]		[[Category: Hakoshima, T]]

OCA at 19:08, 25 December 2014

OCA — Thu, 25 Dec 2014 19:08:35 GMT

←Older revision		Revision as of 19:08, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2irf]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IRF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2irf]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IRF FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [http://www.ebi.ac.uk/pdbsum/2irf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [http://www.ebi.ac.uk/pdbsum/2irf PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IRF2_MOUSE IRF2_MOUSE]] Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Fujii, Y.]]	+	[[Category: Fujii, Y]]
-	[[Category: Hakoshima, T.]]	+	[[Category: Hakoshima, T]]
-	[[Category: Kusumoto, M.]]	+	[[Category: Kusumoto, M]]
-	[[Category: Kyogoku, Y.]]	+	[[Category: Kyogoku, Y]]
-	[[Category: Shimizu, T.]]	+	[[Category: Shimizu, T]]
-	[[Category: Taniguchi, T.]]	+	[[Category: Taniguchi, T]]
	[[Category: Gene regulation-dna complex]]		[[Category: Gene regulation-dna complex]]
	[[Category: Ifn induction]]		[[Category: Ifn induction]]
	[[Category: Irf family]]		[[Category: Irf family]]
	[[Category: Transcription factor]]		[[Category: Transcription factor]]

OCA at 07:51, 30 September 2014

OCA — Tue, 30 Sep 2014 07:51:08 GMT

←Older revision		Revision as of 07:51, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2irf\| PDB=2irf \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.==
-	===CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.===	+	<StructureSection load='2irf' size='340' side='right' caption='[[2irf]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_10487755}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2irf]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IRF FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2irf RCSB], [http://www.ebi.ac.uk/pdbsum/2irf PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ir/2irf_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	There has been growing interest in the role of the IRF (interferon regulatory factor) family of transcription factors in the regulation of immune responses, cytokine signaling, and oncogenesis. These members are characterized by their well-conserved DNA binding domains at the N-terminal regions. Here we report the 2.2 A resolution crystal structure of the DNA binding domain of one such family member, IRF-2, bound to DNA. The structure reveals its recognition sequence, AANNGAAA (here, recognized bases are underlined and in bold, and N indicates any base), and its cooperative binding to a tandem repeat of the GAAA core sequence induced by DNA structure distortions. These facts explain well the diverse binding properties of the IRF family members, which bind to both single and tandemly repeated sequences. Furthermore, we also identified the 'helix-hairpin-strand motif' at the C terminus of the recognition helix as a metal binding site that is commonly found in certain classes of DNA-interactive proteins. Our results provide new insights into the structure and function of this family of transcription factors.

-	~~==About this Structure==~~	+	Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences.,Fujii Y, Shimizu T, Kusumoto M, Kyogoku Y, Taniguchi T, Hakoshima T EMBO J. 1999 Sep 15;18(18):5028-41. PMID:10487755<ref>PMID:10487755</ref>
-	~~[[2irf]] is~~ a ~~12 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2IRF OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Interferon regulatory factor\|Interferon regulatory factor]]		*[[Interferon regulatory factor\|Interferon regulatory factor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010487755<~~/~~ref~~><~~ref group="xtra">PMID:015048824</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Fujii, Y.]]		[[Category: Fujii, Y.]]

OCA at 09:15, 11 March 2013

OCA — Mon, 11 Mar 2013 09:15:21 GMT

←Older revision		Revision as of 09:15, 11 March 2013
Line 1:		Line 1:
-	[[Image:2irf.png\|left\|200px]]
-
	{{STRUCTURE_2irf\| PDB=2irf \| SCENE= }}		{{STRUCTURE_2irf\| PDB=2irf \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.===		===CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.===
-
	{{ABSTRACT_PUBMED_10487755}}		{{ABSTRACT_PUBMED_10487755}}

OCA: Protected "2irf" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 10:23:43 GMT

Protected "2irf" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:23, 7 January 2013

OCA at 10:23, 7 January 2013

OCA — Mon, 07 Jan 2013 10:23:39 GMT

←Older revision		Revision as of 10:23, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2irf.png\|left\|200px]]		[[Image:2irf.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2irf", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2irf\| PDB=2irf \| SCENE= }}		{{STRUCTURE_2irf\| PDB=2irf \| SCENE= }}

	===CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.===		===CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_10487755}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 10487755 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_10487755}}		{{ABSTRACT_PUBMED_10487755}}

	==About this Structure==		==About this Structure==
-	~~2IRF~~ is a 12 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRF OCA].	+	[[2irf]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRF OCA].
		+
		+	==See Also==
		+	*[[Interferon regulatory factor\|Interferon regulatory factor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10487755~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010487755</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Fujii, Y.]]		[[Category: Fujii, Y.]]
Line 31:		Line 22:
	[[Category: Shimizu, T.]]		[[Category: Shimizu, T.]]
	[[Category: Taniguchi, T.]]		[[Category: Taniguchi, T.]]
		+	[[Category: Gene regulation-dna complex]]
	[[Category: Ifn induction]]		[[Category: Ifn induction]]
	[[Category: Irf family]]		[[Category: Irf family]]
	[[Category: Transcription factor]]		[[Category: Transcription factor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:01:22 2009''