2j2c - Revision history

OCA at 14:32, 13 December 2023

OCA — Wed, 13 Dec 2023 14:32:32 GMT

←Older revision		Revision as of 14:32, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2j2c' size='340' side='right'caption='[[2j2c]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2j2c' size='340' side='right'caption='[[2j2c]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J2C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J2C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j2c OCA], [https://pdbe.org/2j2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j2c RCSB], [https://www.ebi.ac.uk/pdbsum/2j2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j2c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j2c OCA], [https://pdbe.org/2j2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j2c RCSB], [https://www.ebi.ac.uk/pdbsum/2j2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j2c ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] Autosomal recessive spastic paraplegia type 45. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:24482476</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~5'-nucleotidase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith, C]]	+	[[Category: Arrowsmith C]]
-	~~[[Category: Berg, S Van Den~~]]	+	[[Category: Berglund H]]
-	[[Category: Berglund, H]]	+	[[Category: Busam R]]
-	[[Category: Busam, R]]	+	[[Category: Collins R]]
-	[[Category: Collins, R]]	+	[[Category: Edwards A]]
-	[[Category: Edwards, A]]	+	[[Category: Ehn M]]
-	[[Category: Ehn, M]]	+	[[Category: Flodin S]]
-	[[Category: Flodin, S]]	+	[[Category: Flores A]]
-	[[Category: Flores, A]]	+	[[Category: Graslund S]]
-	[[Category: Graslund, S]]	+	[[Category: Hallberg BM]]
-	[[Category: Hallberg~~, B M~~]]	+	[[Category: Hammarstrom M]]
-	[[Category: Hammarstrom, M]]	+	[[Category: Hogbom M]]
-	[[Category: Hogbom, M]]	+	[[Category: Holmberg Schiavone L]]
-	[[Category: Karlberg, T]]	+	[[Category: Karlberg T]]
-	[[Category: Kotenyova, T]]	+	[[Category: Kotenyova T]]
-	[[Category: Loppnau, P]]	+	[[Category: Loppnau P]]
-	[[Category: Magnusdottir, A]]	+	[[Category: Magnusdottir A]]
-	[[Category: Nilsson-Ehle, P]]	+	[[Category: Nilsson-Ehle P]]
-	[[Category: Nordlund, P]]	+	[[Category: Nordlund P]]
-	[[Category: Nyman, T]]	+	[[Category: Nyman T]]
-	[[Category: Ogg, D]]	+	[[Category: Ogg D]]
-	[[Category: Persson, C]]	+	[[Category: Persson C]]
-	[[Category: Sagemark, J]]	+	[[Category: Sagemark J]]
-	~~[[Category: Schiavone, L Holmberg~~]]	+	[[Category: Stenmark P]]
-	[[Category: Stenmark, P]]	+	[[Category: Sundstrom M]]
-	[[Category: Sundstrom, M]]	+	[[Category: Thorsell AG]]
-	[[Category: Thorsell~~, A G~~]]	+	[[Category: Uppenberg J]]
-	[[Category: Uppenberg, J]]	+	[[Category: Van Den Berg S]]
-	[[Category: ~~Wallden, K~~]]	+	[[Category: Wallden K]]
-	[[Category: ~~Weigelt, J~~]]	+	[[Category: Weigelt J]]
-	[[Category: ~~Welin, M~~]]	+	[[Category: Welin M]]
-	[[Category: ~~Allosteric enzyme]]~~	+
-	~~[[Category: Cn- ii]]~~	+
-	~~[[Category: Cytosolic 5-prime nucleotidase ii]]~~	+
-	~~[[Category: Cytosolic purine 5- prime nucleotidase]]~~	+
-	~~[[Category: Gmp- imp specific nucleotidase]]~~	+
-	~~[[Category: High km 5-prime nucleotidase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Nt5c2~~]]	+

OCA at 10:36, 8 December 2021

OCA — Wed, 08 Dec 2021 10:36:51 GMT

←Older revision		Revision as of 10:36, 8 December 2021
Line 3:		Line 3:
	<StructureSection load='2j2c' size='340' side='right'caption='[[2j2c]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2j2c' size='340' side='right'caption='[[2j2c]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j2c]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J2C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2J2C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J2C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2j2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j2c OCA], [~~http~~://pdbe.org/2j2c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2j2c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2j2c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2j2c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j2c OCA], [https://pdbe.org/2j2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j2c RCSB], [https://www.ebi.ac.uk/pdbsum/2j2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j2c ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:01, 4 March 2020

OCA — Wed, 04 Mar 2020 07:01:27 GMT

←Older revision		Revision as of 07:01, 4 March 2020
Line 1:		Line 1:

