2j1k - Revision history

OCA at 14:31, 13 December 2023

OCA — Wed, 13 Dec 2023 14:31:49 GMT

←Older revision		Revision as of 14:31, 13 December 2023
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	<StructureSection load='2j1k' size='340' side='right'caption='[[2j1k]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2j1k' size='340' side='right'caption='[[2j1k]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j1k]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Adec2 Adec2~~] and [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J1K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j1k]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Canine_adenovirus_2 Canine adenovirus 2] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J1K FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1kac\|1kac]]~~, [[~~1nob~~\|~~1nob~~]]~~, [[1p69\|1p69]], [[1p6a\|1p6a]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [https://pdbe.org/2j1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [https://www.ebi.ac.uk/pdbsum/2j1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j1k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [https://pdbe.org/2j1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [https://www.ebi.ac.uk/pdbsum/2j1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j1k ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_ADECT SPIKE_ADECT] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Adec2~~]]	+	[[Category: Canine adenovirus 2]]
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Billet, O]]	+	[[Category: Billet O]]
-	[[Category: Cusack, S]]	+	[[Category: Cusack S]]
-	[[Category: Kremer~~, E J~~]]	+	[[Category: Kremer EJ]]
-	[[Category: Lortat-Jacob, H]]	+	[[Category: Lortat-Jacob H]]
-	[[Category: Seiradake, E]]	+	[[Category: Seiradake E]]
-	~~[[Category: Adenovirus]]~~	+
-	~~[[Category: Canine]]~~	+
-	~~[[Category: Car]]~~	+
-	~~[[Category: Cav-2]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Coxsackievirus]]~~	+
-	~~[[Category: Domain d1]]~~	+
-	~~[[Category: Fiber]]~~	+
-	~~[[Category: Fiber head]]~~	+
-	~~[[Category: Fiber protein]]~~	+
-	~~[[Category: Fibre]]~~	+
-	~~[[Category: Fibre head]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Host-virus interaction]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Knob]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Palmitate]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Tight junction]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Virus-receptor complex~~]]	+

OCA at 07:58, 19 January 2022

OCA — Wed, 19 Jan 2022 07:58:57 GMT

←Older revision		Revision as of 07:58, 19 January 2022
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	<StructureSection load='2j1k' size='340' side='right'caption='[[2j1k]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2j1k' size='340' side='right'caption='[[2j1k]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j1k]] is a 24 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Adec2 Adec2] and [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2J1K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j1k]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Adec2 Adec2] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J1K FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kac\|1kac]], [[1nob\|1nob]], [[1p69\|1p69]], [[1p6a\|1p6a]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1kac\|1kac]], [[1nob\|1nob]], [[1p69\|1p69]], [[1p6a\|1p6a]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [~~http~~://pdbe.org/2j1k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2j1k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2j1k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [https://pdbe.org/2j1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [https://www.ebi.ac.uk/pdbsum/2j1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j1k ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:36, 15 April 2020

OCA — Wed, 15 Apr 2020 07:36:44 GMT

←Older revision		Revision as of 07:36, 15 April 2020
Line 1:		Line 1:

	==CAV-2 fibre head in complex with CAR D1==		==CAV-2 fibre head in complex with CAR D1==
-	<StructureSection load='2j1k' size='340' side='right' caption='[[2j1k]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2j1k' size='340' side='right'caption='[[2j1k]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j1k]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Adec2 Adec2] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2J1K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j1k]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Adec2 Adec2] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2J1K FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kac\|1kac]], [[1nob\|1nob]], [[1p69\|1p69]], [[1p6a\|1p6a]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kac\|1kac]], [[1nob\|1nob]], [[1p69\|1p69]], [[1p6a\|1p6a]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [http://pdbe.org/2j1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [http://www.ebi.ac.uk/pdbsum/2j1k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j1k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [http://pdbe.org/2j1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [http://www.ebi.ac.uk/pdbsum/2j1k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j1k ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 32:		Line 32:
	[[Category: Adec2]]		[[Category: Adec2]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Billet, O]]		[[Category: Billet, O]]
	[[Category: Cusack, S]]		[[Category: Cusack, S]]

