2iyt - Revision history

OCA at 14:30, 13 December 2023

OCA — Wed, 13 Dec 2023 14:30:04 GMT

←Older revision		Revision as of 14:30, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2iyt' size='340' side='right'caption='[[2iyt]], [[Resolution\|resolution]] 1.47Å' scene=''>		<StructureSection load='2iyt' size='340' side='right'caption='[[2iyt]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iyt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iyt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IYT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.47Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1l4u\|1l4u]], [[1l4y\|1l4y]], [[1u8a\|1u8a]], [[1zyu\|1zyu]], [[2g1j\|2g1j]], [[2g1k\|2g1k]], [[2iyq\|2iyq]], [[2iyr\|2iyr]], [[2iys\|2iys]], [[2iyu\|2iyu]], [[2iyv\|2iyv]], [[2iyw\|2iyw]], [[2iyx\|2iyx]], [[2iyy\|2iyy]], [[2iyz\|2iyz]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyt OCA], [https://pdbe.org/2iyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iyt RCSB], [https://www.ebi.ac.uk/pdbsum/2iyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyt OCA], [https://pdbe.org/2iyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iyt RCSB], [https://www.ebi.ac.uk/pdbsum/2iyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AROK_MYCTU AROK_MYCTU]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:11483005</ref> <ref>PMID:17020768</ref>	+	[https://www.uniprot.org/uniprot/AROK_MYCTU AROK_MYCTU] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:11483005</ref> <ref>PMID:17020768</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 31:

	==See Also==		==See Also==
-	*[[Shikimate kinase\|Shikimate kinase]]	+	*[[Shikimate kinase 3D structures\|Shikimate kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu]]~~	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	~~[[Category: Shikimate kinase~~]]	+	[[Category: Bartunik HD]]
-	[[Category: Bartunik~~, H D~~]]	+	[[Category: Bourenkov GP]]
-	[[Category: Bourenkov~~, G P~~]]	+	[[Category: Hartmann MD]]
-	[[Category: Hartmann~~, M D~~]]	+	[[Category: Oberschall A]]
-	[[Category: Oberschall, A]]	+	[[Category: Strizhov N]]
-	[[Category: Strizhov, N]]	+
-	~~[[Category: Amino-acid biosynthesis]]~~	+
-	~~[[Category: Aromatic amino acid biosynthesis]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Magnesium]]~~	+
-	~~[[Category: Metal- binding]]~~	+
-	~~[[Category: Nucleotide- binding]]~~	+
-	~~[[Category: P-loop kinase]]~~	+
-	~~[[Category: Shikimate pathway]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:57, 19 January 2022

OCA — Wed, 19 Jan 2022 07:57:17 GMT

←Older revision		Revision as of 07:57, 19 January 2022
Line 3:		Line 3:
	<StructureSection load='2iyt' size='340' side='right'caption='[[2iyt]], [[Resolution\|resolution]] 1.47Å' scene=''>		<StructureSection load='2iyt' size='340' side='right'caption='[[2iyt]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iyt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2IYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iyt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IYT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l4u\|1l4u]], [[1l4y\|1l4y]], [[1u8a\|1u8a]], [[1zyu\|1zyu]], [[2g1j\|2g1j]], [[2g1k\|2g1k]], [[2iyq\|2iyq]], [[2iyr\|2iyr]], [[2iys\|2iys]], [[2iyu\|2iyu]], [[2iyv\|2iyv]], [[2iyw\|2iyw]], [[2iyx\|2iyx]], [[2iyy\|2iyy]], [[2iyz\|2iyz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1l4u\|1l4u]], [[1l4y\|1l4y]], [[1u8a\|1u8a]], [[1zyu\|1zyu]], [[2g1j\|2g1j]], [[2g1k\|2g1k]], [[2iyq\|2iyq]], [[2iyr\|2iyr]], [[2iys\|2iys]], [[2iyu\|2iyu]], [[2iyv\|2iyv]], [[2iyw\|2iyw]], [[2iyx\|2iyx]], [[2iyy\|2iyy]], [[2iyz\|2iyz]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2iyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyt OCA], [~~http~~://pdbe.org/2iyt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2iyt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2iyt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyt OCA], [https://pdbe.org/2iyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iyt RCSB], [https://www.ebi.ac.uk/pdbsum/2iyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AROK_MYCTU AROK_MYCTU]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:11483005</ref> <ref>PMID:17020768</ref>	+	[[https://www.uniprot.org/uniprot/AROK_MYCTU AROK_MYCTU]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:11483005</ref> <ref>PMID:17020768</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:35, 15 April 2020