	==Crystal structure of Human Cytosolic 5'-Nucleotidase II (NT5C2, cN-II)==		==Crystal structure of Human Cytosolic 5'-Nucleotidase II (NT5C2, cN-II)==
-	<StructureSection load='2j2c' size='340' side='right' caption='[[2j2c]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2j2c' size='340' side='right'caption='[[2j2c]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J2C FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J2C FirstGlance]. <br>
Line 33:		Line 33:
	[[Category: 5'-nucleotidase]]		[[Category: 5'-nucleotidase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith, C]]
	[[Category: Berg, S Van Den]]		[[Category: Berg, S Van Den]]

OCA at 07:13, 11 July 2018

OCA — Wed, 11 Jul 2018 07:13:12 GMT

←Older revision		Revision as of 07:13, 11 July 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC~~ 5'-~~NUCLEOTIDASE~~ II (NT5C2, CN-II)==	+
		+	==Crystal structure of Human Cytosolic 5'-Nucleotidase II (NT5C2, cN-II)==
	<StructureSection load='2j2c' size='340' side='right' caption='[[2j2c]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2j2c' size='340' side='right' caption='[[2j2c]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j2c OCA], [http://pdbe.org/2j2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j2c RCSB], [http://www.ebi.ac.uk/pdbsum/2j2c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j2c OCA], [http://pdbe.org/2j2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j2c RCSB], [http://www.ebi.ac.uk/pdbsum/2j2c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j2c ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j2/2j2c_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j2/2j2c_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:48, 9 February 2016

OCA — Tue, 09 Feb 2016 15:48:07 GMT

←Older revision		Revision as of 15:48, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j2c ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:43, 10 September 2015

OCA — Thu, 10 Sep 2015 23:43:32 GMT

←Older revision		Revision as of 23:43, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2j2c' size='340' side='right' caption='[[2j2c]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2j2c' size='340' side='right' caption='[[2j2c]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J2C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J2C FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j2c RCSB], [http://www.ebi.ac.uk/pdbsum/2j2c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j2c OCA], [http://pdbe.org/2j2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j2c RCSB], [http://www.ebi.ac.uk/pdbsum/2j2c PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2j2c" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: 5'-nucleotidase]]		[[Category: 5'-nucleotidase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith, C]]
	[[Category: Berg, S Van Den]]		[[Category: Berg, S Van Den]]

OCA at 15:56, 19 January 2015

OCA — Mon, 19 Jan 2015 15:56:15 GMT

←Older revision		Revision as of 15:56, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J2C FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J2C FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j2c RCSB], [http://www.ebi.ac.uk/pdbsum/2j2c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j2c RCSB], [http://www.ebi.ac.uk/pdbsum/2j2c PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	[[Category: 5'-nucleotidase]]		[[Category: 5'-nucleotidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arrowsmith, C.]]	+	[[Category: Arrowsmith, C]]
-	[[Category: Berg, S Van Den.]]	+	[[Category: Berg, S Van Den]]
-	[[Category: Berglund, H.]]	+	[[Category: Berglund, H]]
-	[[Category: Busam, R.]]	+	[[Category: Busam, R]]
-	[[Category: Collins, R.]]	+	[[Category: Collins, R]]
-	[[Category: Edwards, A.]]	+	[[Category: Edwards, A]]
-	[[Category: Ehn, M.]]	+	[[Category: Ehn, M]]
-	[[Category: Flodin, S.]]	+	[[Category: Flodin, S]]
-	[[Category: Flores, A.]]	+	[[Category: Flores, A]]
-	[[Category: Graslund, S.]]	+	[[Category: Graslund, S]]
-	[[Category: Hallberg, B M.]]	+	[[Category: Hallberg, B M]]
-	[[Category: Hammarstrom, M.]]	+	[[Category: Hammarstrom, M]]
-	[[Category: Hogbom, M.]]	+	[[Category: Hogbom, M]]
-	[[Category: Karlberg, T.]]	+	[[Category: Karlberg, T]]
-	[[Category: Kotenyova, T.]]	+	[[Category: Kotenyova, T]]
-	[[Category: Loppnau, P.]]	+	[[Category: Loppnau, P]]
-	[[Category: Magnusdottir, A.]]	+	[[Category: Magnusdottir, A]]
-	[[Category: Nilsson-Ehle, P.]]	+	[[Category: Nilsson-Ehle, P]]
-	[[Category: Nordlund, P.]]	+	[[Category: Nordlund, P]]
-	[[Category: Nyman, T.]]	+	[[Category: Nyman, T]]
-	[[Category: Ogg, D.]]	+	[[Category: Ogg, D]]
-	[[Category: Persson, C.]]	+	[[Category: Persson, C]]
-	[[Category: Sagemark, J.]]	+	[[Category: Sagemark, J]]
-	[[Category: Schiavone, L Holmberg.]]	+	[[Category: Schiavone, L Holmberg]]
-	[[Category: Stenmark, P.]]	+	[[Category: Stenmark, P]]
-	[[Category: Sundstrom, M.]]	+	[[Category: Sundstrom, M]]
-	[[Category: Thorsell, A G.]]	+	[[Category: Thorsell, A G]]
-	[[Category: Uppenberg, J.]]	+	[[Category: Uppenberg, J]]
-	[[Category: Wallden, K.]]	+	[[Category: Wallden, K]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Welin, M.]]	+	[[Category: Welin, M]]
	[[Category: Allosteric enzyme]]		[[Category: Allosteric enzyme]]
	[[Category: Cn- ii]]		[[Category: Cn- ii]]