OCA at 06:42, 11 July 2018

OCA — Wed, 11 Jul 2018 06:42:26 GMT

←Older revision		Revision as of 06:42, 11 July 2018
Line 1:		Line 1:
-	==CAV-2 ~~FIBRE HEAD IN COMPLEX WITH~~ CAR D1==	+
		+	==CAV-2 fibre head in complex with CAR D1==
	<StructureSection load='2j1k' size='340' side='right' caption='[[2j1k]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2j1k' size='340' side='right' caption='[[2j1k]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j1k]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Adec2 Adec2] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J1K FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j1k]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Adec2 Adec2] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J1K FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kac\|1kac]], [[1nob\|1nob]], [[1p69\|1p69]], [[1p6a\|1p6a]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kac\|1kac]], [[1nob\|1nob]], [[1p69\|1p69]], [[1p6a\|1p6a]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [http://pdbe.org/2j1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [http://www.ebi.ac.uk/pdbsum/2j1k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [http://pdbe.org/2j1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [http://www.ebi.ac.uk/pdbsum/2j1k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j1k ProSAT]</span></td></tr>
	</table>		</table>
-	== Function ==
-	[[http://www.uniprot.org/uniprot/SPIKE_ADECT SPIKE_ADECT]] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j1/2j1k_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j1/2j1k_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:31, 8 February 2016

OCA — Mon, 08 Feb 2016 07:31:17 GMT

←Older revision		Revision as of 07:31, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j1k ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:16, 10 September 2015

OCA — Thu, 10 Sep 2015 09:16:24 GMT

←Older revision		Revision as of 09:16, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2j1k' size='340' side='right' caption='[[2j1k]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2j1k' size='340' side='right' caption='[[2j1k]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j1k]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Canine_adenovirus_2 Canine adenovirus 2~~] and [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J1K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j1k]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Adec2 Adec2] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J1K FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kac\|1kac]], [[1nob\|1nob]], [[1p69\|1p69]], [[1p6a\|1p6a]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kac\|1kac]], [[1nob\|1nob]], [[1p69\|1p69]], [[1p6a\|1p6a]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [http://www.ebi.ac.uk/pdbsum/2j1k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [http://pdbe.org/2j1k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [http://www.ebi.ac.uk/pdbsum/2j1k PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~FIBP_ADECT FIBP_ADECT~~]] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).	+	[[http://www.uniprot.org/uniprot/SPIKE_ADECT SPIKE_ADECT]] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2j1k" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Canine adenovirus 2~~]]	+	[[Category: Adec2]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Billet, O]]		[[Category: Billet, O]]
	[[Category: Cusack, S]]		[[Category: Cusack, S]]

OCA at 21:39, 24 December 2014

OCA — Wed, 24 Dec 2014 21:39:40 GMT

←Older revision		Revision as of 21:39, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j1k]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Canine_adenovirus_2 Canine adenovirus 2] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J1K FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j1k]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Canine_adenovirus_2 Canine adenovirus 2] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J1K FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kac\|1kac]], [[1nob\|1nob]], [[1p69\|1p69]], [[1p6a\|1p6a]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kac\|1kac]], [[1nob\|1nob]], [[1p69\|1p69]], [[1p6a\|1p6a]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [http://www.ebi.ac.uk/pdbsum/2j1k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [http://www.ebi.ac.uk/pdbsum/2j1k PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FIBP_ADECT FIBP_ADECT]] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	[[Category: Canine adenovirus 2]]		[[Category: Canine adenovirus 2]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Billet, O.]]	+	[[Category: Billet, O]]
-	[[Category: Cusack, S.]]	+	[[Category: Cusack, S]]
-	[[Category: Kremer, E J.]]	+	[[Category: Kremer, E J]]
-	[[Category: Lortat-Jacob, H.]]	+	[[Category: Lortat-Jacob, H]]
-	[[Category: Seiradake, E.]]	+	[[Category: Seiradake, E]]
	[[Category: Adenovirus]]		[[Category: Adenovirus]]
	[[Category: Canine]]		[[Category: Canine]]

OCA at 11:35, 3 October 2014

OCA — Fri, 03 Oct 2014 11:35:47 GMT

←Older revision		Revision as of 11:35, 3 October 2014
Line 2:		Line 2:
	<StructureSection load='2j1k' size='340' side='right' caption='[[2j1k]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2j1k' size='340' side='right' caption='[[2j1k]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j1k]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Canine_adenovirus_2 Canine adenovirus 2] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. <br>	+	<table><tr><td colspan='2'>[[2j1k]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Canine_adenovirus_2 Canine adenovirus 2] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J1K FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kac\|1kac]], [[1nob\|1nob]], [[1p69\|1p69]], [[1p6a\|1p6a]]</td></tr>		</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kac\|1kac]], [[1nob\|1nob]], [[1p69\|1p69]], [[1p6a\|1p6a]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [http://www.ebi.ac.uk/pdbsum/2j1k PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [http://www.ebi.ac.uk/pdbsum/2j1k PDBsum]</span></td></tr>
	<table>		<table>
Line 23:		Line 22:
	Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor.,Seiradake E, Lortat-Jacob H, Billet O, Kremer EJ, Cusack S J Biol Chem. 2006 Nov 3;281(44):33704-16. Epub 2006 Aug 21. PMID:16923808<ref>PMID:16923808</ref>		Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor.,Seiradake E, Lortat-Jacob H, Billet O, Kremer EJ, Cusack S J Biol Chem. 2006 Nov 3;281(44):33704-16. Epub 2006 Aug 21. PMID:16923808<ref>PMID:16923808</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 09:52, 1 May 2014