OCA — Wed, 15 Apr 2020 07:35:00 GMT

←Older revision		Revision as of 07:35, 15 April 2020
Line 1:		Line 1:

	==Shikimate kinase from Mycobacterium tuberculosis in unliganded state, open LID (conf. A)==		==Shikimate kinase from Mycobacterium tuberculosis in unliganded state, open LID (conf. A)==
-	<StructureSection load='2iyt' size='340' side='right' caption='[[2iyt]], [[Resolution\|resolution]] 1.47Å' scene=''>	+	<StructureSection load='2iyt' size='340' side='right'caption='[[2iyt]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYT OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2IYT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l4u\|1l4u]], [[1l4y\|1l4y]], [[1u8a\|1u8a]], [[1zyu\|1zyu]], [[2g1j\|2g1j]], [[2g1k\|2g1k]], [[2iyq\|2iyq]], [[2iyr\|2iyr]], [[2iys\|2iys]], [[2iyu\|2iyu]], [[2iyv\|2iyv]], [[2iyw\|2iyw]], [[2iyx\|2iyx]], [[2iyy\|2iyy]], [[2iyz\|2iyz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l4u\|1l4u]], [[1l4y\|1l4y]], [[1u8a\|1u8a]], [[1zyu\|1zyu]], [[2g1j\|2g1j]], [[2g1k\|2g1k]], [[2iyq\|2iyq]], [[2iyr\|2iyr]], [[2iys\|2iys]], [[2iyu\|2iyu]], [[2iyv\|2iyv]], [[2iyw\|2iyw]], [[2iyx\|2iyx]], [[2iyy\|2iyy]], [[2iyz\|2iyz]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2iyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyt OCA], [http://pdbe.org/2iyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iyt RCSB], [http://www.ebi.ac.uk/pdbsum/2iyt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2iyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyt OCA], [http://pdbe.org/2iyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iyt RCSB], [http://www.ebi.ac.uk/pdbsum/2iyt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Shikimate kinase]]		[[Category: Shikimate kinase]]

OCA at 07:22, 11 July 2018

OCA — Wed, 11 Jul 2018 07:22:15 GMT

←Older revision		Revision as of 07:22, 11 July 2018
Line 1:		Line 1:
-	==~~SHIKIMATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS IN UNLIGANDED STATE~~, ~~OPEN~~ LID (~~CONF~~. A)==	+
		+	==Shikimate kinase from Mycobacterium tuberculosis in unliganded state, open LID (conf. A)==
	<StructureSection load='2iyt' size='340' side='right' caption='[[2iyt]], [[Resolution\|resolution]] 1.47Å' scene=''>		<StructureSection load='2iyt' size='340' side='right' caption='[[2iyt]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l4u\|1l4u]], [[1l4y\|1l4y]], [[1u8a\|1u8a]], [[1zyu\|1zyu]], [[2g1j\|2g1j]], [[2g1k\|2g1k]], [[2iyq\|2iyq]], [[2iyr\|2iyr]], [[2iys\|2iys]], [[2iyu\|2iyu]], [[2iyv\|2iyv]], [[2iyw\|2iyw]], [[2iyx\|2iyx]], [[2iyy\|2iyy]], [[2iyz\|2iyz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l4u\|1l4u]], [[1l4y\|1l4y]], [[1u8a\|1u8a]], [[1zyu\|1zyu]], [[2g1j\|2g1j]], [[2g1k\|2g1k]], [[2iyq\|2iyq]], [[2iyr\|2iyr]], [[2iys\|2iys]], [[2iyu\|2iyu]], [[2iyv\|2iyv]], [[2iyw\|2iyw]], [[2iyx\|2iyx]], [[2iyy\|2iyy]], [[2iyz\|2iyz]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyt OCA], [http://pdbe.org/2iyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iyt RCSB], [http://www.ebi.ac.uk/pdbsum/2iyt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyt OCA], [http://pdbe.org/2iyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iyt RCSB], [http://www.ebi.ac.uk/pdbsum/2iyt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iy/2iyt_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iy/2iyt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:51, 7 February 2016