OCA at 09:01, 30 September 2014

OCA — Tue, 30 Sep 2014 09:01:35 GMT

←Older revision		Revision as of 09:01, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2j2c.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II (NT5C2, CN-II)==
		+	<StructureSection load='2j2c' size='340' side='right' caption='[[2j2c]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2j2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J2C FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j2c RCSB], [http://www.ebi.ac.uk/pdbsum/2j2c PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j2/2j2c_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytosolic 5'-nucleotidase II catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates and regulates the IMP and GMP pools within the cell. It possesses phosphotransferase activity and thereby also catalyzes the reverse reaction. Both reactions are allosterically activated by adenine-based nucleotides and 2,3-bisphosphoglycerate. We have solved structures of cytosolic 5'-nucleotidase II as native protein (2.2 Angstrom) and in complex with adenosine (1.5 Angstrom) and beryllium trifluoride (2.15 Angstrom) The tetrameric enzyme is structurally similar to enzymes of the haloacid dehalogenase (HAD) superfamily, including mitochondrial 5'(3')-deoxyribonucleotidase and cytosolic 5'-nucleotidase III but possesses additional regulatory regions that contain two allosteric effector sites. At effector site 1 located near a subunit interface we modeled diadenosine tetraphosphate with one adenosine moiety in each subunit. This efficiently glues the tetramer subunits together in pairs. The model shows why diadenosine tetraphosphate but not diadenosine triphosphate activates the enzyme and supports a role for cN-II during apoptosis when the level of diadenosine tetraphosphate increases. We have also modeled 2,3-bisphosphoglycerate in effector site 1 using one phosphate site from each subunit. By comparing the structure of cytosolic 5'-nucleotidase II with that of mitochondrial 5'(3')-deoxyribonucleotidase in complex with dGMP, we identified residues involved in substrate recognition.

-	~~{{STRUCTURE_2j2c\| PDB=2j2c \| SCENE= }}~~	+	Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition.,Wallden K, Stenmark P, Nyman T, Flodin S, Graslund S, Loppnau P, Bianchi V, Nordlund P J Biol Chem. 2007 Jun 15;282(24):17828-36. Epub 2007 Apr 3. PMID:17405878<ref>PMID:17405878</ref>

-	~~===CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II (NT5C2~~, ~~CN-II)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17405878}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2j2c]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2J2C OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017405878<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: 5'-nucleotidase]]		[[Category: 5'-nucleotidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA: Protected "2j2c" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 11:20:46 GMT

Protected "2j2c" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:20, 7 January 2013

OCA at 11:20, 7 January 2013

OCA — Mon, 07 Jan 2013 11:20:43 GMT

←Older revision		Revision as of 11:20, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2j2c.png\|left\|200px]]		[[Image:2j2c.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2j2c", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2j2c\| PDB=2j2c \| SCENE= }}		{{STRUCTURE_2j2c\| PDB=2j2c \| SCENE= }}

	===CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II (NT5C2, CN-II)===		===CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II (NT5C2, CN-II)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17405878}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17405878 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17405878}}		{{ABSTRACT_PUBMED_17405878}}

	==About this Structure==		==About this Structure==
-	~~2J2C~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J2C OCA].	+	[[2j2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J2C OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17405878~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017405878</ref><references group="xtra"/>
	[[Category: 5'-nucleotidase]]		[[Category: 5'-nucleotidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 58:		Line 46:
	[[Category: Welin, M.]]		[[Category: Welin, M.]]
	[[Category: Allosteric enzyme]]		[[Category: Allosteric enzyme]]
-	[[Category: Cn-ii]]	+	[[Category: Cn- ii]]
	[[Category: Cytosolic 5-prime nucleotidase ii]]		[[Category: Cytosolic 5-prime nucleotidase ii]]
-	[[Category: Cytosolic purine 5-prime nucleotidase]]	+	[[Category: Cytosolic purine 5- prime nucleotidase]]
-	[[Category: Gmp-imp specific nucleotidase]]	+	[[Category: Gmp- imp specific nucleotidase]]
	[[Category: High km 5-prime nucleotidase]]		[[Category: High km 5-prime nucleotidase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Nt5c2]]		[[Category: Nt5c2]]
-	[[Category: Polymorphism]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:56:52 2009''