OCA — Thu, 01 May 2014 09:52:00 GMT

←Older revision		Revision as of 09:52, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='2j1k' size='340' side='right' caption='[[2j1k]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2j1k' size='340' side='right' caption='[[2j1k]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	[[2j1k]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Canine_adenovirus_2 Canine adenovirus 2] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. <br>	+	<table><tr><td colspan='2'>[[2j1k]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Canine_adenovirus_2 Canine adenovirus 2] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. <br>
-	<b>[[Related_structure\|Related:]]</b> [[1kac\|1kac]], [[1nob\|1nob]], [[1p69\|1p69]], [[1p6a\|1p6a]]<br>	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kac\|1kac]], [[1nob\|1nob]], [[1p69\|1p69]], [[1p6a\|1p6a]]</td></tr>
-	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
-	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [http://www.ebi.ac.uk/pdbsum/2j1k PDBsum]</span><br>	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [http://www.ebi.ac.uk/pdbsum/2j1k PDBsum]</span></td></tr>
		+	<table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
-	[[Image:Consurf_key_small.gif\|right]]	+	[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
Line 16:		Line 17:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	Adenovirus fibers from most serotypes bind the D1 domain of coxsackie and adenovirus receptor (CAR), although the binding residues are not strictly conserved. To understand this further, we determined the crystal structures of canine adenovirus serotype 2 (CAV-2) and the human adenovirus serotype 37 (HAd37) in complex with human CAR D1 at 2.3 and 1.5A resolution, respectively. Structure comparison with the HAd12 fiber head-CAR D1 complex showed that the overall topology of the interaction is conserved but that the interfaces differ in number and identity of interacting residues, shape complementarity, and degree of conformational adaptation. Using surface plasmon resonance, we characterized the binding affinity to CAR D1 of wild type and mutant CAV-2 and HAd37 fiber heads. We found that CAV-2 has the highest affinity but fewest direct interactions, with the reverse being true for HAd37. Moreover, we found that conserved interactions can have a minor contribution, whereas serotype-specific interactions can be essential. These results are discussed in the light of virus evolution and design of adenovirus vectors for gene transfer.		Adenovirus fibers from most serotypes bind the D1 domain of coxsackie and adenovirus receptor (CAR), although the binding residues are not strictly conserved. To understand this further, we determined the crystal structures of canine adenovirus serotype 2 (CAV-2) and the human adenovirus serotype 37 (HAd37) in complex with human CAR D1 at 2.3 and 1.5A resolution, respectively. Structure comparison with the HAd12 fiber head-CAR D1 complex showed that the overall topology of the interaction is conserved but that the interfaces differ in number and identity of interacting residues, shape complementarity, and degree of conformational adaptation. Using surface plasmon resonance, we characterized the binding affinity to CAR D1 of wild type and mutant CAV-2 and HAd37 fiber heads. We found that CAV-2 has the highest affinity but fewest direct interactions, with the reverse being true for HAd37. Moreover, we found that conserved interactions can have a minor contribution, whereas serotype-specific interactions can be essential. These results are discussed in the light of virus evolution and design of adenovirus vectors for gene transfer.
Line 22:		Line 24:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:15, 30 April 2014

OCA — Wed, 30 Apr 2014 10:15:20 GMT

←Older revision		Revision as of 10:15, 30 April 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	[[2j1k]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Canine_adenovirus_2 Canine adenovirus 2] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. <br>		[[2j1k]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Canine_adenovirus_2 Canine adenovirus 2] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1K OCA]. <br>
-	<b>Related:</b> [[1kac\|1kac]], [[1nob\|1nob]], [[1p69\|1p69]], [[1p6a\|1p6a]]<br>	+	<b>[[Related_structure\|Related:]]</b> [[1kac\|1kac]], [[1nob\|1nob]], [[1p69\|1p69]], [[1p6a\|1p6a]]<br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j1k RCSB], [http://www.ebi.ac.uk/pdbsum/2j1k PDBsum]</span><br>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|right]]		[[Image:Consurf_key_small.gif\|right]]