OCA — Sun, 07 Feb 2016 17:51:39 GMT

←Older revision		Revision as of 17:51, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iyt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:47, 10 September 2015

OCA — Thu, 10 Sep 2015 03:47:32 GMT

←Older revision		Revision as of 03:47, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2iyt' size='340' side='right' caption='[[2iyt]], [[Resolution\|resolution]] 1.47Å' scene=''>		<StructureSection load='2iyt' size='340' side='right' caption='[[2iyt]], [[Resolution\|resolution]] 1.47Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IYT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l4u\|1l4u]], [[1l4y\|1l4y]], [[1u8a\|1u8a]], [[1zyu\|1zyu]], [[2g1j\|2g1j]], [[2g1k\|2g1k]], [[2iyq\|2iyq]], [[2iyr\|2iyr]], [[2iys\|2iys]], [[2iyu\|2iyu]], [[2iyv\|2iyv]], [[2iyw\|2iyw]], [[2iyx\|2iyx]], [[2iyy\|2iyy]], [[2iyz\|2iyz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l4u\|1l4u]], [[1l4y\|1l4y]], [[1u8a\|1u8a]], [[1zyu\|1zyu]], [[2g1j\|2g1j]], [[2g1k\|2g1k]], [[2iyq\|2iyq]], [[2iyr\|2iyr]], [[2iys\|2iys]], [[2iyu\|2iyu]], [[2iyv\|2iyv]], [[2iyw\|2iyw]], [[2iyx\|2iyx]], [[2iyy\|2iyy]], [[2iyz\|2iyz]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iyt RCSB], [http://www.ebi.ac.uk/pdbsum/2iyt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyt OCA], [http://pdbe.org/2iyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iyt RCSB], [http://www.ebi.ac.uk/pdbsum/2iyt PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2iyt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium tuberculosis~~]]	+	[[Category: Myctu]]
	[[Category: Shikimate kinase]]		[[Category: Shikimate kinase]]
	[[Category: Bartunik, H D]]		[[Category: Bartunik, H D]]

OCA at 17:13, 24 December 2014

OCA — Wed, 24 Dec 2014 17:13:21 GMT

←Older revision		Revision as of 17:13, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2iyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IYT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2iyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IYT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l4u\|1l4u]], [[1l4y\|1l4y]], [[1u8a\|1u8a]], [[1zyu\|1zyu]], [[2g1j\|2g1j]], [[2g1k\|2g1k]], [[2iyq\|2iyq]], [[2iyr\|2iyr]], [[2iys\|2iys]], [[2iyu\|2iyu]], [[2iyv\|2iyv]], [[2iyw\|2iyw]], [[2iyx\|2iyx]], [[2iyy\|2iyy]], [[2iyz\|2iyz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l4u\|1l4u]], [[1l4y\|1l4y]], [[1u8a\|1u8a]], [[1zyu\|1zyu]], [[2g1j\|2g1j]], [[2g1k\|2g1k]], [[2iyq\|2iyq]], [[2iyr\|2iyr]], [[2iys\|2iys]], [[2iyu\|2iyu]], [[2iyv\|2iyv]], [[2iyw\|2iyw]], [[2iyx\|2iyx]], [[2iyy\|2iyy]], [[2iyz\|2iyz]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iyt RCSB], [http://www.ebi.ac.uk/pdbsum/2iyt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iyt RCSB], [http://www.ebi.ac.uk/pdbsum/2iyt PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AROK_MYCTU AROK_MYCTU]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:11483005</ref> <ref>PMID:17020768</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Shikimate kinase]]		[[Category: Shikimate kinase]]
-	[[Category: Bartunik, H D.]]	+	[[Category: Bartunik, H D]]
-	[[Category: Bourenkov, G P.]]	+	[[Category: Bourenkov, G P]]
-	[[Category: Hartmann, M D.]]	+	[[Category: Hartmann, M D]]
-	[[Category: Oberschall, A.]]	+	[[Category: Oberschall, A]]
-	[[Category: Strizhov, N.]]	+	[[Category: Strizhov, N]]
	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]
	[[Category: Aromatic amino acid biosynthesis]]		[[Category: Aromatic amino acid biosynthesis]]
Line 48:		Line 50:
	[[Category: Nucleotide- binding]]		[[Category: Nucleotide- binding]]
	[[Category: P-loop kinase]]		[[Category: P-loop kinase]]
-	[[Category: Shikimate kinase]]
	[[Category: Shikimate pathway]]		[[Category: Shikimate pathway]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:59, 30 September 2014

OCA — Tue, 30 Sep 2014 10:59:54 GMT

←Older revision		Revision as of 10:59, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2iyt.~~png~~\|~~left~~\|200px]]	+	==SHIKIMATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS IN UNLIGANDED STATE, OPEN LID (CONF. A)==
		+	<StructureSection load='2iyt' size='340' side='right' caption='[[2iyt]], [[Resolution\|resolution]] 1.47Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2iyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IYT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l4u\|1l4u]], [[1l4y\|1l4y]], [[1u8a\|1u8a]], [[1zyu\|1zyu]], [[2g1j\|2g1j]], [[2g1k\|2g1k]], [[2iyq\|2iyq]], [[2iyr\|2iyr]], [[2iys\|2iys]], [[2iyu\|2iyu]], [[2iyv\|2iyv]], [[2iyw\|2iyw]], [[2iyx\|2iyx]], [[2iyy\|2iyy]], [[2iyz\|2iyz]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iyt RCSB], [http://www.ebi.ac.uk/pdbsum/2iyt PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iy/2iyt_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structural mechanism of the catalytic functioning of shikimate kinase from Mycobacterium tuberculosis was investigated on the basis of a series of high-resolution crystal structures corresponding to individual steps in the enzymatic reaction. The catalytic turnover of shikimate and ATP into the products shikimate-3-phosphate and ADP, followed by release of ADP, was studied in the crystalline environment. Based on a comparison of the structural states before initiation of the reaction and immediately after the catalytic step, we derived a structural model of the transition state that suggests that phosphoryl transfer proceeds with inversion by an in-line associative mechanism. The random sequential binding of shikimate and nucleotides is associated with domain movements. We identified a synergic mechanism by which binding of the first substrate may enhance the affinity for the second substrate.

-	~~{{STRUCTURE_2iyt\| PDB=2iyt \| SCENE= }}~~	+	Mechanism of phosphoryl transfer catalyzed by shikimate kinase from Mycobacterium tuberculosis.,Hartmann MD, Bourenkov GP, Oberschall A, Strizhov N, Bartunik HD J Mol Biol. 2006 Dec 1;364(3):411-23. Epub 2006 Sep 5. PMID:17020768<ref>PMID:17020768</ref>

-	~~===SHIKIMATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS IN UNLIGANDED STATE~~, ~~OPEN LID (CONF~~. ~~A)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_17020768}}~~	+	==See Also==
-		+	*[[Shikimate kinase\|Shikimate kinase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2iyt~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYT OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:017020768<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Shikimate kinase]]		[[Category: Shikimate kinase]]

OCA: Protected "2iyt" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 15:27:00 GMT

Protected "2iyt" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:27, 7 January 2013

OCA at 15:26, 7 January 2013

OCA — Mon, 07 Jan 2013 15:26:57 GMT

←Older revision		Revision as of 15:26, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2iyt.png\|left\|200px]]		[[Image:2iyt.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2iyt", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2iyt\| PDB=2iyt \| SCENE= }}		{{STRUCTURE_2iyt\| PDB=2iyt \| SCENE= }}

	===SHIKIMATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS IN UNLIGANDED STATE, OPEN LID (CONF. A)===		===SHIKIMATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS IN UNLIGANDED STATE, OPEN LID (CONF. A)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17020768}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17020768 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17020768}}		{{ABSTRACT_PUBMED_17020768}}

	==About this Structure==		==About this Structure==
-	~~2IYT~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYT OCA].	+	[[2iyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYT OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17020768~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017020768</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Shikimate kinase]]		[[Category: Shikimate kinase]]
Line 36:		Line 24:
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Magnesium]]		[[Category: Magnesium]]
-	[[Category: Metal-binding]]	+	[[Category: Metal- binding]]
-	[[Category: Nucleotide-binding]]	+	[[Category: Nucleotide- binding]]
	[[Category: P-loop kinase]]		[[Category: P-loop kinase]]
	[[Category: Shikimate kinase]]		[[Category: Shikimate kinase]]
	[[Category: Shikimate pathway]]		[[Category: Shikimate pathway]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:32:50 2009''